-
|
gap
|
|
|
0
|
3
|
|
|
|
-
|
gap
|
|
|
0
|
3
|
|
|
|
-
|
gap
|
|
|
0
|
4
|
|
|
|
-
|
gap
|
|
|
0
|
2
|
|
|
|
-
|
gap
|
|
|
0
|
5
|
|
|
|
-
|
gap
|
|
|
0
|
2
|
|
|
|
-
|
gap
|
|
|
0
|
1
|
|
|
|
-
|
gap
|
|
|
0
|
2
|
|
|
|
-
|
gap
|
|
|
0
|
1
|
|
|
|
-
|
gap
|
|
|
0
|
5
|
|
|
|
-
|
gap
|
|
|
1
|
0
|
|
|
|
-
|
gap
|
|
|
0
|
3
|
|
|
|
-
|
gap
|
|
|
0
|
6
|
|
|
|
-
|
gap
|
|
|
1
|
0
|
|
|
|
-
|
gap
|
|
|
0
|
10
|
|
|
|
-
|
gap
|
|
|
0
|
19
|
|
|
|
-
|
gap
|
|
|
1
|
0
|
|
|
|
S13-p
|
NFPFRRHsWICFDVD
|
Upstream
|
Downstream
|
5
|
3
|
|
|
Effects on Modified Protein
- molecular association, regulation
|
|
Kinase, in vitro:
|
Treatment
|
|
|
-
|
gap
|
|
|
0
|
2
|
|
|
|
-
|
gap
|
|
|
0
|
1
|
|
|
|
-
|
gap
|
|
|
0
|
1
|
|
|
|
S35
|
SPLDPMTSPGSGLIL
|
|
|
0
|
2
|
|
|
|
S38
|
DPMTSPGSGLILQAN
|
|
|
0
|
2
|
|
|
PDE4D (human)
|
DPMTsPGsGLILQAN
|
S174-p
|
PDE4D iso2 (human)
|
DPMTSPGSGLILQAN
|
S38
|
PDE4D iso4 (human)
|
gap
|
-
|
PDE4D iso5 (human)
|
gap
|
-
|
PDE4D iso6 (human)
|
DPMTSPGSGLILQAN
|
S110
|
PDE4D iso7 (human)
|
DPMTSPGSGLILQAN
|
S110
|
PDE4D iso9 (human)
|
DPMTSPGSGLILQAN
|
S52
|
PDE4D iso10 (human)
|
DPMTSPGSGLILQAN
|
S44
|
PDE4D (mouse)
|
DPMTsPGSGLILQAN
|
S113
|
PDE4D iso2 (mouse)
|
DPMTSPGSGLILQAN
|
S44
|
PDE4D iso3 (mouse)
|
gap
|
-
|
PDE4D iso4 (mouse)
|
gap
|
-
|
PDE4D iso9 (mouse)
|
DPMTSPGSGLILQAN
|
S67
|
PDE4D (rat)
|
DPMTSPGSGLILQAN
|
S169
|
PDE4D iso6 (rat)
|
DPMTSPGSGLILQAN
|
S44
|
PDE4D iso8 (rat)
|
DPMTSPGSGLILQAN
|
S111
|
|
S54-p
|
VHSQRREsFLYRSDS
|
Upstream
|
Downstream
|
10
|
22
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
|
|
Kinase, in vitro:
|
Putative in vivo kinases:
|
Putative upstream phosphatases:
|
Treatment
- ciclosporin
- colforsin
- H2O2
- IBMX
- okadaic_acid
- peptide inhibitor
|
|
|
S61
|
sFLYRSDSDYDLSPK
|
|
|
3
|
27
|
|
|
|
Y63
|
LYRSDSDYDLSPKSM
|
|
|
0
|
5
|
|
|
|
S66
|
SDSDYDLSPKSMSRN
|
|
|
1
|
33
|
|
|
|
K68
|
SDYDLSPKSMSRNSS
|
|
|
1
|
0
|
|
|
PDE4D (human)
|
sDyDLsPKSMSRNSS
|
K204
|
PDE4D iso2 (human)
|
SDYDLSPKSMSRNSS
|
K68
|
PDE4D iso4 (human)
|
gap
|
-
|
PDE4D iso5 (human)
|
gap
|
-
|
PDE4D iso6 (human)
