Other Species / Isoforms
  p53 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
-
gap
1 0
p53 (human) gap -
p53 iso2 (human) gap -
p53 iso4 (human) gap -
p53 (mouse) gap -
p53 iso2 (mouse) RAFQALIkEEsPNC_ K375-sm
p53 (rat) gap -
p53 (rabbit) gap -
p53 (green monkey) gap -
-
gap
0 2
p53 (human) gap -
p53 iso2 (human) gap -
p53 iso4 (human) gap -
p53 (mouse) gap -
p53 iso2 (mouse) QALIkEEsPNC____ S378-p
p53 (rat) gap -
p53 (rabbit) gap -
p53 (green monkey) gap -
-
gap
1 0
p53 (human) gap -
p53 iso2 (human) gap -
p53 iso4 (human) gap -
p53 (mouse) gap -
p53 iso2 (mouse) gap -
p53 (rat) LPTTATGsPNSMEDL S39-p
p53 (rabbit) NLLTTSLNPPVDDLL N37
p53 (green monkey) gap -
R333-me
EyFTLQIrGrErFEM
1 0
p53 (human) EyFTLQIrGrErFEM R333-me
p53 iso2 (human) gap -
p53 iso4 (human) EYFTLQIRGRERFEM R294
p53 (mouse) EyFTLKIRGRKRFEM R330
p53 iso2 (mouse) EYFTLKIRGRKRFEM R330
p53 (rat) EYFTLKIRGRERFEM R331
p53 (rabbit) EYFILKIRGRERFEM R331
p53 (green monkey) EYFTLQIRGRERFEM R333
K370-ac
RAHsSHLkskkGQst
Upstream
Downstream
16 3
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, induced
  • cell growth, inhibited
  • transcription, altered
  • transcription, induced
Treatment
  • etoposide
  • nicotinamide
  • trichostatin_A
p53 (human) RAHsSHLkskkGQst K370-ac
p53 iso2 (human) gap -
p53 iso4 (human) RAHSSHLKSKkGQST K331
p53 (mouse) RAHSSYLKTkkGQsT K367
p53 iso2 (mouse) gap -
p53 (rat) RAHSSYPKTKkGQST K368
p53 (rabbit) RAHSSYLKAKKGQST K368
p53 (green monkey) RAHSSHLkSkkGQST K370-ac
K370-m2
RAHsSHLkskkGQst
2 1
p53 (human) RAHsSHLkskkGQst K370-m2
p53 iso2 (human) gap -
p53 iso4 (human) RAHSSHLKSKkGQST K331
p53 (mouse) RAHSSYLKTkkGQsT K367
p53 iso2 (mouse) gap -
p53 (rat) RAHSSYPKTKkGQST K368
p53 (rabbit) RAHSSYLKAKKGQST K368
p53 (green monkey) RAHSSHLKSkkGQST K370
K373-m1
sSHLkskkGQstsRH
1 0
p53 (human) sSHLkskkGQstsRH K373-m1
p53 iso2 (human) gap -
p53 iso4 (human) SSHLKSKKGQSTSRH K334
p53 (mouse) SSYLkTkKGQsTsRH K370
p53 iso2 (mouse) gap -
p53 (rat) SSYPKTKKGQSTsRH K371
p53 (rabbit) SSYLKAKKGQSTSRH K371
p53 (green monkey) SSHLkSkKGQSTSRH K373
K386-ub
RHkkLMFktEGPDsD
Upstream
Downstream
9 1
Effects on Modified Protein
  • intracellular localization
  • protein degradation
Effects on Biological Processes:
  • transcription, induced
  • transcription, inhibited
Treatment
  • MG132
p53 (human) RHkkLMFktEGPDsD K386-ub
p53 iso2 (human) gap -
p53 iso4 (human) RHKkLMFKTEGPDSD K347
p53 (mouse) RHkkTMVkkVGPDsD K383-ub
p53 iso2 (mouse) gap -
p53 (rat) RHkkPMIKKVGPDsD K384
p53 (rabbit) RHKKPMFKREGPDSD K384
p53 (green monkey) RHkkFMFKTEGPDsD K386
S46-p
AMDDLMLsPDDIEQW
Upstream
Downstream
100 3
p53 (human)
S46-p
Effects on Modified Protein
  • acetylation
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein degradation
  • protein stabilization
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, altered
  • apoptosis, induced
  • carcinogenesis, inhibited
  • cell growth, altered
  • cell growth, inhibited
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • ATM (human)
  • CDK5 (human)
  • DNAPK (human)
  • DYRK2 (human)
  • HIPK2 (human)
  • JNK2 (human)
  • P38A (human)
  • PKCD (human)
Putative in vivo kinases:
  • ATM (human)
  • CDK5 (human)
  • DYRK2 (human)
  • HIPK2 (human)
  • P38A (human)
  • PKCD (human)
Regulatory protein:
  • AMPKA1 (human)
  • AMPKA2 (human)
  • ATM (human)
  • ATR (human)
  • axin 1 (human)
  • axin 1 (mouse)
  • CDK5 (mouse)
  • CDK5R1 (mouse)
  • DAXX (human)
  • FAM189B (human)
  • HIPK2 (human)
  • HRas (human)
  • Huntingtin (human)
  • IGF1R (human)
  • MDM2 (human)
  • Myc (human)
  • NBS1 (human)
  • PIN1 (human)
  • PKCD (human)
  • PML (human)
  • PML iso4 (human)
  • PPM1D (human)
  • PPP2CA (human)
  • RASSF5 (human)
  • SIAH1 (human)
