Other Species / Isoforms
  4E-BP1 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S2-p
______MsAGssCSQ
Upstream
0 8
Treatment
  • insulin
  • LY294002
  • MK-2206
4E-BP1 (human) ______MsGGsSCsQ S2-p
4E-BP1 (mouse) ______MsAGssCSQ S2-p
4E-BP1 (rat) ______MSAGSSCSQ S2
4E-BP1 (fruit fly) ______MSASPTARQ S2
4E-BP1 (cow) ______MSGGSSCSQ S2
S5-p
___MsAGssCSQtPS
Upstream
0 3
Treatment
  • insulin
  • LY294002
  • MK-2206
4E-BP1 (human) ___MsGGsSCsQtPs S5-p
4E-BP1 (mouse) ___MsAGssCSQtPS S5-p
4E-BP1 (rat) ___MSAGSSCSQTPS S5
4E-BP1 (fruit fly) ___MSASPTARQAIT P5
4E-BP1 (cow) ___MSGGSSCSQTPS S5
S6-p
__MsAGssCSQtPSR
Upstream
0 1
Treatment
  • insulin
  • LY294002
  • MK-2206
4E-BP1 (human) __MsGGsSCsQtPsR S6
4E-BP1 (mouse) __MsAGssCSQtPSR S6-p
4E-BP1 (rat) __MSAGSSCSQTPSR S6
4E-BP1 (fruit fly) __MSASPTARQAITQ T6
4E-BP1 (cow) __MSGGSSCSQTPSR S6
S8
MsAGssCSQtPSRAI
1 1
4E-BP1 (human) MsGGsSCsQtPsRAI S8-p
4E-BP1 (mouse) MsAGssCSQtPSRAI S8
4E-BP1 (rat) MSAGSSCSQTPSRAI S8
4E-BP1 (fruit fly) MSASPTARQAITQAL R8
4E-BP1 (cow) MSGGSSCSQTPSRAI S8
T10-p
AGssCSQtPSRAIPT
Upstream
0 5
Treatment
  • insulin
  • LY294002
  • MK-2206
4E-BP1 (human) GGsSCsQtPsRAIPA T10-p
4E-BP1 (mouse) AGssCSQtPSRAIPT T10-p
4E-BP1 (rat) AGSSCSQTPSRAIPT T10
4E-BP1 (fruit fly) ASPTARQAITQALPM A10
4E-BP1 (cow) GGSSCSQTPSRAIPT T10
S12
ssCSQtPSRAIPTRR
0 1
4E-BP1 (human) sSCsQtPsRAIPATR S12-p
4E-BP1 (mouse) ssCSQtPSRAIPTRR S12
4E-BP1 (rat) SSCSQTPSRAIPTRR S12
4E-BP1 (fruit fly) PTARQAITQALPMIT T12
4E-BP1 (cow) SSCSQTPSRAIPTTR S12
D24
TRRVALGDGVQLPPG
0 1
4E-BP1 (human) TRRVVLGdGVQLPPG D25-ca
4E-BP1 (mouse) TRRVALGDGVQLPPG D24
4E-BP1 (rat) TRRVALGDGVQLPPG D24
4E-BP1 (fruit fly) TRKVVISDPIQMPEV D26
4E-BP1 (cow) TRRVVLADGVQLPPG D25
Y33-p
VQLPPGDysttPGGt
Upstream
0 48
Treatment
  • Torin1
4E-BP1 (human) VQLPPGDysttPGGt Y34-p
4E-BP1 (mouse) VQLPPGDysttPGGt Y33-p
4E-BP1 (rat) VQLPPGDYsttPGGt Y33
4E-BP1 (fruit fly) PIQMPEVYSSTPGGT Y34
4E-BP1 (cow) VQLPPGDYSTTPGGT Y34
S34-p
QLPPGDysttPGGtL
Upstream
0 37
Treatment
  • Torin1
4E-BP1 (human) QLPPGDysttPGGtL S35-p
4E-BP1 (mouse) QLPPGDysttPGGtL S34-p
4E-BP1 (rat) QLPPGDYsttPGGtL S34-p
4E-BP1 (fruit fly) IQMPEVYSSTPGGTL S35
4E-BP1 (cow) QLPPGDYSTTPGGTL S35
