Other Species / Isoforms
  HDAC6 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S16-p
TTTRQRRsRQNPQsP
0 5
HDAC6 (human) TTTRQRRsRQNPQsP S16-p
HDAC6 iso2 (human) gap -
HDAC6 (mouse) SSTRQRKsRHNPQsP S15-p
HDAC6 (rat) SSTRQRKSRHNPQsP S15
S22-p
RsRQNPQsPPQDSsV
Upstream
Downstream
5 51
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • molecular association, regulation
Kinase, in vitro:
  • GRK5 (human)
Putative in vivo kinases:
  • GRK5 (human)
Treatment
  • siRNA
HDAC6 (human) RsRQNPQsPPQDSsV S22-p
HDAC6 iso2 (human) gap -
HDAC6 (mouse) KsRHNPQsPLQESsA S21-p
HDAC6 (rat) KSRHNPQsPLQDSSA S21-p
S28-p
QsPPQDSsVtSkRNI
0 2
HDAC6 (human) QsPPQDSsVtSkRNI S28-p
HDAC6 iso2 (human) gap -
HDAC6 (mouse) QsPLQESsAtLKrGG S27-p
HDAC6 (rat) QsPLQDSSATLKRGG S27
T30-p
PPQDSsVtSkRNIkk
0 2
HDAC6 (human) PPQDSsVtSkRNIkk T30-p
HDAC6 iso2 (human) gap -
HDAC6 (mouse) PLQESsAtLKrGGKK T29-p
HDAC6 (rat) PLQDSSATLKRGGKK T29
K32-ub
QDSsVtSkRNIkkGA
0 1
HDAC6 (human) QDSsVtSkRNIkkGA K32-ub
HDAC6 iso2 (human) gap -
HDAC6 (mouse) QESsAtLKrGGKKCA K31
HDAC6 (rat) QDSSATLKRGGKKGA K31
R33
DSsVtSkRNIkkGAV
0 7
HDAC6 (human) DSsVtSkRNIkkGAV R33
HDAC6 iso2 (human) gap -
HDAC6 (mouse) ESsAtLKrGGKKCAV R32-m1
HDAC6 (rat) DSSATLKRGGKKGAV R32
K36-ac
VtSkRNIkkGAVPRs
0 1
HDAC6 (human) VtSkRNIkkGAVPRs K36-ac
HDAC6 iso2 (human) gap -
HDAC6 (mouse) AtLKrGGKKCAVPHs K35
HDAC6 (rat) ATLKRGGKKGAVPHS K35
K37-ac
tSkRNIkkGAVPRsI
0 1
HDAC6 (human) tSkRNIkkGAVPRsI K37-ac
HDAC6 iso2 (human) gap -
HDAC6 (mouse) tLKrGGKKCAVPHss K36
HDAC6 (rat) TLKRGGKKGAVPHSS K36
S43-p
kkGAVPRsIPNLAEV
Downstream
1 3
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell motility, induced
HDAC6 (human) kkGAVPRsIPNLAEV S43-p
HDAC6 iso2 (human) gap -
HDAC6 (mouse) KKCAVPHssPNLAEV S42-p
HDAC6 (rat) KKGAVPHSSPNLAEV S42
I44
kGAVPRsIPNLAEVk
0 11
HDAC6 (human) kGAVPRsIPNLAEVk I44
HDAC6 iso2 (human) gap -
HDAC6 (mouse) KCAVPHssPNLAEVK S43-p
HDAC6 (rat) KGAVPHSSPNLAEVK S43
K51-ub
IPNLAEVkKKGKMKK
0 1
HDAC6 (human) IPNLAEVkKKGKMKK K51-ub
HDAC6 iso2 (human) gap -
HDAC6 (mouse) sPNLAEVKKKGKMKK K50
HDAC6 (rat) SPNLAEVKKKGKMKK K50
G60
KGKMKKLGQAMEEDL
1 6
HDAC6 (human) KGKMKKLGQAMEEDL G60
HDAC6 iso2 (human) gap -
HDAC6 (mouse) KGKMKKLsQPAEEDL S59-p
HDAC6 (rat) KGKMKKLSQPAEEDL S59
G108
WDDSFPEGPERLHAI
0 1
HDAC6 (human) WDDSFPEGPERLHAI G108
HDAC6 iso2 (human) gap -
HDAC6 (mouse) WDDSFPEsPERLHAI S107-p
HDAC6 (rat) WDDSFPENPERLHAI N107
K116-ub
PERLHAIkEQLIQEG
Downstream
1 2
Effects on Modified Protein
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • DNA repair, induced
  • carcinogenesis, induced
  • cell growth, induced