  • ZNHIT1 (human)
Treatment
  • 4-HT
  • actinomycin_D
  • adriamycin
  • asbestos
  • bortezomib
  • caffeine
  • cAMP_analog
  • Cdk2/5_inhibitor
  • celecoxib
  • cell_detachment
  • cisplatin
  • colforsin
  • depsipeptide
  • desferoxamine
  • doxycycline
  • etoposide
  • glucose_starvation
  • heat_shock
  • hypoxia
  • IBMX
  • idarubicin
  • imatinib
  • ionizing_radiation
  • KU-55933
  • lenalidomide
  • LLnL
  • LY294002
  • MG132
  • mitomycin_C
  • nocodazole
  • nutlin-3
  • okadaic_acid
  • PALA
  • PD169316
  • RITA
  • rottlerin
  • SB203580
  • seliciclib
  • serum_starvation
  • siRNA
  • SNP
  • staurosporine
  • Tat
  • taxol
  • TMZ
  • topotecan
  • UV
  • valproic_acid
  • virus infection
  • wortmannin
p53 (human) AMDDLMLsPDDIEQW S46-p
p53 iso2 (human) AMDDLMLSPDDIEQW S46
p53 iso4 (human) _MDDLMLsPDDIEQW S7-p
p53 (mouse) gap -
p53 iso2 (mouse) gap -
p53 (rat) gap -
p53 (rabbit) PPVDDLLSAEDVANW S45
p53 (green monkey) AVDDLMLsPDDLAQW S46-p
P4
____MEEPQsDPsVE
6 0
p53 (human) ____MEEPQsDPsVE P4
p53 iso2 (human) ____MEEPQSDPSVE P4
p53 iso4 (human) gap -
p53 (mouse) _MTAMEEsQsDIsLE S7-p
p53 iso2 (mouse) _MTAMEESQSDISLE S7
p53 (rat) ____MEDsQsDMsIE S4-p
p53 (rabbit) ____MEESQSDLSLE S4
p53 (green monkey) ____MEEPQSDPSIE P4
S6-p
__MEEPQsDPsVEPP
Upstream
Downstream
33 3
p53 (human)
S6-p
p53 (mouse)
S9-p
Effects on Modified Protein
  • acetylation
  • activity, induced
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • transcription, altered
  • transcription, induced
Regulatory protein:
  • LKB1 (human)
Treatment
  • 2-deoxyglucose
  • adriamycin
  • asbestos
  • colforsin
  • DDATHF
  • dexamethasone
  • etoposide
  • heat_shock
  • IBMX
  • ionizing_radiation
  • nocodazole
  • PALA
  • PD98059
  • silibinin
  • siRNA
  • SNP
  • SP600125
  • taxol
  • UV
p53 (human) __MEEPQsDPsVEPP S6-p
p53 iso2 (human) __MEEPQSDPSVEPP S6
p53 iso4 (human) gap -
p53 (mouse) TAMEEsQsDIsLELP S9-p
p53 iso2 (mouse) TAMEESQSDISLELP S9
p53 (rat) __MEDsQsDMsIELP S6-p
p53 (rabbit) __MEESQSDLSLEPP S6
p53 (green monkey) __MEEPQSDPSIEPP S6
S9-p
EEPQsDPsVEPPLsQ
Upstream
Downstream
34 3
p53 (human)
S9-p
Effects on Modified Protein
  • acetylation
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • cell cycle regulation
  • transcription, altered
Kinase, in vitro:
  • CK1D (human)
  • DNAPK (human)
Regulatory protein:
  • DUSP26 (human)
  • LKB1 (human)
Treatment
  • adriamycin
  • asbestos
  • colforsin
  • Go_6976
  • H2O2
  • heat_shock
  • IBMX
  • ionizing_radiation
  • morphine
  • nocodazole
  • PALA
  • PD98059
  • siRNA
  • SNP
  • taxol
  • TMZ
  • UV
  • virus infection
p53 (human) EEPQsDPsVEPPLsQ S9-p
p53 iso2 (human) EEPQSDPSVEPPLSQ S9
p53 iso4 (human) gap -
p53 (mouse) EEsQsDIsLELPLsQ S12-p
p53 iso2 (mouse) EESQSDISLELPLsQ S12
p53 (rat) EDsQsDMsIELPLsQ S9-p
p53 (rabbit) EESQSDLSLEPPLSQ S9
p53 (green monkey) EEPQSDPSIEPPLsQ S9
S15-p
PsVEPPLsQEtFsDL
Upstream
Downstream
403 9
p53 (human)
S15-p
p53 iso2 (human)
S15-p
p53 (mouse)
S18-p
p53 (rat)
S15-p
Effects on Modified Protein
  • acetylation
  • activity, induced
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein conformation
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell growth, altered
  • cell growth, inhibited
  • chromatin organization, altered
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • ATM (human)
  • ATR (human)
  • Btk (human)
  • CDK5 (human)
  • Chk1 (human)
  • Chk2 (human)
  • DNAPK (human)
  • DYRK1A (human)
  • ERK2 (human)
  • ERK2 (mouse)
  • LKB1 (human)
  • P38A (human)
  • PRPK (human)
Phosphatases, in vitro:
  • PPM1D (human)
  • PPP1CA (human)
Putative in vivo kinases:
  • ATM (human)
  • ATM (mouse)
  • ATR (human)
  • Btk (human)
  • Chk1 (human)
