|
S76
|
DGVQLAESNRTRITG
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
DGVQLAESNRTRITG
|
S76
|
|
FGFR1 iso2 (human)
|
DGVQLAESNRTRITG
|
S76
|
|
FGFR1 iso14 (human)
|
gap
|
-
|
|
FGFR1 iso21 (human)
|
DGVQLAESNRTRITG
|
S109
|
|
FGFR1 (mouse)
|
DGVQLVEsnRTRITG
|
S76-p
|
|
FGFR1 (rat)
|
gap
|
-
|
|
FGFR1 iso2 (rat)
|
DGVQLAESNRTRITG
|
S76
|
|
|
N77
|
GVQLAESNRTRITGE
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
GVQLAESNRTRITGE
|
N77
|
|
FGFR1 iso2 (human)
|
GVQLAESNRTRITGE
|
N77
|
|
FGFR1 iso14 (human)
|
gap
|
-
|
|
FGFR1 iso21 (human)
|
GVQLAESNRTRITGE
|
N110
|
|
FGFR1 (mouse)
|
GVQLVEsnRTRITGE
|
N77-ng
|
|
FGFR1 (rat)
|
gap
|
-
|
|
FGFR1 iso2 (rat)
|
GVQLAESNRTRITGE
|
N77
|
|
|
S91-p
|
EEVEVQDsVPADSGL
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
EEVEVQDsVPADSGL
|
S91-p
|
|
FGFR1 iso2 (human)
|
EEVEVQDSVPADSGL
|
S91
|
|
FGFR1 iso14 (human)
|
gap
|
-
|
|
FGFR1 iso21 (human)
|
EEVEVQDSVPADSGL
|
S124
|
|
FGFR1 (mouse)
|
EEVEVRDSIPADSGL
|
S91
|
|
FGFR1 (rat)
|
gap
|
-
|
|
FGFR1 iso2 (rat)
|
EEVEVRDSIPADSGL
|
S91
|
|
|
Y154-p
|
NRMPVAPyWTSPEKM
|
Upstream
|
Downstream
|
2
|
1
|
|
|
|
Effects on Modified Protein
- protein degradation
- receptor desensitization, altered
- receptor internalization, altered
|
|
Effects on Biological Processes:
- cytoskeletal reorganization
|
|
|
Kinase, in vitro:
|
|
Regulatory protein:
|
|
Treatment
|
|
|
FGFR1 (human)
|
NRMPVAPyWTSPEKM
|
Y154-p
|
|
FGFR1 iso2 (human)
|
NRMPVAPYWTSPEKM
|
Y154
|
|
FGFR1 iso14 (human)
|
KPNPVAPYWTSPEKM
|
Y63
|
|
FGFR1 iso21 (human)
|
KPNPVAPYWTSPEKM
|
Y185
|
|
FGFR1 (mouse)
|
NRRPVAPYWTSPEKM
|
Y154
|
|
FGFR1 (rat)
|
KPNPVAPYWTSPEKM
|
Y63
|
|
FGFR1 iso2 (rat)
|
NRRPVAPYWTSPEKM
|
Y154
|
|
|
K164-ac
|
SPEKMEKkLHAVPAA
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
SPEKMEKkLHAVPAA
|
K164-ac
|
|
FGFR1 iso2 (human)
|
SPEKMEKKLHAVPAA
|
K164
|
|
FGFR1 iso14 (human)
|
SPEKMEKKLHAVPAA
|
K73
|
|
FGFR1 iso21 (human)
|
SPEKMEKKLHAVPAA
|
K195
|
|
FGFR1 (mouse)
|
SPEKMEKKLHAVPAA
|
K164
|
|
FGFR1 (rat)
|
SPEKMEKKLHAVPAA
|
K73
|
|
FGFR1 iso2 (rat)
|
SPEKMEKKLHAVPAA
|
K164
|
|
|
K172-ac
|
LHAVPAAkTVKFKCP
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
LHAVPAAkTVKFKCP
|
K172-ac
|
|
FGFR1 iso2 (human)
|
LHAVPAAKTVKFKCP
|
K172
|
|
FGFR1 iso14 (human)
|
LHAVPAAKTVKFKCP
|
K81
|
|
FGFR1 iso21 (human)
|
LHAVPAAKTVKFKCP
|
K203
|
|
FGFR1 (mouse)
|
LHAVPAAKTVKFKCP
|
K172
|
|
FGFR1 (rat)
|
LHAVPAAKTVKFKCP
|
K81
|
|
FGFR1 iso2 (rat)
|
LHAVPAAKTVKFKCP
|
K172
|
|
|
S180
|
TVKFKCPSSGTPNPT
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
TVKFKCPSSGTPNPT
|
S180
|
|
FGFR1 iso2 (human)
|
TVKFKCPSSGTPNPT
|
S180
|
|
FGFR1 iso14 (human)
|
TVKFKCPSSGTPNPT
|
S89
|
|
FGFR1 iso21 (human)
|
TVKFKCPSSGTPNPT
|
S211
|
|
FGFR1 (mouse)
|
TVKFKCPsSGTPNPT
|
S180-p
|
|
FGFR1 (rat)
|