HDAC6 (human) PERLHAIkEQLIQEG K116-ub
HDAC6 iso2 (human) gap -
HDAC6 (mouse) PERLHAIREQLILEG R115
HDAC6 (rat) PERLHAIKEQLILEG K115
S146-p
EELMLVHsLEYIDLM
1 1
HDAC6 (human) EELMLVHsLEYIDLM S146-p
HDAC6 iso2 (human) gap -
HDAC6 (mouse) EELMLVHSLEYIDLM S145
HDAC6 (rat) EELMLVHSLEYIDLM S145
Y319-p
VGMRDADyIAAFLHV
0 1
HDAC6 (human) VGMRDADyIAAFLHV Y319-p
HDAC6 iso2 (human) VGMRDADYIAAFLHV Y167
HDAC6 (mouse) TGMRDADYIAAFLHI Y318
HDAC6 (rat) VGMRDADYIAAFLHI Y318
S412-p
DPCPMLEsPGAPCRS
Downstream
1 2
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell motility, induced
HDAC6 (human) DPCPMLEsPGAPCRS S412-p
HDAC6 iso2 (human) DPCPMLESPGAPCRS S260
HDAC6 (mouse) DPCPMLESCVVPCAS S411
HDAC6 (rat) DPCPMLESPVAPCAS S411
S458-p
EEDNVEEsEEEGPWE
Upstream
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, inhibited
  • autophagy, induced
  • chromatin organization, altered
  • cytoskeletal reorganization
Kinase, in vitro:
  • CK2A1 (mouse)
Putative in vivo kinases:
  • CK2A1 (human)
Treatment
  • DRB
  • siRNA
  • TBB
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HDAC6 (human) EEDNVEEsEEEGPWE S458-p
HDAC6 iso2 (human) EEDNVEESEEEGPWE S306
HDAC6 (mouse) EEAVLEEEEEEGGWE E457
HDAC6 (rat) EGDMLEDEEEEGHWE E457
Y570-p
SSNFDSIyICPSTFA
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
Kinase, in vitro:
  • EGFR (human)
Treatment
  • EGF
HDAC6 (human) SSNFDSIyICPSTFA Y570-p
HDAC6 iso2 (human) SSNFDSIYICPSTFA Y418
HDAC6 (mouse) GANFDSIYICPSTFA Y569
HDAC6 (rat) GANFESIYICPSTFA Y569
T678-p
LHRYDHGtFFPMGDE
0 1
HDAC6 (human) LHRYDHGtFFPMGDE T678-p
HDAC6 iso2 (human) LHRYDHGTFFPMGDE T526
HDAC6 (mouse) LHRYDRGTFFPMGDE T677
HDAC6 (rat) LHRYDRGTFFPMGDE T677
S846-p
VEDREGPssSkLVTk
0 1
HDAC6 (human) VEDREGPssSkLVTk S846-p
HDAC6 iso2 (human) VEDREGPSSSKLVTK S694
HDAC6 (mouse) MEDKEECSSSRLVIK S845
HDAC6 (rat) MEDKEERSSSRLVIK S845
S847-p
EDREGPssSkLVTkk
0 2
HDAC6 (human) EDREGPssSkLVTkk S847-p
HDAC6 iso2 (human) EDREGPSSSKLVTKK S695
HDAC6 (mouse) EDKEECSSSRLVIKK S846
HDAC6 (rat) EDKEERSSSRLVIKK S846
K849-ac
REGPssSkLVTkkAP
0 2
HDAC6 (human) REGPssSkLVTkkAP K849-ac
HDAC6 iso2 (human) REGPSSSKLVTKKAP K697
HDAC6 (mouse) KEECSSSRLVIKKLP R848
HDAC6 (rat) KEERSSSRLVIKKLP R848
K849-ub
REGPssSkLVTkkAP
0 2
HDAC6 (human) REGPssSkLVTkkAP K849-ub
HDAC6 iso2 (human) REGPSSSKLVTKKAP K697
HDAC6 (mouse) KEECSSSRLVIKKLP R848
HDAC6 (rat) KEERSSSRLVIKKLP R848
K853-ac
ssSkLVTkkAPQPAk
0 2
HDAC6 (human) ssSkLVTkkAPQPAk K853-ac
HDAC6 iso2 (human) SSSKLVTKKAPQPAK K701
HDAC6 (mouse) SSSRLVIKKLPPTAs K852
HDAC6 (rat) SSSRLVIKKLPQSAS K852
K854-ac
sSkLVTkkAPQPAkP
0 2
