Other Species / Isoforms
  Chk1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K43-ub
AVKIVDMkRAVDCPE
0 1
Chk1 (human) AVKIVDMkRAVDCPE K43-ub
Chk1 (mouse) AVKIVDMKRAIDCPE K43
Chk1 (rat) AVKIVDMKRAIDCPE K43
Chk1 (chicken) AVKIVDMKRAADCPE K43
K53-ac
VDCPENIkkEICINk
0 1
Chk1 (human) VDCPENIkkEICINk K53-ac
Chk1 (mouse) IDCPENIKKEICINK K53
Chk1 (rat) IDCPENIKKEICINK K53
Chk1 (chicken) ADCPENIKKEICINK K53
K53-ub
VDCPENIkkEICINk
0 1
Chk1 (human) VDCPENIkkEICINk K53-ub
Chk1 (mouse) IDCPENIKKEICINK K53
Chk1 (rat) IDCPENIKKEICINK K53
Chk1 (chicken) ADCPENIKKEICINK K53
K54-ub
DCPENIkkEICINkM
0 1
Chk1 (human) DCPENIkkEICINkM K54-ub
Chk1 (mouse) DCPENIKKEICINKM K54
Chk1 (rat) DCPENIKKEICINKM K54
Chk1 (chicken) DCPENIKKEICINKM K54
K60-ub
kkEICINkMLNHENV
0 2
Chk1 (human) kkEICINkMLNHENV K60-ub
Chk1 (mouse) KKEICINKMLSHENV K60
Chk1 (rat) KKEICINKMLNHENV K60
Chk1 (chicken) KKEICINKMLNHENV K60
K132-ub
GITHRDIkPENLLLD
Downstream
3 3
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Chk1 (human) GITHRDIkPENLLLD K132-ub
Chk1 (mouse) GITHRDIKPENLLLD K132
Chk1 (rat) GITHRDIKPENLLLD K132
Chk1 (chicken) GITHRDLKPENLLLD K132
K145-ub
LDERDNLkISDFGLA
0 2
Chk1 (human) LDERDNLkISDFGLA K145-ub
Chk1 (mouse) LDERDNLKISDFGLA K145
Chk1 (rat) LDERDNLKISDFGLA K145
Chk1 (chicken) LDERDNLKISDFGLA K145
K166-ub
NRERLLNkMCGTLPY
0 2
Chk1 (human) NRERLLNkMCGTLPY K166-ub
Chk1 (mouse) NRERLLNKMCGTLPY K166
Chk1 (rat) NRERLLNKMCGTLPY K166
Chk1 (chicken) GRERLLNKMCGTLPY K166
K180-ub
YVAPELLkRREFHAE
0 2
Chk1 (human) YVAPELLkRREFHAE K180-ub
Chk1 (mouse) YVAPELLKRKEFHAE K180
Chk1 (rat) YVAPELLKRKEFHAE K180
Chk1 (chicken) YVAPELLRRPEFRAE R180
K225-ub
YSDWKEKkTYLNPWK
0 2
Chk1 (human) YSDWKEKkTYLNPWK K225-ub
Chk1 (mouse) YSDWKEKKTYLNPWK K225
Chk1 (rat) YSDWKEKKTYLNPWK K225
Chk1 (chicken) YSDWKERKTYLAPWR K225
K233-ub
TYLNPWKkIDSAPLA
0 2
Chk1 (human) TYLNPWKkIDSAPLA K233-ub
Chk1 (mouse) TYLNPWKKIDSAPLA K233
Chk1 (rat) TYLNPWKKIDSAPLA K233
Chk1 (chicken) TYLAPWRKIDSAPLA K233
K244-ub
APLALLHkILVENPS
0 3
Chk1 (human) APLALLHkILVENPS K244-ub
Chk1 (mouse) APLALLHKILVETPS K244
Chk1 (rat) APLALLHKILVENPS K244
Chk1 (chicken) APLALLHKILTENPT K244
K267-ub
KKDRWYNkPLKKGAK
0 1
Chk1 (human) KKDRWYNkPLKKGAK K267-ub
Chk1 (mouse) KKDRWYNKPLNRGAK K267
Chk1 (rat) KKDRWYNKPLNRGAK K267
Chk1 (chicken) KKDRWYCRPLKKGTK R267
T279-p
GAKRPRVtsGGVsEs
0 15
Chk1 (human) GAKRPRVtsGGVsEs T279-p
Chk1 (mouse) GAKRPRATsGGMSEs T279
Chk1 (rat) GAKRPRATSGGMSES T279
Chk1 (chicken) GTKRGRVSSGGVTEs S279
S280-p
AKRPRVtsGGVsEsP
Upstream
Downstream
11 170
Chk1 (human)
S280-p
Effects on Modified Protein
