SOX9 (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

T11-p

LDPFMKMtDEQEKGL

SOX9 (human)	LDPFMKMtDEQEKGL	T11-p
SOX9 (mouse)	LDPFMKMTDEQEKGL	T11
SOX9 (rat)	LDPFMKMTDEQEKGL	T11
SOX9 (chicken)	LDPFMKMTEEQDKCI	T11

S30-p

SPTMSEDsAGSPCPS

SOX9 (human)	SPTMSEDsAGSPCPS	S30-p
SOX9 (mouse)	SPTMSEDSAGSPCPS	S30
SOX9 (rat)	SPTMSEDSAGSPCPS	S30
SOX9 (chicken)	SPTMSDDSAGSPCPS	S30

T43-p

PSGSGSDtENtRPQE

SOX9 (human)	PSGSGSDtENtRPQE	T43-p
SOX9 (mouse)	PSGSGSDTENTRPQE	T43
SOX9 (rat)	PSGSGSDTENTRPQE	T43
SOX9 (chicken)	PSGSGSDTENTRPQE	T43

T46-p

SGSDtENtRPQENTF

SOX9 (human)	SGSDtENtRPQENTF	T46-p
SOX9 (mouse)	SGSDTENTRPQENTF	T46
SOX9 (rat)	SGSDTENTRPQENTF	T46
SOX9 (chicken)	SGSDTENTRPQENTF	T46

K61-ac

PKGEPDLkKEsEEDk

Upstream

Treatment

siRNA

SOX9 (human)	PKGEPDLkKEsEEDk	K61-ac
SOX9 (mouse)	PKGEPDLKKEsEEDK	K61
SOX9 (rat)	PKGEPDLKKESEEDK	K61
SOX9 (chicken)	PKGDPDLKKEsDEDK	K61

K61

PKGEPDLKKEsEEDk

SOX9 (human)	PKGEPDLKKEsEEDk	K61
SOX9 (mouse)	PKGEPDLKKEsEEDK	K61
SOX9 (rat)	PKGEPDLKKESEEDK	K61
SOX9 (chicken)	PKGDPDLkKEsDEDK	K61-sm

S64-p

EPDLkKEsEEDkFPV

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation

Kinase, in vitro:

PKACA (human)

Putative in vivo kinases:

PKACA (human)

Treatment

BW245C
cAMP_analog
H-89
PGD2

SOX9 (human)	EPDLkKEsEEDkFPV	S64-p
SOX9 (mouse)	EPDLKKEsEEDKFPV	S64-p
SOX9 (rat)	EPDLKKESEEDKFPV	S64
SOX9 (chicken)	DPDLkKEsDEDKFPV	S64-p

K68-ub

kKEsEEDkFPVCIRE

SOX9 (human)	kKEsEEDkFPVCIRE	K68-ub
SOX9 (mouse)	KKEsEEDKFPVCIrE	K68
SOX9 (rat)	KKESEEDKFPVCIRE	K68
SOX9 (chicken)	kKEsDEDKFPVCIRE	K68

R74

DkFPVCIREAVsQVL

SOX9 (human)	DkFPVCIREAVsQVL	R74
SOX9 (mouse)	DKFPVCIrEAVSQVL	R74-me
SOX9 (rat)	DKFPVCIREAVSQVL	R74
SOX9 (chicken)	DKFPVCIREAVSQVL	R74

S78-p

VCIREAVsQVLkGYD

SOX9 (human)	VCIREAVsQVLkGYD	S78-p
SOX9 (mouse)	VCIrEAVSQVLKGYD	S78
SOX9 (rat)	VCIREAVSQVLKGYD	S78
SOX9 (chicken)	VCIREAVSQVLKGYD	S78

K82-ub

EAVsQVLkGYDWTLV

SOX9 (human)	EAVsQVLkGYDWTLV	K82-ub
SOX9 (mouse)	EAVSQVLKGYDWTLV	K82
SOX9 (rat)	EAVSQVLKGYDWTLV	K82
SOX9 (chicken)	EAVSQVLKGYDWTLV	K82