  • DNAPK (human)
  • DYRK1A (human)
  • ERK1 (human)
  • ERK2 (human)
  • LKB1 (human)
  • NuaK1 (human)
  • P38A (human)
  • PRPK (human)
  • SMG1 (human)
Putative upstream phosphatases:
  • PPM1D (human)
  • PPP1CA (human)
Regulatory protein:
  • Akt1 (human)
  • ALOX15 (human)
  • AML2 (human)
  • AMPKA1 (human)
  • ASK1 (human)
  • ATM (human)
  • ATR (human)
  • BARD1 (human)
  • Bcl-2 (human)
  • BMI1 (human)
  • BRCA1 (human)
  • CCNB1 (human)
  • CCNG1 (human)
  • CD44 (human)
  • CD74 (human)
  • CDK5 (mouse)
  • CDK5R1 (mouse)
  • CLK2 (human)
  • DEK (human)
  • DNAPK (human)
  • DUSP26 (human)
  • E2F1 (human)
  • EGFR (human)
  • ERK1 (human)
  • ERK2 (human)
  • FAAP24 (human)
  • FANCM (human)
  • FBXW7 (human)
  • HIPK2 (human)
  • HRas (human)
  • HSPA2 (human)
  • Huntingtin (human)
  • IHPK2 (human)
  • ITGA5 (human)
  • ITGB3 (human)
  • lamin A/C (human)
  • LATS1 (human)
  • LATS2 (human)
  • LKB1 (human)
  • MDC1 (human)
  • MDM2 (human)
  • MKK3 (human)
  • MLL5 (human)
  • Myc (human)
  • NBS1 (human)
  • NKX3-1 (human)
  • NPM1 (human)
  • p16-INK4A (human)
  • P38A (human)
  • P38G (human)
  • p53 (human)
  • p63 (human)
  • PHF1 (human)
  • PKM (human)
  • PLA2G6 (human)
  • PML (human)
  • POLR2A (human)
  • PPM1D (human)
  • PPP1CA (human)
  • PPP4C (human)
  • RACK1 (human)
  • RPA1 (human)
  • RPS3 (human)
  • SIRT1 (human)
  • SIRT6 (human)
  • SMEK2 (human)
  • SOCS1 (human)
  • STAT5A (human)
  • Tax (retrovirus)
  • TERT (human)
  • TTI1 (human)
  • TWIST1 (human)
  • WIPF1 (human)
  • ZNHIT1 (human)
Treatment
  • 15d-PGJ2
  • 4-AP
  • 4-HT
  • 5-aza-CdR
  • acadesine
  • aciclovir
  • actinomycin_D
  • adriamycin
  • AG1433
  • AG1478
  • alpha-dendrotoxin
  • alvocidib
  • amanitin
  • aminoflavone
  • aminothiazole_compound_25
  • androsterone
  • anti-IgM
  • anti-ITGAv
  • anti-ITGB3
  • aphidicolin
  • apigenin
  • As2O3
  • asbestos
  • ascorbic_acid
  • Ba(2+)
  • BDS-I
  • BEL
  • beta-D-(3,4-di-sinapoyl)fructofuranosyl-alpha-D-(6-sinapoyl)glucopyranoside
  • bleomycin
  • bortezomib
  • BPDE
  • C-1027
  • cadmium_chloride
  • caffeine
  • calyculin_A
  • cAMP_analog
  • camptothecin
  • catalase
  • Cd(2+)
  • Cdk2_inhibitor_II
  • celecoxib
  • cell_adhesion
  • cisplatin
  • colforsin
  • compound_C
  • cycloheximide
  • DAMGO
  • DDATHF
  • decursin
  • deferoxamine
  • desferoxamine
  • development
  • dexamethasone
  • doxycycline
  • DPN
  • DRB
  • DSBs
  • eeyarestatin_1
  • EF24
  • EGF
  • estradiol
  • etoposide
  • ETS
  • faslodex
  • fluorouracil
  • genistein
  • glucose
  • glucose_starvation
  • Go_6976
  • granzyme_B
  • grape_seed_extract
  • H2O2
  • heat_shock
  • herbimycin_A
  • high_glucose
  • hydroxyurea
  • hyperoxia
  • hypertonic_buffer
  • hypoxia
  • hypoxia/reoxygenation
  • IBMX
  • IC261
  • ICRF-193
  • idarubicin
  • imatinib
  • ionizing_radiation
  • KU-55933
  • KU-60019
  • leptomycin_B
  • LLnL
  • low_pH
  • LY294002
  • melatonin
  • melphalan
  • methotrexate
  • methylcholanthrene
  • MG132
  • MI-63
  • MIF
  • miR-16
  • mitomycin_C
  • MLN4924
  • MNNG
  • MnTMPyP
  • Na(2)CrO(4)
  • NAC
  • NaF
  • naphthoflavone
  • neocarzinostatin
  • nitric_oxide
  • nocodazole
  • NSC348884
  • NU7441
  • nutlin-3
  • ODQ
  • okadaic_acid
  • olomoucine
  • PALA
  • PD153035
  • PD169316
  • PD98059
  • PGE2
  • phorbol_ester
  • phosphatidylcholine
  • pifithrin-alpha
  • plicamycin
  • plumbagin
  • polyunsaturated_fatty_acid
  • PP2
  • PPT
  • quercetin
  • quinacrine
  • raltitrexed
  • rapamycin
  • resveratrol
  • RGD
  • RITA
  • SB202190
  • SB203580
  • selenite
  • seliciclib
  • serum_starvation
  • silibinin
  • siRNA
  • SJG-136
  • SN-38
  • SN-50
  • SNP
