Other Species / Isoforms
  4E-BP1 (rat)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S2
______MSAGSSCSQ
0 8
4E-BP1 (human) ______MsGGsSCsQ S2-p
4E-BP1 (mouse) ______MsAGssCSQ S2-p
4E-BP1 (rat) ______MSAGSSCSQ S2
4E-BP1 (fruit fly) ______MSASPTARQ S2
4E-BP1 (cow) ______MSGGSSCSQ S2
S5
___MSAGSSCSQTPS
0 3
4E-BP1 (human) ___MsGGsSCsQtPs S5-p
4E-BP1 (mouse) ___MsAGssCSQtPS S5-p
4E-BP1 (rat) ___MSAGSSCSQTPS S5
4E-BP1 (fruit fly) ___MSASPTARQAIT P5
4E-BP1 (cow) ___MSGGSSCSQTPS S5
S6
__MSAGSSCSQTPSR
0 1
4E-BP1 (human) __MsGGsSCsQtPsR S6
4E-BP1 (mouse) __MsAGssCSQtPSR S6-p
4E-BP1 (rat) __MSAGSSCSQTPSR S6
4E-BP1 (fruit fly) __MSASPTARQAITQ T6
4E-BP1 (cow) __MSGGSSCSQTPSR S6
S8
MSAGSSCSQTPSRAI
1 1
4E-BP1 (human) MsGGsSCsQtPsRAI S8-p
4E-BP1 (mouse) MsAGssCSQtPSRAI S8
4E-BP1 (rat) MSAGSSCSQTPSRAI S8
4E-BP1 (fruit fly) MSASPTARQAITQAL R8
4E-BP1 (cow) MSGGSSCSQTPSRAI S8
T10
AGSSCSQTPSRAIPT
0 5
4E-BP1 (human) GGsSCsQtPsRAIPA T10-p
4E-BP1 (mouse) AGssCSQtPSRAIPT T10-p
4E-BP1 (rat) AGSSCSQTPSRAIPT T10
4E-BP1 (fruit fly) ASPTARQAITQALPM A10
4E-BP1 (cow) GGSSCSQTPSRAIPT T10
S12
SSCSQTPSRAIPTRR
0 1
4E-BP1 (human) sSCsQtPsRAIPATR S12-p
4E-BP1 (mouse) ssCSQtPSRAIPTRR S12
4E-BP1 (rat) SSCSQTPSRAIPTRR S12
4E-BP1 (fruit fly) PTARQAITQALPMIT T12
4E-BP1 (cow) SSCSQTPSRAIPTTR S12
D24
TRRVALGDGVQLPPG
0 1
4E-BP1 (human) TRRVVLGdGVQLPPG D25-ca
4E-BP1 (mouse) TRRVALGDGVQLPPG D24
4E-BP1 (rat) TRRVALGDGVQLPPG D24
4E-BP1 (fruit fly) TRKVVISDPIQMPEV D26
4E-BP1 (cow) TRRVVLADGVQLPPG D25
Y33
VQLPPGDYsttPGGt
0 48
4E-BP1 (human) VQLPPGDysttPGGt Y34-p
4E-BP1 (mouse) VQLPPGDysttPGGt Y33-p
4E-BP1 (rat) VQLPPGDYsttPGGt Y33
4E-BP1 (fruit fly) PIQMPEVYSSTPGGT Y34
4E-BP1 (cow) VQLPPGDYSTTPGGT Y34
S34-p
QLPPGDYsttPGGtL
0 37
4E-BP1 (human) QLPPGDysttPGGtL S35-p
4E-BP1 (mouse) QLPPGDysttPGGtL S34-p
4E-BP1 (rat) QLPPGDYsttPGGtL S34-p
4E-BP1 (fruit fly) IQMPEVYSSTPGGTL S35
4E-BP1 (cow) QLPPGDYSTTPGGTL S35
T35-p
LPPGDYsttPGGtLF
Upstream
1 32
Treatment
  • CGP57380
  • phenylephrine
  • rapamycin
  • SB203580
  • U0126
4E-BP1 (human) LPPGDysttPGGtLF T36-p
4E-BP1 (mouse) LPPGDysttPGGtLF T35-p
4E-BP1 (rat) LPPGDYsttPGGtLF T35-p
4E-BP1 (fruit fly) QMPEVYSSTPGGTLY S36
4E-BP1 (cow) LPPGDYSTTPGGTLF T36
T36-p
PPGDYsttPGGtLFS
Upstream
Downstream
114 130
4E-BP1 (human)
T37-p
4E-BP1 (mouse)
T36-p
4E-BP1 (rat)
T36-p
4E-BP1 (fruit fly)
T37-p
