Other Species / Isoforms
  Chk2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S12-p
SDVEAQQsHGsSACs
0 1
Chk2 (human) SDVEAQQsHGsSACs S12-p
Chk2 iso9 (human) SDVEAQQSHGSSACS S12
Chk2 iso11 (human) SDVEAQQSHGSSACS S12
Chk2 iso12 (human) SDVEAQQSHGSSACS S12
Chk2 (mouse) HQSHSSTSSKAHDSA S12
Chk2 (rat) HQSHGSTSSKAHDSA S11
S15-p
EAQQsHGsSACsQPH
0 1
Chk2 (human) EAQQsHGsSACsQPH S15-p
Chk2 iso9 (human) EAQQSHGSSACSQPH S15
Chk2 iso11 (human) EAQQSHGSSACSQPH S15
Chk2 iso12 (human) EAQQSHGSSACSQPH S15
Chk2 (mouse) TSSKAHDSASCSQSQ S18
Chk2 (rat) TSSKAHDSASCSQSQ S17
S19-p
sHGsSACsQPHGsVt
Upstream
Downstream
11 1
Chk2 (human)
S19-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • Chk2 (human)
Phosphatases, in vitro:
  • PPPM1A (human)
Regulatory protein:
  • SOCS1 (human)
Treatment
  • 4-nitroquinoline_1-oxide
  • adriamycin
  • caffeine
  • hydroxyurea
  • ionizing_radiation
  • methylselenocysteine
  • mitomycin_C
  • resveratrol
  • silibinin
  • silymarin
  • SN-38
  • UV
  • VRX0466617
Chk2 (human) sHGsSACsQPHGsVt S19-p
Chk2 iso9 (human) SHGSSACSQPHGSVT S19
Chk2 iso11 (human) SHGSSACSQPHGSVT S19
Chk2 iso12 (human) SHGSSACSQPHGSVT S19
Chk2 (mouse) AHDSASCSQSQGGFS S22
Chk2 (rat) AHDSASCSQSQGGFS S21
S24-p
ACsQPHGsVtQsQGS
0 1
Chk2 (human) ACsQPHGsVtQsQGS S24-p
Chk2 iso9 (human) ACSQPHGSVTQSQGS S24
Chk2 iso11 (human) ACSQPHGSVTQSQGS S24
Chk2 iso12 (human) ACSQPHGSVTQSQGS S24
Chk2 (mouse) SCSQSQGGFSQPQGT G27
Chk2 (rat) SCSQSQGGFSQSQGT G26
T26-p
sQPHGsVtQsQGSSs
Upstream
Downstream
3 1
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Putative in vivo kinases:
  • ATM (human)
Treatment
  • adriamycin
  • caffeine
  • hydroxyurea
  • ionizing_radiation
  • UV
  • wortmannin
Chk2 (human) sQPHGsVtQsQGSSs T26-p
Chk2 iso9 (human) SQPHGSVTQSQGSSS T26
Chk2 iso11 (human) SQPHGSVTQSQGSSS T26
Chk2 iso12 (human) SQPHGSVTQSQGSSS T26
Chk2 (mouse) SQSQGGFSQPQGTPS S29
Chk2 (rat) SQSQGGFSQSQGTPS S28
S28-p
PHGsVtQsQGSSsQs
Upstream
Downstream
3 0
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Putative in vivo kinases:
  • ATM (human)
Treatment
  • adriamycin
  • caffeine
  • hydroxyurea
  • ionizing_radiation
  • UV
  • wortmannin
Chk2 (human) PHGsVtQsQGSSsQs S28-p
Chk2 iso9 (human) PHGSVTQSQGSSSQS S28
Chk2 iso11 (human) PHGSVTQSQGSSSQS S28
Chk2 iso12 (human) PHGSVTQSQGSSSQS S28
Chk2 (mouse) SQGGFSQPQGTPSQL P31
Chk2 (rat) SQGGFSQSQGTPSQL S30
S33-p
tQsQGSSsQsQGIss
Upstream
Downstream
11 1
Chk2 (human)
S33-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • Chk2 (human)
Phosphatases, in vitro:
  • PPM1D (human)
Putative in vivo kinases:
  • ATM (human)
Putative upstream phosphatases:
  • PPM1D (human)