TVKFKCPSSGTPSPT
|
S89
|
|
FGFR1 iso2 (rat)
|
TVKFKCPSSGTPSPT
|
S180
|
|
|
K198
|
LKNGKEFKPDHRIGG
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
LKNGKEFKPDHRIGG
|
K198
|
|
FGFR1 iso2 (human)
|
LKNGKEFKPDHRIGG
|
K198
|
|
FGFR1 iso14 (human)
|
LKNGKEFKPDHRIGG
|
K107
|
|
FGFR1 iso21 (human)
|
LKNGKEFKPDHRIGG
|
K229
|
|
FGFR1 (mouse)
|
LKNGKEFkPDHRIGG
|
K198-ub
|
|
FGFR1 (rat)
|
LKNGKEFKPDHRIGG
|
K107
|
|
FGFR1 iso2 (rat)
|
LKNGKEFKPDHRIGG
|
K198
|
|
|
Y210-p
|
IGGYKVRyATWSIIM
|
|
|
1
|
1
|
|
|
|
FGFR1 (human)
|
IGGYKVRyATWSIIM
|
Y210-p
|
|
FGFR1 iso2 (human)
|
IGGYKVRYATWSIIM
|
Y210
|
|
FGFR1 iso14 (human)
|
IGGYKVRYATWSIIM
|
Y119
|
|
FGFR1 iso21 (human)
|
IGGYKVRYATWSIIM
|
Y241
|
|
FGFR1 (mouse)
|
IGGYKVRYATWSIIM
|
Y210
|
|
FGFR1 (rat)
|
IGGYKVRYATWSIIM
|
Y119
|
|
FGFR1 iso2 (rat)
|
IGGYKVRYATWSIIM
|
Y210
|
|
|
N227
|
VVPSDKGNYTCIVEN
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
VVPSDKGNYTCIVEN
|
N227
|
|
FGFR1 iso2 (human)
|
VVPSDKGNYTCIVEN
|
N227
|
|
FGFR1 iso14 (human)
|
VVPSDKGNYTCIVEN
|
N136
|
|
FGFR1 iso21 (human)
|
VVPSDKGNYTCIVEN
|
N258
|
|
FGFR1 (mouse)
|
VVPSDKGnYTCIVEN
|
N227-ng
|
|
FGFR1 (rat)
|
VVPSDKGNYTCIVEN
|
N136
|
|
FGFR1 iso2 (rat)
|
VVPSDKGNYTCIVEN
|
N227
|
|
|
N240
|
ENEYGSINHTYQLDV
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
ENEYGSINHTYQLDV
|
N240
|
|
FGFR1 iso2 (human)
|
ENEYGSINHTYQLDV
|
N240
|
|
FGFR1 iso14 (human)
|
ENEYGSINHTYQLDV
|
N149
|
|
FGFR1 iso21 (human)
|
ENEYGSINHTYQLDV
|
N271
|
|
FGFR1 (mouse)
|
ENEYGSInHTYQLDV
|
N240-ng
|
|
FGFR1 (rat)
|
ENEYGSINHTYQLDV
|
N149
|
|
FGFR1 iso2 (rat)
|
ENEYGSINHTYQLDV
|
N240
|
|
|
N264
|
LQAGLPANKTVALGS
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
LQAGLPANKTVALGS
|
N264
|
|
FGFR1 iso2 (human)
|
LQAGLPANKTVALGS
|
N264
|
|
FGFR1 iso14 (human)
|
LQAGLPANKTVALGS
|
N173
|
|
FGFR1 iso21 (human)
|
LQAGLPANKTVALGS
|
N295
|
|
FGFR1 (mouse)
|
LQAGLPAnKTVALGS
|
N264-ng
|
|
FGFR1 (rat)
|
LQAGLPANKTVALGS
|
N173
|
|
FGFR1 iso2 (rat)
|
LQAGLPANKTVALGS
|
N264
|
|
|
Y280-p
|
VEFMCKVySDPQPHI
|
|
|
1
|
1
|
|
|
|
FGFR1 (human)
|
VEFMCKVySDPQPHI
|
Y280-p
|
|
FGFR1 iso2 (human)
|
VEFMCKVYSDPQPHI
|
Y280
|
|
FGFR1 iso14 (human)
|
VEFMCKVYSDPQPHI
|
Y189
|
|
FGFR1 iso21 (human)
|
VEFMCKVYSDPQPHI
|
Y311
|
|
FGFR1 (mouse)
|
VEFMCKVYSDPQPHI
|
Y280
|
|
FGFR1 (rat)
|
VEFMCKVYSDPQPHI
|
Y189
|
|
FGFR1 iso2 (rat)
|
VEFMCKVYSDPQPHI
|
Y280
|
|
|
N296
|
WLKHIEVNGSKIGPD
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
WLKHIEVNGSKIGPD
|
N296
|
|
FGFR1 iso2 (human)
|
WLKHIEVNGSKIGPD
|
N296
|
|
FGFR1 iso14 (human)
|
WLKHIEVNGSKIGPD
|
N205
|
|
FGFR1 iso21 (human)
|
WLKHIEVNGSKIGPD
|
N327
|
|
FGFR1 (mouse)
|
WLKHIEVnGSKIGPD
|
N296-ng
|
|
FGFR1 (rat)
|
WLKHIEVNGSKIGPD
|
N205
|
|
FGFR1 iso2 (rat)
|
WLKHIEVNGSKIGPD
|
N296
|
|
|
Y307-p
|
IGPDNLPyVQILKTA
|
|
|
1
|
1
|
|
|
