Other Species / Isoforms
  ASK1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
-
gap
0 4
ASK1 (human) gap -
ASK1 iso5 (human) CLARRARssPELWLA S55-p
ASK1 (mouse) gap -
ASK1 (rat) gap -
-
gap
0 5
ASK1 (human) gap -
ASK1 iso5 (human) LARRARssPELWLAR S56-p
ASK1 (mouse) gap -
ASK1 (rat) gap -
S82-p
SATRGRGssVGGGSr
0 1
ASK1 (human) SATRGRGssVGGGSr S82-p
ASK1 iso5 (human) SATRGRGSSVGGGSR S162
ASK1 (mouse) SATRGRGNsGSGGGR N89
ASK1 (rat) SATRGRGNSGSGGGR N89
S83-p
ATRGRGssVGGGSrR
Upstream
Downstream
16 8
ASK1 (human)
S83-p
Effects on Modified Protein
  • enzymatic activity, induced
  • enzymatic activity, inhibited
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, inhibited
  • carcinogenesis, induced
  • signaling pathway regulation
  • transcription, altered
Kinase, in vitro:
  • Akt1 (human)
  • Akt2 (human)
  • Pim1 (human)
  • RSK2 (human)
Putative in vivo kinases:
  • Akt1 (human)
  • Akt2 (human)
  • Pim1 (human)
  • RSK2 (human)
Regulatory protein:
  • Akt1 (human)
  • HSP90A (human)
  • LKB1 (human)
  • PDK1 (human)
Treatment
  • benzodiazepinones
  • culturing_of_cells
  • DPI
  • estradiol
  • faslodex
  • fluoromethylketone
  • H2O2
  • LY294002
  • nocodazole
  • siRNA
  • tanespimycin
  • wortmannin
ASK1 (human) ATRGRGssVGGGSrR S83-p
ASK1 iso5 (human) ATRGRGSSVGGGSRR S163
ASK1 (mouse) ATRGRGNsGSGGGRR S90-p
ASK1 (rat) ATRGRGNSGSGGGRR S90
R89-me
ssVGGGSrRTTVAYV
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
ASK1 (human) ssVGGGSrRTTVAYV R89-me
ASK1 iso5 (human) SSVGGGSRRTTVAYV R169
ASK1 (mouse) NsGSGGGRRTTVAYV R96
ASK1 (rat) NSGSGGGRRTTVAYV R96
S101-p
AYVINEAsQGQLVVA
0 1
ASK1 (human) AYVINEAsQGQLVVA S101-p
ASK1 iso5 (human) AYVINEASQGQLVVA S181
ASK1 (mouse) AYVINEASQGQLVVA S108
ASK1 (rat) AYVINEASQGQLVVA S108
S425
WFKKAFESEPTLQSG
0 1
ASK1 (human) WFKKAFESEPTLQSG S425
ASK1 iso5 (human) WFKKAFESEPTLQSG S505
ASK1 (mouse) WFKKAFEsEPTLQsG S432-p
ASK1 (rat) WFKKAFESEPTLQSG S432
S431
ESEPTLQSGINYAVL
0 1
ASK1 (human) ESEPTLQSGINYAVL S431
ASK1 iso5 (human) ESEPTLQSGINYAVL S511
ASK1 (mouse) EsEPTLQsGINYAVL S438-p
ASK1 (rat) ESEPTLQSGINYAVL S438
S461-p
KVGVKLSsLLGkKGN
0 1
ASK1 (human) KVGVKLSsLLGkKGN S461-p
ASK1 iso5 (human) KVGVKLSSLLGKKGN S541
ASK1 (mouse) KVGVKLSSLLGKKGN S468
ASK1 (rat) KVGVKLSSLLGKKGN S468
K465-ub
KLSsLLGkKGNLEKL
0 2
ASK1 (human) KLSsLLGkKGNLEKL K465-ub
ASK1 iso5 (human) KLSSLLGKKGNLEKL K545
ASK1 (mouse) KLSSLLGKKGNLEKL K472
ASK1 (rat) KLSSLLGKKGNLEKL K472
T528-p
YKHFVKLtTEQPVAk
0 1
ASK1 (human) YKHFVKLtTEQPVAk T528-p
ASK1 iso5 (human) YKHFVKLTTEQPVAK T608
ASK1 (mouse) YKHFVKLTTEQPSAK T535
ASK1 (rat) YKHFVKLTTEQPTAK T535
K535-sm
tTEQPVAkQELVDFW
1 0
ASK1 (human) tTEQPVAkQELVDFW K535-sm
ASK1 iso5 (human) TTEQPVAKQELVDFW K615
ASK1 (mouse) TTEQPSAKQELVDFW K542