  • PPP1CA (human)
  • PPP2CA (human)
Regulatory protein:
  • Chk2 (human)
Treatment
  • 4-nitroquinoline_1-oxide
  • adriamycin
  • hydroxyurea
  • ionizing_radiation
  • mitomycin_C
  • NAC
  • okadaic_acid
  • UV
  • VRX0466617
  • wortmannin
Chk2 (human) tQsQGSSsQsQGIss S33-p
Chk2 iso9 (human) TQSQGSSSQSQGISS S33
Chk2 iso11 (human) TQSQGSSSQSQGISS S33
Chk2 iso12 (human) TQSQGSSSQSQGISS S33
Chk2 (mouse) SQPQGTPSQLHELSQ S36
Chk2 (rat) SQSQGTPSQLHDLSQ S35
S35-p
sQGSSsQsQGIssss
Upstream
Downstream
10 1
Chk2 (human)
S35-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • Chk2 (human)
Putative in vivo kinases:
  • ATM (human)
Putative upstream phosphatases:
  • PPM1D (human)
  • PPP1CA (human)
  • PPP2CA (human)
Regulatory protein:
  • Chk2 (human)
Treatment
  • 4-nitroquinoline_1-oxide
  • adriamycin
  • hydroxyurea
  • ionizing_radiation
  • mitomycin_C
  • NAC
  • okadaic_acid
  • UV
  • VRX0466617
  • wortmannin
Chk2 (human) sQGSSsQsQGIssss S35-p
Chk2 iso9 (human) SQGSSSQSQGISSSS S35
Chk2 iso11 (human) SQGSSSQSQGISSSS S35
Chk2 iso12 (human) SQGSSSQSQGISSSS S35
Chk2 (mouse) PQGTPSQLHELSQYQ L38
Chk2 (rat) SQGTPSQLHDLSQYQ L37
S39-p
SsQsQGIsssststM
0 1
Chk2 (human) SsQsQGIsssststM S39-p
Chk2 iso9 (human) SSQSQGISSSSTSTM S39
Chk2 iso11 (human) SSQSQGISSSSTSTM S39
Chk2 iso12 (human) SSQSQGISSSSTSTM S39
Chk2 (mouse) LSQYQGSSSSSTGTV S48
Chk2 (rat) LSQYQGASSSSTSTV S47
S40-p
sQsQGIsssststMP
0 1
Chk2 (human) sQsQGIsssststMP S40-p
Chk2 iso9 (human) SQSQGISSSSTSTMP S40
Chk2 iso11 (human) SQSQGISSSSTSTMP S40
Chk2 iso12 (human) SQSQGISSSSTSTMP S40
Chk2 (mouse) SQYQGSSSSSTGTVP S49
Chk2 (rat) SQYQGASSSSTSTVP S48
S41-p
QsQGIsssststMPN
0 1
Chk2 (human) QsQGIsssststMPN S41-p
Chk2 iso9 (human) QSQGISSSSTSTMPN S41
Chk2 iso11 (human) QSQGISSSSTSTMPN S41
Chk2 iso12 (human) QSQGISSSSTSTMPN S41
Chk2 (mouse) QYQGSSSSSTGTVPS S50
Chk2 (rat) QYQGASSSSTSTVPS S49
S42-p
sQGIsssststMPNS
0 1
Chk2 (human) sQGIsssststMPNS S42-p
Chk2 iso9 (human) SQGISSSSTSTMPNS S42
Chk2 iso11 (human) SQGISSSSTSTMPNS S42
Chk2 iso12 (human) SQGISSSSTSTMPNS S42
Chk2 (mouse) YQGSSSSSTGTVPSS S51
Chk2 (rat) YQGASSSSTSTVPSS S50
T43-p
QGIsssststMPNSs
0 1
Chk2 (human) QGIsssststMPNSs T43-p
Chk2 iso9 (human) QGISSSSTSTMPNSS T43
Chk2 iso11 (human) QGISSSSTSTMPNSS T43
Chk2 iso12 (human) QGISSSSTSTMPNSS T43
Chk2 (mouse) QGSSSSSTGTVPSSS T52
Chk2 (rat) QGASSSSTSTVPSSS T51
S44-p
GIsssststMPNSsQ
0 1
Chk2 (human) GIsssststMPNSsQ S44-p
Chk2 iso9 (human) GISSSSTSTMPNSSQ S44
Chk2 iso11 (human) GISSSSTSTMPNSSQ S44
Chk2 iso12 (human) GISSSSTSTMPNSSQ S44
Chk2 (mouse) GSSSSSTGTVPSSSQ G53
Chk2 (rat) GASSSSTSTVPSSSQ S52
T45-p
IsssststMPNSsQs
0 1
Chk2 (human) IsssststMPNSsQs T45-p