|
FGFR1 (human)
|
IGPDNLPyVQILKTA
|
Y307-p
|
|
FGFR1 iso2 (human)
|
IGPDNLPYVQILKTA
|
Y307
|
|
FGFR1 iso14 (human)
|
IGPDNLPYVQILKTA
|
Y216
|
|
FGFR1 iso21 (human)
|
IGPDNLPYVQILKTA
|
Y338
|
|
FGFR1 (mouse)
|
IGPDNLPYVQILKTA
|
Y307
|
|
FGFR1 (rat)
|
IGPDNLPYVQILKTA
|
Y216
|
|
FGFR1 iso2 (rat)
|
IGPDNLPYDQILKTA
|
Y307
|
|
|
N317
|
ILKTAGVNTTDKEME
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
ILKTAGVNTTDKEME
|
N317
|
|
FGFR1 iso2 (human)
|
ILKTAGVNTTDKEME
|
N317
|
|
FGFR1 iso14 (human)
|
ILKTAGVNTTDKEME
|
N226
|
|
FGFR1 iso21 (human)
|
ILKTAGVNTTDKEME
|
N348
|
|
FGFR1 (mouse)
|
ILKTAGVnTTDKEME
|
N317-ng
|
|
FGFR1 (rat)
|
ILKTAGVNTTDKEME
|
N226
|
|
FGFR1 iso2 (rat)
|
ILKTAGVNTTDKEME
|
N317
|
|
|
N330
|
MEVLHLRNVSFEDAG
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
MEVLHLRNVSFEDAG
|
N330
|
|
FGFR1 iso2 (human)
|
MEVLHLRNVSFEDAG
|
N330
|
|
FGFR1 iso14 (human)
|
MEVLHLRNVSFEDAG
|
N239
|
|
FGFR1 iso21 (human)
|
MEVLHLRNVSFEDAG
|
N361
|
|
FGFR1 (mouse)
|
MEVLHLRnVSFEDAG
|
N330-ng
|
|
FGFR1 (rat)
|
MEVLHLRNVSFEDAG
|
N239
|
|
FGFR1 iso2 (rat)
|
MEVLHLRNVSFEDAG
|
N330
|
|
|
T403-p
|
VYKMKSGtKKSDFHs
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
VYKMKSGtKKSDFHs
|
T403-p
|
|
FGFR1 iso2 (human)
|
VYKMKSGTKKSDFHS
|
T403
|
|
FGFR1 iso14 (human)
|
VYKMKSGTKKSDFHS
|
T312
|
|
FGFR1 iso21 (human)
|
VYKMKSGTKKSDFHS
|
T434
|
|
FGFR1 (mouse)
|
IYKMKSGTKKSDFHS
|
T403
|
|
FGFR1 (rat)
|
IYKMKSGTKKSDFHS
|
T312
|
|
FGFR1 iso2 (rat)
|
IYKMKSGTKKSDFHS
|
T403
|
|
|
S410-p
|
tKKSDFHsQMAVHkL
|
|
|
0
|
2
|
|
|
|
FGFR1 (human)
|
tKKSDFHsQMAVHkL
|
S410-p
|
|
FGFR1 iso2 (human)
|
TKKSDFHSQMAVHKL
|
S410
|
|
FGFR1 iso14 (human)
|
TKKSDFHSQMAVHKL
|
S319
|
|
FGFR1 iso21 (human)
|
TKKSDFHSQMAVHKL
|
S441
|
|
FGFR1 (mouse)
|
TKKSDFHSQMAVHKL
|
S410
|
|
FGFR1 (rat)
|
TKKSDFHSQMAVHKL
|
S319
|
|
FGFR1 iso2 (rat)
|
TKKSDFHSQMAVHKL
|
S410
|
|
|
K416-ub
|
HsQMAVHkLAKSIPL
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
HsQMAVHkLAKSIPL
|
K416-ub
|
|
FGFR1 iso2 (human)
|
HSQMAVHKLAKSIPL
|
K416
|
|
FGFR1 iso14 (human)
|
HSQMAVHKLAKSIPL
|
K325
|
|
FGFR1 iso21 (human)
|
HSQMAVHKLAKSIPL
|
K447
|
|
FGFR1 (mouse)
|
HSQMAVHKLAKSIPL
|
K416
|
|
FGFR1 (rat)
|
HSQMAVHKLAKSIPL
|
K325
|
|
FGFR1 iso2 (rat)
|
HSQMAVHKLAKSIPL
|
K416
|
|
|
T428-p
|
IPLRRQVtVSADSSA
|
|
|
0
|
7
|
|
|
|
FGFR1 (human)
|
IPLRRQVtVSADSSA
|
T428-p
|
|
FGFR1 iso2 (human)
|
gap
|
-
|
|
FGFR1 iso14 (human)
|
IPLRRQVTVSADSSA
|
T337
|
|
FGFR1 iso21 (human)
|
IPLRRQVTVSADSSA
|
T459
|
|
FGFR1 (mouse)
|
IPLRRQVTVSADSSA
|
T428
|
|
FGFR1 (rat)
|
gap
|
-
|
|
FGFR1 iso2 (rat)
|
IPLRRQVTVSADSSA
|
T428
|
|
|
S439-p
|
DSSASMNsGVLLVRP
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
DSSASMNsGVLLVRP
|
S439-p
|
|
FGFR1 iso2 (human)
|
DSSASMNSGVLLVRP
|
S437
|
|
FGFR1 iso14 (human)
|
DSSASMNSGVLLVRP
|
S348