T35-p
LPPGDysttPGGtLF
Upstream
1 32
Treatment
  • Torin1
4E-BP1 (human) LPPGDysttPGGtLF T36-p
4E-BP1 (mouse) LPPGDysttPGGtLF T35-p
4E-BP1 (rat) LPPGDYsttPGGtLF T35-p
4E-BP1 (fruit fly) QMPEVYSSTPGGTLY S36
4E-BP1 (cow) LPPGDYSTTPGGTLF T36
T36-p
PPGDysttPGGtLFs
Upstream
Downstream
113 130
4E-BP1 (human)
T37-p
4E-BP1 (mouse)
T36-p
4E-BP1 (rat)
T36-p
4E-BP1 (fruit fly)
T37-p
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • mTOR (mouse)
  • mTOR (rat)
  • P38A (human)
Putative in vivo kinases:
  • MSK1 (human)
  • mTOR (mouse)
  • P38A (human)
Regulatory protein:
  • Akt2 (mouse)
  • CAMK2G (mouse)
  • Ezrin (mouse)
  • FKBP12 (mouse)
  • FOXO1A (mouse)
  • GADD34 (human)
  • GLUT1 (mouse)
  • LIN28A (human)
  • LIN28A (mouse)
  • LIN28B (mouse)
  • LKB1 (mouse)
  • LST8 (mouse)
  • Musashi-1 (mouse)
  • PTGER3 (mouse)
  • Raptor (mouse)
  • RICTOR (mouse)
  • Sin1 (mouse)
  • syndecan-4 (mouse)
  • TDGF1 (mouse)
  • TSC1 (mouse)
  • TSC2 (mouse)
Treatment
  • adiponectin
  • AMDE-1
  • amino_acid_starvation
  • AS252424
  • butaprost
  • BX795
  • cell_detachment
  • culturing_of_cells
  • DEN
  • exercise
  • FGF2
  • glucose
  • glucose_starvation
  • H-89
  • H-CHO
  • IC87114
  • INK-128
  • insulin
  • KU-0063794
  • let-7 miRNA
  • LY294002
  • PD169316
  • PD98059
  • PGE2
  • PIK90
  • PP242
  • PTX
  • rapamycin
  • SB202190
  • serum
  • serum_starvation
  • siRNA
  • sulprostone
  • tamoxifen
  • Torin1
  • U0126
  • UV
  • wortmannin
4E-BP1 (human) PPGDysttPGGtLFs T37-p
4E-BP1 (mouse) PPGDysttPGGtLFs T36-p
4E-BP1 (rat) PPGDYsttPGGtLFS T36-p
4E-BP1 (fruit fly) MPEVYSSTPGGTLYS T37
4E-BP1 (cow) PPGDYSTTPGGTLFS T37
T40-p
ysttPGGtLFsttPG
2 77
4E-BP1 (human) ysttPGGtLFsttPG T41-p
4E-BP1 (mouse) ysttPGGtLFsttPG T40-p
4E-BP1 (rat) YsttPGGtLFSttPG T40-p
4E-BP1 (fruit fly) YSSTPGGTLYSTTPG T41
4E-BP1 (cow) YSTTPGGTLFSTTPG T41
S43-p
tPGGtLFsttPGGtR
0 58
4E-BP1 (human) tPGGtLFsttPGGtR S44-p
4E-BP1 (mouse) tPGGtLFsttPGGtR S43-p
4E-BP1 (rat) tPGGtLFSttPGGtR S43
4E-BP1 (fruit fly) TPGGTLYSTTPGGTK S44
4E-BP1 (cow) TPGGTLFSTTPGGTR S44
T44-p
PGGtLFsttPGGtRI
Upstream
1 68
Regulatory protein:
  • TSC2 (mouse)
Treatment