  • enzymatic activity, induced
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • DNA repair, inhibited
  • carcinogenesis, induced
  • cell cycle regulation
Kinase, in vitro:
  • Akt1 (human)
  • p90RSK (human)
Putative in vivo kinases:
  • Akt1 (human)
  • p90RSK (human)
Regulatory protein:
  • Akt1 (human)
  • COX-2 (human)
  • HRas (human)
  • MEK1 (human)
Treatment
  • 2-deoxyglucose
  • anisomycin
  • antibody
  • BI-D1870
  • camptothecin
  • cisplatin
  • EGF
  • erlotinib
  • estradiol
  • hydroxyurea
  • IGF-1
  • insulin
  • ionizing_radiation
  • LPA
  • LY294002
  • MK-2206
  • PD184352
  • phorbol_ester
  • rapamycin
  • SB203580
  • selumetinib
  • serum
  • siRNA
  • SL0101
  • Su11274
  • TMZ
  • U0126
  • UV
  • vemurafenib
  • wortmannin
Chk1 (human) AKRPRVtsGGVsEsP S280-p
Chk1 (mouse) AKRPRATsGGMSEsS S280-p
Chk1 (rat) AKRPRATSGGMSESS S280
Chk1 (chicken) TKRGRVSSGGVTEsP S280
S284-p
RVtsGGVsEsPsGFs
0 13
Chk1 (human) RVtsGGVsEsPsGFs S284-p
Chk1 (mouse) RATsGGMSEsSSGFS S284
Chk1 (rat) RATSGGMSESSSGFS S284
Chk1 (chicken) RVSSGGVTEsPGALP T284
S286-p
tsGGVsEsPsGFskH
Upstream
Downstream
5 25
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
Treatment
  • hydroxyurea
  • MG132_withdrawal
  • nocodazole
  • PD98059
  • purvalanol
  • SB203580
  • seliciclib
  • SP600125
  • thymidine
  • UV
Chk1 (human) tsGGVsEsPsGFskH S286-p
Chk1 (mouse) TsGGMSEsSSGFSKH S286-p
Chk1 (rat) TSGGMSESSSGFSKH S286
Chk1 (chicken) SSGGVTEsPGALPKH S286-p
S288-p
GGVsEsPsGFskHIQ
Upstream
0 7
Treatment
  • MG132_withdrawal
Chk1 (human) GGVsEsPsGFskHIQ S288-p
Chk1 (mouse) GGMSEsSSGFSKHIH S288
Chk1 (rat) GGMSESSSGFSKHIH S288
Chk1 (chicken) GGVTEsPGALPKHIR G288
S291-p
sEsPsGFskHIQsNL
Upstream
0 4
Kinase, in vitro:
  • Chk1 (human)
Chk1 (human) sEsPsGFskHIQsNL S291-p
Chk1 (mouse) SEsSSGFSKHIHsNL S291
Chk1 (rat) SESSSGFSKHIHSNL S291
Chk1 (chicken) TEsPGALPKHIRSDT P291
K292-ub
EsPsGFskHIQsNLD
0 3
Chk1 (human) EsPsGFskHIQsNLD K292-ub
Chk1 (mouse) EsSSGFSKHIHsNLD K292
Chk1 (rat) ESSSGFSKHIHSNLD K292
Chk1 (chicken) EsPGALPKHIRSDTD K292
S296-p
GFskHIQsNLDFsPV
Upstream
Downstream
26 25
Chk1 (human)
S296-p
Chk1 (mouse)
S296-p
Chk1 (rat)
S296-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell cycle regulation
  • cell growth, altered
  • cell growth, induced
  • signaling pathway regulation
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • ATR (human)
  • Chk1 (human)
Putative in vivo kinases:
  • Chk1 (human)
Regulatory protein:
  • N-Myc (human)
  • p21Cip1 (human)
Treatment
  • actinomycin_D
  • adriamycin
  • aphidicolin
