Other Species / Isoforms
  SIRT1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S14-p
LALQPGGsPsAAGAD
Upstream
2 25
Treatment
  • glucose_starvation
SIRT1 (human) LALQPGGsPsAAGAD S14-p
SIRT1 (mouse) LALQAAGsPsAAAAM S14-p
SIRT1 (rat) LALQAGGSPSAAAAM S14
S16-p
LQPGGsPsAAGADRE
0 3
SIRT1 (human) LQPGGsPsAAGADRE S16-p
SIRT1 (mouse) LQAAGsPsAAAAMEA S16-p
SIRT1 (rat) LQAGGSPSAAAAMEA S16
S26-p
GADREAAssPAGEPL
0 8
SIRT1 (human) GADREAAssPAGEPL S26-p
SIRT1 (mouse) AAAMEAASQPADEPL S25
SIRT1 (rat) AAAMEAASQPADEPL S25
S27-p
ADREAAssPAGEPLR
Upstream
Downstream
5 19
SIRT1 (human)
S27-p
Effects on Modified Protein
  • acetylation
  • activity, induced
  • enzymatic activity, induced
  • intracellular localization
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • CAMKK2 (human)
  • HIPK2 (human)
  • JNK1 (human)
view more >
Putative in vivo kinases:
  • CAMKK2 (human)
  • JNK1 (human)
Treatment
  • anisomycin
  • pulsatile shear stress
  • SB203580
  • siRNA
  • SP600125
  • STO-609
  • U0126
view more >
SIRT1 (human) ADREAAssPAGEPLR S27-p
SIRT1 (mouse) AAMEAASQPADEPLR Q26
SIRT1 (rat) AAMEAASQPADEPLR Q26
S47-p
DGPGLERsPGEPGGA
Upstream
Downstream
8 58
SIRT1 (human)
S47-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • intracellular localization
  • protein stabilization
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell growth, induced
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • CAMKK2 (human)
  • JNK1 (human)
Putative in vivo kinases:
  • CAMKK2 (human)
  • CDK9 (human)
  • JNK1 (human)
view more >
Treatment
  • 5MQ
  • anisomycin
  • JBSF-88
  • LDC067
  • LRRK2-IN-1
  • menadione
  • nocodazole
  • oroxylin A
  • PHA-767491
  • pulsatile shear stress
  • siRNA
  • SP600125
  • STO-609
view more >
SIRT1 (human) DGPGLERsPGEPGGA S47-p
SIRT1 (mouse) DGPGLGRsPGEPsAA S46-p
SIRT1 (rat) DGPGLGRSPGEPSAA S46
G52
ERsPGEPGGAAPERE
0 2
SIRT1 (human) ERsPGEPGGAAPERE G52
SIRT1 (mouse) GRsPGEPsAAVAPAA S51-p
SIRT1 (rat) GRSPGEPSAAAAAAA S51
T154
LFGDEIITNGFHsCE
0 1
SIRT1 (human) LFGDEIITNGFHsCE T154
SIRT1 (mouse) LLTDGLLtNGFHsCE T146-p
SIRT1 (rat) LLADEIITNGFHSCE T148
S159-p
IITNGFHsCEsDEED
0 5
SIRT1 (human) IITNGFHsCEsDEED S159-p
SIRT1 (mouse) LLtNGFHsCEsDDDD S151-p
SIRT1 (rat) IITNGFHSCESDDDD S153
S162-p
NGFHsCEsDEEDRAS
2 4
SIRT1 (human) NGFHsCEsDEEDRAS S162-p
SIRT1 (mouse) NGFHsCEsDDDDRTS S154-p
SIRT1 (rat) NGFHSCESDDDDRAS S156
S172-p
EDRASHAssSDWTPR
1 4
SIRT1 (human) EDRASHAssSDWTPR S172-p
