Other Species / Isoforms
  NHE3 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y396-p
QTWLLNRyRMVQLEP
0 1
NHE3 (human) QTWLLNRyRMVQLEP Y396-p
NHE3 (mouse) QTWILNRYRMVQLET Y391
NHE3 (rat) QTWILNRYRMVQLET Y393
NHE3 (rabbit) QTWLLNRYRMVQLEL Y395
Y502-p
SGQIGHNyLRDKWSH
0 2
NHE3 (human) SGQIGHNyLRDKWSH Y502-p
NHE3 (mouse) SGQIGHNYLRDKWSN Y497
NHE3 (rat) SGQIGHNYLRDKWSN Y499
NHE3 (rabbit) SGQIGHNYLRDKWAN Y501
S516
HFDRKFLSRVLMRRS
1 0
NHE3 (human) HFDRKFLSRVLMRRS S516
NHE3 (mouse) NFDRKFLSkVLMRRS S511
NHE3 (rat) NFDRKFLSKVLMRRS S513
NHE3 (rabbit) NFDRRFLsKLLMRQs S515-p
R517
FDRKFLSRVLMRRSA
0 1
NHE3 (human) FDRKFLSRVLMRRSA R517
NHE3 (mouse) FDRKFLSkVLMRRSA K512-ub
NHE3 (rat) FDRKFLSKVLMRRSA K514
NHE3 (rabbit) FDRRFLsKLLMRQsA K516
S523
SRVLMRRSAQKSRDR
1 0
NHE3 (human) SRVLMRRSAQKSRDR S523
NHE3 (mouse) SkVLMRRSAQKSRDR S518
NHE3 (rat) SKVLMRRSAQKSRDR S520
NHE3 (rabbit) sKLLMRQsAQKsRDR S522-p
S527
MRRSAQKSRDRILNV
1 0
NHE3 (human) MRRSAQKSRDRILNV S527
NHE3 (mouse) MRRSAQKSRDRILNV S522
NHE3 (rat) MRRSAQKSRDRILNV S524
NHE3 (rabbit) MRQsAQKsRDRILNV S526-p
S545-p
LNLKDAIsYVAEGER
0 1
NHE3 (human) LNLKDAIsYVAEGER S545-p
NHE3 (mouse) LNLKDAISYVAEGER S540
NHE3 (rat) LNLKDAISYVAEGER S542
NHE3 (rabbit) LNLKDAISYVTEGER S544
S555-p
AEGERRGsLAFIRSP
Upstream
Downstream
26 9
Effects on Modified Protein
  • activity, inhibited
  • receptor internalization, induced
Effects on Biological Processes:
  • endocytosis, induced
  • signaling pathway regulation
Regulatory protein:
  • PIK3CA (human)
Treatment
  • angiotensin_2
  • BAPTA-AM
  • chelerythrine
  • colforsin
  • gastrin
  • Go_6976
  • losartan
  • PTX
  • U73122
  • wortmannin
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NHE3 (human) AEGERRGsLAFIRSP S555-p
NHE3 (mouse) AEGERRGsLAFIRSP S550-p
NHE3 (rat) AEGERRGsLAFIRSP S552-p
NHE3 (rabbit) TEGERRGsLAFIRSP S554-p
S563-p
LAFIRSPstDNVVNV
0 4
NHE3 (human) LAFIRSPstDNVVNV S563-p
NHE3 (mouse) LAFIRSPSTDNMVNV S558
NHE3 (rat) LAFIRSPsTDNMVNV S560-p
NHE3 (rabbit) LAFIRSPSTDNMVNV S562
T564-p
AFIRSPstDNVVNVD
0 1
NHE3 (human) AFIRSPstDNVVNVD T564-p
NHE3 (mouse) AFIRSPSTDNMVNVD T559
NHE3 (rat) AFIRSPsTDNMVNVD T561
NHE3 (rabbit) AFIRSPSTDNMVNVD T563
S592-p
YLLRENVsAVCLDMQ
0 2
NHE3 (human) YLLRENVsAVCLDMQ S592-p
NHE3 (mouse) YFLRENVsAVCLDMQ S588-p
NHE3 (rat) YFLRENVSAVCLDMQ S590
