Other Species / Isoforms
  Akt1 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
N2
______MNDVAIVKE
0 2
Akt1 (human) ______MsDVAIVkE S2-p
Akt1 iso2 (human) gap -
Akt1 (mouse) ______MNDVAIVKE N2
Akt1 (rat) ______MNDVAIVKE N2
Akt1 (fruit fly) TSGHALTEQTQVVKE E103
Akt1 (cow) ______MNDVAIVKE N2
K8
MNDVAIVKEGWLHKR
1 3
Akt1 (human) MsDVAIVkEGWLHkR K8-ub
Akt1 iso2 (human) gap -
Akt1 (mouse) MNDVAIVKEGWLHKR K8
Akt1 (rat) MNDVAIVKEGWLHKR K8
Akt1 (fruit fly) TEQTQVVKEGWLMKR K109
Akt1 (cow) MNDVAIVKEGWLHKR K8
K14
VKEGWLHKRGEYIKT
1 3
Akt1 (human) VkEGWLHkRGEYIKT K14-ub
Akt1 iso2 (human) gap -
Akt1 (mouse) VKEGWLHKRGEYIKT K14
Akt1 (rat) VKEGWLHKRGEYIKT K14
Akt1 (fruit fly) VKEGWLMKRGEHIKN K115
Akt1 (cow) VKEGWLHKRGEYIKT K14
K14
VKEGWLHKRGEYIKT
1 0
Akt1 (human) VkEGWLHkRGEYIKT K14-m1
Akt1 iso2 (human) gap -
Akt1 (mouse) VKEGWLHKRGEYIKT K14
Akt1 (rat) VKEGWLHKRGEYIKT K14
Akt1 (fruit fly) VKEGWLMKRGEHIKN K115
Akt1 (cow) VKEGWLHKRGEYIKT K14
K30-ub
RPRYFLLkNDGTFIG
0 3
Akt1 (human) RPRYFLLkNDGtFIG K30-ub
Akt1 iso2 (human) gap -
Akt1 (mouse) RPRYFLLkNDGTFIG K30-ub
Akt1 (rat) RPRYFLLKNDGtFIG K30
Akt1 (fruit fly) RQRYFVLHSDGRLMG H131
Akt1 (cow) RPRYFLLKNDGTFIG K30
T34
FLLkNDGTFIGYKER
1 2
Akt1 (human) FLLkNDGtFIGYkER T34-p
Akt1 iso2 (human) gap -
Akt1 (mouse) FLLkNDGTFIGYKER T34
Akt1 (rat) FLLKNDGtFIGYKER T34-p
Akt1 (fruit fly) FVLHSDGRLMGYRSK R135
Akt1 (cow) FLLKNDGTFIGYKER T34
K39
DGTFIGYKERPQDVD
0 3
Akt1 (human) DGtFIGYkERPQDVD K39-ub
Akt1 iso2 (human) gap -
Akt1 (mouse) DGTFIGYKERPQDVD K39
Akt1 (rat) DGtFIGYKERPQDVE K39
Akt1 (fruit fly) DGRLMGYRSKPADSA R140
Akt1 (cow) DGTFIGYKERPQDLE K39
T65
AQCQLMKTERPRPNT
0 1
Akt1 (human) AQCQLMKtERPRPNt T65-p
Akt1 iso2 (human) _____MKTERPRPNT T3
Akt1 (mouse) AQCQLMKTERPRPNT T65
Akt1 (rat) AQCQLMKTERPRPNT T65
Akt1 (fruit fly) VRGCQIMTVDRPKPF T167
Akt1 (cow) AQCQLMKTERPRPNT T65
T72
TERPRPNTFIIRCLQ
2 1
Akt1 (human) tERPRPNtFIIRCLQ T72-p
Akt1 iso2 (human) TERPRPNTFIIRCLQ T10
Akt1 (mouse) TERPRPNTFIIRCLQ T72
Akt1 (rat) TERPRPNTFIIRCLQ T72
Akt1 (fruit fly) VDRPKPFTFIIRGLQ T175
Akt1 (cow) TERPRPNTFIIRCLQ T72
T87
WTTVIERTFHVETPE
0 1
Akt1 (human) WTTVIERtFHVEtPE T87-p
Akt1 iso2 (human) WTTVIERTFHVETPE T25
Akt1 (mouse) WTTVIERTFHVETPE T87
Akt1 (rat) WTTVIERTFHVETPE T87
Akt1 (fruit fly) WTTVIERTFAVESEL T190
Akt1 (cow) WTTVIERTFHVETPE T87
T92
ERTFHVETPEEREEW
1 3
Akt1 (human) ERtFHVEtPEEREEW T92-p
Akt1 iso2 (human) ERTFHVETPEEREEW T30
Akt1 (mouse) ERTFHVETPEEREEW T92
Akt1 (rat) ERTFHVETPEEREEW T92
Akt1 (fruit fly) ERTFAVESELERQQW S195
Akt1 (cow) ERTFHVETPEEREEW T92
T117-p
LKRQEEEtMDFRsGs
0 1
Akt1 (human) LKKQEEEEMDFRsGs E117
Akt1 iso2 (human) LKKQEEEEMDFRSGS E55
Akt1 (mouse) LKRQEEEtMDFRsGs T117-p
Akt1 (rat) LKRQEEETMDFRSGs T117
Akt1 (fruit fly) TPSEQTDMTDVDMAT M229
Akt1 (cow) LKRQEEETMDFRSGS T117
S122-p
EEtMDFRsGsPsDNs
1 14
Akt1 (human) EEEMDFRsGsPsDNs S122-p
Akt1 iso2 (human) EEEMDFRSGSPSDNS S60
Akt1 (mouse) EEtMDFRsGsPsDNs S122-p
Akt1 (rat) EETMDFRSGsPSDNs S122
Akt1 (fruit fly) TDMTDVDMATIAEDE M234
Akt1 (cow) EETMDFRSGSPGENS S122
S124-p
tMDFRsGsPsDNsGA
5 26
Akt1 (human) EMDFRsGsPsDNsGA S124-p
Akt1 iso2 (human) EMDFRSGSPSDNSGA S62
Akt1 (mouse) tMDFRsGsPsDNsGA S124-p
Akt1 (rat) TMDFRSGsPSDNsGA S124-p
Akt1 (fruit fly) MTDVDMATIAEDELS T236
Akt1 (cow) TMDFRSGSPGENSGA S124
S126-p
DFRsGsPsDNsGAEE
Upstream
0 26
Treatment
  • BMP2
Akt1 (human) DFRsGsPsDNsGAEE S126-p
Akt1 iso2 (human) DFRSGSPSDNSGAEE S64
Akt1 (mouse) DFRsGsPsDNsGAEE S126-p
Akt1 (rat) DFRSGsPSDNsGAEE S126