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • translation, altered
Kinase, in vitro:
  • ERK2 (human)
  • mTOR (rat)
Treatment
  • acadesine
  • acetominophen
  • amino_acids
  • development
  • ethanol
  • exercise
  • food deprivation
  • glucagon
  • H2O2
  • IGF-1
  • indinavir
  • insulin
  • Intralipid
  • ischemia
  • ischemia/reperfusion
  • leucine
  • partial_hepatectomy
  • phorbol_ester
  • PP242
  • rapamycin
4E-BP1 (human) PPGDysttPGGtLFs T37-p
4E-BP1 (mouse) PPGDysttPGGtLFs T36-p
4E-BP1 (rat) PPGDYsttPGGtLFS T36-p
4E-BP1 (fruit fly) MPEVYSSTPGGTLYS T37
4E-BP1 (cow) PPGDYSTTPGGTLFS T37
T40-p
YsttPGGtLFSttPG
2 77
4E-BP1 (human) ysttPGGtLFsttPG T41-p
4E-BP1 (mouse) ysttPGGtLFsttPG T40-p
4E-BP1 (rat) YsttPGGtLFSttPG T40-p
4E-BP1 (fruit fly) YSSTPGGTLYSTTPG T41
4E-BP1 (cow) YSTTPGGTLFSTTPG T41
S43
tPGGtLFSttPGGtR
0 58
4E-BP1 (human) tPGGtLFsttPGGtR S44-p
4E-BP1 (mouse) tPGGtLFsttPGGtR S43-p
4E-BP1 (rat) tPGGtLFSttPGGtR S43
4E-BP1 (fruit fly) TPGGTLYSTTPGGTK S44
4E-BP1 (cow) TPGGTLFSTTPGGTR S44
T44-p
PGGtLFSttPGGtRI
Upstream
1 68
Treatment
  • CGP57380
  • phenylephrine
  • rapamycin
  • SB203580
  • U0126
4E-BP1 (human) PGGtLFsttPGGtRI T45-p
4E-BP1 (mouse) PGGtLFsttPGGtRI T44-p
4E-BP1 (rat) PGGtLFSttPGGtRI T44-p
4E-BP1 (fruit fly) PGGTLYSTTPGGTKL T45
4E-BP1 (cow) PGGTLFSTTPGGTRI T45
T45-p
GGtLFSttPGGtRII
Upstream
Downstream
115 125
4E-BP1 (human)
T46-p
4E-BP1 (mouse)
T45-p
4E-BP1 (rat)
T45-p
4E-BP1 (fruit fly)
T46-p
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • translation, altered
Kinase, in vitro:
  • ERK2 (human)
  • mTOR (rat)
Treatment
  • acetominophen
  • amino_acids
  • development
  • ethanol
  • exercise
  • food deprivation
  • glucagon
  • H2O2
  • IGF-1
  • indinavir
  • insulin
  • Intralipid
  • ischemia
  • ischemia/reperfusion
  • leucine
  • partial_hepatectomy
  • phorbol_ester
  • PP242
  • rapamycin
4E-BP1 (human) GGtLFsttPGGtRII T46-p
4E-BP1 (mouse) GGtLFsttPGGtRII T45-p
4E-BP1 (rat) GGtLFSttPGGtRII T45-p
4E-BP1 (fruit fly) GGTLYSTTPGGTKLI T46
4E-BP1 (cow) GGTLFSTTPGGTRII T46
T49-p
FSttPGGtRIIYDRK
2 57
4E-BP1 (human) FsttPGGtRIIyDRk T50-p
4E-BP1 (mouse) FsttPGGtRIIyDRk T49-p
4E-BP1 (rat) FSttPGGtRIIYDRK T49-p
4E-BP1 (fruit fly) YSTTPGGTKLIYERA T50
4E-BP1 (cow) FSTTPGGTRIIYDRK T50
Y53
PGGtRIIYDRKFLME
0 30
4E-BP1 (human) PGGtRIIyDRkFLME Y54-p
4E-BP1 (mouse) PGGtRIIyDRkFLME Y53-p