NHE3 (rabbit) YLLRESASAVCLDMQ S592
S600-p
AVCLDMQsLEQRRRS
0 1
NHE3 (human) AVCLDMQsLEQRRRS S600-p
NHE3 (mouse) AVCLDMQSLEQRRRs S596
NHE3 (rat) AVCLDMQSLEQRRRs S598
NHE3 (rabbit) AVCLDMQSLEQRRRs S600
S607
sLEQRRRSIRDAEDM
13 1
NHE3 (human) sLEQRRRSIRDAEDM S607
NHE3 (mouse) SLEQRRRsIRDTEDM S603-p
NHE3 (rat) SLEQRRRsIRDTEDM S605-p
NHE3 (rabbit) SLEQRRRsVRDAEDV S607-p
T641-p
LYSRHELtPTEDEKQ
0 2
NHE3 (human) LYSRHELtPTEDEKQ T641-p
NHE3 (mouse) LYSRHELTPNEDEKQ T637
NHE3 (rat) LYSRHELtPNEDEKQ T639-p
NHE3 (rabbit) LYSRHVLSPSEDEKQ S641
S663-p
TMRKRLEsFKSTKLG
Upstream
Downstream
4 3
Effects on Modified Protein
  • intracellular localization
Putative in vivo kinases:
  • RSK2 (human)
NHE3 (human) TMRKRLEsFKSTKLG S663-p
NHE3 (mouse) TMRKRLESFKSAKLG S659
NHE3 (rat) TMRKRLEsFKSAKLG S661-p
NHE3 (rabbit) TMRKRLEsFKSAKLG S663-p
K682-ac
KKAAKLYkRERAQKR
0 1
NHE3 (human) KKAAKLYkRERAQKR K682-ac
NHE3 (mouse) KKAAKLYKRERAQKR K678
NHE3 (rat) KKAAKLYKRERAQKR K680
NHE3 (rabbit) KKATKHKRERERAQK R682
S718
KEKDLELSDTEEPPN
3 3
NHE3 (human) KEKDLELSDTEEPPN S718
NHE3 (mouse) KEKDLELSEHEEATN S714
NHE3 (rat) KEKDLELsEPEEATN S716-p
NHE3 (rabbit) KERELELsDPEEAPD S719-p
S794-p
ARTQIPYsPGTFCRL
0 4
NHE3 (human) ARTQIPYsPGTFCRL S794-p
NHE3 (mouse) ARVQIPNsPsNFRRL S789-p
NHE3 (rat) ARVQIPNsPsNFRRL S791-p
NHE3 (rabbit) ARVQIPYSPGNFRRL S797
G796
TQIPYsPGTFCRLMP
0 2
NHE3 (human) TQIPYsPGTFCRLMP G796
NHE3 (mouse) VQIPNsPsNFRRLTP S791-p
NHE3 (rat) VQIPNsPsNFRRLTP S793-p
NHE3 (rabbit) VQIPYSPGNFRRLAP G799
S807
RLMPFRLSSKSVDSF
0 2
NHE3 (human) RLMPFRLSSKSVDSF S807
NHE3 (mouse) RLTPFRLsNKsVDsF S802-p
NHE3 (rat) RLTPFRLsNksVDsF S804-p
NHE3 (rabbit) RLAPFRLSNKSVDSF S810
K809
MPFRLSSKSVDSFLQ
0 1
NHE3 (human) MPFRLSSKSVDSFLQ K809
NHE3 (mouse) TPFRLsNKsVDsFLQ K804
NHE3 (rat) TPFRLsNksVDsFLQ K806-ac
NHE3 (rabbit) APFRLSNKSVDSFLL K812
S810
PFRLSSKSVDSFLQA
0 2
NHE3 (human) PFRLSSKSVDSFLQA S810
NHE3 (mouse) PFRLsNKsVDsFLQA S805-p
NHE3 (rat) PFRLsNksVDsFLQA S807-p
NHE3 (rabbit) PFRLSNKSVDSFLLA S813
S813
LSSKSVDSFLQADGP
0 2
NHE3 (human) LSSKSVDSFLQADGP S813
NHE3 (mouse) LsNKsVDsFLQADGH S808-p
NHE3 (rat) LsNksVDsFLQADGP S810-p
NHE3 (rabbit) LSNKSVDSFLLAEDG S816
L828
EERPPAALPESTHM_
0 1
NHE3 (human) EERPPAALPESTHM_ L828
NHE3 (mouse) EEQLQPAAPESTHM_ A823
NHE3 (rat) EEQLQPAsPESTHM_ S825-p
NHE3 (rabbit) gap -