ASK1 (rat) TTEQPTAKQELVDFW K542
Y570-p
ILEPTKIyQPSyLSI
0 1
ASK1 (human) ILEPTKIyQPSyLSI Y570-p
ASK1 iso5 (human) ILEPTKIYQPSYLSI Y650
ASK1 (mouse) ILEPTKIYQPSYLSI Y577
ASK1 (rat) ILEPTKIYQPSYLSI Y577
Y574-p
TKIyQPSyLSINNEV
0 1
ASK1 (human) TKIyQPSyLSINNEV Y574-p
ASK1 iso5 (human) TKIYQPSYLSINNEV Y654
ASK1 (mouse) TKIYQPSYLSINNEV Y581
ASK1 (rat) TKIYQPSYLSINNEV Y581
Y691
VVLGKGTYGIVYAGR
0 2
ASK1 (human) VVLGKGTYGIVYAGR Y691
ASK1 iso5 (human) VVLGKGTYGIVYAGR Y771
ASK1 (mouse) VVLGKGTYGIVYAGR Y698
ASK1 (rat) VVLGKGTyGIVYAGR Y697-p
Y718-p
IPERDSRySQPLHEE
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
Kinase, in vitro:
  • JAK1 (human)
  • JAK2 (human)
Putative in vivo kinases:
  • JAK2 (human)
Putative upstream phosphatases:
  • SHP-2 (human)
Regulatory protein:
  • SOCS1 (human)
Treatment
  • IFN-beta
  • IFN-gamma
  • TNF
ASK1 (human) IPERDSRySQPLHEE Y718-p
ASK1 iso5 (human) IPERDSRYSQPLHEE Y798
ASK1 (mouse) IPERDSRYSQPLHEE Y725
ASK1 (rat) IPERDSRYSQPLHEE Y724
K730-ub
HEEIALHkHLKHKNI
0 1
ASK1 (human) HEEIALHkHLKHKNI K730-ub
ASK1 iso5 (human) HEEIALHKHLKHKNI K810
ASK1 (mouse) HEEIALHKHLKHKNI K737
ASK1 (rat) HEEIALHKHLKHKNI K736
K785-ub
QTIGFYTkQILEGLK
0 1
ASK1 (human) QTIGFYTkQILEGLK K785-ub
ASK1 iso5 (human) QTIGFYTKQILEGLK K865
ASK1 (mouse) QTIGFYTKQILEGLK K792
ASK1 (rat) QTIGFYTKQILEGLK K791
T813-p
GDNVLINtySGVLKI
Upstream
Downstream
1 0
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • ASK1 (human)
ASK1 (human) GDNVLINtySGVLKI T813-p
ASK1 iso5 (human) GDNVLINTYSGVLKI T893
ASK1 (mouse) GDNVLINTYSGVLKI T820
ASK1 (rat) GDNVLINTYSGVLKI T819
Y814-p
DNVLINtySGVLKIs
0 1
ASK1 (human) DNVLINtySGVLKIs Y814-p
ASK1 iso5 (human) DNVLINTYSGVLKIS Y894
ASK1 (mouse) DNVLINTYSGVLKIS Y821
ASK1 (rat) DNVLINTYSGVLKIS Y820
S821-p
ySGVLKIsDFGtSKR
0 1
ASK1 (human) ySGVLKIsDFGtSKR S821-p
ASK1 iso5 (human) YSGVLKISDFGTSKR S901
ASK1 (mouse) YSGVLKISDFGTSKR S828
ASK1 (rat) YSGVLKISDFGTSKR S827
T825-p
LKIsDFGtSKRLAGI
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
  • protein conformation
Effects on Biological Processes:
  • apoptosis, induced
  • transcription, induced
Kinase, in vitro:
  • LRRK2 (human)
Putative in vivo kinases:
  • LRRK2 (human)
Treatment
  • LRRK2-IN-1
  • oxidative_stress
ASK1 (human) LKIsDFGtSKRLAGI T825-p
ASK1 iso5 (human) LKISDFGTSKRLAGI T905
ASK1 (mouse) LKISDFGTSKRLAGI T832
ASK1 (rat) LKISDFGTSKRLAGI T831
T836
LAGINPCTEtFTGtL
0 1
ASK1 (human) LAGINPCTEtFTGtL T836
ASK1 iso5 (human) LAGINPCTETFTGTL T916
ASK1 (mouse) LAGINPCtEtFTGtL T843-p
ASK1 (rat) LAGINPCTETFTGTL T842
T838-p
GINPCTEtFTGtLQY
Upstream
Downstream
16 2
ASK1 (human)
T838-p
ASK1 (mouse)
T845-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • cell cycle regulation
  • transcription, altered
Kinase, in vitro:
  • ASK1 (human)
