Other Species / Isoforms
  4E-BP1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S2-p
______MsGGsSCsQ
0 8
4E-BP1 (human) ______MsGGsSCsQ S2-p
4E-BP1 (mouse) ______MsAGssCSQ S2-p
4E-BP1 (rat) ______MSAGSSCSQ S2
4E-BP1 (fruit fly) ______MSASPTARQ S2
4E-BP1 (cow) ______MSGGSSCSQ S2
S5-p
___MsGGsSCsQtPs
0 3
4E-BP1 (human) ___MsGGsSCsQtPs S5-p
4E-BP1 (mouse) ___MsAGssCSQtPS S5-p
4E-BP1 (rat) ___MSAGSSCSQTPS S5
4E-BP1 (fruit fly) ___MSASPTARQAIT P5
4E-BP1 (cow) ___MSGGSSCSQTPS S5
S6
__MsGGsSCsQtPsR
0 1
4E-BP1 (human) __MsGGsSCsQtPsR S6
4E-BP1 (mouse) __MsAGssCSQtPSR S6-p
4E-BP1 (rat) __MSAGSSCSQTPSR S6
4E-BP1 (fruit fly) __MSASPTARQAITQ T6
4E-BP1 (cow) __MSGGSSCSQTPSR S6
S8-p
MsGGsSCsQtPsRAI
1 1
4E-BP1 (human) MsGGsSCsQtPsRAI S8-p
4E-BP1 (mouse) MsAGssCSQtPSRAI S8
4E-BP1 (rat) MSAGSSCSQTPSRAI S8
4E-BP1 (fruit fly) MSASPTARQAITQAL R8
4E-BP1 (cow) MSGGSSCSQTPSRAI S8
T10-p
GGsSCsQtPsRAIPA
0 5
4E-BP1 (human) GGsSCsQtPsRAIPA T10-p
4E-BP1 (mouse) AGssCSQtPSRAIPT T10-p
4E-BP1 (rat) AGSSCSQTPSRAIPT T10
4E-BP1 (fruit fly) ASPTARQAITQALPM A10
4E-BP1 (cow) GGSSCSQTPSRAIPT T10
S12-p
sSCsQtPsRAIPATR
0 1
4E-BP1 (human) sSCsQtPsRAIPATR S12-p
4E-BP1 (mouse) ssCSQtPSRAIPTRR S12
4E-BP1 (rat) SSCSQTPSRAIPTRR S12
4E-BP1 (fruit fly) PTARQAITQALPMIT T12
4E-BP1 (cow) SSCSQTPSRAIPTTR S12
D25-ca
TRRVVLGdGVQLPPG
0 1
4E-BP1 (human) TRRVVLGdGVQLPPG D25-ca
4E-BP1 (mouse) TRRVALGDGVQLPPG D24
4E-BP1 (rat) TRRVALGDGVQLPPG D24
4E-BP1 (fruit fly) TRKVVISDPIQMPEV D26
4E-BP1 (cow) TRRVVLADGVQLPPG D25
Y34-p
VQLPPGDysttPGGt
Upstream
0 48
Treatment
  • Torin1
4E-BP1 (human) VQLPPGDysttPGGt Y34-p
4E-BP1 (mouse) VQLPPGDysttPGGt Y33-p
4E-BP1 (rat) VQLPPGDYsttPGGt Y33
4E-BP1 (fruit fly) PIQMPEVYSSTPGGT Y34
4E-BP1 (cow) VQLPPGDYSTTPGGT Y34
S35-p
QLPPGDysttPGGtL
0 37
4E-BP1 (human) QLPPGDysttPGGtL S35-p
4E-BP1 (mouse) QLPPGDysttPGGtL S34-p
4E-BP1 (rat) QLPPGDYsttPGGtL S34-p
4E-BP1 (fruit fly) IQMPEVYSSTPGGTL S35
4E-BP1 (cow) QLPPGDYSTTPGGTL S35
T36-p
LPPGDysttPGGtLF
1 32
4E-BP1 (human) LPPGDysttPGGtLF T36-p
4E-BP1 (mouse) LPPGDysttPGGtLF T35-p
4E-BP1 (rat) LPPGDYsttPGGtLF T35-p
4E-BP1 (fruit fly) QMPEVYSSTPGGTLY S36
4E-BP1 (cow) LPPGDYSTTPGGTLF T36
T37-p
PPGDysttPGGtLFs
Upstream
Downstream
113 130
4E-BP1 (human)
T37-p
4E-BP1 (mouse)
T36-p