Chk2 iso9 (human) ISSSSTSTMPNSSQS T45
Chk2 iso11 (human) ISSSSTSTMPNSSQS T45
Chk2 iso12 (human) ISSSSTSTMPNSSQS T45
Chk2 (mouse) SSSSSTGTVPSSSQS T54
Chk2 (rat) ASSSSTSTVPSSSQS T53
S50-p
tstMPNSsQsSHsSS
0 1
Chk2 (human) tstMPNSsQsSHsSS S50-p
Chk2 iso9 (human) TSTMPNSSQSSHSSS S50
Chk2 iso11 (human) TSTMPNSSQSSHSSS S50
Chk2 iso12 (human) TSTMPNSSQSSHSSS S50
Chk2 (mouse) TGTVPSSSQSSHSSS S59
Chk2 (rat) TSTVPSSSQSSHSSS S58
S52-p
tMPNSsQsSHsSSGT
0 1
Chk2 (human) tMPNSsQsSHsSSGT S52-p
Chk2 iso9 (human) TMPNSSQSSHSSSGT S52
Chk2 iso11 (human) TMPNSSQSSHSSSGT S52
Chk2 iso12 (human) TMPNSSQSSHSSSGT S52
Chk2 (mouse) TVPSSSQSSHSSSGT S61
Chk2 (rat) TVPSSSQSSHSSSGT S60
S55-p
NSsQsSHsSSGTLSs
0 1
Chk2 (human) NSsQsSHsSSGTLSs S55-p
Chk2 iso9 (human) NSSQSSHSSSGTLSS S55
Chk2 iso11 (human) NSSQSSHSSSGTLSS S55
Chk2 iso12 (human) NSSQSSHSSSGTLSS S55
Chk2 (mouse) SSSQSSHSSSGTLSS S64
Chk2 (rat) SSSQSSHSSSGTLSS S63
S62-p
sSSGTLSsLEtVstQ
Upstream
1 0
Kinase, in vitro:
  • PLK3 (human)
Chk2 (human) sSSGTLSsLEtVstQ S62-p
Chk2 iso9 (human) SSSGTLSSLETVSTQ S62
Chk2 iso11 (human) SSSGTLSSLETVSTQ S62
Chk2 iso12 (human) SSSGTLSSLETVSTQ S62
Chk2 (mouse) SSSGTLSSLETVStQ S71
Chk2 (rat) SSSGTLSSLETVSTQ S70
T65-p
GTLSsLEtVstQELY
0 1
Chk2 (human) GTLSsLEtVstQELY T65-p
Chk2 iso9 (human) GTLSSLETVSTQELY T65
Chk2 iso11 (human) GTLSSLETVSTQELY T65
Chk2 iso12 (human) GTLSSLETVSTQELY T65
Chk2 (mouse) GTLSSLETVStQELC T74
Chk2 (rat) GTLSSLETVSTQELC T73
S67-p
LSsLEtVstQELYsI
0 1
Chk2 (human) LSsLEtVstQELYsI S67-p
Chk2 iso9 (human) LSSLETVSTQELYSI S67
Chk2 iso11 (human) LSSLETVSTQELYSI S67
Chk2 iso12 (human) LSSLETVSTQELYSI S67
Chk2 (mouse) LSSLETVStQELCSI S76
Chk2 (rat) LSSLETVSTQELCSI S75
T68-p
SsLEtVstQELYsIP
Upstream
Downstream
166 5
Chk2 (human)
T68-p
Chk2 iso9 (human)
T68-p
Chk2 iso12 (human)
T68-p
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, induced
  • cell cycle regulation
  • cytoskeletal reorganization
  • signaling pathway regulation
  • translation, induced
Kinase, in vitro:
  • ATM (human)
  • ATR (human)
  • Chk2 (human)
  • DNAPK (human)
  • PLK1 (human)
  • TTK (human)
  • ZAK (human)
Phosphatases, in vitro:
  • PPM1D (human)
Putative in vivo kinases:
  • ATM (human)
  • ATR (human)
  • Chk2 (human)
  • DNAPK (human)
  • PLK1 (human)
  • ZAK (human)
Putative upstream phosphatases:
  • PPM1D (human)
  • PPP1CA (human)
  • PPP2CA (human)
Regulatory protein:
  • Abl (mouse)
  • Akt1 (human)
  • ATM (human)
  • ATR (human)
  • Bcl-2 (human)
  • BLM (human)
  • BMI1 (human)
  • BRCA1 (human)
  • BRD8 (human)
  • CDT1 (human)
  • Chk1 (human)
  • Chk2 (human)
  • claspin (human)
  • CtIP (human)
