Other Species / Isoforms
  EZH2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K7-ub
_MGQTGKksEkGPVC
0 1
EZH2 (human) _MGQTGKksEkGPVC K7-ub
EZH2 iso2 (human) _MGQTGKKSEKGPVC K7
EZH2 (mouse) _MGQTGKKSEKGPVC K7
EZH2 (rat) _MGQTGKKSEKGPVC K7
S8-p
MGQTGKksEkGPVCW
0 1
EZH2 (human) MGQTGKksEkGPVCW S8-p
EZH2 iso2 (human) MGQTGKKSEKGPVCW S8
EZH2 (mouse) MGQTGKKSEKGPVCW S8
EZH2 (rat) MGQTGKKSEKGPVCW S8
K10-ub
QTGKksEkGPVCWRK
0 2
EZH2 (human) QTGKksEkGPVCWRK K10-ub
EZH2 iso2 (human) QTGKKSEKGPVCWRK K10
EZH2 (mouse) QTGKKSEKGPVCWRK K10
EZH2 (rat) QTGKKSEKGPVCWRK K10
S21-p
CWRKRVKsEyMRLRQ
Upstream
Downstream
7 2
Effects on Modified Protein
  • enzymatic activity, induced
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell growth, induced
  • transcription, induced
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Regulatory protein:
  • PTEN (human)
Treatment
  • adriamycin
  • LY294002
  • MK-2206
view more >
EZH2 (human) CWRKRVKsEyMRLRQ S21-p
EZH2 iso2 (human) CWRKRVKSEYMRLRQ S21
EZH2 (mouse) CWRKRVKSEYMRLRQ S21
EZH2 (rat) CWRKRVKSEYMRLRQ S21
Y23-p
RKRVKsEyMRLRQLK
0 1
EZH2 (human) RKRVKsEyMRLRQLK Y23-p
EZH2 iso2 (human) RKRVKSEYMRLRQLK Y23
EZH2 (mouse) RKRVKSEYMRLRQLK Y23
EZH2 (rat) RKRVKSEYMRLRQLK Y23
K39-ub
FRRADEVkSMFSSNR
0 1
EZH2 (human) FRRADEVkSMFSSNR K39-ub
EZH2 iso2 (human) FRRADEVKSMFSSNR K39
EZH2 (mouse) FRRADEVKTMFSSNR K39
EZH2 (rat) FRRADEVKTMFSSNR K39
K61-ub
EILNQEWkQRRIQPV
0 5
EZH2 (human) EILNQEWkQRRIQPV K61-ub
EZH2 iso2 (human) EILNQEWKQRRIQPV K61
EZH2 (mouse) ETLNQEWKQRRIQPV K61
EZH2 (rat) ETLNQEWKQRRIQPV K61
S76-p
HILTSVSsLRGTREC
0 1
EZH2 (human) HILTSVSsLRGTREC S76-p
EZH2 iso2 (human) HILTSVSSLRGTREC S76
EZH2 (mouse) HIMTSVSSLRGTREC S76
EZH2 (rat) HIMTSVSSLRGTREC S76
S76-gl
HILTSVSsLRGTREC
Upstream
Downstream
1 1
Effects on Modified Protein
  • methylation
  • protein stabilization
Effects on Biological Processes:
  • carcinogenesis, induced
Treatment
  • PUGNAc
  • siRNA
EZH2 (human) HILTSVSsLRGTREC S76-gl
EZH2 iso2 (human) HILTSVSSLRGTREC S76
EZH2 (mouse) HIMTSVSSLRGTREC S76
EZH2 (rat) HIMTSVSSLRGTREC S76
S212-p
DHRDDKEsRPPRKFP
0 2
EZH2 (human) DHRDDKEsRPPRKFP S212-p
EZH2 iso2 (human) DHRDDKESRPPRKFP S212
EZH2 (mouse) DNRDDKETCPPRKFP T212
EZH2 (rat) DSRDDKETCPPRKFP T212
S220-p
RPPRKFPsDKIFEAI
Upstream
Downstream
1 2