Akt1 (fruit fly) DVDMATIAEDELSEQ A238
Akt1 (cow) DFRSGSPGENSGAEE G126
S126
DFRsGsPSDNsGAEE
0 1
Akt1 (human) DFRsGsPsDNsGAEE S126-gl
Akt1 iso2 (human) DFRSGSPSDNSGAEE S64
Akt1 (mouse) DFRsGsPSDNsGAEE S126
Akt1 (rat) DFRSGsPSDNsGAEE S126
Akt1 (fruit fly) DVDMATIAEDELSEQ A238
Akt1 (cow) DFRSGSPGENSGAEE G126
S129-p
sGsPsDNsGAEEMEV
Upstream
10 47
Akt1 (human)
S129-p
Treatment
  • silmitasertib
Akt1 (human) sGsPsDNsGAEEMEV S129-p
Akt1 iso2 (human) SGSPSDNSGAEEMEV S67
Akt1 (mouse) sGsPsDNsGAEEMEV S129-p
Akt1 (rat) SGsPSDNsGAEEMEV S129-p
Akt1 (fruit fly) MATIAEDELSEQFSV E241
Akt1 (cow) SGSPGENSGAEEMEV S129
S129
sGsPsDNSGAEEMEV
0 1
Akt1 (human) sGsPsDNsGAEEMEV S129-gl
Akt1 iso2 (human) SGSPSDNSGAEEMEV S67
Akt1 (mouse) sGsPsDNSGAEEMEV S129
Akt1 (rat) SGsPSDNSGAEEMEV S129
Akt1 (fruit fly) MATIAEDELSEQFSV E241
Akt1 (cow) SGSPGENSGAEEMEV S129
S137-p
GAEEMEVsLAKPKHR
0 2
Akt1 (human) GAEEMEVsLAkPKHR S137-p
Akt1 iso2 (human) GAEEMEVSLAKPKHR S75
Akt1 (mouse) GAEEMEVsLAKPKHR S137-p
Akt1 (rat) GAEEMEVALAKPKHR A137
Akt1 (fruit fly) FSVQGTTCNSSGVKK C253
Akt1 (cow) GAEEMEVSLAKPKHR S137
K140
EMEVsLAKPKHRVTM
0 1
Akt1 (human) EMEVsLAkPKHRVtM K140-ub
Akt1 iso2 (human) EMEVSLAKPKHRVTM K78
Akt1 (mouse) EMEVsLAKPKHRVTM K140
Akt1 (rat) EMEVALAKPKHRVTM K140
Akt1 (fruit fly) QGTTCNSSGVKKVTL S256
Akt1 (cow) EMEVSLAKPKHRVTM K140
T146
AKPKHRVTMNEFEYL
0 8
Akt1 (human) AkPKHRVtMNEFEYL T146-p
Akt1 iso2 (human) AKPKHRVTMNEFEYL T84
Akt1 (mouse) AKPKHRVTMNEFEYL T146
Akt1 (rat) AKPKHRVTMNEFEYL T146
Akt1 (fruit fly) SSGVKKVTLENFEFL T262
Akt1 (cow) AKPKHRVTMNDFEYL T146
K154
MNEFEYLKLLGKGTF
0 1
Akt1 (human) MNEFEYLkLLGKGTF K154-ub
Akt1 iso2 (human) MNEFEYLKLLGKGTF K92
Akt1 (mouse) MNEFEYLKLLGKGTF K154
Akt1 (rat) MNEFEYLKLLGKGTF K154
Akt1 (fruit fly) LENFEFLKVLGKGTF K270
Akt1 (cow) MNDFEYLKLLGKGTF K154
Y176-p
EKATGRYyAMKILKK
Upstream
Downstream
2 1
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
Effects on Biological Processes:
  • cell cycle regulation
  • transcription, altered
Kinase, in vitro:
  • Ack (mouse)
Putative in vivo kinases:
  • Ack (mouse)
Akt1 (human) EKATGRYyAMKILKK Y176-p
Akt1 iso2 (human) EKATGRYYAMKILKK Y114
Akt1 (mouse) EKATGRYyAMKILKK Y176-p
Akt1 (rat) EKATGRYYAMKILKK Y176
Akt1 (fruit fly) EKATAKLYAIKILKK Y292
Akt1 (cow) EKATGRYYAMKILKK Y176
K189
KKEVIVAKDEVAHTL
0 1
Akt1 (human) KKEVIVAkDEVAHTL K189-ub
Akt1 iso2 (human) KKEVIVAKDEVAHTL K127
Akt1 (mouse) KKEVIVAKDEVAHTL K189
Akt1 (rat) KKEVIVAKDEVAHTL K189
Akt1 (fruit fly) KKEVIIQKDEVAHTL K305
Akt1 (cow) KKEVIVAKDEVAHTL K189
T211
NSRHPFLTALKYSFQ
0 1
Akt1 (human) NSRHPFLtALKYSFQ T211-p
Akt1 iso2 (human) NSRHPFLTALKYSFQ T149
Akt1 (mouse) NSRHPFLTALKYSFQ T211
Akt1 (rat) NSRHPFLTALKYSFQ T211
Akt1 (fruit fly) STNHPFLISLKYSFQ I327
Akt1 (cow) NSRHPFLTALKYSFQ T211
S246
LSRERVFSEDRARFY
1 0
Akt1 (human) LSRERVFsEDRARFY S246-p
Akt1 iso2 (human) LSRERVFSEDRARFY S184
Akt1 (mouse) LSRERVFSEDRARFY S246
Akt1 (rat) LSRERVFSEDRARFY S246
Akt1 (fruit fly) LSHERIFTEDRTRFY T362
Akt1 (cow) LSRERVFSEDRARFY S246
K268
LDYLHSEKNVVYRDL
0 2
Akt1 (human) LDYLHSEkNVVYRDL K268-ub
Akt1 iso2 (human) LDYLHSEKNVVYRDL K206
Akt1 (mouse) LDYLHSEKNVVYRDL K268
Akt1 (rat) LDYLHSEKNVVYRDL K268
Akt1 (fruit fly) gap -
Akt1 (cow) LDYLHSEKEVVYRDL K268
K276-ub
NVVYRDLkLENLMLD
0 3
Akt1 (human) NVVYRDLkLENLMLD K276-ub
Akt1 iso2 (human) NVVYRDLKLENLMLD K214
Akt1 (mouse) NVVYRDLkLENLMLD K276-ub
Akt1 (rat) NVVYRDLKLENLMLD K276
Akt1 (fruit fly) GIIYRDLKLENLLLD K391
Akt1 (cow) EVVYRDLKLENLMLD K276
