Other Species / Isoforms
  H2A.1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S1-p
_______sGrGkQGG
Upstream
Downstream
3 3
Effects on Modified Protein
  • activity, inhibited
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • ChaK2 (human)
  • MSK1 (human)
Putative in vivo kinases:
  • ChaK2 (human)
H2A.1 (human) _______sGrGkQGG S1-p
H2A.1 (mouse) _______sGRGkQGG S1-p
R3-m2
_____sGrGkQGGkA
Upstream
1 1
Regulatory protein:
  • ChaK2 (human)
H2A.1 (human) _____sGrGkQGGkA R3-m2
H2A.1 (mouse) _____sGRGkQGGkA R3
K5-ac
___sGrGkQGGkARA
Upstream
11 152
H2A.1 (human)
K5-ac
Regulatory protein:
  • DNMT1 (human)
  • Myc (human)
  • MYST1 (human)
  • RUVBL1 (human)
  • UHRF1 (human)
Treatment
  • siRNA
  • trichostatin_A
H2A.1 (human) ___sGrGkQGGkARA K5-ac
H2A.1 (mouse) ___sGRGkQGGkARA K5-ac
K9-ac
GrGkQGGkARAkAkT
Upstream
Downstream
4 149
Effects on Biological Processes:
  • transcription, altered
Treatment
  • hemorrhage
  • hypertonic_buffer
  • trichostatin_A
  • valproic acid
  • vorinostat
H2A.1 (human) GrGkQGGkARAkAkT K9-ac
H2A.1 (mouse) GRGkQGGkARAkAkT K9-ac
K13-ac
QGGkARAkAkTRSSR
Downstream
2 2
Effects on Modified Protein
  • molecular association, regulation
H2A.1 (human) QGGkARAkAkTRSSR K13-ac
H2A.1 (mouse) QGGkARAkAkTRSSR K13-ac
K13-ub
QGGkARAkAkTRSSR
Upstream
Downstream
7 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • DNA repair, induced
Regulatory protein:
  • RNF126 (human)
Treatment
  • ionizing_radiation
H2A.1 (human) QGGkARAkAkTRSSR K13-ub
H2A.1 (mouse) QGGkARAKAkTRSSR K13
K15-ac
GkARAkAkTRSSRAG
Downstream
3 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • DNA repair, induced
  • cell cycle regulation
H2A.1 (human) GkARAkAkTRSSRAG K15-ac
H2A.1 (mouse) GkARAkAkTRSSRAG K15-ac
K15-ub
GkARAkAkTRSSRAG
Upstream
Downstream
9 1
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • DNA repair, induced
Regulatory protein:
  • RNF126 (human)
Treatment
  • ionizing_radiation
H2A.1 (human) GkARAkAkTRSSRAG K15-ub
H2A.1 (mouse) GkARAkAKTRSSRAG K15
R29-m2
GLQFPVGrVHRLLRk
Upstream
Downstream
1 1
Effects on Biological Processes:
  • transcription, inhibited
Treatment
  • siRNA
H2A.1 (human) GLQFPVGrVHRLLRk R29-m2
H2A.1 (mouse) GLQFPVGRVHRLLRk R29
K36-ub
rVHRLLRkGNYAERV
0 14
H2A.1 (human) rVHRLLRkGNYAERV K36-ub
H2A.1 (mouse) RVHRLLRkGNYSERV K36-ub
Y57-p
YLAAVLEyLTAEILE
Upstream
Downstream
1 0
Effects on Biological Processes:
  • apoptosis, induced
  • carcinogenesis, inhibited
  • cell growth, inhibited
  • cell motility, inhibited
Kinase, in vitro:
  • CK2A1 (human)
Putative in vivo kinases:
  • CK2A1 (human)
Regulatory protein:
  • Akt1 (human)
Treatment
  • IGF-1
  • LY294002
  • siRNA
H2A.1 (human) YLAAVLEyLTAEILE Y57-p
H2A.1 (mouse) YLAAVLEYLTAEILE Y57
R88-m1
RHLQLAIrNDEELNk
0 2
H2A.1 (human) RHLQLAIrNDEELNk R88-m1
H2A.1 (mouse) RHLQLAIrNDEELNk R88-m1
K95-ac
rNDEELNkLLGkVtI
Upstream
0 11
Treatment
  • vorinostat
H2A.1 (human) rNDEELNkLLGkVtI K95-ac
H2A.1 (mouse) rNDEELNkLLGRVtI K95-ac
K95-ub
rNDEELNkLLGkVtI
0 127
H2A.1 (human) rNDEELNkLLGkVtI K95-ub
H2A.1 (mouse) rNDEELNkLLGRVtI K95-ub
K99-ac
ELNkLLGkVtIAqGG
0 2