  • AZD6738
  • AZD7762
  • BI-D1870
  • caffeine
  • camptothecin
  • compound 13
  • cytarabine
  • evofosfamide
  • gemcitabine
  • Go_6976
  • hydroxyurea
  • hypoxia
  • ionizing_radiation
  • KU-55933
  • mitomycin_C
  • MK-8776
  • olaparib
  • PF477736
  • PHA-767491
  • prexasertib
  • rabusertib
  • serum
  • siRNA
  • SN-38
  • THIF
  • thymidine
  • UCN-01
  • UV
Chk1 (human) GFskHIQsNLDFsPV S296-p
Chk1 (mouse) GFSKHIHsNLDFsPV S296-p
Chk1 (rat) GFSKHIHSNLDFSPI S296
Chk1 (chicken) ALPKHIRSDTDFsPV S296
S301-p
IQsNLDFsPVNsAss
Upstream
Downstream
5 26
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
Putative in vivo kinases:
  • CDK1 (human)
Regulatory protein:
  • CDK1 (human)
  • CDK2 (human)
Treatment
  • 1NM-PP1
  • aphidicolin
  • hydroxyurea
  • nocodazole
  • PD98059
  • purvalanol
  • SB203580
  • seliciclib
  • SP600125
  • UV
Chk1 (human) IQsNLDFsPVNsAss S301-p
Chk1 (mouse) IHsNLDFsPVNNGSs S301-p
Chk1 (rat) IHSNLDFSPINSGSS S301
Chk1 (chicken) IRSDTDFsPVKSALG S301-p
S305-p
LDFsPVNsAssEENV
0 6
Chk1 (human) LDFsPVNsAssEENV S305-p
Chk1 (mouse) LDFsPVNNGSsEETV N305
Chk1 (rat) LDFSPINSGSSEENV S305
Chk1 (chicken) TDFsPVKSALGEDKA S305
S307-p
FsPVNsAssEENVkY
0 2
Chk1 (human) FsPVNsAssEENVkY S307-p
Chk1 (mouse) FsPVNNGSsEETVKF S307
Chk1 (rat) FSPINSGSSEENVKF S307
Chk1 (chicken) FsPVKSALGEDKASY L307
S308-p
sPVNsAssEENVkYs
0 4
Chk1 (human) sPVNsAssEENVkYs S308-p
Chk1 (mouse) sPVNNGSsEETVKFs S308-p
Chk1 (rat) SPINSGSSEENVKFS S308
Chk1 (chicken) sPVKSALGEDKASYS G308
K313-ub
AssEENVkYsssQPE
0 4
Chk1 (human) AssEENVkYsssQPE K313-ub
Chk1 (mouse) GSsEETVKFsSsQPE K313
Chk1 (rat) GSSEENVKFSSSQPE K313
Chk1 (chicken) ALGEDKASYSTSQPE S313
S315-p
sEENVkYsssQPEPR
0 1
Chk1 (human) sEENVkYsssQPEPR S315-p
Chk1 (mouse) sEETVKFsSsQPEPR S315-p
Chk1 (rat) SEENVKFSSSQPEPR S315
Chk1 (chicken) GEDKASYSTSQPEPG S315
S316-p
EENVkYsssQPEPRT
Upstream
0 2
Kinase, in vitro:
  • Chk1 (human)
Chk1 (human) EENVkYsssQPEPRT S316-p
Chk1 (mouse) EETVKFsSsQPEPRT S316
Chk1 (rat) EENVKFSSSQPEPRT S316
Chk1 (chicken) EDKASYSTSQPEPGT T316
S317-p
ENVkYsssQPEPRTG
Upstream
Downstream
94 28
Chk1 (human)
S317-p
Chk1 (mouse)
S317-p
Effects on Modified Protein
  • enzymatic activity, induced
  • enzymatic activity, inhibited
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell cycle regulation
  • signaling pathway regulation
Kinase, in vitro:
  • ATR (human)
Phosphatases, in vitro:
  • PPP2CA (human)
Putative in vivo kinases:
  • ATR (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Regulatory protein:
  • ATM (human)
  • ATR (human)
  • BRCA1 (human)