  • SOD
  • sorbitol
  • SP600125
  • T-oligo
  • tamoxifen
  • Tat
  • taxol
  • THIF
  • TMZ
  • topotecan
  • TRAIL
  • triphala
  • U0126
  • UCN-01
  • UV
  • UVC
  • VE822
  • vinorelbine
  • virus infection
  • VRX0466617
  • wortmannin
p53 (human) PsVEPPLsQEtFsDL S15-p
p53 iso2 (human) PSVEPPLSQETFSDL S15
p53 iso4 (human) gap -
p53 (mouse) IsLELPLsQEtFsGL S18-p
p53 iso2 (mouse) ISLELPLsQETFSGL S18-p
p53 (rat) MsIELPLsQEtFsCL S15-p
p53 (rabbit) LSLEPPLSQETFSDL S15
p53 (green monkey) PSIEPPLsQETFSDL S15-p
T18-p
EPPLsQEtFsDLWkL
Upstream
Downstream
33 0
p53 (human)
T18-p
Effects on Modified Protein
  • acetylation
  • molecular association, regulation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, altered
  • transcription, altered
Kinase, in vitro:
  • AMPKA1 (human)
  • Chk1 (human)
  • Chk2 (human)
  • CK1D (human)
  • DAPK1 (human)
  • DNAPK (human)
  • VRK1 (human)
Putative in vivo kinases:
  • CK1A (human)
  • VRK1 (human)
Regulatory protein:
  • LKB1 (human)
  • plakophilin 2 (human)
  • TERT (human)
  • VRK1 (human)
Treatment
  • adriamycin
  • As2O3
  • bleomycin
  • depsipeptide
  • development
  • high_glucose
  • IC261
  • ionizing_radiation
  • leptomycin_B
  • low_glucose
  • nocodazole
  • PALA
  • serum_starvation
  • siRNA
  • taxol
  • UV
p53 (human) EPPLsQEtFsDLWkL T18-p
p53 iso2 (human) EPPLSQETFSDLWKL T18
p53 iso4 (human) gap -
p53 (mouse) ELPLsQEtFsGLWKL T21-p
p53 iso2 (mouse) ELPLsQETFSGLWKL T21
p53 (rat) ELPLsQEtFsCLWKL T18-p
p53 (rabbit) EPPLSQETFSDLWKL T18
p53 (green monkey) EPPLsQETFSDLWKL T18
S20-p
PLsQEtFsDLWkLLP
Upstream
Downstream
118 2
p53 (human)
S20-p
p53 (mouse)
S23-p
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein conformation
  • protein degradation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • cell cycle regulation
  • cell growth, altered
  • transcription, altered
Kinase, in vitro:
  • AMPKA1 (human)
  • Chk1 (human)
  • Chk2 (human)
  • CK1A (human)
  • CK1D (human)
  • DAPK1 (human)
  • DAPK3 (human)
  • DNAPK (human)
  • DRAK1 (human)
  • JNK1 (human)
  • JNK2 (human)
  • MAPKAPK2 (human)
  • PLK3 (human)
Phosphatases, in vitro:
  • DUSP26 (human)
Putative in vivo kinases:
  • ATM (human)
  • CDK5 (human)
  • Chk1 (human)
  • Chk2 (human)
  • CK1A (human)
  • DAPK1 (human)
  • JNK1 (human)
  • JNK2 (human)
  • PLK3 (human)
Putative upstream phosphatases:
  • DUSP26 (human)
Regulatory protein:
  • ATM (human)
  • BRCA1 (human)
  • DUSP26 (human)
  • E2F1 (human)
  • Myc (human)
  • NBS1 (human)
  • p53 (human)
  • PLK3 (human)
  • Tax (retrovirus)
Treatment
  • 11,11'-dideoxyverticillin
  • 15d-PGJ2
  • adriamycin
  • As2O3
  • asbestos
  • bortezomib
  • BPDE
  • caffeine
  • cAMP_analog
  • Cdk2/5_inhibitor
  • cisplatin
  • colforsin
  • cycloheximide
  • D4476
  • DDATHF
  • doxycycline
  • etoposide
  • Go_6976
  • grape_seed_extract
  • H2O2
  • heat_shock
  • high_glucose
  • hyperoxia
  • IBMX
  • idarubicin
  • ionizing_radiation
  • KU-55933
  • MG132
  • nocodazole
  • okadaic_acid
  • PALA
  • PD98059
  • SB202190
  • SB203580
  • siRNA
  • SJG-136
  • SP600125
  • taxol
  • TMZ
  • UCN-01
  • UV
  • vinorelbine
  • virus infection
  • VRX0466617
  • wortmannin
p53 (human) PLsQEtFsDLWkLLP S20-p
p53 iso2 (human) PLSQETFSDLWKLLP S20
p53 iso4 (human) gap -
p53 (mouse) PLsQEtFsGLWKLLP S23-p
p53 iso2 (mouse) PLsQETFSGLWKLLP S23
p53 (rat) PLsQEtFsCLWKLLP S20-p
p53 (rabbit) PLSQETFSDLWKLLP S20
p53 (green monkey) PLsQETFSDLWKLLP S20
K24-ub
EtFsDLWkLLPENNV
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell growth, inhibited
p53 (human) EtFsDLWkLLPENNV K24-ub
p53 iso2 (human) ETFSDLWKLLPENNV K24
p53 iso4 (human) gap -
p53 (mouse) EtFsGLWKLLPPEDI K27
p53 iso2 (mouse) ETFSGLWKLLPPEDI K27