4E-BP1 (rat)
T36-p
4E-BP1 (fruit fly)
T37-p
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • translation, altered
  • translation, induced
Kinase, in vitro:
  • ERK2 (human)
  • GSK3B (human)
  • mTOR (human)
  • mTOR (mouse)
Putative in vivo kinases:
  • GSK3B (human)
  • mTOR (human)
  • mTOR (rat)
Regulatory protein:
  • 4E-BP1 (human)
  • CIP2A (human)
  • FAK (human)
  • GSK3A (human)
  • LRRK2 (human)
  • mTOR (human)
  • NOX4 (human)
  • PHLPP (human)
  • PHLPP2 (human)
  • PKM (human)
  • PPP2CA (human)
  • PRAS40 (human)
  • PRAS40 iso3 (human)
  • RAG1 (human)
  • Raptor (human)
  • RHEB (human)
  • RICTOR (human)
  • SLC1A5 (human)
  • TBK1 (human)
  • TSC2 (human)
Treatment
  • 1-azakenpaullone
  • 2-deoxyglucose
  • 8-CPT-2Me-cAMP
  • AG2037
  • amino_acid_starvation
  • amino_acids
  • anti-HLA
  • AR-A014418
  • As2O3
  • AZD8055
  • bisindolylmaleimide
  • caffeine
  • dactolisib
  • EGF
  • exercise
  • fibronectin
  • FMK-MEA
  • Go_6796
  • IFN-beta
  • IFN-gamma
  • imatinib
  • insulin
  • KPT-185
  • LY294002
  • mifepristone
  • MK-2206
  • nilotinib
  • OSI-027
  • PD0325901
  • PD184352
  • PD98059
  • phorbol_ester
  • PI-103
  • pimenta doica
  • PKI-402
  • PP242
  • RAD001
  • rapamycin
  • retinoic_acid
  • SB216763
  • serum
  • serum_starvation
  • siRNA
  • temsirolimus
  • TGF-beta
  • Torin1
  • U0126
  • virus infection
  • wortmannin
  • XL413
4E-BP1 (human) PPGDysttPGGtLFs T37-p
4E-BP1 (mouse) PPGDysttPGGtLFs T36-p
4E-BP1 (rat) PPGDYsttPGGtLFS T36-p
4E-BP1 (fruit fly) MPEVYSSTPGGTLYS T37
4E-BP1 (cow) PPGDYSTTPGGTLFS T37
T41-p
ysttPGGtLFsttPG
Upstream
Downstream
2 77
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • cell growth, induced
  • translation, induced
Kinase, in vitro:
  • CK1E (human)
Putative in vivo kinases:
  • CK1E (human)
  • mTOR (human)
Treatment
  • gefitinib
  • imatinib
  • insulin
  • Torin1
4E-BP1 (human) ysttPGGtLFsttPG T41-p
4E-BP1 (mouse) ysttPGGtLFsttPG T40-p
4E-BP1 (rat) YsttPGGtLFSttPG T40-p
4E-BP1 (fruit fly) YSSTPGGTLYSTTPG T41
4E-BP1 (cow) YSTTPGGTLFSTTPG T41
S44-p
tPGGtLFsttPGGtR
Upstream
0 58
Putative in vivo kinases:
  • mTOR (human)
Treatment
  • imatinib
  • rapamycin
  • Torin1
4E-BP1 (human) tPGGtLFsttPGGtR S44-p