Phosphatases, in vitro:
  • CDC25C (human)
Putative in vivo kinases:
  • LRRK2 (human)
  • PRKD1 (human)
Putative upstream phosphatases:
  • CDC25C (human)
Regulatory protein:
  • HSP90A (human)
  • PDK1 (human)
  • PGAM5 (human)
  • RSK2 (human)
  • SHP-2 (human)
Treatment
  • benzodiazepinones
  • dolastatin_10
  • EUK8
  • Go_6976
  • Go_6983
  • H2O2
  • IOA
  • LRRK2-IN-1
  • LY294002
  • monastrol
  • NAC
  • nocodazole
  • oxidative_stress
  • tanespimycin
  • taxol
  • TNF
ASK1 (human) GINPCTEtFTGtLQY T838-p
ASK1 iso5 (human) GINPCTETFTGTLQY T918
ASK1 (mouse) GINPCtEtFTGtLQY T845-p
ASK1 (rat) GINPCTETFTGTLQY T844
T842-p
CTEtFTGtLQYMAPE
Upstream
Downstream
3 0
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • ASK1 (human)
ASK1 (human) CTEtFTGtLQYMAPE T842-p
ASK1 iso5 (human) CTETFTGTLQYMAPE T922
ASK1 (mouse) CtEtFTGtLQYMAPE T849-p
ASK1 (rat) CTETFTGTLQYMAPE T848
K946-ac
KVSSKKKkTQPKLSA
0 1
ASK1 (human) KVSSKKKkTQPKLSA K946-ac
ASK1 iso5 (human) KVSSKKKKTQPKLSA K1026
ASK1 (mouse) KVSSKKKKTQPKLSA K953
ASK1 (rat) KVSSKKKKTQPKLSA K952
A956
PKLSALSAGsNEYLR
0 1
ASK1 (human) PKLSALSAGsNEYLR A956
ASK1 iso5 (human) PKLSALSAGSNEYLR A1036
ASK1 (mouse) PKLSALStGsNEYLR T963-p
ASK1 (rat) PKLSALMTDSNQYLR T962
S958-p
LSALSAGsNEYLRsI
0 13
ASK1 (human) LSALSAGsNEYLRsI S958-p
ASK1 iso5 (human) LSALSAGSNEYLRSI S1038
ASK1 (mouse) LSALStGsNEYLRSI S965-p
ASK1 (rat) LSALMTDSNQYLRSI S964
S964-p
GsNEYLRsIsLPVPV
0 1
ASK1 (human) GsNEYLRsIsLPVPV S964-p
ASK1 iso5 (human) GSNEYLRSISLPVPV S1044
ASK1 (mouse) GsNEYLRSIsLPVPV S971
ASK1 (rat) DSNQYLRSISLPVPV S970
S966-p
NEYLRsIsLPVPVLV
Upstream
Downstream
16 4
ASK1 (human)
S966-p
ASK1 (mouse)
S973-p
Effects on Modified Protein
  • activity, inhibited
  • enzymatic activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • apoptosis, inhibited
  • signaling pathway regulation
  • transcription, altered
Kinase, in vitro:
  • ASK1 (human)
Phosphatases, in vitro:
  • PPP3CA (human)
Putative in vivo kinases:
  • PDK1 (human)
Putative upstream phosphatases:
  • PPP3CA (human)
Regulatory protein:
  • LKB1 (human)
  • PDK1 (human)
  • RSK2 (human)
Treatment
  • angiotensin_2
  • benzodiazepinones
  • beta-amyloid_42
  • calyculin_A
  • ciclosporin
  • EUK8
  • Go_6976
  • Go_6983
  • H2O2
  • IOA
  • ionomycin
  • isoproterenol
  • NAC
  • nocodazole
  • okadaic_acid
  • phenylephrine
  • siRNA
  • thapsigargin
ASK1 (human) NEYLRsIsLPVPVLV S966-p
ASK1 iso5 (human) NEYLRSISLPVPVLV S1046
ASK1 (mouse) NEYLRSIsLPVPVLV S973-p
ASK1 (rat) NQYLRSISLPVPVLV S972
Y982-p
DTSSSSEyGSVsPDT
0 1
ASK1 (human) DTSSSSEyGSVsPDT Y982-p
ASK1 iso5 (human) DTSSSSEYGSVSPDD Y1062
ASK1 (mouse) DTSSSSEYGSVsPDT Y989
ASK1 (rat) DTSSSSEYGSVsPDT Y988
S986-p
SSEyGSVsPDTELKV
1 3
ASK1 (human) SSEyGSVsPDTELKV S986-p