K276
NVVYRDLKLENLMLD
3 1
Akt1 (human) NVVYRDLkLENLMLD K276-sm
Akt1 iso2 (human) NVVYRDLKLENLMLD K214
Akt1 (mouse) NVVYRDLKLENLMLD K276
Akt1 (rat) NVVYRDLKLENLMLD K276
Akt1 (fruit fly) GIIYRDLKLENLLLD K391
Akt1 (cow) EVVYRDLKLENLMLD K276
T291
KDGHIKITDFGLCKE
0 1
Akt1 (human) KDGHIKItDFGLCkE T291-p
Akt1 iso2 (human) KDGHIKITDFGLCKE T229
Akt1 (mouse) KDGHIKITDFGLCKE T291
Akt1 (rat) KDGHIKITDFGLCKE T291
Akt1 (fruit fly) KDGHIKVADFGLCKE A406
Akt1 (cow) KDGHIKITDFGLCKE T291
K297
ITDFGLCKEGIKDGA
0 1
Akt1 (human) ItDFGLCkEGIkDGA K297-ub
Akt1 iso2 (human) ITDFGLCKEGIKDGA K235
Akt1 (mouse) ITDFGLCKEGIKDGA K297
Akt1 (rat) ITDFGLCKEGIKDGA K297
Akt1 (fruit fly) VADFGLCKEDITYGR K412
Akt1 (cow) ITDFGLCKEGIKDGA K297
K301
GLCKEGIKDGAtMKt
1 0
Akt1 (human) GLCkEGIkDGAtMKt K301-sm
Akt1 iso2 (human) GLCKEGIKDGATMKT K239
Akt1 (mouse) GLCKEGIKDGAtMKt K301
Akt1 (rat) GLCKEGIKDGATMKt K301
Akt1 (fruit fly) GLCKEDITYGRTTKT T416
Akt1 (cow) GLCKEGIKDGATMKt K301
K301
GLCKEGIKDGAtMKt
0 2
Akt1 (human) GLCkEGIkDGAtMKt K301-ub
Akt1 iso2 (human) GLCKEGIKDGATMKT K239
Akt1 (mouse) GLCKEGIKDGAtMKt K301
Akt1 (rat) GLCKEGIKDGATMKt K301
Akt1 (fruit fly) GLCKEDITYGRTTKT T416
Akt1 (cow) GLCKEGIKDGATMKt K301
T305-p
EGIKDGAtMKtFCGt
0 7
Akt1 (human) EGIkDGAtMKtFCGt T305-p
Akt1 iso2 (human) EGIKDGATMKTFCGT T243
Akt1 (mouse) EGIKDGAtMKtFCGt T305-p
Akt1 (rat) EGIKDGATMKtFCGT T305
Akt1 (fruit fly) EDITYGRTTKTFCGT T420
Akt1 (cow) EGIKDGATMKtFCGT T305
T305
EGIKDGATMKtFCGt
1 1
Akt1 (human) EGIkDGAtMKtFCGt T305-gl
Akt1 iso2 (human) EGIKDGATMKTFCGT T243
Akt1 (mouse) EGIKDGATMKtFCGt T305
Akt1 (rat) EGIKDGATMKtFCGT T305
Akt1 (fruit fly) EDITYGRTTKTFCGT T420
Akt1 (cow) EGIKDGATMKtFCGT T305
T308-p
KDGAtMKtFCGtPEy
Upstream
Downstream
582 31
Akt1 (human)
T308-p
Akt1 (mouse)
T308-p
Akt1 (rat)
T308-p
Akt1 (cow)
T308-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • RNA splicing, induced
  • apoptosis, altered
  • apoptosis, inhibited
  • cell differentiation, induced
  • cell growth, altered
  • cell growth, induced
  • cytoskeletal reorganization
  • neural plasticity
  • signaling pathway regulation
Kinase, in vitro:
  • PDK1 (human)
  • PDK1 (mouse)
Phosphatases, in vitro:
  • PPP2CA (mouse)
Putative in vivo kinases:
  • ERK1 (mouse)
  • P38A (mouse)
  • PDK1 (human)
  • PDK1 (mouse)
Putative upstream phosphatases:
  • PPP2CA (human)
  • PTEN (mouse)
Regulatory protein:
  • 14-3-3 zeta (mouse)
  • Akt2 (mouse)
  • Akt3 (mouse)
  • APPL (human)
  • ASK1 (human)
  • ASK1 (mouse)
  • BAG1 (mouse)
  • BAG4 (mouse)
  • BCAP (mouse)
  • Brk (human)
  • CAMKK1 (mouse)
  • caveolin-1 (mouse)
  • CD19 (mouse)
  • CDC42 iso1 (human)
  • CLK2 (human)
  • DICER1 (mouse)
  • DNAPK (mouse)
  • ERK5 (human)
  • FOXO1A (mouse)
  • GILZ (human)
  • GPX1 (mouse)
  • GRB10 (human)
  • ICAM1 (mouse)
  • ILK (human)
  • ILK (mouse)
  • IRS1 (human)
  • IRS2 (human)
  • ITGB1 (mouse)
  • JNK1 (mouse)
  • K17 (mouse)
  • LIMS1 (human)
  • LIMS1 (mouse)
  • LIN28A (mouse)
  • MCF2 (human)
  • MEK5 (human)
  • mTOR (mouse)
  • Musashi-1 (mouse)
  • NFkB-p100 (mouse)
  • p70S6K (mouse)
  • PDHK4 (mouse)
  • PDK1 (human)
  • PDK1 (mouse)
  • PGGT1B (mouse)
  • PHB (human)
  • PIK3CA (mouse)
  • PIK3CG (human)
  • PIK3R1 (mouse)
  • PKCI (mouse)
  • PKCT (mouse)
  • PLCB2 (human)
  • PPP2CA (mouse)
  • PPP2CB (mouse)
  • PPP2R5B (human)
  • PPP2R5B (mouse)
  • PTEN (mouse)
  • RAC1 (human)
  • RAP1B (mouse)
  • Raptor (mouse)
  • RHEB (mouse)
  • RHOA (human)
  • RICTOR (human)
  • RICTOR (mouse)
  • ROCK1 (mouse)
  • SCD (mouse)
  • SH3BP2 (mouse)
  • SHP-2 (mouse)
  • SIGLEC7 (mouse)
  • Sin1 (mouse)
  • SMO (mouse)
  • syndecan-4 (mouse)
  • TCL1A (mouse)
  • TMEM55B (mouse)
  • TSC1 (mouse)
  • TSC2 (mouse)
  • TTC3 (human)
Treatment
  • acadesine
  • activin
  • adiponectin
  • Akt_inhibitor_VIII
  • alpha-mangostin
  • AM251
  • amino_acids
  • anti-CD28
  • anti-CD3
  • anti-CD3/CD28
  • anti-IgB
  • anti-IgM
  • anti-ITGAL
  • apomorphine
  • AS252424
  • atorvastatin
  • axatomy
  • BAPTA-AM
  • BDNF
  • butaprost
  • BX795
  • calphostin_C
  • calyculin_A
  • cangrelor
  • catalase
  • cholera_toxin
  • cocaine
  • colforsin
  • culturing_of_cells
  • dactolisib
  • doconexent
  • EGF
  • Epo
  • estradiol
  • exercise
  • exercise training
  • fasting
  • FGF1
  • FGF2
  • fibrinogen
  • fMLP
  • fostriecin
  • GDNF
  • GF109203X
  • glucose
  • GM-CSF
  • Go_6976
  • H2O2
  • haloperidol
  • high-fat diet
  • HU-210
  • hypoxia
  • hypoxia/reoxygenation
  • IBMX
  • IC87114
  • IgE
  • IGF-1
  • IL-22
  • IL-6
  • inflammation
  • insulin
  • ionizing_radiation
  • ipatasertib
  • ischemia
  • KN-62
  • KU-0063794
  • L803-mts
  • laminar flow
  • levamfetamine
  • LIF
  • linoleic_acid
  • long-term_potentiation
  • low_cell_density
  • LPA
  • LPS
  • lupeol
  • LY294002
  • M-CSF
  • meal feeding
  • mechanical stress
  • memantine
  • methyl-beta-cyclodextrin
  • miR-143
  • miRNA
  • MK-2206
  • muscle contraction
  • NAC
  • neurotensin
  • normal chow diet
  • okadaic_acid
  • palmitate
  • PAR1-activating_peptide
  • PAR4-activating_peptide
  • PD98059
  • PDGF
  • PGE2
  • phorbol_ester
  • physostigmine
  • PIK90
  • pilocarpine
  • piroxicam
  • PP242
  • progesterone
  • PTX
  • PUGNAc
  • QL9_peptide
  • quinpirole
  • rapamycin
  • refeeding
  • SB202190
  • SB203580
  • serum
  • serum_starvation
  • serum_withdrawal
  • siRNA
  • SKF38393
  • skin aging
  • SP600125
  • sphingomyelinase
  • sphingosine_1-phosphate
  • SR48527
  • SR49711
  • staurosporine
  • sulprostone
  • TGF-beta
  • Theophylline
  • thrombin
  • TNF
  • Torin1
  • triciribine
  • troglitazone
  • U0126
  • UV
  • UVB
  • vanadate
  • wortmannin
  • Y27632
Akt1 (human) kDGAtMKtFCGtPEy T308-p
Akt1 iso2 (human) KDGATMKTFCGTPEY T246
Akt1 (mouse) KDGAtMKtFCGtPEy T308-p
Akt1 (rat) KDGATMKtFCGTPEy T308-p
Akt1 (fruit fly) TYGRTTKTFCGTPEY T423
Akt1 (cow) KDGATMKtFCGTPEY T308-p
T308
KDGAtMKTFCGtPEy
1 0
Akt1 (human) kDGAtMKtFCGtPEy T308-gl
Akt1 iso2 (human) KDGATMKTFCGTPEY T246
Akt1 (mouse) KDGAtMKTFCGtPEy T308
Akt1 (rat) KDGATMKTFCGTPEy T308
Akt1 (fruit fly) TYGRTTKTFCGTPEY T423
Akt1 (cow) KDGATMKTFCGTPEY T308
T312-p
tMKtFCGtPEyLAPE
0 7
Akt1 (human) tMKtFCGtPEyLAPE T312-p
Akt1 iso2 (human) TMKTFCGTPEYLAPE T250
Akt1 (mouse) tMKtFCGtPEyLAPE T312-p
Akt1 (rat) TMKtFCGTPEyLAPE T312
Akt1 (fruit fly) TTKTFCGTPEYLAPE T427
Akt1 (cow) TMKtFCGTPEYLAPE T312
T312
tMKtFCGTPEyLAPE
1 1
Akt1 (human) tMKtFCGtPEyLAPE T312-gl
Akt1 iso2 (human) TMKTFCGTPEYLAPE T250
Akt1 (mouse) tMKtFCGTPEyLAPE T312
Akt1 (rat) TMKtFCGTPEyLAPE T312
Akt1 (fruit fly) TTKTFCGTPEYLAPE T427
Akt1 (cow) TMKtFCGTPEYLAPE T312
Y315-p
tFCGtPEyLAPEVLE
Upstream
Downstream
5 15
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, altered
Kinase, in vitro:
  • Src (mouse)
Phosphatases, in vitro:
  • PTPRB (mouse)
Putative in vivo kinases:
  • Src (mouse)
Treatment
  • EGF