  • BRCA2 (human)
  • CASP2 (human)
  • CDK1 (human)
  • CDK2 (human)
  • CDK5 (human)
  • CDT1 (human)
  • claspin (human)
  • CLK2 (human)
  • CtIP (human)
  • DKFZp686L1814 (human)
  • DMAP1 (human)
  • ETAA16 (human)
  • FAAP24 (human)
  • FAM44A (human)
  • FANCM (human)
  • FBXW7 (human)
  • FOXM1 (human)
  • Geminin (human)
  • LSD1 (human)
  • MCM7 (human)
  • NBS1 (human)
  • OBFC2B (human)
  • p16-INK4A (human)
  • p53 (human)
  • PERK (human)
  • POLH (human)
  • POLK (human)
  • PPP1CA (human)
  • PPP2CA (human)
  • SIRT6 (human)
  • TICRR (human)
  • TRAF4 (human)
  • USP28 (human)
  • USP29 (human)
  • WDHD1 (human)
Treatment
  • 1NM-PP1
  • 2-deoxyglucose
  • actinomycin_D
  • adriamycin
  • aphidicolin
  • ATM_inhibitor
  • AZ20
  • bleomycin
  • caffeine
  • camptothecin
  • carboplatin
  • CBP-93872
  • cell_adhesion
  • Ceralasertib
  • cisplatin
  • CPT
  • Et743
  • etoposide
  • fluorouracil
  • formaldehyde
  • fostriecin
  • gefitinib
  • Go_6976
  • hydroxyurea
  • ICRF-193
  • ionizing_radiation
  • KU-55933
  • lurbinectedin
  • MG132
  • mimosine
  • mitomycin_C
  • mitoxantrone
  • MK1775
  • MMS
  • nocodazole
  • okadaic_acid
  • olaparib
  • PD98059
  • PERK inhibitor 1
  • PF477736
  • PHA-767491
  • phorbol_ester
  • prexasertib
  • purvalanol
  • R03306
  • resveratrol
  • RO-3306
  • ryuvidine
  • SB203580
  • seliciclib
  • siRNA
  • SJG-136
  • SP600125
  • thapsigargin
  • thymidine
  • tioguanine
  • TMZ removal
  • topotecan
  • trichostatin_A
  • U0126
  • UCN-01
  • UV
  • UVC
  • VE-821
  • VRX0466617
Chk1 (human) ENVkYsssQPEPRTG S317-p
Chk1 (mouse) ETVKFsSsQPEPRTG S317-p
Chk1 (rat) ENVKFSSSQPEPRTG S317
Chk1 (chicken) DKASYSTSQPEPGTG S317
T330-p
TGLSLWDtsPsYIDK
0 1
Chk1 (human) TGLSLWDtsPsYIDK T330-p
Chk1 (mouse) TGLSLWDTGPSNVDK T330
Chk1 (rat) TGLSLWDTGPSNVDK T330
Chk1 (chicken) TGGALWDSSTGSIDR S330
S331-p
GLSLWDtsPsYIDKL
Upstream
0 8
Treatment
  • MG132
  • nocodazole
  • thymidine
Chk1 (human) GLSLWDtsPsYIDKL S331-p
Chk1 (mouse) GLSLWDTGPSNVDKL G331
Chk1 (rat) GLSLWDTGPSNVDKL G331
Chk1 (chicken) GGALWDSSTGSIDRL S331
S333-p
SLWDtsPsYIDKLVQ
0 3
Chk1 (human) SLWDtsPsYIDKLVQ S333-p
Chk1 (mouse) SLWDTGPSNVDKLVQ S333
Chk1 (rat) SLWDTGPSNVDKLVQ S333
Chk1 (chicken) ALWDSSTGSIDRLVQ G333
S343-p
DKLVQGIsFsQPtCP
0 3
Chk1 (human) DKLVQGIsFsQPtCP S343-p
Chk1 (mouse) DKLVQGISFsQPTCP S343
Chk1 (rat) DKLVQGISFSQPTCP S343
Chk1 (chicken) DRLVQGISFsQPACP S343
S345-p
LVQGIsFsQPtCPDH
Upstream
Downstream
188 16
Chk1 (human)
S345-p
Chk1 (mouse)
S345-p
Chk1 (rat)
S345-p