ASK1 iso5 (human) SSEYGSVSPDDTELK S1066
ASK1 (mouse) SSEYGSVsPDTELKA S993-p
ASK1 (rat) SSEYGSVsPDTELKA S992-p
S997-p
ELKVDPFsFKTRAKS
0 1
ASK1 (human) ELKVDPFsFKTRAKS S997-p
ASK1 iso5 (human) ELKVDPFSFKTRAKS S1078
ASK1 (mouse) ELKADPFSFKARAKS S1004
ASK1 (rat) ELKADPFSFKTRAKS S1003
S1029-p
DENFEDHsAPPsPEE
Upstream
0 20
Treatment
  • ischemia
ASK1 (human) DENFEDHsAPPsPEE S1029-p
ASK1 iso5 (human) DENFEDHSAPPSPEE S1110
ASK1 (mouse) DENFEDHsAPPsPEE S1036-p
ASK1 (rat) DENFEDHsAPPsPEE S1035-p
S1033-p
EDHsAPPsPEEKDSG
Upstream
Downstream
1 30
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • apoptosis, altered
Treatment
  • ischemia
ASK1 (human) EDHsAPPsPEEKDSG S1033-p
ASK1 iso5 (human) EDHSAPPSPEEKDSG S1114
ASK1 (mouse) EDHsAPPsPEEKDSG S1040-p
ASK1 (rat) EDHsAPPsPEEKDSG S1039-p
T1059-p
ATLHRILtEDQDkIV
0 3
ASK1 (human) ATLHRILtEDQDkIV T1059-p
ASK1 iso5 (human) ATLHRILTEDQDKIV T1140
ASK1 (mouse) ATLHRILtEDQDKVV T1066-p
ASK1 (rat) ATLHRILTEDQDKVV T1065
K1064-ub
ILtEDQDkIVRNLME
0 1
ASK1 (human) ILtEDQDkIVRNLME K1064-ub
ASK1 iso5 (human) ILTEDQDKIVRNLME K1145
ASK1 (mouse) ILtEDQDKVVRNLME K1071
ASK1 (rat) ILTEDQDKVVRNLME K1070
S1072
IVRNLMESLAQGAEE
0 1
ASK1 (human) IVRNLMESLAQGAEE S1072
ASK1 iso5 (human) IVRNLMESLAQGAEE S1153
ASK1 (mouse) VVRNLMEsLAQGAEE S1079-p
ASK1 (rat) VVRNLMESLAQGPEE S1078
K1083-sm
GAEEPKLkWEHITTL
1 0
ASK1 (human) GAEEPKLkWEHITTL K1083-sm
ASK1 iso5 (human) GAEEPKLKWEHITTL K1164
ASK1 (mouse) GAEEPKLKWEHITTL K1090
ASK1 (rat) GPEEPKLKWEHITTL K1089
T1109-p
DRKIIATtLSKLkLE
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • carcinogenesis, induced
Kinase, in vitro:
  • RSK2 (human)
Putative in vivo kinases:
  • RSK2 (human)
Treatment
  • fluoromethylketone
  • siRNA
ASK1 (human) DRKIIATtLSKLkLE T1109-p
ASK1 iso5 (human) DRKIIATTLSKLKLE T1190
ASK1 (mouse) DRKIIATTLSKLKLE T1116
ASK1 (rat) DRKIIATTLSRLKLE T1115
K1114-sm
ATtLSKLkLELDFDS
1 0
ASK1 (human) ATtLSKLkLELDFDS K1114-sm
ASK1 iso5 (human) ATTLSKLKLELDFDS K1195
ASK1 (mouse) ATTLSKLKLELDFDS K1121
ASK1 (rat) ATTLSRLKLELDFDS K1120
S1240-p
DSQSAHRsLNVQLGR
0 3
ASK1 (human) DSQSAHRsLNVQLGR S1240-p
ASK1 iso5 (human) DSQSAHRSLNVQLGR S1321
ASK1 (mouse) DSQNAHRSLNVQLGR S1247
ASK1 (rat) DSQNAHRSLNVQLGR S1246
S1303
LPVFHLNSSGTNTED
0 2
ASK1 (human) LPVFHLNSSGTNTED S1303
ASK1 iso5 (human) LPVFHLNSSGTNTED S1384
ASK1 (mouse) FPVCHLNsPGTTTED S1310-p
ASK1 (rat) FPVCHLNAPGTAIED A1309
T1326-p
VNGADEDtISRFLAE
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • carcinogenesis, induced
Kinase, in vitro:
  • RSK2 (human)
Putative in vivo kinases:
  • RSK2 (human)
Treatment
  • fluoromethylketone
  • siRNA
ASK1 (human) VNGADEDtISRFLAE T1326-p
ASK1 iso5 (human) VNGADEDTISRFLAE T1407
ASK1 (mouse) ENGADEDTISRFLAE T1333
ASK1 (rat) ENGADEDTISRFLAE T1332