SIRT1 (mouse) DDRTSHAsSSDWTPR S164-p
SIRT1 (rat) DDRASHASSSDWTPR S166
S173-p
DRASHAssSDWTPRP
0 2
SIRT1 (human) DRASHAssSDWTPRP S173-p
SIRT1 (mouse) DRTSHAsSSDWTPRP S165
SIRT1 (rat) DRASHASSSDWTPRP S167
K238-ub
PPKRKKRkDINTIED
0 6
SIRT1 (human) PPKRKKRkDINTIED K238-ub
SIRT1 (mouse) PPKRKKRKDINTIED K230
SIRT1 (rat) PPKRKKRKDINTIED K232
K248-ub
NTIEDAVkLLQECKK
0 1
SIRT1 (human) NTIEDAVkLLQECKK K248-ub
SIRT1 (mouse) NTIEDAVKLLQECKK K240
SIRT1 (rat) NTIEDAVKLLQECKK K242
Y280-p
FRSRDGIyARLAVDF
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Putative in vivo kinases:
  • JAK1 (human)
Treatment
  • IL-6
  • PF-04965842
SIRT1 (human) FRSRDGIyARLAVDF Y280-p
SIRT1 (mouse) FRSRDGIYARLAVDF Y272
SIRT1 (rat) FRSRDGIYARLAVDF Y274
Y301-p
QAMFDIEyFRKDPRP
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Putative in vivo kinases:
  • JAK1 (human)
Treatment
  • IL-6
  • PF-04965842
SIRT1 (human) QAMFDIEyFRKDPRP Y301-p
SIRT1 (mouse) QAMFDIEYFRKDPRP Y293
SIRT1 (rat) QAMFDIEYFRKDPRP Y295
K311-ub
KDPRPFFkFAkEIYP
0 1
SIRT1 (human) KDPRPFFkFAkEIYP K311-ub
SIRT1 (mouse) KDPRPFFKFAKEIYP K303
SIRT1 (rat) KDPRPFFKFAKEIYP K305
K314-ub
RPFFkFAkEIYPGQF
0 3
SIRT1 (human) RPFFkFAkEIYPGQF K314-ub
SIRT1 (mouse) RPFFKFAKEIYPGQF K306
SIRT1 (rat) RPFFKFAKEIYPGQF K308
K328-ub
FQPSLCHkFIALsDk
0 1
SIRT1 (human) FQPSLCHkFIALsDk K328-ub
SIRT1 (mouse) FQPSLCHKFIALSDK K320
SIRT1 (rat) FQPSLCHKFIALSDK K322
S333-p
CHkFIALsDkEGkLL
0 2
SIRT1 (human) CHkFIALsDkEGkLL S333-p
SIRT1 (mouse) CHKFIALSDKEGKLL S325
SIRT1 (rat) CHKFIALSDKEGKLL S327
K335-ub
kFIALsDkEGkLLRN
0 1
SIRT1 (human) kFIALsDkEGkLLRN K335-ub
SIRT1 (mouse) KFIALSDKEGKLLRN K327
SIRT1 (rat) KFIALSDKEGKLLRN K329
K338-ub
ALsDkEGkLLRNYtQ
0 1
SIRT1 (human) ALsDkEGkLLRNYtQ K338-ub
SIRT1 (mouse) ALSDKEGKLLRNYTQ K330
SIRT1 (rat) ALSDKEGKLLRNYTQ K332
T344-p
GkLLRNYtQNIDTLE
Upstream
Downstream
3 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
  • cytoskeletal reorganization
Kinase, in vitro:
  • AurA (human)
Putative in vivo kinases:
  • AurA (human)
SIRT1 (human) GkLLRNYtQNIDTLE T344-p
SIRT1 (mouse) GKLLRNYTQNIDTLE T336
SIRT1 (rat) GKLLRNYTQNIDTLE T338
Y428-p
QFHRAMKyDkDEVDL
0 1
SIRT1 (human) QFHRAMKyDkDEVDL Y428-p
SIRT1 (mouse) QFHRAMKYDKDEVDL Y420
SIRT1 (rat) QFHRAMKYDKDEVDL Y422
K430-ac
HRAMKyDkDEVDLLI
0 1
SIRT1 (human) HRAMKyDkDEVDLLI K430-ac
SIRT1 (mouse) HRAMKYDKDEVDLLI K422
SIRT1 (rat) HRAMKYDKDEVDLLI K424
S441-p
DLLIVIGssLkVRPV
0 1
SIRT1 (human) DLLIVIGssLkVRPV S441-p