p53 (rat) EtFsCLWKLLPPDDI K24
p53 (rabbit) ETFSDLWKLLPENNL K24
p53 (green monkey) ETFSDLWKLLPENNV K24
S33-p
LPENNVLsPLPsQAM
Upstream
Downstream
30 3
p53 (human)
S33-p
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, induced
  • cell cycle regulation
  • cell growth, altered
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • CDK5 (human)
  • CDK7 (human)
  • CDK9 (human)
  • P38A (human)
  • P38G (human)
Putative in vivo kinases:
  • CDK9 (human)
  • P38A (human)
  • P38G (human)
Regulatory protein:
  • ASK1 (human)
  • CDK5 (mouse)
  • CDK5R1 (mouse)
  • HRas (human)
  • MKK6 (human)
  • Myc (human)
  • P38A (human)
  • P38B (human)
  • P38G (human)
  • PPM1D (human)
  • RACK1 (human)
  • RPS3 (human)
Treatment
  • 15d-PGJ2
  • adriamycin
  • Cdk2_inhibitor_II
  • etoposide
  • H2O2
  • ionizing_radiation
  • LLnL
  • MG132
  • mitomycin_C
  • nocodazole
  • okadaic_acid
  • osmotic_stress
  • PALA
  • SB202190
  • SB203580
  • seliciclib
  • siRNA
  • SNP
  • SP600125
  • taxol
  • UV
  • virus infection
  • wortmannin
p53 (human) LPENNVLsPLPsQAM S33-p
p53 iso2 (human) LPENNVLSPLPSQAM S33
p53 iso4 (human) gap -
p53 (mouse) gap -
p53 iso2 (mouse) gap -
p53 (rat) LPPDDILPTTATGsP P33
p53 (rabbit) gap -
p53 (green monkey) LPENNVLsPLPSQAV S33-p
L35
ENNVLsPLPsQAMDD
4 1
p53 (human) ENNVLsPLPsQAMDD L35
p53 iso2 (human) ENNVLSPLPSQAMDD L35
p53 iso4 (human) gap -
p53 (mouse) PPEDILPsPHCMDDL S37-p
p53 iso2 (mouse) PPEDILPSPHCMDDL S37
p53 (rat) PDDILPTTATGsPNS T35
p53 (rabbit) LPENNLLTTSLNPPV T33
p53 (green monkey) ENNVLsPLPSQAVDD L35
S37-p
NVLsPLPsQAMDDLM
Upstream
Downstream
63 2
p53 (human)
S37-p
Effects on Modified Protein
  • acetylation
  • activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, altered
  • apoptosis, induced
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • ATR (human)
  • Chk1 (human)
  • Chk2 (human)
  • CK1A (human)
  • DNAPK (human)
  • MAPKAPK5 (human)
Phosphatases, in vitro:
  • DUSP26 (human)
  • PPP1CA (human)
  • PPP2CA (human)
Putative in vivo kinases:
  • MAPKAPK5 (human)
Putative upstream phosphatases:
  • DUSP26 (human)
  • PPP1CA (human)
Regulatory protein:
  • ATM (human)
  • ATR (human)
  • DUSP26 (human)
  • HRas (human)
  • MAPKAPK5 (human)
  • MKK3 (human)
  • Myc (human)
  • PPP1CA (human)
  • PPP2R5C (human)
Treatment
  • 15d-PGJ2
  • adriamycin
  • asbestos
  • caffeine
  • calyculin_A
  • colforsin
  • depsipeptide
  • desferoxamine
  • dexamethasone
  • etoposide
  • Go_6976
  • granzyme_B
  • H2O2
  • heat_shock
  • hydroxyurea
  • hyperoxia
  • hypoxia
  • IBMX
  • idarubicin
  • ionizing_radiation
  • MI-63
  • nocodazole
  • nutlin-3
  • okadaic_acid
  • PALA
  • PGE2
  • pifithrin-alpha
  • SB203580
  • siRNA
  • SP600125
  • taxol
  • TMZ
  • UV
  • virus infection
p53 (human) NVLsPLPsQAMDDLM S37-p
p53 iso2 (human) NVLSPLPSQAMDDLM S37
p53 iso4 (human) gap -
p53 (mouse) gap -
p53 iso2 (mouse) gap -
p53 (rat) DILPTTATGsPNSME T37
p53 (rabbit) ENNLLTTSLNPPVDD S35
p53 (green monkey) NVLsPLPSQAVDDLM S37
K370-m3
RAHsSHLkskkGQst
2 0
p53 (human) RAHsSHLkskkGQst K370-m3
p53 iso2 (human) gap -
p53 iso4 (human) RAHSSHLKSKkGQST K331
p53 (mouse) RAHSSYLKTkkGQsT K367
p53 iso2 (mouse) gap -
p53 (rat) RAHSSYPKTKkGQST K368
p53 (rabbit) RAHSSYLKAKKGQST K368
p53 (green monkey) RAHSSHLKSkkGQST K370
K370-ub
RAHsSHLkskkGQst
Upstream
Downstream
9 1
Effects on Modified Protein
  • intracellular localization
  • protein degradation
Effects on Biological Processes:
  • transcription, inhibited
Treatment
  • MG132
p53 (human) RAHsSHLkskkGQst K370-ub
p53 iso2 (human) gap -
p53 iso4 (human) RAHSSHLKSKkGQST K331
p53 (mouse) RAHSSYLkTkkGQsT K367-ub
p53 iso2 (mouse) gap -
p53 (rat) RAHSSYPKTKkGQST K368