HDAC6 (human) sSkLVTkkAPQPAkP K854-ac
HDAC6 iso2 (human) SSKLVTKKAPQPAKP K702
HDAC6 (mouse) SSRLVIKKLPPTAsP K853
HDAC6 (rat) SSRLVIKKLPQSASP K853
K854-ub
sSkLVTkkAPQPAkP
0 1
HDAC6 (human) sSkLVTkkAPQPAkP K854-ub
HDAC6 iso2 (human) SSKLVTKKAPQPAKP K702
HDAC6 (mouse) SSRLVIKKLPPTAsP K853
HDAC6 (rat) SSRLVIKKLPQSASP K853
K860
kkAPQPAKPRLAERM
0 3
HDAC6 (human) kkAPQPAKPRLAERM K860
HDAC6 iso2 (human) KKAPQPAKPRLAERM K708
HDAC6 (mouse) KKLPPTAsPVSAKEM S859-p
HDAC6 (rat) KKLPQSASPVSAKGM S859
K860-ub
kkAPQPAkPRLAERM
0 1
HDAC6 (human) kkAPQPAkPRLAERM K860-ub
HDAC6 iso2 (human) KKAPQPAKPRLAERM K708
HDAC6 (mouse) KKLPPTASPVSAKEM S859
HDAC6 (rat) KKLPQSASPVSAKGM S859
T868-p
PRLAERMtTREKkVL
0 1
HDAC6 (human) PRLAERMtTREKkVL T868-p
HDAC6 iso2 (human) PRLAERMTTREKKVL T716
HDAC6 (mouse) PVSAKEMTTPKGKVP T867
HDAC6 (rat) PVSAKGMTTPKGKVL T867
K873-ac
RMtTREKkVLEAGMG
0 1
HDAC6 (human) RMtTREKkVLEAGMG K873-ac
HDAC6 iso2 (human) RMTTREKKVLEAGMG K721
HDAC6 (mouse) EMTTPKGKVPEESVR K872
HDAC6 (rat) GMTTPKGKVLEAGMR K872
K881-ac
VLEAGMGkVTSASFG
0 1
HDAC6 (human) VLEAGMGkVTSASFG K881-ac
HDAC6 iso2 (human) VLEAGMGKVTSASFG K729
HDAC6 (mouse) VPEESVRKTIAALPG K880
HDAC6 (rat) VLEAGMRKPTAALPT K880
P910
VALTQDQPSEAATGG
0 4
HDAC6 (human) VALTQDQPSEAATGG P910
HDAC6 iso2 (human) VALTQDQPSEAATGG P758
HDAC6 (mouse) AVLAQGQssEQAAKG S909-p
HDAC6 (rat) ALLAQGQsSEQAAKG S909-p
S911
ALTQDQPSEAATGGA
0 1
HDAC6 (human) ALTQDQPSEAATGGA S911
HDAC6 iso2 (human) ALTQDQPSEAATGGA S759
HDAC6 (mouse) VLAQGQssEQAAKGT S910-p
HDAC6 (rat) LLAQGQsSEQAAKGT S910
T923-p
GGATLAQtIsEAAIG
0 1
HDAC6 (human) GGATLAQtIsEAAIG T923-p
HDAC6 iso2 (human) GGATLAQTISEAAIG T771
HDAC6 (mouse) gap -
HDAC6 (rat) gap -
S925-p
ATLAQtIsEAAIGGA
0 1
HDAC6 (human) ATLAQtIsEAAIGGA S925-p
HDAC6 iso2 (human) ATLAQTISEAAIGGA S773
HDAC6 (mouse) gap -
HDAC6 (rat) gap -
T993-p
GGATLAQtTsEAAME
0 1
HDAC6 (human) GGATLAQtTsEAAME T993-p
HDAC6 iso2 (human) GGATLAQTTSEAAME T841
HDAC6 (mouse) gap -
HDAC6 (rat) GGATTDQCASVAATE C936
S995-p
ATLAQtTsEAAMEGA
0 1
HDAC6 (human) ATLAQtTsEAAMEGA S995-p
HDAC6 iso2 (human) ATLAQTTSEAAMEGA S843
HDAC6 (mouse) gap -
HDAC6 (rat) ATTDQCASVAATENS S938
T1003-p
EAAMEGAtLDQTTSE
0 1
HDAC6 (human) EAAMEGAtLDQTTSE T1003-p
HDAC6 iso2 (human) EAAMEGATLDQTTSE T851
HDAC6 (mouse) AAAPENFPNQTTSVE P946
HDAC6 (rat) VAATENSANQTTSGE A946
T1016-p
SEEAPGGtELIQtPL
0 1
HDAC6 (human) SEEAPGGtELIQtPL T1016-p
HDAC6 iso2 (human) SEEAPGGTELIQTPL T864
HDAC6 (mouse) SVEALGETEPtPPAS T958
HDAC6 (rat) GEEASGETESFGTSP T959
T1021-p
GGtELIQtPLASStD
0 2
HDAC6 (human) GGtELIQtPLASStD T1021-p
HDAC6 iso2 (human) GGTELIQTPLASSTD T869