K141-ac

ELSKTLGkLWRLLNE

SOX9 (human)	ELSKTLGkLWRLLNE	K141-ac
SOX9 (mouse)	ELSKTLGKLWRLLNE	K141
SOX9 (rat)	ELSKTLGKLWRLLNE	K141
SOX9 (chicken)	ELSKTLGKLWRLLNE	K141

R152

LLNESEKRPFVEEAE

SOX9 (human)	LLNESEKRPFVEEAE	R152
SOX9 (mouse)	LLNESEKrPFVEEAE	R152-me
SOX9 (rat)	LLNESEKRPFVEEAE	R152
SOX9 (chicken)	LLNESEKRPFVEEAE	R152

R177

PDYKYQPRRRKsVKN

SOX9 (human)	PDYKYQPRRRKsVKN	R177
SOX9 (mouse)	PDYKYQPrrrKsVKN	R177-me
SOX9 (rat)	PDYKYQPRRRKSVKN	R177
SOX9 (chicken)	PDYKYQPRRRKsVKN	R177

R178

DYKYQPRRRKsVKNG

SOX9 (human)	DYKYQPRRRKsVKNG	R178
SOX9 (mouse)	DYKYQPrrrKsVKNG	R178-me
SOX9 (rat)	DYKYQPRRRKSVKNG	R178
SOX9 (chicken)	DYKYQPRRRKsVKNG	R178

R179

YKYQPRRRKsVKNGQ

SOX9 (human)	YKYQPRRRKsVKNGQ	R179
SOX9 (mouse)	YKYQPrrrKsVKNGQ	R179-me
SOX9 (rat)	YKYQPRRRKSVKNGQ	R179
SOX9 (chicken)	YKYQPRRRKsVKNGQ	R179

S181-p

YQPRRRKsVKNGQAE

Upstream

Downstream

Effects on Modified Protein

activity, induced
intracellular localization
molecular association, regulation

Effects on Biological Processes:

carcinogenesis, induced
cell differentiation, induced
cell motility, induced
cytoskeletal reorganization
signaling pathway regulation
transcription, induced

Kinase, in vitro:

PKACA (human)
ROCK1 (human)

Putative in vivo kinases:

ADCK5 (human)
PKACA (human)
ROCK1 (human)

Regulatory protein:

PTHR (human)
RHOA (human)

Treatment

BW245C
cAMP_analog
FGF2
H-89
hydroxyfasudil
okadaic_acid
PGD2
PTHrP
siRNA
tamoxifen
TGF-beta

SOX9 (human)	YQPRRRKsVKNGQAE	S181-p
SOX9 (mouse)	YQPrrrKsVKNGQAE	S181-p
SOX9 (rat)	YQPRRRKSVKNGQAE	S181
SOX9 (chicken)	YQPRRRKsVKNGQSE	S181-p

T196-p

AEEATEQtHIsPNAI

SOX9 (human)	AEEATEQtHIsPNAI	T196-p
SOX9 (mouse)	AEEATEQTHIsPNAI	T196
SOX9 (rat)	AEEATEQTHISPNAI	T196
SOX9 (chicken)	QEEGSEQTHISPNAI	T196

S199-p

ATEQtHIsPNAIFKA

SOX9 (human)	ATEQtHIsPNAIFKA	S199-p
SOX9 (mouse)	ATEQTHIsPNAIFKA	S199-p
SOX9 (rat)	ATEQTHISPNAIFKA	S199
SOX9 (chicken)	GSEQTHISPNAIFKA	S199

S211-p

FKALQADsPHsSSGM

Upstream

Downstream

Effects on Modified Protein

protein stabilization

Effects on Biological Processes:

transcription, induced

Putative in vivo kinases:

P38A (human)

Regulatory protein:

SMAD2 (human)
SMAD3 (human)

Treatment

SB202190
SB203580
TGF-beta

SOX9 (human)	FKALQADsPHsSSGM	S211-p
SOX9 (mouse)	FKALQADsPHSSSGM	S211-p
SOX9 (rat)	FKALQADSPHSSSGM	S211
SOX9 (chicken)	FKALQADSPQSSSSI	S211

S214-p

LQADsPHsSSGMSEV

SOX9 (human)	LQADsPHsSSGMSEV	S214-p
SOX9 (mouse)	LQADsPHSSSGMSEV	S214
SOX9 (rat)	LQADSPHSSSGMSEV	S214
SOX9 (chicken)	LQADSPQSSSSISEV	S214