  • DNAPK (human)
  • E2F1 (human)
  • ERK1 (human)
  • ERK2 (human)
  • FBXW7 (human)
  • Geminin (human)
  • HMGA2 (human)
  • HRas (human)
  • HSPA2 (human)
  • KIBRA (human)
  • Ku70 (human)
  • Ku80 (human)
  • MPG (human)
  • NBS1 (human)
  • NCK1 (human)
  • OBFC2B (human)
  • p16-INK4A iso5 (human)
  • p53 (human)
  • PDE1A (human)
  • PIN1 (human)
  • PINX1 (human)
  • PPM1D (mouse)
  • PPP4C (human)
  • PTEN (human)
  • RAD17 (human)
  • SMEK2 (human)
  • SOCS1 (human)
  • SOCS7 (human)
  • Tax (retrovirus)
  • TERT (human)
  • Tip60 (human)
  • TRF1 (human)
  • VCP (human)
Treatment
  • 11,11'-dideoxyverticillin
  • 4-nitroquinoline_1-oxide
  • adriamycin
  • aminothiazole_compound_25
  • AP20187
  • AZ20
  • AZD7762
  • BI2536
  • C-1027
  • caffeine
  • camptothecin
  • CBP-93872
  • Chk2_inhibitor_II
  • colforsin
  • cyclophosphamide
  • DNA-PK_inhibitor_II
  • doxycycline
  • DSBs
  • Et743
  • etoposide
  • eusynstyelamide B
  • galiellalactone
  • gemcitabine
  • genistein
  • Go_6976
  • grape_seed_extract
  • H2O2
  • herbimycin_A
  • hydroxyurea
  • hyperoxia
  • IBMX
  • IC86621
  • ICRF-193
  • ionizing_radiation
  • irofulven
  • KU-55933
  • KU-60019
  • lurbinectedin
  • methylselenocysteine
  • MG132
  • mimosine
  • mitomycin_C
  • mitoxantrone
  • MMS
  • Na(2)CrO(4)
  • NAC
  • nelfinavir
  • neocarzinostatin
  • NMS-873
  • nocodazole
  • NU7026
  • NU7441
  • okadaic_acid
  • olaparib
  • PDTC
  • peptide inhibitor
  • PHA-767491
  • phorbol_ester
  • phytohaemagglutinin
  • rapamycin
  • resveratrol
  • ryuvidine
  • SB203580
  • silibinin
  • silymarin
  • siRNA
  • SJG-136
  • SN-38
  • thymidine
  • tioguanine
  • TMZ
  • U0126
  • UCN-01
  • UV
  • VE-821
  • virus infection
  • VRX0466617
  • wortmannin
Chk2 (human) SsLEtVstQELYsIP T68-p
Chk2 iso9 (human) SSLETVSTQELYSIP T68
Chk2 iso11 (human) SSLETVSTQELYSIP T68
Chk2 iso12 (human) SSLETVSTQELYSIP T68
Chk2 (mouse) SSLETVStQELCSIP T77-p
Chk2 (rat) SSLETVSTQELCSIP T76
S73-p
VstQELYsIPEDQEP
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • PLK3 (human)
Chk2 (human) VstQELYsIPEDQEP S73-p
Chk2 iso9 (human) VSTQELYSIPEDQEP S73
Chk2 iso11 (human) VSTQELYSIPEVLVS S73
Chk2 iso12 (human) VSTQELYSIPEDQEP S73
Chk2 (mouse) VStQELCSIPEDQEP S82
Chk2 (rat) VSTQELCSIPEDQEP S81
K119-ub
NYWFGRDksCEYCFD
0 1
Chk2 (human) NYWFGRDksCEYCFD K119-ub
Chk2 iso9 (human) NYWFGRDKSCEYCFD K162
Chk2 iso11 (human) under review -
Chk2 iso12 (human) NYWFGRDKSCEYCFD K119
Chk2 (mouse) NYWFGRDKSCEYCFD K123
Chk2 (rat) NYWFGRDKSCEYCFD K122
S120-p
YWFGRDksCEYCFDE
Upstream
2 7
Kinase, in vitro:
  • Chk2 (human)
Chk2 (human) YWFGRDksCEYCFDE S120-p