H2A.1 (human) ELNkLLGkVtIAqGG K99-ac
H2A.1 (mouse) ELNkLLGRVtIAQGG R99
K99-ub
ELNkLLGkVtIAqGG
0 73
H2A.1 (human) ELNkLLGkVtIAqGG K99-ub
H2A.1 (mouse) ELNkLLGRVtIAQGG R99
T101-p
NkLLGkVtIAqGGVL
0 10
H2A.1 (human) NkLLGkVtIAqGGVL T101-p
H2A.1 (mouse) NkLLGRVtIAQGGVL T101-p
Q104-me
LGkVtIAqGGVLPNI
1 0
H2A.1 (human) LGkVtIAqGGVLPNI Q104-me
H2A.1 (mouse) LGRVtIAQGGVLPNI Q104
K118-ac
IQAVLLPkktESHHk
0 41
H2A.1 (human) IQAVLLPkktESHHk K118-ac
H2A.1 (mouse) IQAVLLPkktESHHk K118-ac
K118
IQAVLLPKktESHHk
0 1
H2A.1 (human) IQAVLLPKktESHHk K118
H2A.1 (mouse) IQAVLLPkktESHHk K118-m1
K118
IQAVLLPKktESHHk
0 1
H2A.1 (human) IQAVLLPKktESHHk K118
H2A.1 (mouse) IQAVLLPkktESHHk K118-m2
K118-ub
IQAVLLPkktESHHk
Upstream
Downstream
12 170
Effects on Modified Protein
  • enzymatic activity, inhibited
  • methylation
Effects on Biological Processes:
  • DNA repair, induced
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell growth, induced
  • cell growth, inhibited
  • chromatin organization, altered
  • transcription, inhibited
Regulatory protein:
  • ASXL1 (human)
  • BMI1 (human)
  • PLK1 (human)
  • RBBP4 (human)
Treatment
  • BI2536
  • MG132
  • NaB
  • siRNA
H2A.1 (human) IQAVLLPkktESHHk K118-ub
H2A.1 (mouse) IQAVLLPkktESHHk K118-ub
K119-ac
QAVLLPkktESHHkA
1 16
H2A.1 (human) QAVLLPkktESHHkA K119-ac
H2A.1 (mouse) QAVLLPkktESHHkA K119-ac
K119-ub
QAVLLPkktESHHkA
Upstream
Downstream
45 159
H2A.1 (human)
K119-ub
H2A.1 (mouse)
K119-ub
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • ubiquitination
Effects on Biological Processes:
  • DNA repair, induced
  • autophagy, induced
  • carcinogenesis, induced
  • cell cycle regulation
  • cell differentiation, inhibited
  • cell growth, induced
  • cell growth, inhibited
  • cell motility, induced
  • chromatin organization, altered
  • cytoskeletal reorganization
  • transcription, inhibited
Regulatory protein:
  • ASXL1 (human)
  • ASXL2 (human)
  • RNF2 (human)
  • USP7 (human)
Treatment
  • C-209
  • LY-411575
  • PTC-209
  • siRNA
  • Trolox
  • UV
  • virus infection
H2A.1 (human) QAVLLPkktESHHkA K119-ub
H2A.1 (mouse) QAVLLPkktESHHkA K119-ub
K119-cro
QAVLLPkktESHHkA
1 0
H2A.1 (human) QAVLLPkktESHHkA K119-cro
H2A.1 (mouse) QAVLLPkKtESHHkA K119
T120-p
AVLLPkktESHHkAk
Upstream
Downstream
15 8
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell cycle regulation
  • cell growth, induced
  • chromatin organization, altered
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • BUB1 (human)
  • VRK1 (human)
Putative in vivo kinases:
  • BUB1 (human)
  • VPRBP (human)
  • VRK1 (human)
Regulatory protein:
  • ATM (human)
  • CASC5 (human)
Treatment
  • 2OH-BNPP1
  • B32B3
  • BAY-320
  • hesperadin
  • ionizing_radiation
  • nocodazole
  • siRNA
  • ZM447439
H2A.1 (human) AVLLPkktESHHkAk T120-p
H2A.1 (mouse) AVLLPkktESHHkAK T120-p
K125-ub
kktESHHkAkGk___
2 134
H2A.1 (human) kktESHHkAkGk___ K125-ub
H2A.1 (mouse) kktESHHkAKGK___ K125-ub
K127-ub
tESHHkAkGk_____
2 3
H2A.1 (human) tESHHkAkGk_____ K127-ub
H2A.1 (mouse) tESHHkAKGK_____ K127
K129-ub
SHHkAkGk_______
2 2
H2A.1 (human) SHHkAkGk_______ K129-ub
H2A.1 (mouse) SHHkAKGK_______ K129