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein degradation
Effects on Biological Processes:
  • DNA repair, induced
  • DNA repair, inhibited
  • apoptosis, altered
  • apoptosis, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell growth, induced
  • cell growth, inhibited
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • ATR (human)
  • Cot (human)
Phosphatases, in vitro:
  • PPM1D (human)
  • PPP2CA (human)
Putative in vivo kinases:
  • ATM (human)
  • ATR (human)
Putative upstream phosphatases:
  • PPM1D (human)
  • PPP2CA (human)
Regulatory protein:
  • Akt1 (human)
  • AMBRA1 (human)
  • ATM (human)
  • ATR (human)
  • BAT1 (human)
  • CDC5L (human)
  • CDC6 (human)
  • CDCA2 (human)
  • CDK1 (human)
  • CDK2 (human)
  • CDT1 (human)
  • claspin (human)
  • CtIP (human)
  • DKFZp686L1814 (human)
  • DNAPK (human)
  • E4F1 (human)
  • EDEM1 (human)
  • EGFR (human)
  • ER-alpha (human)
  • FAM44A (human)
  • FANCD2 (human)
  • FBXO44 (human)
  • FOXM1 (human)
  • HDAC6 (human)
  • HER2 (human)
  • HRas (human)
  • HSP27 (human)
  • HSPA2 (human)
  • Ku70 (human)
  • MCM3 (human)
  • MCM7 (human)
  • MCPH1 (human)
  • N-Myc (human)
  • NBS1 (human)
  • NEIL1 (human)
  • NKX3-1 (human)
  • NONO (human)
  • OTUD6A (human)
  • p14ARF (human)
  • p16-INK4A (human)
  • p21Cip1 (human)
  • p53 (human)
  • PARG (human)
  • PCNT (human)
  • PERK (human)
  • POLK (human)
  • PPP1CA (human)
  • PPP2CA (human)
  • PPP2CB (human)
  • PPP4C (human)
  • PRPF19 (human)
  • PRPF3 (human)
  • PTEN (human)
  • RAD17 (human)
  • RNH1 (human)
  • RPA1 (human)
  • SAMHD1 (human)
  • SLFN11 (human)
  • SMEK2 (human)
  • SMG7 (human)
  • syndecan-4 (human)
  • TELO2 (human)
  • TICRR (human)
  • Tip60 (human)
  • TOPBP1 (human)
  • TRAF4 (human)
  • vpr p15 (retrovirus)
  • WDHD1 (human)
Treatment
  • 11,11'-dideoxyverticillin
  • 1NM-PP1
  • 680C91
  • actinomycin_D
  • adavosertib
  • adriamycin
  • AG1478
  • alpelisib
  • aminothiazole_compound_25
  • AP21967
  • aphidicolin
  • AZ20
  • AZD1775
  • AZD5896
  • AZD6738
  • AZD7762
  • B02
  • Bersavine
  • beta-lapachone
  • BI-D1870
  • bleomycin
  • caffeine
  • camptothecin
  • carmustine
  • Caspase 9 inhibitor III
  • CBP-93872
  • cisplatin
  • compound 13
  • CPT
  • cycloheximide
  • doxycycline
  • DPN
  • EGF
  • Epo
  • estradiol
  • etoposide
  • eusynstyelamide B
  • Far-infrared
  • faslodex
  • fluorouracil
  • g_DNA
  • galiellalactone
  • gemcitabine
  • Go_6976
  • H2O2
  • hydroxyurea
  • hyperoxia
  • hypoxia
  • ICRF-193
  • IL-3
  • ionizing_radiation
  • ionomycin