  • Torin1
4E-BP1 (human) PGGtLFsttPGGtRI T45-p
4E-BP1 (mouse) PGGtLFsttPGGtRI T44-p
4E-BP1 (rat) PGGtLFSttPGGtRI T44-p
4E-BP1 (fruit fly) PGGTLYSTTPGGTKL T45
4E-BP1 (cow) PGGTLFSTTPGGTRI T45
T45-p
GGtLFsttPGGtRII
Upstream
Downstream
114 125
4E-BP1 (human)
T46-p
4E-BP1 (mouse)
T45-p
4E-BP1 (rat)
T45-p
4E-BP1 (fruit fly)
T46-p
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • mTOR (mouse)
  • mTOR (rat)
  • P38A (human)
Putative in vivo kinases:
  • mTOR (mouse)
Regulatory protein:
  • Akt2 (mouse)
  • AMPKA2 (mouse)
  • CAMK2G (mouse)
  • FKBP12 (mouse)
  • FOXO1A (mouse)
  • GADD34 (human)
  • LIN28A (human)
  • LIN28A (mouse)
  • LIN28B (mouse)
  • LKB1 (mouse)
  • LST8 (mouse)
  • MPRIP (mouse)
  • Musashi-1 (mouse)
  • PTGER3 (mouse)
  • Raptor (mouse)
  • RICTOR (mouse)
  • Sin1 (mouse)
  • syndecan-4 (mouse)
  • TDGF1 (mouse)
  • TSC1 (mouse)
  • TSC2 (mouse)
Treatment
  • adiponectin
  • AMDE-1
  • amino_acid_starvation
  • AS252424
  • butaprost
  • BX795
  • cell_detachment
  • culturing_of_cells
  • DEN
  • exercise
  • FGF2
  • glucose
  • glucose_starvation
  • H-CHO
  • IC87114
  • INK-128
  • insulin
  • KU-0063794
  • let-7 miRNA
  • LY294002
  • PGE2
  • PIK90
  • PP242
  • pressure
  • PTX
  • rapamycin
  • serum
  • serum_starvation
  • sulprostone
  • tamoxifen
  • Torin1
  • UV
  • wortmannin
4E-BP1 (human) GGtLFsttPGGtRII T46-p
4E-BP1 (mouse) GGtLFsttPGGtRII T45-p
4E-BP1 (rat) GGtLFSttPGGtRII T45-p
4E-BP1 (fruit fly) GGTLYSTTPGGTKLI T46
4E-BP1 (cow) GGTLFSTTPGGTRII T46
T49-p
FsttPGGtRIIyDRk
Upstream
2 57
Treatment
  • Torin1
4E-BP1 (human) FsttPGGtRIIyDRk T50-p
4E-BP1 (mouse) FsttPGGtRIIyDRk T49-p
4E-BP1 (rat) FSttPGGtRIIYDRK T49-p
4E-BP1 (fruit fly) YSTTPGGTKLIYERA T50
4E-BP1 (cow) FSTTPGGTRIIYDRK T50
Y53-p
PGGtRIIyDRkFLME
0 30
4E-BP1 (human) PGGtRIIyDRkFLME Y54-p
4E-BP1 (mouse) PGGtRIIyDRkFLME Y53-p
4E-BP1 (rat) PGGtRIIYDRKFLME Y53
4E-BP1 (fruit fly) PGGTKLIYERAFMKN Y54
4E-BP1 (cow) PGGTRIIYDRKFLME Y54
K56-ub
tRIIyDRkFLMECRN
0 2
4E-BP1 (human) tRIIyDRkFLMECrN K57-ub
4E-BP1 (mouse) tRIIyDRkFLMECRN K56-ub
4E-BP1 (rat) tRIIYDRKFLMECRN K56
4E-BP1 (fruit fly) TKLIYERAFMKNLRG A57
4E-BP1 (cow) TRIIYDRKFLMECRN K57