Chk2 iso9 (human) YWFGRDKSCEYCFDE S163
Chk2 iso11 (human) gap -
Chk2 iso12 (human) YWFGRDKSCEYCFDE S120
Chk2 (mouse) YWFGRDKSCEYCFDG S124
Chk2 (rat) YWFGRDKSCEYCFDG S123
K131-ub
CFDEPLLkRTDKYRT
0 2
Chk2 (human) CFDEPLLkRTDKYRT K131-ub
Chk2 iso9 (human) CFDEPLLKRTDKYRT K174
Chk2 iso11 (human) gap -
Chk2 iso12 (human) CFDEPLLKRTDKYRT K131
Chk2 (mouse) CFDGPLLRRTDKYRT R135
Chk2 (rat) CFDGPLLKRTDKYRT K134
S140-p
TDKYRTYsKKHFRIF
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • protein conformation
Kinase, in vitro:
  • Chk2 (human)
Chk2 (human) TDKYRTYsKKHFRIF S140-p
Chk2 iso9 (human) TDKYRTYSKKHFRIF S183
Chk2 iso11 (human) gap -
Chk2 iso12 (human) TDKYRTYSKKHFRIF S140
Chk2 (mouse) TDKYRTYSKKHFRIF S144
Chk2 (rat) TDKYRTYSKKHFRIF S143
S164-p
IAYIEDHsGNGTFVN
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • cell cycle regulation
Putative in vivo kinases:
  • PLK1 (human)
Treatment
  • BI2536
Chk2 (human) IAYIEDHsGNGTFVN S164-p
Chk2 iso9 (human) IAYIEDHSGNGTFVN S207
Chk2 iso11 (human) gap -
Chk2 iso12 (human) IAYIEDHSGNGTFVN S164
Chk2 (mouse) IVYIEDHSGNGTFVN S168
Chk2 (rat) IVYLEDHSGNGTFVN S167
T205-p
VFVFFDLtVDDQsVY
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • cell cycle regulation
Putative in vivo kinases:
  • PLK1 (human)
Treatment
  • BI2536
Chk2 (human) VFVFFDLtVDDQsVY T205-p
Chk2 iso9 (human) VFVFFDLTVDDQSVY T248
Chk2 iso11 (human) gap -
Chk2 iso12 (human) VFVFFDLTVDDQSVY T205
Chk2 (mouse) VFVFFDLTVDDQSVY T209
Chk2 (rat) VFVFFDLTVDDQSVY T208
S210-p
DLtVDDQsVYPKALR
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • cell cycle regulation
Putative in vivo kinases:
  • PLK1 (human)
Treatment
  • BI2536
Chk2 (human) DLtVDDQsVYPKALR S210-p
Chk2 iso9 (human) DLTVDDQSVYPKALR S253
Chk2 iso11 (human) gap -
Chk2 iso12 (human) DLTVDDQSVYPKALR S210
Chk2 (mouse) DLTVDDQSVYPKELR S214
Chk2 (rat) DLTVDDQSVYPKELR S213
K224-ub
RDEYIMSktLGSGAC
0 2
Chk2 (human) RDEYIMSktLGSGAC K224-ub
Chk2 iso9 (human) RDEYIMSKTLGSGAC K267
Chk2 iso11 (human) gap -
Chk2 iso12 (human) RDEYIMSKTLGSGAC K224
Chk2 (mouse) RDEYIMSKTLGSGAC K228
Chk2 (rat) RDEYIMSKTLGSGAC K227
T225-p
DEYIMSktLGSGACG
Upstream
1 2
Kinase, in vitro:
  • Chk2 (human)
Chk2 (human) DEYIMSktLGSGACG T225-p
Chk2 iso9 (human) DEYIMSKTLGSGACG T268
Chk2 iso11 (human) gap -
Chk2 iso12 (human) DEYIMSKTLGSGACG T225
Chk2 (mouse) DEYIMSKTLGSGACG T229
Chk2 (rat) DEYIMSKTLGSGACG T228
K235-ac
SGACGEVkLAFERKT
0 1
Chk2 (human) SGACGEVkLAFERKT K235-ac
Chk2 iso9 (human) SGACGEVKLAFERKT K278
Chk2 iso11 (human) gap -
Chk2 iso12 (human) SGACGEVKLAFERKT K235
Chk2 (mouse) SGACGEVKMAFERKT K239
Chk2 (rat) SGACGEVKMAFERKT K238
S260-p
KRKFAIGsAREADPA
Upstream