|
|
FGFR1 iso21 (human)
|
DSSASMNSGVLLVRP
|
S470
|
|
FGFR1 (mouse)
|
DSSASMNSGVLLVRP
|
S439
|
|
FGFR1 (rat)
|
DSSASMNSGVLLVRP
|
S346
|
|
FGFR1 iso2 (rat)
|
DSSASMNSGVLLVRP
|
S439
|
|
|
S447-p
|
GVLLVRPsRLsssGt
|
Upstream
|
|
0
|
2
|
|
|
|
|
|
FGFR1 (human)
|
GVLLVRPsRLsssGt
|
S447-p
|
|
FGFR1 iso2 (human)
|
GVLLVRPSRLSSSGT
|
S445
|
|
FGFR1 iso14 (human)
|
GVLLVRPSRLSSSGT
|
S356
|
|
FGFR1 iso21 (human)
|
GVLLVRPSRLSSSGT
|
S478
|
|
FGFR1 (mouse)
|
GVLLVRPSRLssSGT
|
S447
|
|
FGFR1 (rat)
|
GVLLVRPSRLSSSGT
|
S354
|
|
FGFR1 iso2 (rat)
|
GVLLVRPSRLSSSGT
|
S447
|
|
|
S450-p
|
LVRPsRLsssGtPML
|
Upstream
|
|
0
|
10
|
|
|
|
|
|
FGFR1 (human)
|
LVRPsRLsssGtPML
|
S450-p
|
|
FGFR1 iso2 (human)
|
LVRPSRLSSSGTPML
|
S448
|
|
FGFR1 iso14 (human)
|
LVRPSRLSSSGTPML
|
S359
|
|
FGFR1 iso21 (human)
|
LVRPSRLSSSGTPML
|
S481
|
|
FGFR1 (mouse)
|
LVRPSRLssSGTPML
|
S450-p
|
|
FGFR1 (rat)
|
LVRPSRLSSSGTPML
|
S357
|
|
FGFR1 iso2 (rat)
|
LVRPSRLSSSGTPML
|
S450
|
|
|
S451-p
|
VRPsRLsssGtPMLA
|
Upstream
|
|
0
|
8
|
|
|
|
|
|
FGFR1 (human)
|
VRPsRLsssGtPMLA
|
S451-p
|
|
FGFR1 iso2 (human)
|
VRPSRLSSSGTPMLA
|
S449
|
|
FGFR1 iso14 (human)
|
VRPSRLSSSGTPMLA
|
S360
|
|
FGFR1 iso21 (human)
|
VRPSRLSSSGTPMLA
|
S482
|
|
FGFR1 (mouse)
|
VRPSRLssSGTPMLA
|
S451-p
|
|
FGFR1 (rat)
|
VRPSRLSSSGTPMLA
|
S358
|
|
FGFR1 iso2 (rat)
|
VRPSRLSSSGTPMLA
|
S451
|
|
|
S452-p
|
RPsRLsssGtPMLAG
|
Upstream
|
|
0
|
4
|
|
|
|
|
|
FGFR1 (human)
|
RPsRLsssGtPMLAG
|
S452-p
|
|
FGFR1 iso2 (human)
|
RPSRLSSSGTPMLAG
|
S450
|
|
FGFR1 iso14 (human)
|
RPSRLSSSGTPMLAG
|
S361
|
|
FGFR1 iso21 (human)
|
RPSRLSSSGTPMLAG
|
S483
|
|
FGFR1 (mouse)
|
RPSRLssSGTPMLAG
|
S452
|
|
FGFR1 (rat)
|
RPSRLSSSGTPMLAG
|
S359
|
|
FGFR1 iso2 (rat)
|
RPSRLSSSGTPMLAG
|
S452
|
|
|
T454-p
|
sRLsssGtPMLAGVS
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
sRLsssGtPMLAGVS
|
T454-p
|
|
FGFR1 iso2 (human)
|
SRLSSSGTPMLAGVS
|
T452
|
|
FGFR1 iso14 (human)
|
SRLSSSGTPMLAGVS
|
T363
|
|
FGFR1 iso21 (human)
|
SRLSSSGTPMLAGVS
|
T485
|
|
FGFR1 (mouse)
|
SRLssSGTPMLAGVS
|
T454
|
|
FGFR1 (rat)
|
SRLSSSGTPMLAGVS
|
T361
|
|
FGFR1 iso2 (rat)
|
SRLSSSGTPMLAGVS
|
T454
|
|
|
Y463-p
|
MLAGVSEyELPEDPR
|
Upstream
|
Downstream
|
6
|
12
|
|
|
|
Effects on Modified Protein
- molecular association, regulation
|
|
Effects on Biological Processes:
- cell cycle regulation
- cell growth, altered
- transcription, altered
|
|
|
Kinase, in vitro:
|
|
Putative in vivo kinases:
|
|
Treatment
|
|
|
FGFR1 (human)
|
MLAGVSEyELPEDPR
|
Y463-p
|
|
FGFR1 iso2 (human)
|
MLAGVSEYELPEDPR
|
Y461
|
|
FGFR1 iso14 (human)
|
MLAGVSEYELPEDPR
|
Y372
|
|
FGFR1 iso21 (human)
|
MLAGVSEYELPEDPR
|
Y494
|
|
FGFR1 (mouse)
|
MLAGVSEYELPEDPR
|
Y463
|
|
FGFR1 (rat)
|
MLAGVSEYELPEDPR
|
Y370
|
|
FGFR1 iso2 (rat)
|
MLAGVSEYELPEDPR
|
Y463
|
|
|
K482-ub
|
RDRLVLGkPLGEGCF