  • LY294002
  • PP2
Akt1 (human) tFCGtPEyLAPEVLE Y315-p
Akt1 iso2 (human) TFCGTPEYLAPEVLE Y253
Akt1 (mouse) tFCGtPEyLAPEVLE Y315-p
Akt1 (rat) tFCGTPEyLAPEVLE Y315-p
Akt1 (fruit fly) TFCGTPEYLAPEVLD Y430
Akt1 (cow) tFCGTPEYLAPEVLE Y315
Y326-p
EVLEDNDyGRAVDWW
Upstream
Downstream
3 28
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, altered
Kinase, in vitro:
  • Src (mouse)
Phosphatases, in vitro:
  • PTPRB (mouse)
Putative in vivo kinases:
  • Src (mouse)
Treatment
  • EGF
  • LY294002
  • PP2
Akt1 (human) EVLEDNDyGRAVDWW Y326-p
Akt1 iso2 (human) EVLEDNDYGRAVDWW Y264
Akt1 (mouse) EVLEDNDyGRAVDWW Y326-p
Akt1 (rat) EVLEDNDYGRAVDWW Y326
Akt1 (fruit fly) EVLDDNDYGQAVDWW Y441
Akt1 (cow) EVLEDNDYGRAVDWW Y326
K377
RTLGPEAKSLLSGLL
0 4
Akt1 (human) RTLGPEAksLLSGLL K377-ub
Akt1 iso2 (human) RTLGPEAKSLLSGLL K315
Akt1 (mouse) RTLGPEAKSLLSGLL K377
Akt1 (rat) RTLGPEAKSLLSGLL K377
Akt1 (fruit fly) RNITDEAKNLLAGLL K492
Akt1 (cow) RTLSPEAKSLLSGLL K377
S378
TLGPEAKSLLSGLLK
0 2
Akt1 (human) TLGPEAksLLSGLLK S378-p
Akt1 iso2 (human) TLGPEAKSLLSGLLK S316
Akt1 (mouse) TLGPEAKSLLSGLLK S378
Akt1 (rat) TLGPEAKSLLSGLLK S378
Akt1 (fruit fly) NITDEAKNLLAGLLA N493
Akt1 (cow) TLSPEAKSLLSGLLK S378
S396
TQRLGGGSEDAKEIM
0 1
Akt1 (human) KQRLGGGsEDAkEIM S396-p
Akt1 iso2 (human) KQRLGGGSEDAKEIM S334
Akt1 (mouse) TQRLGGGSEDAKEIM S396
Akt1 (rat) TQRLGGGSEDAKEIM S396
Akt1 (fruit fly) KKRLGGGKDDVKEIQ K511
Akt1 (cow) KQRLGGGSEDAKEIM S396
K400
GGGSEDAKEIMQHRF
0 1
Akt1 (human) GGGsEDAkEIMQHRF K400-ub
Akt1 iso2 (human) GGGSEDAKEIMQHRF K338
Akt1 (mouse) GGGSEDAKEIMQHRF K400
Akt1 (rat) GGGSEDAKEIMQHRF K400
Akt1 (fruit fly) GGGKDDVKEIQAHPF K515
Akt1 (cow) GGGSEDAKEIMQHRF K400
Y417
NIVWQDVYEKKLSPP
0 2
Akt1 (human) GIVWQHVyEKkLSPP Y417-p
Akt1 iso2 (human) GIVWQHVYEKKLSPP Y355
Akt1 (mouse) NIVWQDVYEKKLSPP Y417
Akt1 (rat) NIVWQDVYEKKLSPP Y417
Akt1 (fruit fly) SINWTDLVLKKIPPP V532
Akt1 (cow) SIVWQDVYEKKLSPP Y417
K420
WQDVYEKKLSPPFKP
0 1
Akt1 (human) WQHVyEKkLSPPFkP K420-ac
Akt1 iso2 (human) WQHVYEKKLSPPFKP K358
Akt1 (mouse) WQDVYEKKLSPPFKP K420
Akt1 (rat) WQDVYEKKLSPPFKP K420
Akt1 (fruit fly) WTDLVLKKIPPPFKP K535
Akt1 (cow) WQDVYEKKLSPPFKP K420
K426
KKLSPPFKPQVTSET
0 1
Akt1 (human) KkLSPPFkPQVTSET K426-ac
Akt1 iso2 (human) KKLSPPFKPQVTSET K364
Akt1 (mouse) KKLSPPFKPQVTSET K426
Akt1 (rat) KKLSPPFKPQVTSET K426
Akt1 (fruit fly) KKIPPPFKPQVTSDT K541
Akt1 (cow) KKLSPPFKPQVTSET K426
K426
KKLSPPFKPQVTSET
0 1
Akt1 (human) KkLSPPFkPQVTSET K426-ub
Akt1 iso2 (human) KKLSPPFKPQVTSET K364
Akt1 (mouse) KKLSPPFKPQVTSET K426
Akt1 (rat) KKLSPPFKPQVTSET K426
Akt1 (fruit fly) KKIPPPFKPQVTSDT K541
Akt1 (cow) KKLSPPFKPQVTSET K426
Y437
TSETDTRYFDEEFTA
0 2
Akt1 (human) TSETDTRyFDEEFtA Y437-p
Akt1 iso2 (human) TSETDTRYFDEEFTA Y375
Akt1 (mouse) TSETDTRYFDEEFTA Y437
Akt1 (rat) TSETDTRYFDEEFTA Y437
Akt1 (fruit fly) TSDTDTRYFDKEFTG Y552
Akt1 (cow) TSETDTRYFDEEFTA Y437
T443
RYFDEEFTAQMITIt
0 1
Akt1 (human) RyFDEEFtAQMItIt T443-p
Akt1 iso2 (human) RYFDEEFTAQMITIT T381
Akt1 (mouse) RYFDEEFTAQMITIt T443
Akt1 (rat) RYFDEEFTAQMITIt T443
Akt1 (fruit fly) RYFDKEFTGESVELT T558
Akt1 (cow) RYFDEEFTAQMITIT T443
T448
EFTAQMITItPPDQD
0 1
Akt1 (human) EFtAQMItItPPDQD T448-p
Akt1 iso2 (human) EFTAQMITITPPDQD T386
Akt1 (mouse) EFTAQMITItPPDQD T448
Akt1 (rat) EFTAQMITItPPDQD T448
Akt1 (fruit fly) EFTGESVELTPPDPT E563
Akt1 (cow) EFTAQMITITPPDQD T448
T450-p
TAQMITItPPDQDDS
Upstream
Downstream
24 5
Akt1 (human)
T450-p
Akt1 (mouse)
T450-p
Akt1 (rat)
T450-p
Effects on Modified Protein