SIRT1 (mouse) DLLIVIGSsLKVRPV S433
SIRT1 (rat) DLLIVIGSSLKVRPV S435
S442-p
LLIVIGssLkVRPVA
1 2
SIRT1 (human) LLIVIGssLkVRPVA S442-p
SIRT1 (mouse) LLIVIGSsLKVRPVA S434-p
SIRT1 (rat) LLIVIGSSLKVRPVA S436
K444-ac
IVIGssLkVRPVALI
0 1
SIRT1 (human) IVIGssLkVRPVALI K444-ac
SIRT1 (mouse) IVIGSsLKVRPVALI K436
SIRT1 (rat) IVIGSSLKVRPVALI K438
K499-ub
RLGGEYAkLCCNPVk
Downstream
1 5
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • carcinogenesis, inhibited
  • cell growth, inhibited
  • cell motility, inhibited
SIRT1 (human) RLGGEYAkLCCNPVk K499-ub
SIRT1 (mouse) RLGGEYAKLCCNPVK K491
SIRT1 (rat) RLGGEYAKLCCNPVK K493
K506-ub
kLCCNPVkLSEITEk
0 1
SIRT1 (human) kLCCNPVkLSEITEk K506-ub
SIRT1 (mouse) KLCCNPVKLSEITEK K498
SIRT1 (rat) KLCCNPVKLSEITEK K500
K513-ub
kLSEITEkPPRTQkE
0 2
SIRT1 (human) kLSEITEkPPRTQkE K513-ub
SIRT1 (mouse) KLSEITEKPPRPQKE K505
SIRT1 (rat) KLSEITEKPPRTQKE K507
K519-ub
EkPPRTQkELAYLSE
Downstream
1 1
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • carcinogenesis, inhibited
  • cell growth, inhibited
  • cell motility, inhibited
SIRT1 (human) EkPPRTQkELAYLSE K519-ub
SIRT1 (mouse) EKPPRPQKELVHLSE K511
SIRT1 (rat) EKPPRTQKELVHLSE K513
T530-p
YLSELPPtPLHVsED
Upstream
Downstream
7 43
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • autophagy, induced
  • cell cycle regulation
  • cytoskeletal reorganization
Kinase, in vitro:
  • CDK1 (human)
  • JNK1 (human)
Putative in vivo kinases:
  • JNK1 (human)
Regulatory protein:
  • AMPKA1 (human)
  • CDK1 (human)
Treatment
  • acadesine
  • anisomycin
  • compound_C
  • glucose_starvation
  • SP600125
view more >
SIRT1 (human) YLSELPPtPLHVsED T530-p
SIRT1 (mouse) HLSELPPtPLHIsED T522-p
SIRT1 (rat) HLSELPPTPLHISED T524
S535-p
PPtPLHVsEDsssPE
0 12
SIRT1 (human) PPtPLHVsEDsssPE S535-p
SIRT1 (mouse) PPtPLHIsEDsssPE S527-p
SIRT1 (rat) PPTPLHISEDSSsPE S529
S538-p
PLHVsEDsssPERts
0 8
SIRT1 (human) PLHVsEDsssPERts S538-p
SIRT1 (mouse) PLHIsEDsssPERTV S530-p
SIRT1 (rat) PLHISEDSSsPERTV S532
S539-p
LHVsEDsssPERtsP
0 4
SIRT1 (human) LHVsEDsssPERtsP S539-p
SIRT1 (mouse) LHIsEDsssPERTVP S531-p
SIRT1 (rat) LHISEDSSsPERTVP S533
S540-p
HVsEDsssPERtsPP
Upstream
Downstream
2 9
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • intracellular localization
Effects on Biological Processes:
  • cell cycle regulation
  • cytoskeletal reorganization
Kinase, in vitro:
  • CDK1 (human)
Regulatory protein:
  • CDK1 (human)
SIRT1 (human) HVsEDsssPERtsPP S540-p
SIRT1 (mouse) HIsEDsssPERTVPQ S532-p
SIRT1 (rat) HISEDSSsPERTVPQ S534-p
T544-p
DsssPERtsPPDsSV
0 2
SIRT1 (human) DsssPERtsPPDsSV T544-p
SIRT1 (mouse) DsssPERTVPQDSSV T536
SIRT1 (rat) DSSsPERTVPQDSSV T538
S545-p
sssPERtsPPDsSVI
0 1
SIRT1 (human) sssPERtsPPDsSVI S545-p
SIRT1 (mouse) sssPERTVPQDSSVI V537
SIRT1 (rat) SSsPERTVPQDSSVI V539
S549-p
ERtsPPDsSVIVTLL
0 1
SIRT1 (human) ERtsPPDsSVIVTLL S549-p
SIRT1 (mouse) ERTVPQDSSVIATLV S541
SIRT1 (rat) ERTVPQDSSVIATLV S543
K561-ub
TLLDQAAksNDDLDV
0 1
SIRT1 (human) TLLDQAAksNDDLDV K561-ub
SIRT1 (mouse) TLVDQATNNNVNDLE N553
SIRT1 (rat) TLVDQTIKNKVDDLE K555
S562-p
LLDQAAksNDDLDVs
0 2
SIRT1 (human) LLDQAAksNDDLDVs S562-p
SIRT1 (mouse) LVDQATNNNVNDLEV N554
SIRT1 (rat) LVDQTIKNKVDDLEV N556
S569-p
sNDDLDVsESkGCME
0 2
SIRT1 (human) sNDDLDVsESkGCME S569-p
SIRT1 (mouse) NVNDLEVSESSCVEE S562
SIRT1 (rat) KVDDLEVSEPKSCVE S564
K572-ub
DLDVsESkGCMEEkP
0 1
SIRT1 (human) DLDVsESkGCMEEkP K572-ub
SIRT1 (mouse) NDLEVSESSCVEEKP S564
SIRT1 (rat) DLEVSEPKSCVEEKS K567
K578-ac
SkGCMEEkPQEVQTS
0 1
SIRT1 (human) SkGCMEEkPQEVQTS K578-ac
SIRT1 (mouse) ESSCVEEKPQEVQTS K570
SIRT1 (rat) PKSCVEEKSQEVQTY K573
K578-ub
SkGCMEEkPQEVQTS
0 1
SIRT1 (human) SkGCMEEkPQEVQTS K578-ub
SIRT1 (mouse) ESSCVEEKPQEVQTS K570
SIRT1 (rat) PKSCVEEKSQEVQTY K573
S590-p
QTSRNVEsIAEQMEN
0 1
SIRT1 (human) QTSRNVEsIAEQMEN S590-p
SIRT1 (mouse) QTSRNVENINVENPD N582
SIRT1 (rat) QTYRNVESINVENPD S585
K601-ub
QMENPDLkNVGSSTG
0 5
SIRT1 (human) QMENPDLkNVGSSTG K601-ub
SIRT1 (mouse) NVENPDFKAVGSSTA K591
SIRT1 (rat) NVENPDFKAVGSSTG K594
K610-ub
VGSSTGEkNERtsVA
0 2
SIRT1 (human) VGSSTGEkNERtsVA K610-ub
SIRT1 (mouse) VGSSTADKNERTSVA K600
SIRT1 (rat) VGSSTGDKNERTSVA K603
T614-p
TGEkNERtsVAGtVR
0 1
SIRT1 (human) TGEkNERtsVAGtVR T614-p
SIRT1 (mouse) TADKNERTSVAETVR T604
SIRT1 (rat) TGDKNERTSVAETVR T607
S615-p
GEkNERtsVAGtVRk
Upstream
Downstream
1 13
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • LKB1 (human)
Putative in vivo kinases:
  • LKB1 (human)
Regulatory protein:
  • AMPKA1 (human)
Treatment
  • nicotinamide
  • resveratrol
  • selisistat
  • siRNA
view more >
SIRT1 (human) GEkNERtsVAGtVRk S615-p
SIRT1 (mouse) ADKNERTSVAETVRK S605
SIRT1 (rat) GDKNERTSVAETVRK S608
T619-p
ERtsVAGtVRkCWPN
0 2
SIRT1 (human) ERtsVAGtVRkCWPN T619-p
SIRT1 (mouse) ERTSVAETVRKCWPN T609
SIRT1 (rat) ERTSVAETVRKCWPN T612
K622-me
sVAGtVRkCWPNRVA
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
SIRT1 (human) sVAGtVRkCWPNRVA K622-me