S223-p

SGMSEVHsPGEHSGQ

SOX9 (human)	SGMSEVHsPGEHSGQ	S223-p
SOX9 (mouse)	SGMSEVHSPGEHSGQ	S223
SOX9 (rat)	SGMSEVHSPGEHSGQ	S223
SOX9 (chicken)	SSISEVHSPGEHSGQ	S223

T236-p

GQSQGPPtPPtTPKT

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation
protein degradation
ubiquitination

Effects on Biological Processes:

apoptosis, induced
transcription, altered

Kinase, in vitro:

GSK3B (human)

SOX9 (human)	GQSQGPPtPPtTPKT	T236-p
SOX9 (mouse)	GQSQGPPTPPTTPKT	T236
SOX9 (rat)	GQSQGPPTPPTTPKT	T236
SOX9 (chicken)	GQSQGPPTPPTTPKT	T236

T239-p

QGPPtPPtTPKTDVQ

SOX9 (human)	QGPPtPPtTPKTDVQ	T239-p
SOX9 (mouse)	QGPPTPPTTPKTDVQ	T239
SOX9 (rat)	QGPPTPPTTPKTDVQ	T239
SOX9 (chicken)	QGPPTPPTTPKTDAQ	T239

K249-ub

KTDVQPGkADLkREG

SOX9 (human)	KTDVQPGkADLkREG	K249-ub
SOX9 (mouse)	KTDVQAGKVDLKREG	K249
SOX9 (rat)	KTDVQAGKVDLKREG	K249
SOX9 (chicken)	TDAQQPGKQDLkREG	K250

K253-ac

QPGkADLkREGRPLP

Upstream

Treatment

siRNA

SOX9 (human)	QPGkADLkREGRPLP	K253-ac
SOX9 (mouse)	QAGKVDLKREGRPLA	K253
SOX9 (rat)	QAGKVDLKREGRPLA	K253
SOX9 (chicken)	QPGKQDLKREGRPLA	K254

K253

QPGkADLKREGRPLP

SOX9 (human)	QPGkADLKREGRPLP	K253
SOX9 (mouse)	QAGKVDLKREGRPLA	K253
SOX9 (rat)	QAGKVDLKREGRPLA	K253
SOX9 (chicken)	QPGKQDLkREGRPLA	K254-sm

K398-ac

QSQRTHIkTEQLSPS

Upstream

Treatment

siRNA

SOX9 (human)	QSQRTHIkTEQLSPS	K398-ac
SOX9 (mouse)	QSQRTHIKTEQLSPS	K396
SOX9 (rat)	QSQRTHIKTEQLSPS	K396
SOX9 (chicken)	AQQRPHIKTEQLSPS	K376

K398

QSQRTHIKTEQLSPS

SOX9 (human)	QSQRTHIKTEQLSPS	K398
SOX9 (mouse)	QSQRTHIKTEQLSPS	K396
SOX9 (rat)	QSQRTHIKTEQLSPS	K396
SOX9 (chicken)	AQQRPHIkTEQLSPS	K376-sm

S414-p

YSEQQQHsPQQIAYS

SOX9 (human)	YSEQQQHsPQQIAYS	S414-p
SOX9 (mouse)	YSEQQQHSPQQISYS	S412
SOX9 (rat)	YSEQQQHSPQQISYS	S412
SOX9 (chicken)	YSEQQQHSPQQQQQQ	S392

Y442-p

ITRSQYDyTDHQNSS

SOX9 (human)	ITRSQYDyTDHQNSS	Y442-p
SOX9 (mouse)	ITRSQYDYADHQNSG	Y440
SOX9 (rat)	ITRSQYDYTDHQNSG	Y440
SOX9 (chicken)	ITRSQYDYTEHQNSG	Y427

S494

PSIPQTHSPQHWEQP

SOX9 (human)	PSIPQTHSPQHWEQP	S494
SOX9 (mouse)	PSIPQTHsPQHWEQP	S492-p
SOX9 (rat)	PSIPQTHSPQHWEQP	S492
SOX9 (chicken)	PSIPQTHSPQHWEQP	S479