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
RDRLVLGkPLGEGCF
|
K482-ub
|
|
FGFR1 iso2 (human)
|
RDRLVLGKPLGEGCF
|
K480
|
|
FGFR1 iso14 (human)
|
RDRLVLGKPLGEGCF
|
K391
|
|
FGFR1 iso21 (human)
|
RDRLVLGKPLGEGCF
|
K513
|
|
FGFR1 (mouse)
|
RDRLVLGKPLGEGCF
|
K482
|
|
FGFR1 (rat)
|
RDRLVLGKPLGEGCF
|
K389
|
|
FGFR1 iso2 (rat)
|
RDRLVLGKPLGEGCF
|
K482
|
|
|
K510-ub
|
DKPNRVTkVAVKMLK
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
DKPNRVTkVAVKMLK
|
K510-ub
|
|
FGFR1 iso2 (human)
|
DKPNRVTKVAVKMLK
|
K508
|
|
FGFR1 iso14 (human)
|
DKPNRVTKVAVKMLK
|
K419
|
|
FGFR1 iso21 (human)
|
DKPNRVTKVAVKMLK
|
K541
|
|
FGFR1 (mouse)
|
DKPNRVTKVAVKMLK
|
K510
|
|
FGFR1 (rat)
|
DKPNRVTKVAVKMLK
|
K417
|
|
FGFR1 iso2 (rat)
|
DKPNRVTKVAVKMLK
|
K510
|
|
|
Y572-p
|
SKGNLREyLQARRPP
|
|
|
0
|
2
|
|
|
|
FGFR1 (human)
|
SKGNLREyLQARRPP
|
Y572-p
|
|
FGFR1 iso2 (human)
|
SKGNLREYLQARRPP
|
Y570
|
|
FGFR1 iso14 (human)
|
SKGNLREYLQARRPP
|
Y481
|
|
FGFR1 iso21 (human)
|
SKGNLREYLQARRPP
|
Y603
|
|
FGFR1 (mouse)
|
SKGNLREYLQARRPP
|
Y572
|
|
FGFR1 (rat)
|
SKGNLREYLQARRPP
|
Y479
|
|
FGFR1 iso2 (rat)
|
SKGNLREYLQARRPP
|
Y572
|
|
|
Y583-p
|
RRPPGLEyCyNPsHN
|
Upstream
|
|
4
|
68
|
|
|
|
Kinase, in vitro:
|
|
Putative in vivo kinases:
|
|
Treatment
|
|
|
FGFR1 (human)
|
RRPPGLEyCyNPsHN
|
Y583-p
|
|
FGFR1 iso2 (human)
|
RRPPGLEYCYNPSHN
|
Y581
|
|
FGFR1 iso14 (human)
|
RRPPGLEYCYNPSHN
|
Y492
|
|
FGFR1 iso21 (human)
|
RRPPGLEYCYNPSHN
|
Y614
|
|
FGFR1 (mouse)
|
RRPPGLEyCyNPSHN
|
Y583-p
|
|
FGFR1 (rat)
|
RRPPGLEYCYNPSHN
|
Y490
|
|
FGFR1 iso2 (rat)
|
RRPPGLEYCYNPSHN
|
Y583
|
|
|
Y585-p
|
PPGLEyCyNPsHNPE
|
Upstream
|
|
4
|
44
|
|
|
|
Kinase, in vitro:
|
|
Putative in vivo kinases:
|
|
Treatment
|
|
|
FGFR1 (human)
|
PPGLEyCyNPsHNPE
|
Y585-p
|
|
FGFR1 iso2 (human)
|
PPGLEYCYNPSHNPE
|
Y583
|
|
FGFR1 iso14 (human)
|
PPGLEYCYNPSHNPE
|
Y494
|
|
FGFR1 iso21 (human)
|
PPGLEYCYNPSHNPE
|
Y616
|
|
FGFR1 (mouse)
|
PPGLEyCyNPSHNPE
|
Y585-p
|
|
FGFR1 (rat)
|
PPGLEYCYNPSHNPE
|
Y492
|
|
FGFR1 iso2 (rat)
|
PPGLEYCYNPSHNPE
|
Y585
|
|
|
S588-p
|
LEyCyNPsHNPEEQL
|
|
|
0
|
2
|
|
|
|
FGFR1 (human)
|
LEyCyNPsHNPEEQL
|
S588-p
|
|
FGFR1 iso2 (human)
|
LEYCYNPSHNPEEQL
|
S586
|
|
FGFR1 iso14 (human)
|
LEYCYNPSHNPEEQL
|
S497
|
|
FGFR1 iso21 (human)
|
LEYCYNPSHNPEEQL
|
S619
|
|
FGFR1 (mouse)
|
LEyCyNPSHNPEEQL
|
S588
|
|
FGFR1 (rat)
|
LEYCYNPSHNPEEQL
|
S495
|
|
FGFR1 iso2 (rat)
|
LEYCYNPSHNPEEQL
|
S588
|
|
|
Y605-p
|
KDLVSCAyQVARGME
|
Upstream
|
|
1
|
13
|
|
|
|
Putative in vivo kinases:
|
|
|
FGFR1 (human)
|
KDLVSCAyQVARGME
|
Y605-p
|
|
FGFR1 iso2 (human)
|
KDLVSCAYQVARGME
|
Y603
|
|
FGFR1 iso14 (human)
|
KDLVSCAYQVARGME
|
Y514
|
|
FGFR1 iso21 (human)
|
KDLVSCAYQVARGME
|
Y636
|
|
FGFR1 (mouse)
|
KDLVSCAyQVARGME
|
Y605-p
|
|
FGFR1 (rat)
|
KDLVSCAYQVARGME
|
Y512
|
|
FGFR1 iso2 (rat)
|
KDLVSCAYQVARGME
|
Y605
|