4E-BP1 (mouse) tPGGtLFsttPGGtR S43-p
4E-BP1 (rat) tPGGtLFSttPGGtR S43
4E-BP1 (fruit fly) TPGGTLYSTTPGGTK S44
4E-BP1 (cow) TPGGTLFSTTPGGTR S44
T45-p
PGGtLFsttPGGtRI
Upstream
1 68
Treatment
  • gefitinib
  • imatinib
  • Torin1
4E-BP1 (human) PGGtLFsttPGGtRI T45-p
4E-BP1 (mouse) PGGtLFsttPGGtRI T44-p
4E-BP1 (rat) PGGtLFSttPGGtRI T44-p
4E-BP1 (fruit fly) PGGTLYSTTPGGTKL T45
4E-BP1 (cow) PGGTLFSTTPGGTRI T45
T46-p
GGtLFsttPGGtRII
Upstream
Downstream
114 125
4E-BP1 (human)
T46-p
4E-BP1 (mouse)
T45-p
4E-BP1 (rat)
T45-p
4E-BP1 (fruit fly)
T46-p
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • autophagy, induced
  • carcinogenesis, induced
  • cell growth, induced
  • translation, altered
  • translation, induced
Kinase, in vitro:
  • ERK2 (human)
  • GSK3B (human)
  • mTOR (human)
  • mTOR (mouse)
Putative in vivo kinases:
  • GSK3B (human)
  • mTOR (human)
  • mTOR (rat)
Regulatory protein:
  • 4E-BP1 (human)
  • CIP2A (human)
  • FAK (human)
  • GSK3A (human)
  • LKB1 (human)
  • LRRK2 (human)
  • mTOR (human)
  • NOX4 (human)
  • PHLPP (human)
  • PHLPP2 (human)
  • PKM (human)
  • PRAS40 (human)
  • PRAS40 iso3 (human)
  • RAG1 (human)
  • Raptor (human)
  • RHEB (human)
  • SLC1A5 (human)
  • TSC2 (human)
Treatment
  • 1-azakenpaullone
  • 8-CPT-2Me-cAMP
  • AG2037
  • amino_acid_starvation
  • amino_acids
  • anti-HLA
  • AR-A014418
  • As2O3
  • AZD8055
  • bisindolylmaleimide
  • dactolisib
  • exercise
  • fasting
  • fibronectin
  • FMK-MEA
  • gefitinib
  • Go_6796
  • IFN-beta
  • IFN-gamma
  • imatinib
  • insulin
  • KPT-185
  • LY294002
  • mifepristone
  • MK-2206
  • nilotinib
  • OSI-027
  • PD0325901
  • PD184352
  • PD98059
  • phorbol_ester
  • PI-103
  • pimenta doica
  • PKI-402
  • PP242
  • RAD001
  • rapamycin
  • SB216763
  • serum
  • serum_starvation
  • siRNA
  • temsirolimus
  • TGF-beta
  • Torin1
  • U0126
  • virus infection
  • wortmannin
  • XL413
4E-BP1 (human) GGtLFsttPGGtRII T46-p
4E-BP1 (mouse) GGtLFsttPGGtRII T45-p
4E-BP1 (rat) GGtLFSttPGGtRII T45-p
4E-BP1 (fruit fly) GGTLYSTTPGGTKLI T46
4E-BP1 (cow) GGTLFSTTPGGTRII T46
T50-p
FsttPGGtRIIyDRk
Upstream
Downstream
2 57
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • cell growth, induced
  • translation, induced