p53 (rabbit) RAHSSYLKAKKGQST K368
p53 (green monkey) RAHSSHLKSkkGQST K370
K370-ne
RAHsSHLkskkGQst
1 0
p53 (human) RAHsSHLkskkGQst K370-ne
p53 iso2 (human) gap -
p53 iso4 (human) RAHSSHLKSKkGQST K331
p53 (mouse) RAHSSYLKTkkGQsT K367
p53 iso2 (mouse) gap -
p53 (rat) RAHSSYPKTKkGQST K368
p53 (rabbit) RAHSSYLKAKKGQST K368
p53 (green monkey) RAHSSHLKSkkGQST K370
T55-p
DDIEQWFtEDPGPDE
Upstream
Downstream
22 0
Effects on Modified Protein
  • activity, induced
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell cycle regulation
  • cell growth, induced
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • ERK2 (human)
  • GRK5 (human)
  • TAF1 (human)
Phosphatases, in vitro:
  • PPP2R5C (human)
Putative in vivo kinases:
  • ERK2 (human)
  • GRK2 (human)
  • GRK5 (human)
  • TAF1 (human)
Putative upstream phosphatases:
  • PPP2CA (human)
  • PPP2R5C (human)
Regulatory protein:
  • ATM (human)
  • PPP2CA (human)
  • PPP2R5A (human)
  • PPP2R5C (human)
  • small T antigen (polyomavirus)
  • TAF1 (human)
Treatment
  • 4-AN
  • adriamycin
  • apigenin
  • caffeine
  • calyculin_A
  • compound_C
  • high_glucose
  • ionizing_radiation
  • KU-55933
  • lenalidomide
  • leptomycin_B
  • MG132
  • NSC59984
  • nutlin-3
  • okadaic_acid
  • PD98059
  • siRNA
  • U0126
  • UV
  • virus infection
  • wortmannin
p53 (human) DDIEQWFtEDPGPDE T55-p
p53 iso2 (human) DDIEQWFTEDPGPDE T55
p53 iso4 (human) DDIEQWFTEDPGPDE T16
p53 (mouse) QDVEEFFEGPsEALR E55
p53 iso2 (mouse) QDVEEFFEGPSEALR E55
p53 (rat) QDVAELLEGPEEALQ E57
p53 (rabbit) EDVANWLNEDPEEGL N54
p53 (green monkey) DDLAQWLTEDPGPDE T55
D61
FtEDPGPDEAPRMPE
2 0
p53 (human) FtEDPGPDEAPRMPE D61
p53 iso2 (human) FTEDPGPDEAPRMPE D61
p53 iso4 (human) FTEDPGPDEAPRMPE D22
p53 (mouse) EEFFEGPsEALRVSG S58-p
p53 iso2 (mouse) EEFFEGPSEALRVSG S58
p53 (rat) AELLEGPEEALQVSA E60
p53 (rabbit) NWLNEDPEEGLRVPA E58
p53 (green monkey) LTEDPGPDEAPRMSE D61
T81-p
APAPAAPtPAAPAPA
Upstream
Downstream
9 2
p53 (human)
T81-p
Effects on Modified Protein
  • acetylation
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, induced
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • JNK1 (human)
Putative in vivo kinases:
  • JNK1 (human)
Treatment
  • 15d-PGJ2
  • LLnL
  • SB203580
  • SP600125
  • UV
  • WR1065
p53 (human) APAPAAPtPAAPAPA T81-p
p53 iso2 (human) APAPAAPTPAAPAPA T81
p53 iso4 (human) APAPAAPTPAAPAPA T42
p53 (mouse) DPVTETPGPVAPAPA G78
p53 iso2 (mouse) DPVTETPGPVAPAPA G78
p53 (rat) EPGTEAPAPVAPASA A79
p53 (rabbit) APAPAAPALAAPAPA A78
p53 (green monkey) APTPAAPTPAAPAPA T81
S99-p
PLSSSVPsQkTYQGs
0 2
p53 (human) PLSSSVPsQkTYQGs S99-p
p53 iso2 (human) PLSSSVPSQKTYQGS S99
p53 iso4 (human) PLSSSVPSQKTYQGS S60
p53 (mouse) PLSSFVPSQKTYQGN S96
p53 iso2 (mouse) PLSSFVPSQkTYQGN S96
p53 (rat) PLSSSVPSQKTYQGN S97
p53 (rabbit) PLSSSVPSQKTYHGN S96
p53 (green monkey) PLSSSVPSQKTYHGS S99
K101
SSSVPsQKTYQGsYG
1 1
p53 (human) SSSVPsQKTYQGsYG K101
p53 iso2 (human) SSSVPSQKTYQGSYG K101
p53 iso4 (human) SSSVPSQKTYQGSYG K62
p53 (mouse) SSFVPSQKTYQGNYG K98
p53 iso2 (mouse) SSFVPSQkTYQGNYG K98-ac
p53 (rat) SSSVPSQKTYQGNYG K99
p53 (rabbit) SSSVPSQKTYHGNYG K98
p53 (green monkey) SSSVPSQKTYHGSYG K101
K101-ub
SSSVPsQkTYQGsYG
Downstream
1 2
Effects on Modified Protein
  • intracellular localization
  • protein degradation
p53 (human) SSSVPsQkTYQGsYG K101-ub
p53 iso2 (human) SSSVPSQKTYQGSYG K101
p53 iso4 (human) SSSVPSQKTYQGSYG K62
p53 (mouse) SSFVPSQKTYQGNYG K98
p53 iso2 (mouse) SSFVPSQKTYQGNYG K98
p53 (rat) SSSVPSQKTYQGNYG K99
p53 (rabbit) SSSVPSQKTYHGNYG K98
p53 (green monkey) SSSVPSQKTYHGSYG K101
S106-p
sQkTYQGsYGFrLGF
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein stabilization
Kinase, in vitro:
  • AurA (human)
Putative in vivo kinases:
  • AurA (human)