|
sDYDLSPkSMSRNSS
|
K140-ub
|
PDE4D iso7 (human)
|
SDYDLSPKSMSRNSS
|
K140
|
PDE4D iso9 (human)
|
SDYDLSPKSMSRNSS
|
K82
|
PDE4D iso10 (human)
|
SDYDLSPKSMSRNSS
|
K74
|
PDE4D (mouse)
|
sDyDLsPKSMSRNSS
|
K143
|
PDE4D iso2 (mouse)
|
SDYDLSPKSMSRNSS
|
K74
|
PDE4D iso3 (mouse)
|
gap
|
-
|
PDE4D iso4 (mouse)
|
gap
|
-
|
PDE4D iso9 (mouse)
|
SDYDLSPKSMSRNSS
|
K97
|
PDE4D (rat)
|
sDYDLsPKSMSRNSS
|
K199
|
PDE4D iso6 (rat)
|
sDYDLSPKSMSRNSs
|
K74
|
PDE4D iso8 (rat)
|
SDYDLSPKSMSRNSS
|
K141
|
|
S75
|
KSMSRNSSIASDIHG
|
|
|
1
|
0
|
|
|
PDE4D (human)
|
KSMSRNSSIAsDIHG
|
S211
|
PDE4D iso2 (human)
|
KSMSRNSSIASDIHG
|
S75
|
PDE4D iso4 (human)
|
gap
|
-
|
PDE4D iso5 (human)
|
gap
|
-
|
PDE4D iso6 (human)
|
kSMSRNSSIASDIHG
|
S147
|
PDE4D iso7 (human)
|
KSMSRNSSIASDIHG
|
S147
|
PDE4D iso9 (human)
|
KSMSRNSSIASDIHG
|
S89
|
PDE4D iso10 (human)
|
KSMSRNSSIASDIHG
|
S81
|
PDE4D (mouse)
|
KSMSRNSSIAsDIHG
|
S150
|
PDE4D iso2 (mouse)
|
KSMSRNSSIASDIHG
|
S81
|
PDE4D iso3 (mouse)
|
gap
|
-
|
PDE4D iso4 (mouse)
|
gap
|
-
|
PDE4D iso9 (mouse)
|
KSMSRNSSIASDIHG
|
S104
|
PDE4D (rat)
|
KSMSRNSSIASDIHG
|
S206
|
PDE4D iso6 (rat)
|
KSMSRNSsIASDIHG
|
S81-p
|
PDE4D iso8 (rat)
|
KSMSRNSSIASDIHG
|
S148
|
|
S78
|
SRNSSIASDIHGDDL
|
|
|
0
|
2
|
|
|
|
S116
|
NLQDRAPSKRSPMCN
|
|
|
0
|
2
|
|
|
PDE4D (human)
|
NLQDRAPsKRsPMCN
|
S252-p
|
PDE4D iso2 (human)
|
NLQDRAPSKRSPMCN
|
S116
|
PDE4D iso4 (human)
|
gap
|
-
|
PDE4D iso5 (human)
|
gap
|
-
|
PDE4D iso6 (human)
|
NLQDRAPSKRSPMCN
|
S188
|
PDE4D iso7 (human)
|
NLQDRAPSKRSPMCN
|
S188
|
PDE4D iso9 (human)
|
NLQDRAPSKRSPMCN
|
S130
|
PDE4D iso10 (human)
|
NLQDRAPSKRSPMCN
|
S122
|
PDE4D (mouse)
|
NLQDRAPSKRSPMCN
|
S191
|
PDE4D iso2 (mouse)
|
NLQDRAPSKRSPMCN
|
S122
|
PDE4D iso3 (mouse)
|
gap
|
-
|
PDE4D iso4 (mouse)
|
gap
|
-
|
PDE4D iso9 (mouse)
|
NLQDRAPSKRSPMCN
|
S145
|
PDE4D (rat)
|
NLQDRAPSKRSPMCN
|
S247
|
PDE4D iso6 (rat)
|
NLQDRAPSKRSPMCN
|
S122
|
PDE4D iso8 (rat)
|
NLQDRAPSKRSPMCN
|
S189
|
|
S119
|
DRAPSKRSPMCNQPS
|
|
|
0
|
2
|
|
|
PDE4D (human)
|
DRAPsKRsPMCNQPs
|
S255-p
|
PDE4D iso2 (human)
|
DRAPSKRSPMCNQPS
|
S119
|
PDE4D iso4 (human)
|
gap
|
-
|