4E-BP1 (rat) PGGtRIIYDRKFLME Y53
4E-BP1 (fruit fly) PGGTKLIYERAFMKN Y54
4E-BP1 (cow) PGGTRIIYDRKFLME Y54
K56
tRIIYDRKFLMECRN
0 2
4E-BP1 (human) tRIIyDRkFLMECrN K57-ub
4E-BP1 (mouse) tRIIyDRkFLMECRN K56-ub
4E-BP1 (rat) tRIIYDRKFLMECRN K56
4E-BP1 (fruit fly) TKLIYERAFMKNLRG A57
4E-BP1 (cow) TRIIYDRKFLMECRN K57
R62
RKFLMECRNsPVAKt
0 1
4E-BP1 (human) RkFLMECrNsPVtkt R63-m1
4E-BP1 (mouse) RkFLMECRNsPVAKt R62
4E-BP1 (rat) RKFLMECRNsPVAKt R62
4E-BP1 (fruit fly) RAFMKNLRGSPLSQT R63
4E-BP1 (cow) RKFLMECRNSPVTKT R63
S64-p
FLMECRNsPVAKtPP
Upstream
Downstream
79 65
4E-BP1 (human)
S65-p
4E-BP1 (mouse)
S64-p
4E-BP1 (rat)
S64-p
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • translation, altered
Kinase, in vitro:
  • CK2A1 (human)
  • ERK2 (human)
  • mTOR (rat)
  • PKCA (human)
Treatment
  • amino_acids
  • angiotensin
  • DPI
  • ebselen
  • glucagon
  • insulin
  • ischemia
  • ischemia/reperfusion
  • LY294002
  • NAC
  • okadaic_acid
  • partial_hepatectomy
  • phorbol_ester
  • PP242
  • rapamycin
  • SB203580
  • U0126
4E-BP1 (human) FLMECrNsPVtktPP S65-p
4E-BP1 (mouse) FLMECRNsPVAKtPP S64-p
4E-BP1 (rat) FLMECRNsPVAKtPP S64-p
4E-BP1 (fruit fly) FMKNLRGSPLSQTPP S65
4E-BP1 (cow) FLMECRNSPVTKTPP S65
A67
ECRNsPVAKtPPKDL
0 8
4E-BP1 (human) ECrNsPVtktPPRDL T68-p
4E-BP1 (mouse) ECRNsPVAKtPPKDL A67
4E-BP1 (rat) ECRNsPVAKtPPKDL A67
4E-BP1 (fruit fly) NLRGSPLSQTPPSNV S68
4E-BP1 (cow) ECRNSPVTKTPPRDL T68
K68
CRNsPVAKtPPKDLP
0 3
4E-BP1 (human) CrNsPVtktPPRDLP K69-ub
4E-BP1 (mouse) CRNsPVAKtPPKDLP K68
4E-BP1 (rat) CRNsPVAKtPPKDLP K68
4E-BP1 (fruit fly) LRGSPLSQTPPSNVP Q69
4E-BP1 (cow) CRNSPVTKTPPRDLP K69
T69-p
RNsPVAKtPPKDLPT
Upstream
Downstream
47 66
4E-BP1 (human)
T70-p
4E-BP1 (mouse)
T69-p
4E-BP1 (rat)
T69-p
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • translation, altered
Kinase, in vitro:
  • ERK2 (human)
  • mTOR (rat)
Treatment
  • amino_acids
  • angiotensin
  • ethanol
  • exercise
  • insulin
  • ischemia
  • ischemia/reperfusion
  • LY294002
  • partial_hepatectomy
  • phorbol_ester
  • rapamycin
  • U0126
4E-BP1 (human) rNsPVtktPPRDLPt T70-p
4E-BP1 (mouse) RNsPVAKtPPKDLPA T69-p
4E-BP1 (rat) RNsPVAKtPPKDLPT T69-p
4E-BP1 (fruit fly) RGSPLSQTPPSNVPS T70
4E-BP1 (cow) RNSPVTKTPPRDLPT T70
T76
tPPKDLPTIPGVTsP
0 11
4E-BP1 (human) tPPRDLPtIPGVtsP T77-p
4E-BP1 (mouse) tPPKDLPAIPGVtsP A76
4E-BP1 (rat) tPPKDLPTIPGVTsP T76