Effects on Modified Protein
  • molecular association, regulation
  • protein stabilization
  • ubiquitination
Kinase, in vitro:
  • MELK (human)
Putative in vivo kinases:
  • MELK (human)
Treatment
  • bortezomib
  • OTSSP167
EZH2 (human) RPPRKFPsDKIFEAI S220-p
EZH2 iso2 (human) RPPRKFPSDKIFEAI S220
EZH2 (mouse) CPPRKFPADKIFEAI A220
EZH2 (rat) CPPRKFPADKIFEAI A220
K234-ac
ISSMFPDkGTAEELK
1 1
EZH2 (human) ISSMFPDkGTAEELK K234-ac
EZH2 iso2 (human) ISSMFPDKGTAEELK K234
EZH2 (mouse) ISSMFPDKGTAEELK K234
EZH2 (rat) ISSMFPDKGTAEELK K234
K234-ub
ISSMFPDkGTAEELK
0 1
EZH2 (human) ISSMFPDkGTAEELK K234-ub
EZH2 iso2 (human) ISSMFPDKGTAEELK K234
EZH2 (mouse) ISSMFPDKGTAEELK K234
EZH2 (rat) ISSMFPDKGTAEELK K234
Y244-p
AEELKEKyKELTEQQ
Upstream
Downstream
2 0
Effects on Modified Protein
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • cell growth, induced
  • transcription, induced
Putative in vivo kinases:
  • JAK3 (human)
EZH2 (human) AEELKEKyKELTEQQ Y244-p
EZH2 iso2 (human) AEELKEKYKELTEQQ Y244
EZH2 (mouse) AEELKEKYKELTEQQ Y244
EZH2 (rat) AEELKEKYKELTEQQ Y244
T261-p
GALPPECtPNIDGPN
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • cell motility, inhibited
  • transcription, inhibited
Regulatory protein:
  • CDK5 (human)
EZH2 (human) GALPPECtPNIDGPN T261-p
EZH2 iso2 (human) GALPPECTPNIDGPN T261
EZH2 (mouse) GALPPECTPNIDGPN T261
EZH2 (rat) GALPPECTPNIDGPN T261
T302-p
FLHPFHAtPNtYkRK
0 4
EZH2 (human) FLHPFHAtPNtYkRK T302-p
EZH2 iso2 (human) CNYSFHATPNTYKRK T307
EZH2 (mouse) FLHPFHATPNTYKRk T302
EZH2 (rat) FLHPFHATPNTYKRK T302
T305-p
PFHAtPNtYkRKNtE
0 1
EZH2 (human) PFHAtPNtYkRKNtE T305-p
EZH2 iso2 (human) SFHATPNTYKRKNTE T310
EZH2 (mouse) PFHATPNTYKRkNTE T305
EZH2 (rat) PFHATPNTYKRKNTE T305
K307-m2
HAtPNtYkRKNtETA
Downstream
1 0
Effects on Modified Protein
  • protein stabilization
Effects on Biological Processes:
  • transcription, inhibited
EZH2 (human) HAtPNtYkRKNtETA K307-m2
EZH2 iso2 (human) HATPNTYKRKNTETA K312
EZH2 (mouse) HATPNTYKRkNTETA K307
EZH2 (rat) HATPNTYKRKNTETA K307
K309
tPNtYkRKNtETALD
0 1
EZH2 (human) tPNtYkRKNtETALD K309
EZH2 iso2 (human) TPNTYKRKNTETALD K314
EZH2 (mouse) TPNTYKRkNTETALD K309-ac
EZH2 (rat) TPNTYKRKNTETALD K309
T311-p
NtYkRKNtETALDNk
Upstream
Downstream
4 2
EZH2 (human)
T311-p
EZH2 iso2 (human)
T316-p
EZH2 (mouse)
T311-p
EZH2 (rat)
T311-p
Effects on Modified Protein
  • enzymatic activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, inhibited
  • cell growth, inhibited
  • transcription, induced
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA1 (human)
Regulatory protein:
  • PRMT1 (human)
Treatment
  • 2-deoxyglucose
  • A-769662
EZH2 (human) NtYkRKNtETALDNk T311-p
EZH2 iso2 (human) NTYKRKNTETALDNK T316
EZH2 (mouse) NTYKRkNTETALDNK T311
EZH2 (rat) NTYKRKNTETALDNK T311
K318-ub
tETALDNkPCGPQCY
0 1
EZH2 (human) tETALDNkPCGPQCY K318-ub
EZH2 iso2 (human) TETALDNKPCGPQCY K323
EZH2 (mouse) TETALDNKPCGPQCY K318
EZH2 (rat) TETALDNKPCGPQCY K318
K332-ub
YQHLEGAkEFAAALt
1 0
EZH2 (human) YQHLEGAkEFAAALt K332-ub
EZH2 iso2 (human) YQHLEGAKEFAAALT K337
EZH2 (mouse) YQHLEGAKEFAAALt K332
EZH2 (rat) YQHLEGAKEFAAALT K332
T339-p
kEFAAALtAERIKtP
0 7
EZH2 (human) kEFAAALtAERIKtP T339-p
EZH2 iso2 (human) KEFAAALTAERIKTP T344
EZH2 (mouse) KEFAAALtAERIKtP T339-p
EZH2 (rat) KEFAAALTAERIKTP T339
T345-p
LtAERIKtPPkRPGG
Upstream
Downstream
10 14
EZH2 (human)
T345-p
EZH2 iso2 (human)
T350-p
EZH2 (mouse)
T345-p
EZH2 (rat)
T345-p
Effects on Modified Protein
  • molecular association, regulation
  • protein conformation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • carcinogenesis, altered
  • carcinogenesis, induced
  • cell growth, altered
  • cell growth, induced
  • cell motility, altered
  • transcription, altered
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
  • PKCI (human)
view more >
Putative in vivo kinases:
  • CDK1 (human)
  • CDK2 (human)
Regulatory protein:
  • p21Cip1 (human)
  • p27Kip1 (human)
  • Rb (human)
view more >
Treatment
  • RO-3306
  • seliciclib
  • siRNA
view more >
EZH2 (human) LtAERIKtPPkRPGG T345-p
EZH2 iso2 (human) LTAERIKTPPKRPGG T350
EZH2 (mouse) LtAERIKtPPKRPGG T345-p
EZH2 (rat) LTAERIKTPPKRPGG T345
K348-ac
ERIKtPPkRPGGRRR
Upstream
Downstream
2 0
Effects on Modified Protein
  • protein stabilization
Treatment
  • DEN
EZH2 (human) ERIKtPPkRPGGRRR K348-ac
EZH2 iso2 (human) ERIKTPPKRPGGRRR K353
EZH2 (mouse) ERIKtPPKRPGGRRR K348
EZH2 (rat) ERIKTPPKRPGGRRR K348
S362-p
RGRLPNNssRPstPt
1 13
EZH2 (human) RGRLPNNssRPstPt S362-p
EZH2 iso2 (human) RGRLPNNSSRPSTPT S367
EZH2 (mouse) RGRLPNNssRPstPt S362-p
EZH2 (rat) RGRLPNNSsRPStPt S362
S363-p
GRLPNNssRPstPtI
Upstream
Downstream
1 40
Effects on Biological Processes:
  • cell growth, inhibited
  • cell motility, inhibited
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3B (human)
EZH2 (human) GRLPNNssRPstPtI S363-p
EZH2 iso2 (human) GRLPNNSSRPSTPTI S368
EZH2 (mouse) GRLPNNssRPstPtI S363-p
EZH2 (rat) GRLPNNSsRPStPtI S363-p
S366-p
PNNssRPstPtINVL
Upstream
1 37
Treatment
  • MLN8054
EZH2 (human) PNNssRPstPtINVL S366-p
EZH2 iso2 (human) PNNSSRPSTPTINVL S371
EZH2 (mouse) PNNssRPstPtISVL S366-p
EZH2 (rat) PNNSsRPStPtIsVL S366
T367-p
NNssRPstPtINVLE
Upstream
Downstream
3 63
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • cell differentiation, induced
  • cell growth, inhibited
  • cell motility, inhibited
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • GSK3B (human)
  • P38A (human)
Putative in vivo kinases:
  • GSK3B (human)
  • P38A (human)
Regulatory protein:
  • EZH2 (human)
  • MKK6 (human)
Treatment
  • high_glucose
  • MLN8054
  • SB203580
view more >
EZH2 (human) NNssRPstPtINVLE T367-p
EZH2 iso2 (human) NNSSRPSTPTINVLE T372
EZH2 (mouse) NNssRPstPtISVLE T367-p
EZH2 (rat) NNSsRPStPtIsVLE T367-p
T369-p
ssRPstPtINVLEsK
0 12
EZH2 (human) ssRPstPtINVLEsK T369-p
EZH2 iso2 (human) SSRPSTPTINVLESK T374
EZH2 (mouse) ssRPstPtISVLESK T369-p
EZH2 (rat) SsRPStPtIsVLESK T369-p
N371
RPstPtINVLEsKDT
0 1
EZH2 (human) RPstPtINVLEsKDT N371
EZH2 iso2 (human) RPSTPTINVLESKDT N376
EZH2 (mouse) RPstPtISVLESKDT S371
EZH2 (rat) RPStPtIsVLESKDT S371-p
S375-p
PtINVLEsKDTDsDR
0 1
EZH2 (human) PtINVLEsKDTDsDR S375-p
EZH2 iso2 (human) PTINVLESKDTDSDR S380
EZH2 (mouse) PtISVLESKDTDsDR S375
EZH2 (rat) PtIsVLESKDTDsDR S375
S380-p
LEsKDTDsDREAGTE
0 7
EZH2 (human) LEsKDTDsDREAGTE S380-p
EZH2 iso2 (human) LESKDTDSDREAGTE S385
EZH2 (mouse) LESKDTDsDREAGTE S380-p
EZH2 (rat) LESKDTDsDREAGTE S380-p
T388-p
DREAGTEtGGENNDK
0 2
EZH2 (human) DREAGTEtGGENNDK T388-p
EZH2 iso2 (human) DREAGTETGGENNDK T393
EZH2 (mouse) DREAGTETGGENNDK T388
EZH2 (rat) DREAGTETGGENNDK T388
S405-p
EEKKDETssSsEANs
0 1
EZH2 (human) EEKKDETssSsEANs S405-p
EZH2 iso2 (human) EEKKDETSSSSEANS S410
EZH2 (mouse) EEKKDETSSSsEANs S405
EZH2 (rat) EEKKDETSSSSEANS S405
S406-p
EKKDETssSsEANsR
0 3
EZH2 (human) EKKDETssSsEANsR S406-p
EZH2 iso2 (human) EKKDETSSSSEANSR S411
EZH2 (mouse) EKKDETSSSsEANsR S406
EZH2 (rat) EKKDETSSSSEANSR S406
S408-p
KDETssSsEANsRCQ
0 2
EZH2 (human) KDETssSsEANsRCQ S408-p
EZH2 iso2 (human) KDETSSSSEANSRCQ S413
EZH2 (mouse) KDETSSSsEANsRCQ S408-p
EZH2 (rat) KDETSSSSEANSRCQ S408
S412-p
ssSsEANsRCQtPIK
0 6
EZH2 (human) ssSsEANsRCQtPIK S412-p
EZH2 iso2 (human) SSSSEANSRCQTPIK S417
EZH2 (mouse) SSSsEANsRCQtPIK S412-p
EZH2 (rat) SSSSEANSRCQTPIK S412
T416-p
EANsRCQtPIKMKPN
Upstream
Downstream
5 11
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • CDK2 (human)
Putative in vivo kinases:
  • CDK2 (human)
Regulatory protein:
  • CCNE1 (human)
  • NIPP-1 (human)
  • PPP1CA (human)
view more >
Treatment
  • Cdk2_inhibitor_II
  • dinaciclib
  • seliciclib
  • siRNA
  • SNSO32
view more >
EZH2 (human) EANsRCQtPIKMKPN T416-p
EZH2 iso2 (human) EANSRCQTPIKMKPN T421
EZH2 (mouse) EANsRCQtPIKMKPN T416-p
EZH2 (rat) EANSRCQTPIKMKPN T416
T460-p
AIARLIGtkTCRQVY
0 1
EZH2 (human) AIARLIGtkTCRQVY T460-p
EZH2 iso2 (human) AIARLIGTKTCRQVY T465
EZH2 (mouse) AIARLIGTKTCRQVY T460
EZH2 (rat) AIARLIGTKTCRQVY T460
K461-ub
IARLIGtkTCRQVYE
0 1
EZH2 (human) IARLIGtkTCRQVYE K461-ub
EZH2 iso2 (human) IARLIGTKTCRQVYE K466
EZH2 (mouse) IARLIGTKTCRQVYE K461
EZH2 (rat) IARLIGTKTCRQVYE K461
K472-ub
QVYEFRVkESSIIAP
0 2
EZH2 (human) QVYEFRVkESSIIAP K472-ub
EZH2 iso2 (human) QVYEFRVKESSIIAP K477
EZH2 (mouse) QVYEFRVKESSIIAP K472
EZH2 (rat) QVYEFRVKESSIIAP K472
T487-p
APAEDVDtPPRKKKR
Upstream
Downstream
11 119
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
  • transcription, induced
Kinase, in vitro:
  • CDK1 (human)
  • PKCI (human)
Putative in vivo kinases:
  • CDK1 (human)
Treatment
  • dasatinib
  • GSK126
  • LRRK2-IN-1
  • nocodazole
  • RO-3306
  • seliciclib
view more >
EZH2 (human) APAEDVDtPPRKKKR T487-p
EZH2 iso2 (human) APAEDVDTPPRKKKR T492
EZH2 (mouse) VPTEDVDtPPRKKKR T487-p
EZH2 (rat) VPTEDVDtPPRKKKR T487-p
K505-m2
LWAAHCRkIQLkkDG
0 3
EZH2 (human) LWAAHCRkIQLkkDG K505-m2
EZH2 iso2 (human) LWAAHCRKIQLKKDG K510
EZH2 (mouse) LWAAHCRKIQLKKDG K505
EZH2 (rat) LWAAHCRKIQLKKDG K505
K509-m2
HCRkIQLkkDGSSNH
0 1
EZH2 (human) HCRkIQLkkDGSSNH K509-m2
EZH2 iso2 (human) HCRKIQLKKDGSSNH K514
EZH2 (mouse) HCRKIQLKKDGSSNH K509
EZH2 (rat) HCRKIQLKKDGSSNH K509
K510-m2
CRkIQLkkDGSSNHV
0 3
EZH2 (human) CRkIQLkkDGSSNHV K510-m2
EZH2 iso2 (human) CRKIQLKKDGSSNHV K515
EZH2 (mouse) CRKIQLKKDGSSNHV K510
EZH2 (rat) CRKIQLKKDGSSNHV K510
T568
RCKAQCNTkQCPCYL
0 1
EZH2 (human) RCKAQCNTkQCPCYL T568
EZH2 iso2 (human) RCKAQCNTKQCPCYL T573
EZH2 (mouse) RCKAQCNtKQCPCYL T568-p
EZH2 (rat) RCKAQCNTKQCPCYL T568
K569-ub
CKAQCNTkQCPCYLA
0 3
EZH2 (human) CKAQCNTkQCPCYLA K569-ub
EZH2 iso2 (human) CKAQCNTKQCPCYLA K574
EZH2 (mouse) CKAQCNtKQCPCYLA K569
EZH2 (rat) CKAQCNTKQCPCYLA K569
K597-ub
AADHWDSkNVSCkNC
0 1
EZH2 (human) AADHWDSkNVSCkNC K597-ub
EZH2 iso2 (human) AADHWDSKNVSCKNC K602
EZH2 (mouse) AADHWDSKNVSCKNC K597
EZH2 (rat) AADHWDSKNVSCKNC K597
K602-ub
DSkNVSCkNCSIQRG
0 2
EZH2 (human) DSkNVSCkNCSIQRG K602-ub
EZH2 iso2 (human) DSKNVSCKNCSIQRG K607
EZH2 (mouse) DSKNVSCKNCSIQRG K602
EZH2 (rat) DSKNVSCKNCSIQRG K602
K629-ub
AGWGIFIkDPVQkNE
0 1
EZH2 (human) AGWGIFIkDPVQkNE K629-ub
EZH2 iso2 (human) AGWGIFIKDPVQKNE K634
EZH2 (mouse) AGWGIFIKDPVQKNE K629
EZH2 (rat) AGWGIFIKDPVQKNE K629
K634-ub
FIkDPVQkNEFISEy
0 1
EZH2 (human) FIkDPVQkNEFISEy K634-ub
EZH2 iso2 (human) FIKDPVQKNEFISEY K639
EZH2 (mouse) FIKDPVQKNEFISEY K634
EZH2 (rat) FIKDPVQKNEFISEY K634
Y641-p
kNEFISEyCGEIISQ
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
  • protein stabilization
  • ubiquitination
Kinase, in vitro:
  • JAK2 (human)
Putative in vivo kinases:
  • JAK2 (human)
EZH2 (human) kNEFISEyCGEIISQ Y641-p
EZH2 iso2 (human) KNEFISEYCGEIIsQ Y646
EZH2 (mouse) KNEFISEYCGEIISQ Y641
EZH2 (rat) KNEFISEYCGEIISQ Y641
S647
EyCGEIISQDEADRR
1 0
EZH2 (human) EyCGEIISQDEADRR S647
EZH2 iso2 (human) EYCGEIIsQDEADRR S652-p
EZH2 (mouse) EYCGEIISQDEADRR S647
EZH2 (rat) EYCGEIISQDEADRR S647
S690-p
KIRFANHsVNPNCyA
Upstream
0 1
Kinase, in vitro:
  • PKCI (human)
EZH2 (human) KIRFANHsVNPNCyA S690-p
EZH2 iso2 (human) KIRFANHSVNPNCYA S695
EZH2 (mouse) KIRFANHSVNPNCyA S690
EZH2 (rat) KIRFANHSVNPNCYA S690
Y696-p
HsVNPNCyAKVMMVN
1 2
EZH2 (human) HsVNPNCyAKVMMVN Y696-p
EZH2 iso2 (human) HSVNPNCYAKVMMVN Y701
EZH2 (mouse) HSVNPNCyAKVMMVN Y696-p
EZH2 (rat) HSVNPNCYAKVMMVN Y696
T718-p
FAKRAIQtGEELFFD
0 1
EZH2 (human) FAKRAIQtGEELFFD T718-p
EZH2 iso2 (human) FAKRAIQTGEELFFD T723
EZH2 (mouse) FAKRAIQTGEELFFD T718
EZH2 (rat) FAKRAIQTGEELFFD T718
S729
LFFDYRYSQADALKY
1 0
EZH2 (human) LFFDYRYSQADALKY S729
EZH2 iso2 (human) LFFDYRYsQADALKY S734-p
EZH2 (mouse) LFFDYRYSQADALKY S729
EZH2 (rat) LFFDYRYSQADALKY S729