1 12
Kinase, in vitro:
  • Chk2 (human)
Treatment
  • ischemia
Chk2 (human) KRKFAIGsAREADPA S260-p
Chk2 iso9 (human) KRKFAIGSAREADPA S303
Chk2 iso11 (human) gap -
Chk2 iso12 (human) KRKFAIGSAREADPA S260
Chk2 (mouse) KRRFALGSSREADTA S264
Chk2 (rat) KRRFALGSSREADTA S263
K279-ub
TEIEILKkLNHPCII
0 1
Chk2 (human) TEIEILKkLNHPCII K279-ub
Chk2 iso9 (human) TEIEILKKLNHPCII K322
Chk2 iso11 (human) under review -
Chk2 iso12 (human) TEIEILKKLNHPCII K279
Chk2 (mouse) TEIEILKKLNHPCII K283
Chk2 (rat) TEIEILKKLNHPCII K282
K287-ub
LNHPCIIkIKNFFDA
0 1
Chk2 (human) LNHPCIIkIKNFFDA K287-ub
Chk2 iso9 (human) LNHPCIIKIKNFFDA K330
Chk2 iso11 (human) under review -
Chk2 iso12 (human) LNHPCIIKIKNFFDA K287
Chk2 (mouse) LNHPCIIKIKDVFDA K291
Chk2 (rat) LNHPCIIKIKDVFDV K290
S372-p
KITDFGHskILGEts
Upstream
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
Treatment
  • ionizing_radiation
Chk2 (human) KITDFGHskILGEts S372-p
Chk2 iso9 (human) KITDFGHSKILGETS S415
Chk2 iso11 (human) gap -
Chk2 iso12 (human) QITDFGHSKILGETS S343
Chk2 (mouse) KITDFGQSKILGEts S376
Chk2 (rat) KITDFGQSKILGETS S375
K373-ub
ITDFGHskILGEtsL
0 1
Chk2 (human) ITDFGHskILGEtsL K373-ub
Chk2 iso9 (human) ITDFGHSKILGETSL K416
Chk2 iso11 (human) gap -
Chk2 iso12 (human) ITDFGHSKILGETSL K344
Chk2 (mouse) ITDFGQSKILGEtsL K377
Chk2 (rat) ITDFGQSKILGETSL K376
T378-p
HskILGEtsLMRtLC
Upstream
Downstream
2 4
Effects on Modified Protein
  • intracellular localization
Regulatory protein:
  • Tax (retrovirus)
Treatment
  • ionizing_radiation
Chk2 (human) HskILGEtsLMRtLC T378-p
Chk2 iso9 (human) HSKILGETSLMRTLC T421
Chk2 iso11 (human) gap -
Chk2 iso12 (human) HSKILGETSLMRTLC T349
Chk2 (mouse) QSKILGEtsLMRTLC T382-p
Chk2 (rat) QSKILGETSLMRTLC T381
S379-p
skILGEtsLMRtLCG
Upstream
Downstream
4 12
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
Kinase, in vitro:
  • Chk2 (human)
Putative in vivo kinases:
  • Chk2 (human)
Regulatory protein:
  • Tax (retrovirus)
Treatment
  • ionizing_radiation
Chk2 (human) skILGEtsLMRtLCG S379-p
Chk2 iso9 (human) SKILGETSLMRTLCG S422
Chk2 iso11 (human) gap -
Chk2 iso12 (human) SKILGETSLMRTLCG S350
Chk2 (mouse) SKILGEtsLMRTLCG S383-p
Chk2 (rat) SKILGETSLMRTLCG S382
T383-p
GEtsLMRtLCGtPty
Upstream
Downstream
8 8
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • protein conformation
  • ubiquitination
Kinase, in vitro:
  • Chk2 (human)
  • DNAPK (human)
Putative in vivo kinases:
  • Chk2 (human)
Regulatory protein:
  • Tax (retrovirus)
Treatment
  • camptothecin
  • etoposide
  • ionizing_radiation
  • nocodazole
  • taxol
Chk2 (human) GEtsLMRtLCGtPty T383-p
Chk2 iso9 (human) GETSLMRTLCGTPTY T426
Chk2 iso11 (human) gap -