p53 (human) sQkTYQGsYGFrLGF S106-p
p53 iso2 (human) SQKTYQGSYGFRLGF S106
p53 iso4 (human) SQKTYQGSYGFRLGF S67
p53 (mouse) SQKTYQGNYGFHLGF N103
p53 iso2 (mouse) SQkTYQGNYGFHLGF N103
p53 (rat) SQKTYQGNYGFHLGF N104
p53 (rabbit) SQKTYHGNYGFRLGF N103
p53 (green monkey) SQKTYHGSYGFRLGF S106
R110-m1
YQGsYGFrLGFLhSG
0 1
p53 (human) YQGsYGFrLGFLhSG R110-m1
p53 iso2 (human) YQGSYGFRLGFLHSG R110
p53 iso4 (human) YQGSYGFRLGFLHSG R71
p53 (mouse) YQGNYGFHLGFLQSG H107
p53 iso2 (mouse) YQGNYGFHLGFLQSG H107
p53 (rat) YQGNYGFHLGFLQSG H108
p53 (rabbit) YHGNYGFRLGFLHSG R107
p53 (green monkey) YHGSYGFRLGFLHSG R110
H115-m1
GFrLGFLhSGTAkSV
0 1
p53 (human) GFrLGFLhSGTAkSV H115-m1
p53 iso2 (human) GFRLGFLHSGTAKSV H115
p53 iso4 (human) GFRLGFLHSGTAKSV H76
p53 (mouse) GFHLGFLQSGTAkSV Q112
p53 iso2 (mouse) GFHLGFLQSGTAkSV Q112
p53 (rat) GFHLGFLQSGTAkSV Q113
p53 (rabbit) GFRLGFLHSGTAKSV H112
p53 (green monkey) GFRLGFLHSGTAKSV H115
K120-ac
FLhSGTAkSVTCTyS
Upstream
Downstream
31 5
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell growth, inhibited
  • transcription, altered
  • transcription, induced
Regulatory protein:
  • CCDC8 (human)
  • ING5 (human)
  • MYST2 (human)
  • p16-INK4A (human)
  • PDCD5 (human)
  • TRIM29 (human)
  • UHRF1 (human)
Treatment
  • actinomycin_D
  • adriamycin
  • butyrate
  • cisplatin
  • CPT
  • etoposide
  • ionizing_radiation
  • KN-92
  • KN-93
  • linsitinib
  • nicotinamide
  • nutlin-3
  • siRNA
  • tiron
  • trichostatin_A
  • UV
  • valproic acid
p53 (human) FLhSGTAkSVTCTyS K120-ac
p53 iso2 (human) FLHSGTAKSVTCTYS K120
p53 iso4 (human) FLHSGTAKSVTCTYS K81
p53 (mouse) FLQSGTAkSVMCTYS K117-ac
p53 iso2 (mouse) FLQSGTAkSVMCTYS K117-ac
p53 (rat) FLQSGTAkSVMCTYS K118-ac
p53 (rabbit) FLHSGTAKSVTCTYS K117
p53 (green monkey) FLHSGTAKSVTCTYS K120
K120-ub
FLhSGTAkSVTCTyS
Downstream
1 20
Effects on Modified Protein
  • intracellular localization
  • protein degradation
p53 (human) FLhSGTAkSVTCTyS K120-ub
p53 iso2 (human) FLHSGTAKSVTCTYS K120
p53 iso4 (human) FLHSGTAKSVTCTYS K81
p53 (mouse) FLQSGTAKSVMCTYS K117
p53 iso2 (mouse) FLQSGTAKSVMCTYS K117
p53 (rat) FLQSGTAKSVMCTYS K118
p53 (rabbit) FLHSGTAKSVTCTYS K117
p53 (green monkey) FLHSGTAKSVTCTYS K120
Y126-p
AkSVTCTySPALNkM
Upstream
Downstream
1 0
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • DNA repair, inhibited
  • carcinogenesis, induced
Kinase, in vitro:
  • Src (human)
Putative in vivo kinases:
  • Src (human)
p53 (human) AkSVTCTySPALNkM Y126-p
p53 iso2 (human) AKSVTCTYSPALNKM Y126
p53 iso4 (human) AKSVTCTYSPALNKM Y87
p53 (mouse) AkSVMCTYSPPLNKL Y123
p53 iso2 (mouse) AkSVMCTYSPPLNKL Y123
p53 (rat) AkSVMCTYSISLNKL Y124
p53 (rabbit) AKSVTCTYSPCLNKL Y123
p53 (green monkey) AKSVTCTYSPDLNKM Y126
K132-ub
TySPALNkMFCQLAk
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
  • protein degradation
p53 (human) TySPALNkMFCQLAk K132-ub
p53 iso2 (human) TYSPALNKMFCQLAK K132
p53 iso4 (human) TYSPALNKMFCQLAK K93
p53 (mouse) TYSPPLNKLFCQLAK K129
p53 iso2 (mouse) TYSPPLNKLFCQLAK K129
p53 (rat) TYSISLNKLFCQLAK K130
p53 (rabbit) TYSPCLNKLFCQLAK K129
p53 (green monkey) TYSPDLNKMFCQLAK K132
K139-ub
kMFCQLAkTCPVQLW
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
  • protein degradation
p53 (human) kMFCQLAkTCPVQLW K139-ub
p53 iso2 (human) KMFCQLAKTCPVQLW K139
p53 iso4 (human) KMFCQLAKTCPVQLW K100
p53 (mouse) KLFCQLAKTCPVQLW K136
p53 iso2 (mouse) KLFCQLAKTCPVQLW K136
p53 (rat) KLFCQLAKTCPVQLW K137
p53 (rabbit) KLFCQLAKTCPVQLW K136
p53 (green monkey) KMFCQLAKTCPVQLW K139
S149-p
PVQLWVDstPPPGtR
Upstream
Downstream
3 1
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • cell cycle regulation
  • cell growth, inhibited
  • transcription, induced
Kinase, in vitro:
  • CK2A1 (human)
Treatment
  • MG132