PDE4D iso5 (human)
|
gap
|
-
|
PDE4D iso6 (human)
|
DRAPSKRSPMCNQPS
|
S191
|
PDE4D iso7 (human)
|
DRAPSKRSPMCNQPS
|
S191
|
PDE4D iso9 (human)
|
DRAPSKRSPMCNQPS
|
S133
|
PDE4D iso10 (human)
|
DRAPSKRSPMCNQPS
|
S125
|
PDE4D (mouse)
|
DRAPSKRSPMCNQPs
|
S194
|
PDE4D iso2 (mouse)
|
DRAPSKRSPMCNQPS
|
S125
|
PDE4D iso3 (mouse)
|
gap
|
-
|
PDE4D iso4 (mouse)
|
gap
|
-
|
PDE4D iso9 (mouse)
|
DRAPSKRSPMCNQPS
|
S148
|
PDE4D (rat)
|
DRAPSKRSPMCNQPS
|
S250
|
PDE4D iso6 (rat)
|
DRAPSKRSPMCNQPS
|
S125
|
PDE4D iso8 (rat)
|
DRAPSKRSPMCNQPS
|
S192
|
|
S126
|
SPMCNQPSINKATIT
|
|
|
0
|
3
|
|
|
PDE4D (human)
|
sPMCNQPsINKATIT
|
S262-p
|
PDE4D iso2 (human)
|
SPMCNQPSINKATIT
|
S126
|
PDE4D iso4 (human)
|
gap
|
-
|
PDE4D iso5 (human)
|
gap
|
-
|
PDE4D iso6 (human)
|
SPMCNQPSINKATIT
|
S198
|
PDE4D iso7 (human)
|
SPMCNQPSINKATIT
|
S198
|
PDE4D iso9 (human)
|
SPMCNQPSINKATIT
|
S140
|
PDE4D iso10 (human)
|
SPMCNQPSINKATIT
|
S132
|
PDE4D (mouse)
|
SPMCNQPsINKATIT
|
S201-p
|
PDE4D iso2 (mouse)
|
SPMCNQPSINKATIT
|
S132
|
PDE4D iso3 (mouse)
|
gap
|
-
|
PDE4D iso4 (mouse)
|
gap
|
-
|
PDE4D iso9 (mouse)
|
SPMCNQPSINKATIT
|
S155
|
PDE4D (rat)
|
SPMCNQPSINKATIT
|
S257
|
PDE4D iso6 (rat)
|
SPMCNQPSINKATIT
|
S132
|
PDE4D iso8 (rat)
|
SPMCNQPSINKATIT
|
S199
|
|
-
|
gap
|
|
|
0
|
1
|
|
|
|
-
|
gap
|
|
|
0
|
1
|
|
|
|
S163
|
ETLQTRHSVSEMASN
|
|
|
0
|
2
|
|
|
PDE4D (human)
|
ETLQTRHsVsEMASN
|
S299-p
|
PDE4D iso2 (human)
|
ETLQTRHSVSEMASN
|
S163
|
PDE4D iso4 (human)
|
ETLQTRHSVSEMASN
|
S74
|
PDE4D iso5 (human)
|
gap
|
-
|
PDE4D iso6 (human)
|
ETLQTRHSVSEMASN
|
S235
|
PDE4D iso7 (human)
|
gap
|
-
|
PDE4D iso9 (human)
|
ETLQTRHSVSEMASN
|
S177
|
PDE4D iso10 (human)
|
ETLQTRHSVSEMASN
|
S169
|
PDE4D (mouse)
|
ETLQTRHSVsEMASN
|
S238
|
PDE4D iso2 (mouse)
|
ETLQTRHSVSEMASN
|
S169
|
PDE4D iso3 (mouse)
|
ETLQTRHSVSEMASN
|
S75
|
PDE4D iso4 (mouse)
|
gap
|
-
|
PDE4D iso9 (mouse)
|
ETLQTRHSVSEMASN
|
S192
|
PDE4D (rat)
|
ETLQTRHSVSEMASN
|
S294
|
PDE4D iso6 (rat)
|
ETLQTRHSVSEMASN
|
S169
|
PDE4D iso8 (rat)
|
ETLQTRHSVSEMASN
|
S236
|
|
S165
|
LQTRHSVSEMASNKF
|
|
|
0
|
2
|
|
|
PDE4D (human)
|
LQTRHsVsEMASNkF
| |