  • ISRIB
  • KU-55933
  • kynurenine
  • lithium
  • lncRNAs
  • LY2606368
  • LY294002
  • M4344
  • MG132
  • mimosine
  • miRNA
  • mitomycin_C
  • MK-8776
  • MMS
  • NAC
  • nocodazole
  • NPB
  • nutlin-3
  • okadaic_acid
  • olaparib
  • PD173955
  • PD179483
  • PD98059
  • PDTC
  • peptide inhibitor
  • PERK inhibitor 1
  • PHA-767491
  • PPT
  • prexasertib
  • progesterone
  • psoralen
  • purvalanol
  • pyrvinium pamoate
  • rabusertib
  • resveratrol
  • ricolinostat
  • RO-3306
  • rucaparib
  • SB203580
  • SB216763
  • SB218078
  • seliciclib
  • serum
  • siRNA
  • SP600125
  • staurosporine
  • TAK-243
  • Talazoparib
  • taxol
  • testosterone
  • thapsigargin
  • thymidine
  • tivantinib
  • TMZ
  • TMZ removal
  • TNF
  • UCN-01
  • UV
  • UVC
  • VE-821
  • virus infection
  • vorinostat
  • VRX0466617
  • wortmannin
Chk1 (human) LVQGIsFsQPtCPDH S345-p
Chk1 (mouse) LVQGISFsQPTCPEH S345-p
Chk1 (rat) LVQGISFSQPTCPDH S345
Chk1 (chicken) LVQGISFsQPACPEH S345-p
T348-p
GIsFsQPtCPDHMLL
0 6
Chk1 (human) GIsFsQPtCPDHMLL T348-p
Chk1 (mouse) GISFsQPTCPEHMLV T348
Chk1 (rat) GISFSQPTCPDHMLV T348
Chk1 (chicken) GISFsQPACPEHMLL A348
S357-p
PDHMLLNsQLLGtPG
0 8
Chk1 (human) PDHMLLNsQLLGtPG S357-p
Chk1 (mouse) PEHMLVNSQLLGTPG S357
Chk1 (rat) PDHMLVNSQLLGTPG S357
Chk1 (chicken) PEHMLLNSQLLGTPG S357
T362-p
LNsQLLGtPGssQNP
0 13
Chk1 (human) LNsQLLGtPGssQNP T362-p
Chk1 (mouse) VNSQLLGTPGSSQNP T362
Chk1 (rat) VNSQLLGTPGSSQNP T362
Chk1 (chicken) LNSQLLGTPGSSQSP T362
S365-p
QLLGtPGssQNPWQR
0 2
Chk1 (human) QLLGtPGssQNPWQR S365-p
Chk1 (mouse) QLLGTPGSSQNPWQR S365
Chk1 (rat) QLLGTPGSSQNPWQR S365
Chk1 (chicken) QLLGTPGSSQSPWQR S365
S366-p
LLGtPGssQNPWQRL
0 1
Chk1 (human) LLGtPGssQNPWQRL S366-p
Chk1 (mouse) LLGTPGSSQNPWQRL S366
Chk1 (rat) LLGTPGSSQNPWQRL S366
Chk1 (chicken) LLGTPGSSQSPWQRL S366
T378-p
QRLVKRMtRFFtkLD
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • protein degradation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • Chk1 (human)
Putative in vivo kinases:
  • Chk1 (human)
Treatment
  • AZD7762
  • etoposide
  • hydroxyurea
  • UCN-01
Chk1 (human) QRLVKRMtRFFtkLD T378-p
Chk1 (mouse) QRLVKRMTRFFTKLD T378
Chk1 (rat) QRLVKRMTRFFTKLD T378
Chk1 (chicken) QRLVRRMTRFFTKLD T378
T382-p
KRMtRFFtkLDADks
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • protein degradation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • Chk1 (human)
Putative in vivo kinases:
  • Chk1 (human)
Treatment
  • AZD7762
  • etoposide
  • hydroxyurea
  • UCN-01
Chk1 (human) KRMtRFFtkLDADks T382-p
Chk1 (mouse) KRMTRFFTKLDADKS T382