Chk2 iso12 (human) GETSLMRTLCGTPTY T354
Chk2 (mouse) GEtsLMRTLCGTPTY T387
Chk2 (rat) GETSLMRTLCGTPTY T386
T387-p
LMRtLCGtPtyLAPE
Upstream
Downstream
17 5
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • protein conformation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • Chk2 (human)
  • DNAPK (human)
Putative in vivo kinases:
  • Chk2 (human)
Putative upstream phosphatases:
  • PPM1D (human)
  • PPP1CA (human)
  • PPP2CA (human)
Regulatory protein:
  • Tax (retrovirus)
Treatment
  • caffeine
  • camptothecin
  • etoposide
  • ionizing_radiation
  • methylselenocysteine
  • resveratrol
  • SN-38
  • VRX0466617
Chk2 (human) LMRtLCGtPtyLAPE T387-p
Chk2 iso9 (human) LMRTLCGTPTYLAPE T430
Chk2 iso11 (human) gap -
Chk2 iso12 (human) LMRTLCGTPTYLAPE T358
Chk2 (mouse) LMRTLCGTPTYLAPE T391
Chk2 (rat) LMRTLCGTPTYLAPE T390
T389-p
RtLCGtPtyLAPEVL
Upstream
Downstream
2 2
Effects on Modified Protein
  • intracellular localization
  • phosphorylation
Regulatory protein:
  • Tax (retrovirus)
Treatment
  • ionizing_radiation
Chk2 (human) RtLCGtPtyLAPEVL T389-p
Chk2 iso9 (human) RTLCGTPTYLAPEVL T432
Chk2 iso11 (human) gap -
Chk2 iso12 (human) RTLCGTPTYLAPEVL T360
Chk2 (mouse) RTLCGTPTYLAPEVL T393
Chk2 (rat) RTLCGTPTYLAPEVL T392
Y390-p
tLCGtPtyLAPEVLV
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
Treatment
  • ionizing_radiation
Chk2 (human) tLCGtPtyLAPEVLV Y390-p
Chk2 iso9 (human) TLCGTPTYLAPEVLV Y433
Chk2 iso11 (human) gap -
Chk2 iso12 (human) TLCGTPTYLAPEVLV Y361
Chk2 (mouse) TLCGTPTYLAPEVLV Y394
Chk2 (rat) TLCGTPTYLAPEVLI Y393
T432-p
PPFSEHRtQVsLkDQ
Upstream
4 2
Kinase, in vitro:
  • Chk2 (human)
Phosphatases, in vitro:
  • PPPM1A (human)
Treatment
  • methylselenocysteine
  • SN-38
Chk2 (human) PPFSEHRtQVsLkDQ T432-p
Chk2 iso9 (human) PPFSEHRTQVSLKDQ T475
Chk2 iso11 (human) PPFSEHRTQVSLKDQ T114
Chk2 iso12 (human) PPFSEHRTQVSLKDQ T403
Chk2 (mouse) PPFSEHKTQVSLKDQ T436
Chk2 (rat) PPFSEHKTQVSLKDQ T435
S435-p
SEHRtQVsLkDQITS
Upstream
1 2
Kinase, in vitro:
  • Chk2 (human)
Chk2 (human) SEHRtQVsLkDQITS S435-p
Chk2 iso9 (human) SEHRTQVSLKDQITS S478
Chk2 iso11 (human) SEHRTQVSLKDQITS S117
Chk2 iso12 (human) SEHRTQVSLKDQITS S406
Chk2 (mouse) SEHKTQVSLKDQITS S439
Chk2 (rat) SEHKTQVSLKDQITS S438
K437-ub
HRtQVsLkDQITSGk
0 1
Chk2 (human) HRtQVsLkDQITSGk K437-ub
Chk2 iso9 (human) HRTQVSLKDQITSGK K480
Chk2 iso11 (human) HRTQVSLKDQITSGK K119
Chk2 iso12 (human) HRTQVSLKDQITSGK K408
Chk2 (mouse) HKTQVSLKDQITSGK K441
Chk2 (rat) HKTQVSLKDQITSGK K440
K444-ub
kDQITSGkYNFIPEV
0 1
Chk2 (human) kDQITSGkYNFIPEV K444-ub
Chk2 iso9 (human) KDQITSGKYNFIPEV K487
Chk2 iso11 (human) KDQITSGKYNFIPEV K126