|
|
Y613-p
|
QVARGMEyLASKKCI
|
|
|
0
|
6
|
|
|
|
FGFR1 (human)
|
QVARGMEyLASKKCI
|
Y613-p
|
|
FGFR1 iso2 (human)
|
QVARGMEYLASKKCI
|
Y611
|
|
FGFR1 iso14 (human)
|
QVARGMEYLASKKCI
|
Y522
|
|
FGFR1 iso21 (human)
|
QVARGMEYLASKKCI
|
Y644
|
|
FGFR1 (mouse)
|
QVARGMEyLASKKCI
|
Y613-p
|
|
FGFR1 (rat)
|
QVARGMEYLASKKCI
|
Y520
|
|
FGFR1 iso2 (rat)
|
QVARGMEYLASKKCI
|
Y613
|
|
|
K638-ub
|
VTEDNVMkIADFGLA
|
|
|
0
|
2
|
|
|
|
FGFR1 (human)
|
VTEDNVMkIADFGLA
|
K638-ub
|
|
FGFR1 iso2 (human)
|
VTEDNVMKIADFGLA
|
K636
|
|
FGFR1 iso14 (human)
|
VTEDNVMKIADFGLA
|
K547
|
|
FGFR1 iso21 (human)
|
VTEDNVMKIADFGLA
|
K669
|
|
FGFR1 (mouse)
|
VTEDNVMKIADFGLA
|
K638
|
|
FGFR1 (rat)
|
VTEDNVMKIADFGLA
|
K545
|
|
FGFR1 iso2 (rat)
|
VTEDNVMKIADFGLA
|
K638
|
|
|
Y653-p
|
RDIHHIDyykKTTNG
|
Upstream
|
Downstream
|
18
|
338
|
|
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- phosphorylation
|
|
Effects on Biological Processes:
- cell differentiation, altered
- cell growth, altered
- cell motility, altered
|
|
|
Kinase, in vitro:
|
|
Putative in vivo kinases:
- Etk (human)
- FGFR1 (mouse)
|
|
Regulatory protein:
- API5 (human)
- Bcr (human)
- FGF12 (human)
- FGFR2 (human)
- PTPRH (human)
|
|
Treatment
- antibody
- FGF1
- FGF2
- FGF7
- JAK_inhibitor_I
- MK-2461
- PD173074
- serum
- SU5402
- SU6656
|
|
|
FGFR1 (human)
|
RDIHHIDyykKTTNG
|
Y653-p
|
|
FGFR1 iso2 (human)
|
RDIHHIDYYKKTTNG
|
Y651
|
|
FGFR1 iso14 (human)
|
RDIHHIDYYKKTTNG
|
Y562
|
|
FGFR1 iso21 (human)
|
RDIHHIDYYKKTTNG
|
Y684
|
|
FGFR1 (mouse)
|
RDIHHIDyyKKTTNG
|
Y653-p
|
|
FGFR1 (rat)
|
RDIHHIDyyKKTTNG
|
Y560-p
|
|
FGFR1 iso2 (rat)
|
RDIHHIDYYKKTTNG
|
Y653
|
|
|
Y654-p
|
DIHHIDyykKTTNGR
|
Upstream
|
Downstream
|
18
|
189
|
|
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- phosphorylation
|
|
Effects on Biological Processes:
- cell differentiation, altered
- cell growth, altered
- cell motility, altered
|
|
|
Kinase, in vitro:
|
|
Putative in vivo kinases:
- Etk (human)
- FGFR1 (mouse)
|
|
Regulatory protein:
- API5 (human)
- Bcr (human)
- FGF12 (human)
- FGFR2 (human)
- PTPRH (human)
|
|
Treatment
- antibody
- dovitinib
- FGF1
- FGF2
- FGF7
- infigratinib
- JAK_inhibitor_I
- MK-2461
- PD173074
- serum
- SU5402
- SU6656
|
|
|
FGFR1 (human)
|
DIHHIDyykKTTNGR
|
Y654-p
|
|
FGFR1 iso2 (human)
|
DIHHIDYYKKTTNGR
|
Y652
|
|
FGFR1 iso14 (human)
|
DIHHIDYYKKTTNGR
|
Y563
|
|
FGFR1 iso21 (human)
|
DIHHIDYYKKTTNGR
|
Y685
|
|
FGFR1 (mouse)
|
DIHHIDyyKKTTNGR
|
Y654-p
|
|
FGFR1 (rat)
|
DIHHIDyyKKTTNGR
|
Y561-p
|
|
FGFR1 iso2 (rat)
|
DIHHIDYYKKTTNGR
|
Y654
|
|
|
K655-ub
|
IHHIDyykKTTNGRL
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
IHHIDyykKTTNGRL
|
K655-ub
|
|
FGFR1 iso2 (human)
|
IHHIDYYKKTTNGRL
|
K653
|
|
FGFR1 iso14 (human)
|
IHHIDYYKKTTNGRL
|
K564
|
|
FGFR1 iso21 (human)
|
IHHIDYYKKTTNGRL