  • ubiquitination
Effects on Biological Processes:
  • translation, altered
Regulatory protein:
  • RICTOR (human)
  • RICTOR (mouse)
  • Sin1 (mouse)
Treatment
  • BX795
  • cycloheximide
  • IGF-1
  • insulin
  • ischemia
  • PAN
  • PDGF
  • PIK90
  • PP242
  • rapamycin
  • serum
  • SP600125
  • Torin1
Akt1 (human) tAQMItItPPDQDDs T450-p
Akt1 iso2 (human) TAQMITITPPDQDDS T388
Akt1 (mouse) TAQMITItPPDQDDS T450-p
Akt1 (rat) TAQMITItPPDQDDS T450-p
Akt1 (fruit fly) TGESVELTPPDPTGP T565
Akt1 (cow) TAQMITITPPDQDDS T450
S457
tPPDQDDSMECVDSE
0 1
Akt1 (human) tPPDQDDsMECVDSE S457-p
Akt1 iso2 (human) TPPDQDDSMECVDSE S395
Akt1 (mouse) tPPDQDDSMECVDSE S457
Akt1 (rat) tPPDQDDSMECVDSE S457
Akt1 (fruit fly) TPPDPTGPLGSIAEE P572
Akt1 (cow) TPPDQDDSMEGVDSE S457
S473-p
RPHFPQFsysAsGtA
Upstream
Downstream
1402 69
Akt1 (human)
S473-p
Akt1 (mouse)
S473-p
Akt1 (rat)
S473-p
Akt1 (fruit fly)
S586-p
Akt1 (cow)
S473-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • RNA splicing, induced
  • apoptosis, altered
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell cycle regulation
  • cell differentiation, induced
  • cell growth, altered
  • cell growth, induced
  • cell motility, induced
  • cytoskeletal reorganization
  • neural plasticity
  • signaling pathway regulation
  • transcription, induced
  • transcription, inhibited
  • translation, inhibited
Kinase, in vitro:
  • Akt1 (mouse)
  • mTOR (human)
  • mTOR (mouse)
  • PKCA (mouse)
Putative in vivo kinases:
  • Akt1 (mouse)
  • ILK (human)
  • P38A (mouse)
  • PIK3C2A (human)
  • PKCB (mouse)
Putative upstream phosphatases:
  • PPP2CA (human)
  • PTEN (mouse)
Regulatory protein:
  • 14-3-3 zeta (mouse)
  • ACVR2B (mouse)
  • ADRB1 (mouse)
  • Akt1 (human)
  • Akt1 (mouse)
  • Akt2 (mouse)
  • Akt3 (mouse)
  • ALK (human)
  • AMPKA2 (mouse)
  • APP (mouse)
  • APPL (human)
  • APPL2 (human)
  • ATF6A (mouse)
  • BAFF (mouse)
  • BAG1 (mouse)
  • BAG4 (mouse)
  • BCAP (mouse)
  • BCR-ABL1 (human)
  • BRCA1 (human)
  • Brk (human)
  • Btk (mouse)
  • C3aR (mouse)
  • C5aR (mouse)
  • CASP1 (mouse)
  • caveolin-1 (mouse)
  • CBL (mouse)
  • CD151 (mouse)
  • CD19 (mouse)
  • CDC42 iso1 (mouse)
  • CDH2 (mouse)
  • CDK5 (mouse)
  • CDK5R1 (mouse)
  • CLK2 (human)
  • DICER1 (mouse)
  • DNAPK (mouse)
  • EIF4E (mouse)
  • ERK5 (human)
  • F2RL1 (mouse)
  • FAK (mouse)
  • FGFR1 (human)
  • FOXO1A (human)
  • FOXO1A (mouse)
  • Fyn (mouse)
  • GAB2 (mouse)
  • GADD34 (human)
  • GCN2 (mouse)
  • GILZ (human)
  • GLRX1 (mouse)
  • GPM6A (human)
  • GPX1 (mouse)
  • GRB10 (human)
  • GRB10 (mouse)
  • Huntingtin (mouse)
  • ICMT (mouse)
  • IFI16 (mouse)
  • IGF1R (mouse)
  • IKKA (human)
  • IKKA (mouse)
  • IKKB (human)
  • IKKG (human)
  • IKKG (mouse)
  • ILK (human)
  • ILK (mouse)
  • IRS1 (human)
  • IRS1 (mouse)
  • IRS2 (human)
  • IRS2 (mouse)
  • ITGA9 (human)
  • ITGB1 (human)
  • ITGB1 (mouse)
  • JAK2 (mouse)
  • JIP1 (mouse)
  • JNK1 (mouse)
  • JNK2 (mouse)
  • K17 (mouse)
  • KRas (mouse)
  • LAB (mouse)
  • laforin (mouse)
  • LAMTOR1 (human)
  • LAMTOR2 (mouse)
  • LIMS1 (human)
  • LIMS1 (mouse)
  • LIN28A (mouse)
  • LIN28B (mouse)
  • LKB1 (mouse)
  • LPIN1 (mouse)
  • LST8 (mouse)
  • LYN (mouse)
  • MEK5 (human)
  • Mnk1 (mouse)
  • Mnk2 (mouse)
  • MT1 (mouse)
  • mTOR (mouse)
  • Musashi-1 (mouse)
  • MYD88 (human)
  • N-CoR1 (mouse)
  • NF1 (mouse)
  • NFkB-p100 (mouse)
  • NLRP3 (mouse)