Chk2 iso12 (human) KDQITSGKYNFIPEV K415
Chk2 (mouse) KDQITSGKYNFIPEV K448
Chk2 (rat) KDQITSGKYNLIPEV K447
S456-p
PEVWAEVsEkALDLV
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
Treatment
  • neocarzinostatin
Chk2 (human) PEVWAEVsEkALDLV S456-p
Chk2 iso9 (human) PEVWAEVSEKALDLV S499
Chk2 iso11 (human) PEVWAEVSEKALDLV S138
Chk2 iso12 (human) PEVWAEVSEKALDLV S427
Chk2 (mouse) PEVWTDVSEEALDLV S460
Chk2 (rat) PEVWTDVSEKALDLV S459
K458-ub
VWAEVsEkALDLVKK
0 1
Chk2 (human) VWAEVsEkALDLVKK K458-ub
Chk2 iso9 (human) VWAEVSEKALDLVKK K501
Chk2 iso11 (human) VWAEVSEKALDLVKK K140
Chk2 iso12 (human) VWAEVSEKALDLVKK K429
Chk2 (mouse) VWTDVSEEALDLVKK E462
Chk2 (rat) VWTDVSEKALDLVKK K461
K472-ub
KLLVVDPkARFTTEE
0 1
Chk2 (human) KLLVVDPkARFTTEE K472-ub
Chk2 iso9 (human) KLLVVDPKARFTTEE K515
Chk2 iso11 (human) KLLVVDPKARFTTEE K154
Chk2 iso12 (human) KLLVVDPKARFTTEE K443
Chk2 (mouse) KLLVVDPKARLTTEE K476
Chk2 (rat) KLLVVDPKARLTTEE K475
K472-m1
KLLVVDPkARFTTEE
0 1
Chk2 (human) KLLVVDPkARFTTEE K472-m1
Chk2 iso9 (human) KLLVVDPKARFTTEE K515
Chk2 iso11 (human) KLLVVDPKARFTTEE K154
Chk2 iso12 (human) KLLVVDPKARFTTEE K443
Chk2 (mouse) KLLVVDPKARLTTEE K476
Chk2 (rat) KLLVVDPKARLTTEE K475
K494-ub
QDEDMKRkFQDLLSE
0 2
Chk2 (human) QDEDMKRkFQDLLSE K494-ub
Chk2 iso9 (human) QDEDMKRKFQDLLSE K537
Chk2 iso11 (human) QDEDMKRKFQDLLSE K176
Chk2 iso12 (human) QDEDMKRKFQDLLSE K465
Chk2 (mouse) QDEYMKKKFQDLLVQ K498
Chk2 (rat) QDEHMKKKFQDLLVQ K497
S516-p
PQVLAQPstSRKRPR
Upstream
Downstream
14 3
Chk2 (human)
S516-p
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • Chk2 (human)
Phosphatases, in vitro:
  • PPM1D (human)
  • PPPM1A (human)
Putative in vivo kinases:
  • Chk2 (human)
Regulatory protein:
  • Chk2 (human)
  • FBXW7 (human)
Treatment
  • 2-deoxyglucose
  • Chk2_inhibitor_II
  • gemcitabine
  • ionizing_radiation
  • MK-8776
Chk2 (human) PQVLAQPstSRKRPR S516-p
Chk2 iso9 (human) PQVLAQPSTSRKRPR S559
Chk2 iso11 (human) PQVLAQPSTSRKRPR S198
Chk2 iso12 (human) PQVLAQPSTSRKRPR S487
Chk2 (mouse) PVAPAQTSSQKRPLE S520
Chk2 (rat) PLAPAQTSGQKRPLE S519
T517-p
QVLAQPstSRKRPRE
Upstream
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
Regulatory protein:
  • Tax (retrovirus)
Treatment
  • ionizing_radiation
Chk2 (human) QVLAQPstSRKRPRE T517-p
Chk2 iso9 (human) QVLAQPSTSRKRPRE T560
Chk2 iso11 (human) QVLAQPSTSRKRPRE T199
Chk2 iso12 (human) QVLAQPSTSRKRPRE T488
Chk2 (mouse) gap -
Chk2 (rat) gap -
A537
AETTKRPAVCAAVL_
0 2
Chk2 (human) AETTKRPAVCAAVL_ A537
Chk2 iso9 (human) AETTKRPAVCAAVL_ A580
Chk2 iso11 (human) AETTKRPAVCAAVL_ A219
Chk2 iso12 (human) AETTKRPAVCAAVL_ A508
Chk2 (mouse) MPSTKRLsVCGAVL_ S540-p
Chk2 (rat) AESSKRLAVCKAVL_ A539