R62
RkFLMECRNsPVAKt
0 1
4E-BP1 (human) RkFLMECrNsPVtkt R63-m1
4E-BP1 (mouse) RkFLMECRNsPVAKt R62
4E-BP1 (rat) RKFLMECRNsPVAKt R62
4E-BP1 (fruit fly) RAFMKNLRGSPLSQT R63
4E-BP1 (cow) RKFLMECRNSPVTKT R63
S64-p
FLMECRNsPVAKtPP
Upstream
78 65
4E-BP1 (human)
S65-p
4E-BP1 (mouse)
S64-p
4E-BP1 (rat)
S64-p
Kinase, in vitro:
  • MSK1 (human)
Putative in vivo kinases:
  • MSK1 (human)
  • mTOR (mouse)
  • P38A (human)
Regulatory protein:
  • AMPKA1 (mouse)
  • CAMK2G (mouse)
  • Fyn (mouse)
  • LKB1 (mouse)
  • LST8 (mouse)
  • RHEB (mouse)
  • RRAGC (mouse)
  • Sin1 (mouse)
Treatment
  • acadesine
  • amino_acids
  • benzo(a)pyrene
  • BX795
  • DEN
  • dexamethasone
  • glucose
  • H-89
  • IBMX
  • IGF-1
  • INK-128
  • insulin
  • ischemia
  • LY294002
  • meal feeding
  • NKH_477
  • NTCU
  • PD169316
  • PD98059
  • PIK90
  • pomegranate_wine
  • PP242
  • PTH(1-34)
  • rapamycin
  • SB202190
  • serum_starvation
  • Torin1
  • U0126
  • UV
  • wortmannin
  • XL-147
4E-BP1 (human) FLMECrNsPVtktPP S65-p
4E-BP1 (mouse) FLMECRNsPVAKtPP S64-p
4E-BP1 (rat) FLMECRNsPVAKtPP S64-p
4E-BP1 (fruit fly) FMKNLRGSPLSQTPP S65
4E-BP1 (cow) FLMECRNSPVTKTPP S65
A67
ECRNsPVAKtPPKDL
0 8
4E-BP1 (human) ECrNsPVtktPPRDL T68-p
4E-BP1 (mouse) ECRNsPVAKtPPKDL A67
4E-BP1 (rat) ECRNsPVAKtPPKDL A67
4E-BP1 (fruit fly) NLRGSPLSQTPPSNV S68
4E-BP1 (cow) ECRNSPVTKTPPRDL T68
K68
CRNsPVAKtPPKDLP
0 3
4E-BP1 (human) CrNsPVtktPPRDLP K69-ub
4E-BP1 (mouse) CRNsPVAKtPPKDLP K68
4E-BP1 (rat) CRNsPVAKtPPKDLP K68
4E-BP1 (fruit fly) LRGSPLSQTPPSNVP Q69
4E-BP1 (cow) CRNSPVTKTPPRDLP K69
T69-p
RNsPVAKtPPKDLPA
Upstream
Downstream
46 66
4E-BP1 (human)
T70-p
4E-BP1 (mouse)
T69-p
4E-BP1 (rat)
T69-p
Effects on Biological Processes:
  • signaling pathway regulation
Putative in vivo kinases:
  • mTOR (mouse)
Regulatory protein:
  • syndecan-4 (mouse)
Treatment
  • FGF2
  • glucose
  • IL-33
  • insulin
  • LPS
  • LY294002
  • MK-2206
  • PTH(1-34)
  • rapamycin
  • Torin1
  • UV
4E-BP1 (human) rNsPVtktPPRDLPt T70-p
4E-BP1 (mouse) RNsPVAKtPPKDLPA T69-p
4E-BP1 (rat) RNsPVAKtPPKDLPT T69-p
4E-BP1 (fruit fly) RGSPLSQTPPSNVPS T70
4E-BP1 (cow) RNSPVTKTPPRDLPT T70
A76
tPPKDLPAIPGVtsP
0 11