Kinase, in vitro:
  • CK1E (human)
Putative in vivo kinases:
  • CK1E (human)
Treatment
  • insulin
4E-BP1 (human) FsttPGGtRIIyDRk T50-p
4E-BP1 (mouse) FsttPGGtRIIyDRk T49-p
4E-BP1 (rat) FSttPGGtRIIYDRK T49-p
4E-BP1 (fruit fly) YSTTPGGTKLIYERA T50
4E-BP1 (cow) FSTTPGGTRIIYDRK T50
Y54-p
PGGtRIIyDRkFLME
0 30
4E-BP1 (human) PGGtRIIyDRkFLME Y54-p
4E-BP1 (mouse) PGGtRIIyDRkFLME Y53-p
4E-BP1 (rat) PGGtRIIYDRKFLME Y53
4E-BP1 (fruit fly) PGGTKLIYERAFMKN Y54
4E-BP1 (cow) PGGTRIIYDRKFLME Y54
K57-ub
tRIIyDRkFLMECrN
0 2
4E-BP1 (human) tRIIyDRkFLMECrN K57-ub
4E-BP1 (mouse) tRIIyDRkFLMECRN K56-ub
4E-BP1 (rat) tRIIYDRKFLMECRN K56
4E-BP1 (fruit fly) TKLIYERAFMKNLRG A57
4E-BP1 (cow) TRIIYDRKFLMECRN K57
R63-m1
RkFLMECrNsPVtkt
0 1
4E-BP1 (human) RkFLMECrNsPVtkt R63-m1
4E-BP1 (mouse) RkFLMECRNsPVAKt R62
4E-BP1 (rat) RKFLMECRNsPVAKt R62
4E-BP1 (fruit fly) RAFMKNLRGSPLSQT R63
4E-BP1 (cow) RKFLMECRNSPVTKT R63
S65-p
FLMECrNsPVtktPP
Upstream
Downstream
78 65
4E-BP1 (human)
S65-p
4E-BP1 (mouse)
S64-p
4E-BP1 (rat)
S64-p
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • translation, altered
  • translation, induced
  • translation, inhibited
Kinase, in vitro:
  • DYRK2 (human)
  • ERK1 (human)
  • ERK2 (human)
  • GSK3B (human)
  • mTOR (human)
  • mTOR (mouse)
Putative in vivo kinases:
  • mTOR (human)
Putative upstream phosphatases:
  • PPM1G (human)
Regulatory protein:
  • GSK3A (human)
  • IKKB (human)
  • Notch 1 (human)
  • p53 (human)
  • Pim1 (human)
  • Pim2 (human)
  • RAG1 (human)
  • RHEB (human)
  • SESN1 (human)
  • SESN2 (mouse)
  • TSC1 (human)
Treatment
  • 1-azakenpaullone
  • 4-HT
  • 5(S)-HETE
  • 9cRA
  • acadesine
  • AG490
  • amino_acid_starvation
  • amino_acids
  • angiotensin_2
  • anti-CD3/CD28
  • AR-A014418
  • AZD8055
  • batimastat
  • bisindolylmaleimide
  • compound_C
  • CRM197
  • dexamethasone
  • EGF
  • H2O2
  • hyperoxia
  • hypertonic_buffer
  • hypoxia
  • IFN-gamma
  • imatinib
  • insulin
  • LPS
  • LY294002
  • metformin
  • MK-2206
  • ML120B
  • OSI-027
  • PAR1-activating_peptide
  • PD184352
  • PD98059
  • PF-4708671
  • phorbol_ester
  • PP242
  • QLT0254
  • rapamycin
  • retinoic_acid
  • rottlerin
  • SB202190
  • SEL24-B489
  • sertraline
  • serum
  • serum_starvation
  • SHP2_inhibitor
  • tamoxifen
  • U0126
  • UV
  • virus infection
  • XL413
4E-BP1 (human) FLMECrNsPVtktPP S65-p
4E-BP1 (mouse) FLMECRNsPVAKtPP S64-p
4E-BP1 (rat) FLMECRNsPVAKtPP S64-p
4E-BP1 (fruit fly) FMKNLRGSPLSQTPP S65
4E-BP1 (cow) FLMECRNSPVTKTPP S65
T68-p
ECrNsPVtktPPRDL
0 8
4E-BP1 (human) ECrNsPVtktPPRDL T68-p
4E-BP1 (mouse) ECRNsPVAKtPPKDL A67
4E-BP1 (rat) ECRNsPVAKtPPKDL A67
4E-BP1 (fruit fly) NLRGSPLSQTPPSNV S68
4E-BP1 (cow) ECRNSPVTKTPPRDL T68
K69-ub
CrNsPVtktPPRDLP
0 3
4E-BP1 (human) CrNsPVtktPPRDLP K69-ub
4E-BP1 (mouse) CRNsPVAKtPPKDLP K68
4E-BP1 (rat) CRNsPVAKtPPKDLP K68
4E-BP1 (fruit fly) LRGSPLSQTPPSNVP Q69
4E-BP1 (cow) CRNSPVTKTPPRDLP K69
T70-p
rNsPVtktPPRDLPt
Upstream
Downstream
46 66
4E-BP1 (human)
T70-p
4E-BP1 (mouse)
T69-p
4E-BP1 (rat)
T69-p
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • cell cycle regulation
  • transcription, altered
  • translation, altered
  • translation, induced
  • translation, inhibited
Kinase, in vitro:
  • CDK1 (human)
  • Cot (human)
  • ERK2 (human)
  • GSK3B (human)
  • mTOR (human)
Putative in vivo kinases:
  • mTOR (human)
Putative upstream phosphatases:
  • PPM1G (human)
Regulatory protein:
  • 4E-BP1 (human)
  • GSK3A (human)
  • LYN (human)
  • mTOR (human)
  • PLK1 (human)
  • PRAS40 iso3 (human)
  • Raptor (human)
  • RICTOR (human)
  • TSC1 (human)
  • TSC2 (human)
Treatment
  • 1-azakenpaullone
  • AG1296
  • AG490
  • amino_acids
  • AR-A014418
  • As2O3
  • AZD8055
  • bisindolylmaleimide
  • dasatinib
  • EGF
  • estradiol
  • fetal growth restriction
  • IFN-beta
  • IFN-gamma
  • IGF-1
  • imatinib
  • insulin
  • LRRK2-IN-1
  • LY294002
  • MK-2206
  • nocodazole
  • OSI-027
  • PD184352
  • PD98059
  • phorbol_ester
  • PP2
  • PP242
  • rapamycin
  • retinoic_acid
  • serum
  • siRNA
  • U0126
  • XL413
4E-BP1 (human) rNsPVtktPPRDLPt T70-p
4E-BP1 (mouse) RNsPVAKtPPKDLPA T69-p
4E-BP1 (rat) RNsPVAKtPPKDLPT T69-p
4E-BP1 (fruit fly) RGSPLSQTPPSNVPS T70
4E-BP1 (cow) RNSPVTKTPPRDLPT T70
T77-p
tPPRDLPtIPGVtsP
Upstream
0 11
Treatment
  • EGF
4E-BP1 (human) tPPRDLPtIPGVtsP T77-p
4E-BP1 (mouse) tPPKDLPAIPGVtsP A76
4E-BP1 (rat) tPPKDLPTIPGVTsP T76
4E-BP1 (fruit fly) TPPSNVPSCLLRGTP S77
4E-BP1 (cow) TPPRDLPTIPGVTSP T77
T82-p
LPtIPGVtsPssDEP
0 4
4E-BP1 (human) LPtIPGVtsPssDEP T82-p
4E-BP1 (mouse) LPAIPGVtsPtsDEP T81-p
4E-BP1 (rat) LPTIPGVTsPTSDEP T81
4E-BP1 (fruit fly) VPSCLLRGTPRTPFR G82
4E-BP1 (cow) LPTIPGVTSPTGDEP T82
S83-p
PtIPGVtsPssDEPP
Upstream
Downstream
5 8
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • carcinogenesis, induced
Kinase, in vitro:
  • CDK1 (human)
Putative in vivo kinases:
  • CDK1 (human)
4E-BP1 (human) PtIPGVtsPssDEPP S83-p
4E-BP1 (mouse) PAIPGVtsPtsDEPP S82-p
4E-BP1 (rat) PTIPGVTsPTSDEPP S82-p
4E-BP1 (fruit fly) PSCLLRGTPRTPFRK T83
4E-BP1 (cow) PTIPGVTSPTGDEPP S83
S85-p
IPGVtsPssDEPPME
0 2
4E-BP1 (human) IPGVtsPssDEPPME S85-p
4E-BP1 (mouse) IPGVtsPtsDEPPMQ T84-p
4E-BP1 (rat) IPGVTsPTSDEPPMQ T84
4E-BP1 (fruit fly) CLLRGTPRTPFRKCV R85
4E-BP1 (cow) IPGVTSPTGDEPPTE T85
S86-p
PGVtsPssDEPPMEA
0 5
4E-BP1 (human) PGVtsPssDEPPMEA S86-p
4E-BP1 (mouse) PGVtsPtsDEPPMQA S85-p
4E-BP1 (rat) PGVTsPTSDEPPMQA S85
4E-BP1 (fruit fly) LLRGTPRTPFRKCVP T86
4E-BP1 (cow) PGVTSPTGDEPPTEA G86
S94-p
DEPPMEAsQSHLRNs
Upstream
1 9
Kinase, in vitro:
  • ATM (human)
4E-BP1 (human) DEPPMEAsQSHLRNs S94-p
4E-BP1 (mouse) DEPPMQAsQsQLPss S93-p
4E-BP1 (rat) DEPPMQASQSHLHsS S93
4E-BP1 (fruit fly) gap -
4E-BP1 (cow) DEPPTEARQNHLRSS R94
S96
PPMEAsQSHLRNsPE
0 2
4E-BP1 (human) PPMEAsQSHLRNsPE S96
4E-BP1 (mouse) PPMQAsQsQLPssPE S95-p
4E-BP1 (rat) PPMQASQSHLHsSPE S95
4E-BP1 (fruit fly) gap -
4E-BP1 (cow) PPTEARQNHLRSSPE N96
N100
AsQSHLRNsPEDKRA
1 4
4E-BP1 (human) AsQSHLRNsPEDKRA N100
4E-BP1 (mouse) AsQsQLPssPEDKRA S99-p
4E-BP1 (rat) ASQSHLHsSPEDKRA S99-p
4E-BP1 (fruit fly) gap -
4E-BP1 (cow) ARQNHLRSSPEDKPA S100
S101-p
sQSHLRNsPEDKRAG
Upstream
2 22
Kinase, in vitro:
  • DYRK2 (human)
Treatment
  • insulin
  • rapamycin
4E-BP1 (human) sQSHLRNsPEDKRAG S101-p
4E-BP1 (mouse) sQsQLPssPEDKRAG S100-p
4E-BP1 (rat) SQSHLHsSPEDKRAG S100
4E-BP1 (fruit fly) gap -
4E-BP1 (cow) RQNHLRSSPEDKPAG S101
S112-p
KRAGGEEsQFEMDI_
Upstream
Downstream
5 42
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Kinase, in vitro:
  • CK2A1 (human)
Treatment
  • insulin
  • rapamycin
  • wortmannin
4E-BP1 (human) KRAGGEEsQFEMDI_ S112-p
4E-BP1 (mouse) KRAGGEEsQFEMDI_ S111-p
4E-BP1 (rat) KRAGGEEsQFEMDI_ S111-p
4E-BP1 (fruit fly) gap -
4E-BP1 (cow) KPAGGEESQFEMDI_ S112