|
K686
|
|
FGFR1 (mouse)
|
IHHIDyyKKTTNGRL
|
K655
|
|
FGFR1 (rat)
|
IHHIDyyKKTTNGRL
|
K562
|
|
FGFR1 iso2 (rat)
|
IHHIDYYKKTTNGRL
|
K655
|
|
|
Y677-p
|
EALFDRIyTHQSDVW
|
|
Downstream
|
2
|
0
|
|
|
|
Effects on Modified Protein
- molecular association, regulation
|
|
|
FGFR1 (human)
|
EALFDRIyTHQSDVW
|
Y677-p
|
|
FGFR1 iso2 (human)
|
EALFDRIYTHQSDVW
|
Y675
|
|
FGFR1 iso14 (human)
|
EALFDRIYTHQSDVW
|
Y586
|
|
FGFR1 iso21 (human)
|
EALFDRIYTHQSDVW
|
Y708
|
|
FGFR1 (mouse)
|
EALFDRIYTHQSDVW
|
Y677
|
|
FGFR1 (rat)
|
EALFDRIyTHQSDVW
|
Y584-p
|
|
FGFR1 iso2 (rat)
|
EALFDRIYTHQSDVW
|
Y677
|
|
|
Y701
|
FTLGGSPYPGVPVEE
|
|
|
1
|
0
|
|
|
|
FGFR1 (human)
|
FTLGGSPYPGVPVEE
|
Y701
|
|
FGFR1 iso2 (human)
|
FTLGGSPYPGVPVEE
|
Y699
|
|
FGFR1 iso14 (human)
|
FTLGGSPYPGVPVEE
|
Y610
|
|
FGFR1 iso21 (human)
|
FTLGGSPYPGVPVEE
|
Y732
|
|
FGFR1 (mouse)
|
FTLGGSPYPGVPVEE
|
Y701
|
|
FGFR1 (rat)
|
FTLGGSPyPGVPVEE
|
Y608-p
|
|
FGFR1 iso2 (rat)
|
FTLGGSPNPGVPVEE
|
N701
|
|
|
Y730-p
|
SNCTNELyMMMRDCW
|
Upstream
|
Downstream
|
5
|
2
|
|
|
|
Effects on Biological Processes:
- cell cycle regulation
- transcription, altered
|
|
|
Kinase, in vitro:
|
|
Treatment
|
|
|
FGFR1 (human)
|
SNCTNELyMMMRDCW
|
Y730-p
|
|
FGFR1 iso2 (human)
|
SNCTNELYMMMRDCW
|
Y728
|
|
FGFR1 iso14 (human)
|
SNCTNELYMMMRDCW
|
Y639
|
|
FGFR1 iso21 (human)
|
SNCTNELYMMMRDCW
|
Y761
|
|
FGFR1 (mouse)
|
SNCTNELYMMMRDCW
|
Y730
|
|
FGFR1 (rat)
|
SNCTNELyMMMRDCW
|
Y637-p
|
|
FGFR1 iso2 (rat)
|
SNCTNELYMMMRDCW
|
Y730
|
|
|
K748-ub
|
PSQRPTFkQLVEDLD
|
|
|
0
|
2
|
|
|
|
FGFR1 (human)
|
PSQRPTFkQLVEDLD
|
K748-ub
|
|
FGFR1 iso2 (human)
|
PSQRPTFKQLVEDLD
|
K746
|
|
FGFR1 iso14 (human)
|
PSQRPTFKQLVEDLD
|
K657
|
|
FGFR1 iso21 (human)
|
PSQRPTFKQLVEDLD
|
K779
|
|
FGFR1 (mouse)
|
PSQRPTFKQLVEDLD
|
K748
|
|
FGFR1 (rat)
|
PSQRPTFKQLVEDLD
|
K655
|
|
FGFR1 iso2 (rat)
|
PSQRPTFKQLVEDLD
|
K748
|
|
|
Y766-p
|
ALTSNQEyLDLSMPL
|
Upstream
|
Downstream
|
10
|
1
|
|
|
|
|
|
Effects on Modified Protein
- molecular association, regulation
- phosphorylation
|
|
Effects on Biological Processes:
- carcinogenesis, induced
- cell growth, induced
|
|
|
Kinase, in vitro:
|
|
Treatment
|
|
|
FGFR1 (human)
|
ALTSNQEyLDLSMPL
|
Y766-p
|
|
FGFR1 iso2 (human)
|
ALTSNQEYLDLSMPL
|
Y764
|
|
FGFR1 iso14 (human)
|
ALTSNQEYLDLSMPL
|
Y675
|
|
FGFR1 iso21 (human)
|
ALTSNQEYLDLSMPL
|
Y797
|
|
FGFR1 (mouse)
|
ALTSNQEyLDLSIPL
|
Y766-p
|
|
FGFR1 (rat)
|
ALTSNQEyLDLSMPL
|
Y673-p
|
|
FGFR1 iso2 (rat)
|
ALTSNQEYLDLSMPL
|
Y766
|
|
|
Y776-p
|
LSMPLDQysPsFPDT
|
|
|
2
|
3
|
|
|
|
FGFR1 (human)
|
LSMPLDQysPsFPDT
|
Y776-p
|
|
FGFR1 iso2 (human)
|
LSMPLDQYSPSFPDT
|
Y774
|
|
FGFR1 iso14 (human)
|
LSMPLDQYSPSFPDT
|
Y685
|
|
FGFR1 iso21 (human)
|
LSMPLDQYSPSFPDT
|
Y807
|
|
FGFR1 (mouse)
|
LSIPLDQYSPSFPDT
|
Y776
|
|
FGFR1 (rat)
|
LSMPLDQySPSFPDT
|
Y683-p
|