HDAC6 (mouse) ALGETEPtPPASHTN T961-p
HDAC6 (rat) GETESFGTSPSSNAS T964
T1027-p
QtPLASStDHQtPPt
0 1
HDAC6 (human) QtPLASStDHQtPPt T1027-p
HDAC6 iso2 (human) QTPLASSTDHQTPPT T875
HDAC6 (mouse) PtPPASHTNKQTTGA T967
HDAC6 (rat) GTSPSSNASKQTTGA A970
T1031-p
ASStDHQtPPtsPVQ
Upstream
1 2
Kinase, in vitro:
  • ERK1 (human)
Putative in vivo kinases:
  • ERK1 (human)
  • ERK2 (human)
HDAC6 (human) ASStDHQtPPtsPVQ T1031-p
HDAC6 iso2 (human) ASSTDHQTPPTSPVQ T879
HDAC6 (mouse) ASHTNKQTTGASPLQ T971
HDAC6 (rat) SSNASKQTTGASPLH T974
T1034-p
tDHQtPPtsPVQGtt
0 1
HDAC6 (human) tDHQtPPtsPVQGtt T1034-p
HDAC6 iso2 (human) TDHQTPPTSPVQGTT T882
HDAC6 (mouse) TNKQTTGASPLQGVT A974
HDAC6 (rat) ASKQTTGASPLHGAA A977
S1035-p
DHQtPPtsPVQGttP
Upstream
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • cell motility, induced
Kinase, in vitro:
  • ERK1 (human)
Treatment
  • EGF
  • U0126
HDAC6 (human) DHQtPPtsPVQGttP S1035-p
HDAC6 iso2 (human) DHQTPPTSPVQGTTP S883
HDAC6 (mouse) NKQTTGASPLQGVTA S975
HDAC6 (rat) SKQTTGASPLHGAAA S978
T1040-p
PtsPVQGttPQISPS
0 1
HDAC6 (human) PtsPVQGttPQISPS T1040-p
HDAC6 iso2 (human) PTSPVQGTTPQISPS T888
HDAC6 (mouse) GASPLQGVTAQQSLQ V980
HDAC6 (rat) GASPLHGAAAQQSPE A983
T1041-p
tsPVQGttPQISPSt
0 1
HDAC6 (human) tsPVQGttPQISPSt T1041-p
HDAC6 iso2 (human) TSPVQGTTPQISPST T889
HDAC6 (mouse) ASPLQGVTAQQSLQL T981
HDAC6 (rat) ASPLHGAAAQQSPEL A984
T1048-p
tPQISPStLIGSLRt
0 1
HDAC6 (human) tPQISPStLIGSLRt T1048-p
HDAC6 iso2 (human) TPQISPSTLIGSLRT T896
HDAC6 (mouse) GVTAQQSLQLGVLST L986
HDAC6 (rat) gap -
T1055-p
tLIGSLRtLELGSEs
0 1
HDAC6 (human) tLIGSLRtLELGSEs T1055-p
HDAC6 iso2 (human) TLIGSLRTLELGSES T903
HDAC6 (mouse) LQLGVLSTLELSREA T993
HDAC6 (rat) PELGLSSTLELSSEA T996
S1062-p
tLELGSEsQGASESQ
0 2
HDAC6 (human) tLELGSEsQGASESQ S1062-p
HDAC6 iso2 (human) TLELGSESQGASESQ S910
HDAC6 (mouse) TLELSREAEEAHDSE A1000
HDAC6 (rat) TLELSSEAQEVQESE A1003
D1088-ca
AGGQDMAdSMLMQGS
0 1
HDAC6 (human) AGGQDMAdSMLMQGS D1088-ca
HDAC6 iso2 (human) AGGQDMADSMLMQGS D936
HDAC6 (mouse) AGGQDMNSLMLTQGF S1022
HDAC6 (rat) AGGQDMNSLMLTQGF S1025
D1100
QGSRGLTDQAIFYAV
0 1
HDAC6 (human) QGSRGLTDQAIFYAV D1100
HDAC6 iso2 (human) QGSRGLTDQAIFYAV D948
HDAC6 (mouse) QGFGDFNtQDVFYAV T1034-p
HDAC6 (rat) QGFGDFNTQDVFYAV T1037
K1206-ub
KNIAHQNkFGEDMPH
0 1
HDAC6 (human) KNIAHQNkFGEDMPH K1206-ub
HDAC6 iso2 (human) KNIAHQNKFGEDMPH K1054
HDAC6 (mouse) KNAAHQNKFGEDMPH K1140
HDAC6 (rat) KNAAHQNKFGEGMPH K1143
P1214
FGEDMPHPH______
0 6
HDAC6 (human) FGEDMPHPH______ P1214
HDAC6 iso2 (human) FGEDMPHPH______ P1062
HDAC6 (mouse) FGEDMPHsH______ S1148-p
HDAC6 (rat) FGEGMPHLQ______ L1151