4E-BP1 (human) tPPRDLPtIPGVtsP T77-p
4E-BP1 (mouse) tPPKDLPAIPGVtsP A76
4E-BP1 (rat) tPPKDLPTIPGVTsP T76
4E-BP1 (fruit fly) TPPSNVPSCLLRGTP S77
4E-BP1 (cow) TPPRDLPTIPGVTSP T77
T81-p
LPAIPGVtsPtsDEP
0 4
4E-BP1 (human) LPtIPGVtsPssDEP T82-p
4E-BP1 (mouse) LPAIPGVtsPtsDEP T81-p
4E-BP1 (rat) LPTIPGVTsPTSDEP T81
4E-BP1 (fruit fly) VPSCLLRGTPRTPFR G82
4E-BP1 (cow) LPTIPGVTSPTGDEP T82
S82-p
PAIPGVtsPtsDEPP
5 8
4E-BP1 (human) PtIPGVtsPssDEPP S83-p
4E-BP1 (mouse) PAIPGVtsPtsDEPP S82-p
4E-BP1 (rat) PTIPGVTsPTSDEPP S82-p
4E-BP1 (fruit fly) PSCLLRGTPRTPFRK T83
4E-BP1 (cow) PTIPGVTSPTGDEPP S83
T84-p
IPGVtsPtsDEPPMQ
0 2
4E-BP1 (human) IPGVtsPssDEPPME S85-p
4E-BP1 (mouse) IPGVtsPtsDEPPMQ T84-p
4E-BP1 (rat) IPGVTsPTSDEPPMQ T84
4E-BP1 (fruit fly) CLLRGTPRTPFRKCV R85
4E-BP1 (cow) IPGVTSPTGDEPPTE T85
S85-p
PGVtsPtsDEPPMQA
0 5
4E-BP1 (human) PGVtsPssDEPPMEA S86-p
4E-BP1 (mouse) PGVtsPtsDEPPMQA S85-p
4E-BP1 (rat) PGVTsPTSDEPPMQA S85
4E-BP1 (fruit fly) LLRGTPRTPFRKCVP T86
4E-BP1 (cow) PGVTSPTGDEPPTEA G86
S93-p
DEPPMQAsQsQLPss
1 9
4E-BP1 (human) DEPPMEAsQSHLRNs S94-p
4E-BP1 (mouse) DEPPMQAsQsQLPss S93-p
4E-BP1 (rat) DEPPMQASQSHLHsS S93
4E-BP1 (fruit fly) PFRKCVPVPTELIKQ V94
4E-BP1 (cow) DEPPTEARQNHLRSS R94
S95-p
PPMQAsQsQLPssPE
0 2
4E-BP1 (human) PPMEAsQSHLRNsPE S96
4E-BP1 (mouse) PPMQAsQsQLPssPE S95-p
4E-BP1 (rat) PPMQASQSHLHsSPE S95
4E-BP1 (fruit fly) RKCVPVPTELIKQTK T96
4E-BP1 (cow) PPTEARQNHLRSSPE N96
S99-p
AsQsQLPssPEDKRA
Upstream
1 4
Treatment
  • insulin
  • MK-2206
4E-BP1 (human) AsQSHLRNsPEDKRA N100
4E-BP1 (mouse) AsQsQLPssPEDKRA S99-p
4E-BP1 (rat) ASQSHLHsSPEDKRA S99-p
4E-BP1 (fruit fly) PVPTELIKQTKSLKI K100
4E-BP1 (cow) ARQNHLRSSPEDKPA S100
S100-p
sQsQLPssPEDKRAG
Upstream
2 22
Treatment
  • insulin
  • MK-2206
4E-BP1 (human) sQSHLRNsPEDKRAG S101-p
4E-BP1 (mouse) sQsQLPssPEDKRAG S100-p
4E-BP1 (rat) SQSHLHsSPEDKRAG S100
4E-BP1 (fruit fly) VPTELIKQTKSLKIE Q101
4E-BP1 (cow) RQNHLRSSPEDKPAG S101
S111-p
KRAGGEEsQFEMDI_
Upstream
5 42
Treatment
  • insulin
  • LY294002
4E-BP1 (human) KRAGGEEsQFEMDI_ S112-p
4E-BP1 (mouse) KRAGGEEsQFEMDI_ S111-p
4E-BP1 (rat) KRAGGEEsQFEMDI_ S111-p
4E-BP1 (fruit fly) SLKIEDQEQFQLDL_ E111
4E-BP1 (cow) KPAGGEESQFEMDI_ S112