Chk1 (rat) KRMTRFFTKLDADKS T382
Chk1 (chicken) RRMTRFFTKLDADGS T382
K383-ub
RMtRFFtkLDADksY
0 3
Chk1 (human) RMtRFFtkLDADksY K383-ub
Chk1 (mouse) RMTRFFTKLDADKSY K383
Chk1 (rat) RMTRFFTKLDADKSY K383
Chk1 (chicken) RMTRFFTKLDADGSY K383
K388-ub
FtkLDADksYQCLKE
0 2
Chk1 (human) FtkLDADksYQCLKE K388-ub
Chk1 (mouse) FTKLDADKSYQCLKE K388
Chk1 (rat) FTKLDADKSYQCLKE K388
Chk1 (chicken) FTKLDADGSYRSLRD G388
S389-p
tkLDADksYQCLKET
0 1
Chk1 (human) tkLDADksYQCLKET S389-p
Chk1 (mouse) TKLDADKSYQCLKET S389
Chk1 (rat) TKLDADKSYQCLKET S389
Chk1 (chicken) TKLDADGSYRSLRDV S389
K399-ub
CLKETCEkLGYQWKK
0 5
Chk1 (human) CLKETCEkLGYQWKK K399-ub
Chk1 (mouse) CLKETFEKLGYQWKK K399
Chk1 (rat) CLKETFEKLGYQWKK K399
Chk1 (chicken) SLRDVCEKMGYGWKQ K399
S407-p
LGYQWKKsCMNQVTI
0 1
Chk1 (human) LGYQWKKsCMNQVTI S407-p
Chk1 (mouse) LGYQWKKSCMNQVTV S407
Chk1 (rat) LGYQWKKSCMNQVTV S407
Chk1 (chicken) MGYGWKQSCTNQVTI S407
K423-ub
TTDRRNNkLIFKVNL
0 1
Chk1 (human) TTDRRNNkLIFKVNL K423-ub
Chk1 (mouse) TTDRRNNKLIFKINL K423
Chk1 (rat) TMDRRNNKLIFKINL K423
Chk1 (chicken) TTDRRNNKLIFKVNL K423
K436-ub
NLLEMDDkILVDFRL
Upstream
Downstream
2 1
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • apoptosis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
Treatment
  • siRNA
Chk1 (human) NLLEMDDkILVDFRL K436-ub
Chk1 (mouse) NLVEMDEKILVDFRL K436
Chk1 (rat) NLVEMDEKILVDFRL K436
Chk1 (chicken) NLLEMESRILVDFRL R436
K445-ub
LVDFRLSkGDGLEFk
0 2
Chk1 (human) LVDFRLSkGDGLEFk K445-ub
Chk1 (mouse) LVDFRLSKGDGLEFK K445
Chk1 (rat) LVDFRLSKGDGLEFK K445
Chk1 (chicken) LVDFRLSKGDGLEFK K445
K452-ac
kGDGLEFkRHFLKIK
0 2
Chk1 (human) kGDGLEFkRHFLKIK K452-ac
Chk1 (mouse) KGDGLEFKRHFLKIK K452
Chk1 (rat) KGDGLEFKRHFLKIK K452
Chk1 (chicken) KGDGLEFKRHFLKIK K452
K452-ub
kGDGLEFkRHFLKIK
0 1
Chk1 (human) kGDGLEFkRHFLKIK K452-ub
Chk1 (mouse) KGDGLEFKRHFLKIK K452
Chk1 (rat) KGDGLEFKRHFLKIK K452
Chk1 (chicken) KGDGLEFKRHFLKIK K452
K461-ub
HFLKIKGkLIDIVss
0 2
Chk1 (human) HFLKIKGkLIDIVss K461-ub
Chk1 (mouse) HFLKIKGKLsDVVSS K461
Chk1 (rat) HFLKIKGKLSDIVSS K461
Chk1 (chicken) HFLKIKGKLSDVVST K461
I463
LKIKGkLIDIVssQK
0 3
Chk1 (human) LKIKGkLIDIVssQK I463
Chk1 (mouse) LKIKGKLsDVVSSQK S463-p
Chk1 (rat) LKIKGKLSDIVSSQK S463
Chk1 (chicken) LKIKGKLSDVVSTQK S463
S467-p
GkLIDIVssQKIWLP
0 4
Chk1 (human) GkLIDIVssQKIWLP S467-p
Chk1 (mouse) GKLsDVVSSQKVWFP S467
Chk1 (rat) GKLSDIVSSQKVWFP S467
Chk1 (chicken) GKLSDVVSTQKVWLP S467
S468-p
kLIDIVssQKIWLPA
0 4
Chk1 (human) kLIDIVssQKIWLPA S468-p
Chk1 (mouse) KLsDVVSSQKVWFPV S468
Chk1 (rat) KLSDIVSSQKVWFPV S468
Chk1 (chicken) KLSDVVSTQKVWLPP T468