  • NPM1 (human)
  • NRas (mouse)
  • NYAP2 (mouse)
  • P38A (mouse)
  • p53 (mouse)
  • p70S6K (mouse)
  • PAG (rat)
  • PDGFRA (mouse)
  • PDK1 (mouse)
  • PERK (mouse)
  • PGGT1B (mouse)
  • PHB (human)
  • PIK3C2A (mouse)
  • PIK3CA (mouse)
  • PIK3CG (human)
  • PIK3R1 (human)
  • PIKFYVE (human)
  • PIKFYVE (mouse)
  • Pim1 (human)
  • PKCA (human)
  • PKCA (mouse)
  • PKCD (human)
  • PKCE (human)
  • PKCI (mouse)
  • PKCT (mouse)
  • PKR (mouse)
  • PLCB2 (human)
  • PPP2R5B (human)
  • PPP2R5B (mouse)
  • PSEN1 (mouse)
  • PTEN (mouse)
  • PTGER3 (mouse)
  • PTGER4 (mouse)
  • PYCARD (mouse)
  • Raptor (mouse)
  • Rb (mouse)
  • RBPJ (mouse)
  • Ret (human)
  • RHEB (mouse)
  • RICTOR (human)
  • RICTOR (mouse)
  • ROCK1 (mouse)
  • SCD (mouse)
  • SGK1 (mouse)
  • SH3BP2 (mouse)
  • SHC1 (mouse)
  • SHP-2 (mouse)
  • SIGLEC7 (mouse)
  • SIK (human)
  • Sin1 (human)
  • Sin1 (mouse)
  • SIRT1 (human)
  • SIRT1 (mouse)
  • SMO (mouse)
  • SPHK1 (human)
  • Src (human)
  • STAT3 (human)
  • Syk (mouse)
  • syndecan-4 (mouse)
  • TBK1 (mouse)
  • TCL1A (mouse)
  • TDGF1 (mouse)
  • TMEM55B (mouse)
  • TORC2 (mouse)
  • TREM2 (mouse)
  • TSC1 (mouse)
  • TSC2 (mouse)
  • TTC3 (human)
  • VEGF (human)
Treatment
  • 1-butanol
  • 4-HT
  • 8-(3-chlorostyryl) caffeine
  • 8-Rp-cAMP
  • A-443654
  • acadesine
  • ACh
  • actinomycin_D
  • activin
  • adiponectin
  • adriamycin
  • AG1433
  • AG1478
  • Akt-I-1
  • Akt_activator_compound_11
  • Akt_inhibitor_VIII
  • Akt_inhibitor_X
  • alloxazine
  • alpha-lipoic_acid
  • AM251
  • amino_acid_starvation
  • amino_acids
  • angiopoietin-1
  • angiopoietin-2
  • angiotensin_2
  • anti-CD3
  • anti-CD3/CD28
  • anti-CD4
  • anti-CTLA-4
  • anti-IgB
  • anti-IgE
  • anti-IgM
  • anti-integrin_alpha9beta1
  • anti-ITGA4
  • anti-ITGA6
  • anti-ITGB1
  • anti-ITGB3
  • anti-kappa chain antibody
  • anti-TCR
  • anti-TNFalpha
  • arsenite
  • AS252424
  • atorvastatin
  • axatomy
  • AZD8055
  • bacterial infection
  • BAPTA-AM
  • BDNF
  • BI-D1870
  • bicuculline
  • bisindolylmaleimide
  • blood pressure
  • bromocriptine
  • butaprost
  • BX795
  • C3aR_antagonist
  • C5aR_antagonist
  • calphostin_C
  • calyculin_A
  • canertinib
  • cangrelor
  • CAS_227449-73-2
  • castration
  • catalase
  • cell_adhesion
  • ciclopirox_olamine
  • cisplatin
  • clonidine
  • cold_water_stress
  • colforsin
  • ConA
  • cpd22
  • CRP
  • culturing_of_cells
  • CXCL12
  • CXCL5
  • cyclic_stretch
  • cycloheximide
  • dactolisib
  • development
  • dexamethasone
  • DI-PHPB
  • DNP
  • doconexent
  • DPCPX
  • Dynasore
  • EDTA
  • EGF
  • EGTA
  • eplerenone
  • Epo
  • estradiol
  • ethanol
  • ether
  • etoposide
  • exercise
  • exercise training
  • faslodex
  • fasting
  • FGF2
  • fibrinogen
  • fingolimod
  • fMLP
  • food deprivation
  • fostriecin
  • G-CSF
  • GDNF
  • gefitinib
  • genistein
  • GF109203X
  • glucosamine
  • glucose
  • glucose_starvation
  • glycine
  • GM-CSF
  • Go_6976
  • GSK2334470
  • guanosine
  • H-89
  • H-CHO
  • H2O2
  • haloperidol
  • herstatin
  • HGF
  • high-fat diet
  • high_glucose
  • honokiol
  • HU-210
  • hypertension
  • hypoxia/reoxygenation
  • IBMX
  • IC87114
  • ICAM-1
  • icatibant
  • IFN-gamma
  • IgE
  • IGF-1
  • IGF-2
  • IGFBP-4
  • IL-10
  • IL-1b
  • IL-2
  • IL-21
  • IL-3
  • IL-4
  • IL-6
  • IL-7
  • imatinib
  • inflammation
  • insulin
  • ionizing_radiation
  • ionomycin