4E-BP1 (fruit fly) TPPSNVPSCLLRGTP S77
4E-BP1 (cow) TPPRDLPTIPGVTSP T77
T81
LPTIPGVTsPTSDEP
0 4
4E-BP1 (human) LPtIPGVtsPssDEP T82-p
4E-BP1 (mouse) LPAIPGVtsPtsDEP T81-p
4E-BP1 (rat) LPTIPGVTsPTSDEP T81
4E-BP1 (fruit fly) VPSCLLRGTPRTPFR G82
4E-BP1 (cow) LPTIPGVTSPTGDEP T82
S82-p
PTIPGVTsPTSDEPP
Upstream
Downstream
5 8
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • translation, altered
Kinase, in vitro:
  • ERK2 (human)
  • mTOR (rat)
Treatment
  • amino_acids
  • insulin
  • rapamycin
4E-BP1 (human) PtIPGVtsPssDEPP S83-p
4E-BP1 (mouse) PAIPGVtsPtsDEPP S82-p
4E-BP1 (rat) PTIPGVTsPTSDEPP S82-p
4E-BP1 (fruit fly) PSCLLRGTPRTPFRK T83
4E-BP1 (cow) PTIPGVTSPTGDEPP S83
T84
IPGVTsPTSDEPPMQ
0 2
4E-BP1 (human) IPGVtsPssDEPPME S85-p
4E-BP1 (mouse) IPGVtsPtsDEPPMQ T84-p
4E-BP1 (rat) IPGVTsPTSDEPPMQ T84
4E-BP1 (fruit fly) CLLRGTPRTPFRKCV R85
4E-BP1 (cow) IPGVTSPTGDEPPTE T85
S85
PGVTsPTSDEPPMQA
0 5
4E-BP1 (human) PGVtsPssDEPPMEA S86-p
4E-BP1 (mouse) PGVtsPtsDEPPMQA S85-p
4E-BP1 (rat) PGVTsPTSDEPPMQA S85
4E-BP1 (fruit fly) LLRGTPRTPFRKCVP T86
4E-BP1 (cow) PGVTSPTGDEPPTEA G86
S93
DEPPMQASQSHLHsS
1 9
4E-BP1 (human) DEPPMEAsQSHLRNs S94-p
4E-BP1 (mouse) DEPPMQAsQsQLPss S93-p
4E-BP1 (rat) DEPPMQASQSHLHsS S93
4E-BP1 (fruit fly) PFRKCVPVPTELIKQ V94
4E-BP1 (cow) DEPPTEARQNHLRSS R94
S95
PPMQASQSHLHsSPE
0 2
4E-BP1 (human) PPMEAsQSHLRNsPE S96
4E-BP1 (mouse) PPMQAsQsQLPssPE S95-p
4E-BP1 (rat) PPMQASQSHLHsSPE S95
4E-BP1 (fruit fly) RKCVPVPTELIKQTK T96
4E-BP1 (cow) PPTEARQNHLRSSPE N96
S99-p
ASQSHLHsSPEDKRA
Upstream
1 4
Kinase, in vitro:
  • CK2A1 (rabbit)
4E-BP1 (human) AsQSHLRNsPEDKRA N100
4E-BP1 (mouse) AsQsQLPssPEDKRA S99-p
4E-BP1 (rat) ASQSHLHsSPEDKRA S99-p
4E-BP1 (fruit fly) PVPTELIKQTKSLKI K100
4E-BP1 (cow) ARQNHLRSSPEDKPA S100
S100
SQSHLHsSPEDKRAG
2 22
4E-BP1 (human) sQSHLRNsPEDKRAG S101-p
4E-BP1 (mouse) sQsQLPssPEDKRAG S100-p
4E-BP1 (rat) SQSHLHsSPEDKRAG S100
4E-BP1 (fruit fly) VPTELIKQTKSLKIE Q101
4E-BP1 (cow) RQNHLRSSPEDKPAG S101
S111-p
KRAGGEEsQFEMDI_
Upstream
Downstream
5 42
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • ATM (human)
  • CK2A1 (rabbit)
Putative in vivo kinases:
  • ATM (human)
Treatment
  • insulin
  • rapamycin
  • wortmannin
4E-BP1 (human) KRAGGEEsQFEMDI_ S112-p
4E-BP1 (mouse) KRAGGEEsQFEMDI_ S111-p
4E-BP1 (rat) KRAGGEEsQFEMDI_ S111-p
4E-BP1 (fruit fly) SLKIEDQEQFQLDL_ E111
4E-BP1 (cow) KPAGGEESQFEMDI_ S112