SIRT1 (mouse) SVAETVRKCWPNRLA K612
SIRT1 (rat) SVAETVRKCWPNRLA K615
S659-p
FHGAEVYsDsEDDVL
Upstream
2 0
Kinase, in vitro:
  • CK2A1 (human)
Putative in vivo kinases:
  • CK2A1 (human)
SIRT1 (human) FHGAEVYsDsEDDVL S659-p
SIRT1 (mouse) FHGAEVYsDsEDDVL S649-p
SIRT1 (rat) FHGAEVYSDSEDDAL S652
S661-p
GAEVYsDsEDDVLSS
Upstream
2 0
Kinase, in vitro:
  • CK2A1 (human)
Putative in vivo kinases:
  • CK2A1 (human)
SIRT1 (human) GAEVYsDsEDDVLSS S661-p
SIRT1 (mouse) GAEVYsDsEDDVLSS S651-p
SIRT1 (rat) GAEVYSDSEDDALSS S654
S669-p
EDDVLSSsSCGSNSD
Upstream
Downstream
1 1
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • LKB1 (human)
Putative in vivo kinases:
  • LKB1 (human)
Regulatory protein:
  • AMPKA1 (human)
Treatment
  • nicotinamide
  • resveratrol
  • selisistat
  • siRNA
view more >
SIRT1 (human) EDDVLSSsSCGSNSD S669-p
SIRT1 (mouse) EDDVLSSSSCGSNSD S659
SIRT1 (rat) EDDALSSSSCGSNSD S662
S682-p
SDSGTCQsPSLEEPM
Upstream
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • apoptosis, induced
  • transcription, induced
Kinase, in vitro:
  • HIPK2 (human)
Putative in vivo kinases:
  • HIPK2 (human)
Treatment
  • adriamycin
SIRT1 (human) SDSGTCQsPSLEEPM S682-p
SIRT1 (mouse) SDSGTCQSPSLEEPL S672
SIRT1 (rat) SDSGTCQSPSLEEPL S675
S693
EEPMEDESEIEEFYN
1 0
SIRT1 (human) EEPMEDESEIEEFYN S693
SIRT1 (mouse) EEPLEDEsEIEEFYN S683-p
SIRT1 (rat) EEPLEDESEIEEFYN S686
T719-p
AGGAGFGtDGDDQEA
Upstream
2 30
Regulatory protein:
  • AMPKA1 (human)
Treatment
  • acadesine
  • compound_C
  • glucose_starvation
view more >
SIRT1 (human) AGGAGFGtDGDDQEA T719-p
SIRT1 (mouse) AGGSGFGADGGDQEV A709
SIRT1 (rat) ECAGGSGADGGDQEA A710
S732-p
EAINEAIsVkQEVTD
Upstream
Downstream
1 1
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • LKB1 (human)
Putative in vivo kinases:
  • LKB1 (human)
Regulatory protein:
  • AMPKA1 (human)
Treatment
  • nicotinamide
  • resveratrol
  • selisistat
  • siRNA
view more >
SIRT1 (human) EAINEAIsVkQEVTD S732-p
SIRT1 (mouse) EVVNEAIATRQELTD A722
SIRT1 (rat) EAVNEAIAMkQELTD A723
K734-sm
INEAIsVkQEVTDMN
Upstream
Downstream
2 1
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, inhibited
  • transcription, inhibited
Treatment
  • H2O2
  • UV
SIRT1 (human) INEAIsVkQEVTDMN K734-sm
SIRT1 (mouse) VNEAIATRQELTDVN R724
SIRT1 (rat) VNEAIAMkQELTDVN K725-sm
S747-p
MNYPSNKs_______
Upstream
0 4
Treatment
  • ischemia
SIRT1 (human) MNYPSNKs_______ S747-p
SIRT1 (mouse) VNYPSDKS_______ S737
SIRT1 (rat) VNCTPDKSEHY____ S738