  • ischemia
  • ischemia/reperfusion
  • isoproterenol
  • JAK_inhibitor_I
  • JNK_inhibitor_I
  • KGF
  • KP-392
  • KU-0063794
  • laminar flow
  • latrunculin_A
  • let-7 miRNA
  • leucine
  • levamfetamine
  • LG268
  • LIF
  • LIF withdrawal
  • lithium
  • long-term_potentiation
  • LPS
  • LY294002
  • M-CSF
  • meal feeding
  • mechanical stress
  • memantine
  • metformin
  • methotrexate
  • methyl-beta-cyclodextrin
  • MG132
  • miR-143
  • miRNA
  • MK-2206
  • MK801
  • MMS
  • MPTP
  • MRS-1523
  • mutation
  • myocardial infarction
  • myostatin
  • N-cadherin
  • NAC
  • NBD_peptide
  • nerve_damage
  • NGF
  • Ni(2+)
  • nicardipine
  • nitric_oxide
  • NKH_477
  • NP68
  • nutlin-3
  • NVP-BKM120
  • okadaic_acid
  • OVA
  • PA
  • palmitate
  • PAN
  • PAR1-activating_peptide
  • PAR4-activating_peptide
  • PD123319
  • PD98059
  • PDGF
  • PF-4708671
  • PGE2
  • phentolamine
  • phorbol_ester
  • physostigmine
  • PI-103
  • picropodophyllin
  • PIF
  • PIK90
  • pilocarpine
  • pleiotrophin
  • poly(I-C)
  • PP2
  • PP242
  • pregnancy
  • pressure
  • PTX
  • RAD001
  • RANKL
  • rapamycin
  • refeeding
  • resveratrol
  • RGD
  • RGE
  • rosiglitazone
  • rottlerin
  • SB202190
  • SB203580
  • SCF
  • serum
  • serum_starvation
  • serum_withdrawal
  • Shh
  • siRNA
  • skin aging
  • SN-50
  • SP600125
  • sphingomyelinase
  • sphingosine_1-phosphate
  • SPT
  • starvation_medium
  • staurosporine
  • SU5402
  • SU6656
  • sulforaphane
  • sulprostone
  • sVCAM-1
  • t-butanol
  • tamoxifen
  • TGF-alpha
  • TGF-beta
  • thapsigargin
  • Theophylline
  • thrombin
  • TNF
  • topotecan
  • Torin1
  • TPCK
  • triciribine
  • troglitazone
  • TUG-891
  • tunicamycin
  • U0126
  • UV
  • UVB
  • vanadate
  • VEGF
  • VIIa
  • vitronectin
  • WIN
  • Wnt
  • Wnt3a
  • wortmannin
  • XL-147
  • YM-254890
Akt1 (human) RPHFPQFsysAsGtA S473-p
Akt1 iso2 (human) RPHFPQFSYSASGTA S411
Akt1 (mouse) RPHFPQFsysAsGtA S473-p
Akt1 (rat) RPHFPQFsYSASGTA S473-p
Akt1 (fruit fly) EPLFPQFSYQGDMAS S586
Akt1 (cow) RPHFPQFsYSASATA S473-p
S473-gl
RPHFPQFsysAsGtA
Downstream
5 0
Effects on Biological Processes:
  • apoptosis, altered
Akt1 (human) RPHFPQFsysAsGtA S473-gl
Akt1 iso2 (human) RPHFPQFSYSASGTA S411
Akt1 (mouse) RPHFPQFsysAsGtA S473-gl
Akt1 (rat) RPHFPQFsYSASGTA S473-gl
Akt1 (fruit fly) EPLFPQFSYQGDMAS S586
Akt1 (cow) RPHFPQFSYSASATA S473
Y474-p
PHFPQFsysAsGtA_
1 14
Akt1 (human) PHFPQFsysAsGtA_ Y474-p
Akt1 iso2 (human) PHFPQFSYSASGTA_ Y412
Akt1 (mouse) PHFPQFsysAsGtA_ Y474-p
Akt1 (rat) PHFPQFsYSASGTA_ Y474
Akt1 (fruit fly) PLFPQFSYQGDMAST Y587
Akt1 (cow) PHFPQFsYSASATA_ Y474
S475-p
HFPQFsysAsGtA__
0 3
Akt1 (human) HFPQFsysAsGtA__ S475-p
Akt1 iso2 (human) HFPQFSYSASGTA__ S413
Akt1 (mouse) HFPQFsysAsGtA__ S475-p
Akt1 (rat) HFPQFsYSASGTA__ S475
Akt1 (fruit fly) LFPQFSYQGDMASTL Q588
Akt1 (cow) HFPQFsYSASATA__ S475
S477-p
PQFsysAsGtA____
Upstream
2 7
Treatment
  • insulin
  • LY294002
Akt1 (human) PQFsysAsGtA____ S477-p
Akt1 iso2 (human) PQFSYSASGTA____ S415
Akt1 (mouse) PQFsysAsGtA____ S477-p
Akt1 (rat) PQFsYSASGTA____ S477
Akt1 (fruit fly) GTSSHISTSTSLASM T603
Akt1 (cow) PQFsYSASATA____ S477
T479-p
FsysAsGtA______
Upstream
2 16
Treatment
  • insulin
  • MK-2206
Akt1 (human) FsysAsGtA______ T479-p
Akt1 iso2 (human) FSYSASGTA______ T417
Akt1 (mouse) FsysAsGtA______ T479-p
Akt1 (rat) FsYSASGTA______ T479
Akt1 (fruit fly) SSHISTSTSLASMQ_ T605
Akt1 (cow) FsYSASATA______ T479