p53 (human) PVQLWVDstPPPGtR S149-p
p53 iso2 (human) PVQLWVDSTPPPGTR S149
p53 iso4 (human) PVQLWVDSTPPPGTR S110
p53 (mouse) PVQLWVSATPPAGsR A146
p53 iso2 (mouse) PVQLWVSATPPAGSR A146
p53 (rat) PVQLWVTSTPPPGTR S147
p53 (rabbit) PVQLWVDSTPPPGTR S146
p53 (green monkey) PVQLWVDSTPPPGSR S149
S149-gl
PVQLWVDstPPPGtR
Upstream
Downstream
1 1
Effects on Modified Protein
  • phosphorylation
  • protein stabilization
  • ubiquitination
Treatment
  • streptozotocin
p53 (human) PVQLWVDstPPPGtR S149-gl
p53 iso2 (human) PVQLWVDSTPPPGTR S149
p53 iso4 (human) PVQLWVDSTPPPGTR S110
p53 (mouse) PVQLWVSATPPAGsR A146
p53 iso2 (mouse) PVQLWVSATPPAGSR A146
p53 (rat) PVQLWVTSTPPPGTR S147
p53 (rabbit) PVQLWVDSTPPPGTR S146
p53 (green monkey) PVQLWVDSTPPPGSR S149
T150-p
VQLWVDstPPPGtRV
Upstream
Downstream
4 8
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • cell cycle regulation
  • cell growth, inhibited
  • transcription, induced
Kinase, in vitro:
  • CK2A1 (human)
Regulatory protein:
  • COPS5 (human)
Treatment
  • MG132
p53 (human) VQLWVDstPPPGtRV T150-p
p53 iso2 (human) VQLWVDSTPPPGTRV T150
p53 iso4 (human) VQLWVDSTPPPGTRV T111
p53 (mouse) VQLWVSATPPAGsRV T147
p53 iso2 (mouse) VQLWVSATPPAGSRV T147
p53 (rat) VQLWVTSTPPPGTRV T148
p53 (rabbit) VQLWVDSTPPPGTRV T147
p53 (green monkey) VQLWVDSTPPPGSRV T150
T155-p
DstPPPGtRVRAMAI
Upstream
Downstream
4 1
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • cell cycle regulation
  • cell growth, inhibited
  • transcription, induced
Kinase, in vitro:
  • CK2A1 (human)
Regulatory protein:
  • COPS5 (human)
Treatment
  • adriamycin
  • MG132
  • PUGNAc
  • streptozotocin
p53 (human) DstPPPGtRVRAMAI T155-p
p53 iso2 (human) DSTPPPGTRVRAMAI T155
p53 iso4 (human) DSTPPPGTRVRAMAI T116
p53 (mouse) SATPPAGsRVRAMAI S152-p
p53 iso2 (mouse) SATPPAGSRVRAMAI S152
p53 (rat) TSTPPPGTRVRAMAI T153
p53 (rabbit) DSTPPPGTRVRAMAI T152
p53 (green monkey) DSTPPPGSRVRAMAI S155
K164-ac
VRAMAIYkQSQHMTE
Upstream
Downstream
7 1
Effects on Biological Processes:
  • apoptosis, induced
  • transcription, altered
Treatment
  • etoposide
  • nicotinamide
  • trichostatin_A
p53 (human) VRAMAIYkQSQHMTE K164-ac
p53 iso2 (human) VRAMAIYKQSQHMTE K164
p53 iso4 (human) VRAMAIYKQSQHMTE K125
p53 (mouse) VRAMAIYKKSQHMTE K161
p53 iso2 (mouse) VRAMAIYkkSQHMTE K161-ac
p53 (rat) VRAMAIYKKSQHMTE K162
p53 (rabbit) VRAMAIYKKSQHMTE K161
p53 (green monkey) VRAMAIYKQSQHMTE K164
K164-ub
VRAMAIYkQSQHMTE
Downstream
2 2
Effects on Modified Protein
  • intracellular localization
  • protein degradation
p53 (human) VRAMAIYkQSQHMTE K164-ub
p53 iso2 (human) VRAMAIYKQSQHMTE K164
p53 iso4 (human) VRAMAIYKQSQHMTE K125
p53 (mouse) VRAMAIYKKSQHMTE K161
p53 iso2 (mouse) VRAMAIYKkSQHMTE K161
p53 (rat) VRAMAIYKKSQHMTE K162
p53 (rabbit) VRAMAIYKKSQHMTE K161
p53 (green monkey) VRAMAIYKQSQHMTE K164
Q165
RAMAIYkQSQHMTEV
1 0
p53 (human) RAMAIYkQSQHMTEV Q165
p53 iso2 (human) RAMAIYKQSQHMTEV Q165
p53 iso4 (human) RAMAIYKQSQHMTEV Q126
p53 (mouse) RAMAIYKKSQHMTEV K162
p53 iso2 (mouse) RAMAIYkkSQHMTEV K162-ac
p53 (rat) RAMAIYKKSQHMTEV K163
p53 (rabbit) RAMAIYKKSQHMTEV K162
p53 (green monkey) RAMAIYKQSQHMTEV Q165
S183-p
CPHHERCsDsDGLAP
Upstream
Downstream
3 1
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell cycle regulation
  • transcription, inhibited
Kinase, in vitro:
  • AurB (human)
Putative in vivo kinases:
  • AurB (human)
Treatment
  • AZD1152
p53 (human) CPHHERCsDsDGLAP S183-p
p53 iso2 (human) CPHHERCSDSDGLAP S183
p53 iso4 (human) CPHHERCSDSDGLAP S144
p53 (mouse) CPHHERCsDGDGLAP S180-p
p53 iso2 (mouse) CPHHERCSDGDGLAP S180
p53 (rat) CPHHERCSDGDGLAP S181
p53 (rabbit) CPHHERCSDSDGLAP S180
p53 (green monkey) CPHHERCSDSDGLAP S183
S185-p
HHERCsDsDGLAPPQ
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation