Other Species / Isoforms
  SMAD2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S2-p
______MsSILPFtP
Upstream
0 1
Treatment
  • nocodazole
SMAD2 (human) ______MsSILPFtP S2-p
SMAD2 (mouse) ______MSSILPFtP S2
SMAD2 (rat) ______MSSILPFtP S2
SMAD2 (cow) ______MSSILPFTP S2
T8-p
MsSILPFtPPVVkRL
Upstream
Downstream
3 29
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • ERK1 (human)
Putative in vivo kinases:
  • ERK1 (human)
Treatment
  • EGF
  • ischemia
  • LRRK2-IN-1
  • nocodazole
  • U0126
SMAD2 (human) MsSILPFtPPVVkRL T8-p
SMAD2 (mouse) MSSILPFtPPVVKRL T8-p
SMAD2 (rat) MSSILPFtPPVVKRL T8-p
SMAD2 (cow) MSSILPFTPPVVKRL T8
K13-ub
PFtPPVVkRLLGWkk
0 4
SMAD2 (human) PFtPPVVkRLLGWkk K13-ub
SMAD2 (mouse) PFtPPVVKRLLGWKK K13
SMAD2 (rat) PFtPPVVKRLLGWKK K13
SMAD2 (cow) PFTPPVVKRLLGWKK K13
K19-ac
VkRLLGWkksAGGSG
Upstream
Downstream
2 5
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, inhibited
  • signaling pathway regulation
  • transcription, induced
Treatment
  • anacardic acid
  • TGF-beta
  • trichostatin_A
SMAD2 (human) VkRLLGWkksAGGSG K19-ac
SMAD2 (mouse) VKRLLGWKKSAGGSG K19
SMAD2 (rat) VKRLLGWKKSAGGSG K19
SMAD2 (cow) VKRLLGWKKSAGGSG K19
K20-ac
kRLLGWkksAGGSGG
Upstream
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, inhibited
  • signaling pathway regulation
  • transcription, induced
Treatment
  • TGF-beta
  • trichostatin_A
SMAD2 (human) kRLLGWkksAGGSGG K20-ac
SMAD2 (mouse) KRLLGWKKSAGGSGG K20
SMAD2 (rat) KRLLGWKKSAGGSGG K20
SMAD2 (cow) KRLLGWKKSAGGSGG K20
S21-p
RLLGWkksAGGSGGA
0 1
SMAD2 (human) RLLGWkksAGGSGGA S21-p
SMAD2 (mouse) RLLGWKKSAGGSGGA S21
SMAD2 (rat) RLLGWKKSAGGSGGA S21
SMAD2 (cow) RLLGWKKSAGGSGGA S21
K39-ac
EQNGQEEkWCEKAVK
Upstream
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, inhibited
  • signaling pathway regulation
  • transcription, induced
Treatment
  • TGF-beta
  • trichostatin_A
SMAD2 (human) EQNGQEEkWCEKAVK K39-ac
SMAD2 (mouse) EQNGQEEKWCEKAVK K39
SMAD2 (rat) EQNGQEEKWCEKAVK K39
SMAD2 (cow) EQNGQEEKWCEKAVK K39
K63-ub
GRLDELEkAITTQNC
0 1
SMAD2 (human) GRLDELEkAITTQNC K63-ub
SMAD2 (mouse) GRLDELEKAITTQNC K63
SMAD2 (rat) GRLDELEKAITTQNC K63
SMAD2 (cow) GRLDELEKAITTQNC K63
Y102-p
QWDTTGLySFSEQTR
0 14
SMAD2 (human) QWDTTGLySFSEQTR Y102-p
SMAD2 (mouse) QWDTTGLySFSEQTR Y102-p
SMAD2 (rat) QWDTTGLYSFSEQTR Y102
SMAD2 (cow) QWDTTGLYSFSEQTR Y102
S110-p
SFSEQTRsLDGRLQV
Upstream
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Kinase, in vitro:
  • CAMK2A (human)
Putative in vivo kinases:
  • CAMK2A (human)
SMAD2 (human) SFSEQTRsLDGRLQV S110-p
SMAD2 (mouse) SFSEQTRSLDGRLQV S110
SMAD2 (rat) SFSEQTRSLDGRLQV S110
SMAD2 (cow) SFSEQTRSLDGRLQV S110
K156-sm
CEYAFNLkkDEVCVN
0 1
SMAD2 (human) CEYAFNLkkDEVCVN K156-sm
SMAD2 (mouse) CEYAFNLKKDEVCVN K156
SMAD2 (rat) CEYAFSLKKDEVCVN K156
SMAD2 (cow) CEYAFNLKKDEVCVN K156
K156-ub
CEYAFNLkkDEVCVN
0 1
SMAD2 (human) CEYAFNLkkDEVCVN K156-ub
SMAD2 (mouse) CEYAFNLKKDEVCVN K156
SMAD2 (rat) CEYAFSLKKDEVCVN K156
SMAD2 (cow) CEYAFNLKKDEVCVN K156
K157-ub
EYAFNLkkDEVCVNP
0 1
SMAD2 (human) EYAFNLkkDEVCVNP K157-ub
SMAD2 (mouse) EYAFNLKKDEVCVNP K157
SMAD2 (rat) EYAFSLKKDEVCVNP K157
SMAD2 (cow) EYAFNLKKDEVCVNP K157
T172-p
YHYQRVEtPVLPPVL
0 8
SMAD2 (human) YHYQRVEtPVLPPVL T172-p
SMAD2 (mouse) YHYQRVEtPVLPPVL T172-p
SMAD2 (rat) YHYQRVETPVLPPVL T172
SMAD2 (cow) YHYQRVETPVLPPVL T172
T197-p
LPPLDDYtHSIPENT
Upstream
1 0
Kinase, in vitro:
  • GRK2 (human)
SMAD2 (human) LPPLDDYtHSIPENT T197-p
SMAD2 (mouse) LPPLDDYTHSIPENT T197
SMAD2 (rat) LPPLDDYTHSIPENT T197
SMAD2 (cow) LPPLDDYTHSIPENT T197
T220-p
QSNYIPEtPPPGYIS
Upstream
Downstream
10 0
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • carcinogenesis, induced
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
  • OSR1 (human)
Putative in vivo kinases:
  • ERK1 (human)
  • OSR1 (human)
Regulatory protein:
  • FOXO4 (human)
  • HRas (human)
  • MEK1 (human)
  • NEDD4L (human)
  • TGFB1 (human)
Treatment
  • alvocidib
  • BMP2
  • EGF
  • MG132
  • PD98059
  • SB203580
  • siRNA
  • TGF-beta
  • wortmannin
  • Y27632
SMAD2 (human) QSNYIPEtPPPGYIS T220-p
SMAD2 (mouse) QSNYIPETPPPGYIS T220
SMAD2 (rat) QSNYIPETPPPGYIS T220
SMAD2 (cow) QSNYIPEtPPPGYIS T220-p
S240-p
SDQQLNQsMDTGsPA
Upstream
Downstream
2 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Kinase, in vitro:
  • CAMK2A (human)
Putative in vivo kinases:
  • CAMK2A (human)
Treatment
  • decorin
  • EGF
  • KN-93
  • TGF-beta
SMAD2 (human) SDQQLNQsMDTGsPA S240-p
SMAD2 (mouse) SDQQLNQSMDTGsPA S240
SMAD2 (rat) SDQQLNQSMDTGSPA S240
SMAD2 (cow) SDQQLNQSMDTGsPA S240
S245-p
NQsMDTGsPAELsPT
Upstream
Downstream
8 0
SMAD2 (human)
S245-p
SMAD2 (mouse)
S245-p
SMAD2 (rat)
S245-p
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • cell motility, altered
  • transcription, induced
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
  • MELK (mouse)
Putative in vivo kinases:
  • ERK1 (human)
  • MELK (mouse)
Regulatory protein:
  • HRas (human)
  • MEK1 (human)
Treatment
  • alvocidib
  • EGF
  • LY2109761
  • LY294002
  • PD98059
  • SB202190
  • SB431542
  • TGF-beta
  • U0126
  • wortmannin
SMAD2 (human) NQsMDTGsPAELsPT S245-p
SMAD2 (mouse) NQSMDTGsPAELSPT S245-p
SMAD2 (rat) NQSMDTGSPAELSPT S245
SMAD2 (cow) NQSMDTGsPAELsPT S245-p
S250-p
TGsPAELsPTTLsPV
Upstream
Downstream
6 0
SMAD2 (human)
S250-p
SMAD2 (mouse)
S250-p
SMAD2 (rat)
S250-p
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • cell motility, altered
  • transcription, induced
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
Putative in vivo kinases:
  • ERK1 (human)
Regulatory protein:
  • HRas (human)
  • MEK1 (human)
Treatment
  • EGF
  • LY2109761
  • PD98059
  • TGF-beta
  • U0126
  • wortmannin
SMAD2 (human) TGsPAELsPTTLsPV S250-p
SMAD2 (mouse) TGsPAELSPTTLSPV S250
SMAD2 (rat) TGSPAELSPTTLSPV S250
SMAD2 (cow) TGsPAELsPTTLsPV S250-p
S255-p
ELsPTTLsPVNHsLD
Upstream
Downstream
6 0
SMAD2 (human)
S255-p
SMAD2 (mouse)
S255-p
SMAD2 (rat)
S255-p
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • cell motility, altered
  • transcription, induced
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
Putative in vivo kinases:
  • ERK1 (human)
Regulatory protein:
  • HRas (human)
  • MEK1 (human)
Treatment
  • alvocidib
  • EGF
  • LY2109761
  • LY294002
  • PD98059
  • SB202190
  • TGF-beta
  • U0126
  • wortmannin
SMAD2 (human) ELsPTTLsPVNHsLD S255-p
SMAD2 (mouse) ELSPTTLSPVNHSLD S255
SMAD2 (rat) ELSPTTLSPVNHSLD S255
SMAD2 (cow) ELsPTTLsPVNHSLD S255-p
S260-p
TLsPVNHsLDLQPVT
Upstream
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Kinase, in vitro:
  • CAMK2A (human)
Putative in vivo kinases:
  • CAMK2A (human)
SMAD2 (human) TLsPVNHsLDLQPVT S260-p
SMAD2 (mouse) TLSPVNHSLDLQPVT S260
SMAD2 (rat) TLSPVNHSLDLQPVT S260
SMAD2 (cow) TLsPVNHSLDLQPVT S260
T324-p
SNVNRNAtVEMTRRH
1 1
SMAD2 (human) SNVNRNAtVEMTRRH T324-p
SMAD2 (mouse) SNVNRNAtVEMTRRH T324-p
SMAD2 (rat) SNVNRNATVEMTRRH T324
SMAD2 (cow) SNVNRNATVEMTRRH T324
S417-p
RMCTIRMsFVkGWGA
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, inhibited
Kinase, in vitro:
  • PAK2 (human)
Putative in vivo kinases:
  • PAK2 (human)
Treatment
  • IPA-3
SMAD2 (human) RMCTIRMsFVkGWGA S417-p
SMAD2 (mouse) RMCTIRMSFVKGWGA S417
SMAD2 (rat) RMCTIRMSFVKGWGA S417
SMAD2 (cow) RMCTIRMSFVKGWGA S417
K420-ac
TIRMsFVkGWGAEYR
0 4
SMAD2 (human) TIRMsFVkGWGAEYR K420-ac
SMAD2 (mouse) TIRMSFVKGWGAEYR K420
SMAD2 (rat) TIRMSFVKGWGAEYR K420
SMAD2 (cow) TIRMSFVKGWGAEYR K420
S433
YRRQTVTSTPCWIEL
1 0
SMAD2 (human) YRRQTVTSTPCWIEL S433
SMAD2 (mouse) YRRQTVTsTPCWIEL S433-p
SMAD2 (rat) YRRQTVTSTPCWIEL S433
SMAD2 (cow) YRRQTVTSTPCWIEL S433
S458-p
KVLTQMGsPsVRCss
Upstream
0 12
Treatment
  • nocodazole
SMAD2 (human) KVLTQMGsPsVRCss S458-p
SMAD2 (mouse) KVLTQMGsPSVRCSs S458-p
SMAD2 (rat) KVLTQMGSPSVRCSs S458
SMAD2 (cow) KVLTQMGSPSVRCSS S458
S460-p
LTQMGsPsVRCssMs
Upstream
0 3
Treatment
  • nocodazole
SMAD2 (human) LTQMGsPsVRCssMs S460-p
SMAD2 (mouse) LTQMGsPSVRCSsMs S460
SMAD2 (rat) LTQMGSPSVRCSsMs S460
SMAD2 (cow) LTQMGSPSVRCSSMS S460
S464-p
GsPsVRCssMs____
Upstream
Downstream
5 2
Effects on Modified Protein
  • activity, induced
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • PAK2 (human)
  • TGFBR1 (human)
Putative in vivo kinases:
  • BMPR1B (human)
  • TGFBR1 (human)
Treatment
  • TGF-beta
SMAD2 (human) GsPsVRCssMs____ S464-p
SMAD2 (mouse) GsPSVRCSsMs____ S464
SMAD2 (rat) GSPSVRCSsMs____ S464
SMAD2 (cow) GSPSVRCSSMS____ S464
S465-p
sPsVRCssMs_____
Upstream
Downstream
37 6
SMAD2 (human)
S465-p
SMAD2 (mouse)
S465-p
SMAD2 (rat)
S465-p
SMAD2 (cow)
S465-p
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • PAK2 (human)
  • TGFBR1 (human)
Putative in vivo kinases:
  • BMPR1B (human)
  • TGFBR1 (human)
Regulatory protein:
  • Akt1 (human)
  • GDF11 (human)
  • GRK2 (human)
  • Lmr2 (human)
  • MSTN (human)
  • MURF1 (human)
  • PTPRK (human)
  • RHEB (human)
  • SMAD4 (human)
  • SMAD7 (human)
  • TGFBR1 (human)
  • TSC1 (human)
Treatment
  • 5(S)-HETE
  • activin
  • AG538
  • ALK5_Inhibitor_I
  • angiotensin_2
  • anti-CD44
  • anti-HER2
  • ascorbic_acid
  • caffeic_acid
  • CRM197
  • decorin
  • EGF
  • FGF2
  • gefitinib
  • heregulin
  • hyaluronan
  • IGF-1
  • IL-6
  • insulin
  • LY294002
  • masoprocol
  • Nodal
  • oncostatin_M
  • picropodophyllin
  • rapamycin
  • SB202190
  • SB203580
  • siRNA
  • starvation_medium
  • TGF-beta
  • U0126
  • UV
  • Y27632
SMAD2 (human) sPsVRCssMs_____ S465-p
SMAD2 (mouse) sPSVRCSsMs_____ S465-p
SMAD2 (rat) SPSVRCSsMs_____ S465-p
SMAD2 (cow) SPSVRCSSMS_____ S465
S467-p
sVRCssMs_______
Upstream
Downstream
37 6
SMAD2 (human)
S467-p
SMAD2 (mouse)
S467-p
SMAD2 (rat)
S467-p
SMAD2 (cow)
S467-p
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • PAK2 (human)
  • TGFBR1 (human)
Putative in vivo kinases:
  • BMPR1B (human)
  • TGFBR1 (human)
Regulatory protein:
  • Akt1 (human)
  • GDF11 (human)
  • GRK2 (human)
  • Lmr2 (human)
  • MSTN (human)
  • MURF1 (human)
  • PTPRK (human)
  • RHEB (human)
  • SMAD4 (human)
  • SMAD7 (human)
  • TGFBR1 (human)
  • TSC1 (human)
Treatment
  • 5(S)-HETE
  • activin
  • AG538
  • ALK5_Inhibitor_I
  • angiotensin_2
  • anti-CD44
  • anti-HER2
  • ascorbic_acid
  • caffeic_acid
  • CRM197
  • decorin
  • EGF
  • FGF2
  • gefitinib
  • heregulin
  • hyaluronan
  • IGF-1
  • IL-6
  • insulin
  • LY294002
  • masoprocol
  • Nodal
  • oncostatin_M
  • picropodophyllin
  • rapamycin
  • SB202190
  • SB203580
  • siRNA
  • starvation_medium
  • TGF-beta
  • U0126
  • UV
  • Y27632
SMAD2 (human) sVRCssMs_______ S467-p
SMAD2 (mouse) SVRCSsMs_______ S467-p
SMAD2 (rat) SVRCSsMs_______ S467-p
SMAD2 (cow) SVRCSSMS_______ S467