|
FGFR1 iso2 (rat)
|
LSMPLDQDSPSFPDT
|
D776
|
|
|
S777-p
|
SMPLDQysPsFPDTR
|
Upstream
|
Downstream
|
4
|
1
|
|
|
|
Effects on Modified Protein
- intracellular localization
|
|
Effects on Biological Processes:
- cell growth, inhibited
- cell motility, inhibited
|
|
|
Kinase, in vitro:
- ERK1 (human)
- ERK2 (human)
- P38A (human)
|
|
Putative in vivo kinases:
- ERK1 (human)
- P38A (human)
|
|
Treatment
- anisomycin
- BI-D1870
- EGF
- FGF1
- phorbol_ester
- SB203580
- serum
- U0126
- wortmannin
|
|
|
FGFR1 (human)
|
SMPLDQysPsFPDTR
|
S777-p
|
|
FGFR1 iso2 (human)
|
SMPLDQYSPSFPDTR
|
S775
|
|
FGFR1 iso14 (human)
|
SMPLDQYSPSFPDTR
|
S686
|
|
FGFR1 iso21 (human)
|
SMPLDQYSPSFPDTR
|
S808
|
|
FGFR1 (mouse)
|
SIPLDQYSPSFPDTR
|
S777
|
|
FGFR1 (rat)
|
SMPLDQySPSFPDTR
|
S684
|
|
FGFR1 iso2 (rat)
|
SMPLDQDSPSFPDTR
|
S777
|
|
|
S779-p
|
PLDQysPsFPDTRSS
|
Upstream
|
Downstream
|
1
|
0
|
|
|
|
Effects on Biological Processes:
- apoptosis, inhibited
- cell differentiation, induced
|
|
|
Kinase, in vitro:
|
|
Putative in vivo kinases:
|
|
|
FGFR1 (human)
|
PLDQysPsFPDTRSS
|
S779-p
|
|
FGFR1 iso2 (human)
|
PLDQYSPSFPDTRSS
|
S777
|
|
FGFR1 iso14 (human)
|
PLDQYSPSFPDTRSS
|
S688
|
|
FGFR1 iso21 (human)
|
PLDQYSPSFPDTRSS
|
S810
|
|
FGFR1 (mouse)
|
PLDQYSPSFPDTRSS
|
S779
|
|
FGFR1 (rat)
|
PLDQySPSFPDTRSS
|
S686
|
|
FGFR1 iso2 (rat)
|
PLDQDSPSFPDTRSS
|
S779
|
|
|
S789-p
|
DTRSSTCsSGEDSVF
|
Upstream
|
Downstream
|
1
|
2
|
|
|
|
Effects on Modified Protein
- phosphorylation
- ubiquitination
|
|
Effects on Biological Processes:
- endocytosis, induced
- signaling pathway regulation
|
|
|
Kinase, in vitro:
|
|
Putative in vivo kinases:
|
|
Treatment
- BI-D1870
- EGF
- FGF1
- siRNA
- SL0101
- U0126
|
|
|
FGFR1 (human)
|
DTRSSTCsSGEDSVF
|
S789-p
|
|
FGFR1 iso2 (human)
|
DTRSSTCSSGEDSVF
|
S787
|
|
FGFR1 iso14 (human)
|
DTRSSTCSSGEDSVF
|
S698
|
|
FGFR1 iso21 (human)
|
DTRSSTCSSGEDSVF
|
S820
|
|
FGFR1 (mouse)
|
DTRSSTCssGEDSVF
|
S789-p
|
|
FGFR1 (rat)
|
DTRSSTCSSGEDSVF
|
S696
|
|
FGFR1 iso2 (rat)
|
DTRSSTCSSGEDSVF
|
S789
|
|
|
S790
|
TRSSTCsSGEDSVFS
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
TRSSTCsSGEDSVFS
|
S790
|
|
FGFR1 iso2 (human)
|
TRSSTCSSGEDSVFS
|
S788
|
|
FGFR1 iso14 (human)
|
TRSSTCSSGEDSVFS
|
S699
|
|
FGFR1 iso21 (human)
|
TRSSTCSSGEDSVFS
|
S821
|
|
FGFR1 (mouse)
|
TRSSTCssGEDSVFS
|
S790-p
|
|
FGFR1 (rat)
|
TRSSTCSSGEDSVFS
|
S697
|
|
FGFR1 iso2 (rat)
|
TRSSTCSSGEDSVFS
|
S790
|
|
|
G817
|
HPAQLANGGLKRR__
|
|
|
0
|
1
|
|
|
|
FGFR1 (human)
|
HPAQLANGGLKRR__
|
G817
|
|
FGFR1 iso2 (human)
|
HPAQLANGGLKRR__
|
G815
|
|
FGFR1 iso14 (human)
|
HPAQLANGGLKRR__
|
G726
|
|
FGFR1 iso21 (human)
|
HPAQLANGGLKRR__
|
G848
|
|
FGFR1 (mouse)
|
HPTQLANsGLKRR__
|
S817-p
|
|
FGFR1 (rat)
|
HPTQLANGGLKRR__
|
G724
|
|
FGFR1 iso2 (rat)
|
HPTQLANGGLNRR__
|
G817
|
|
