T23-p
|
EMRERLGtGGFGNVC
|
Upstream
|
Downstream
|
7
|
4
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- phosphorylation
|
Effects on Biological Processes:
- apoptosis, altered
- apoptosis, inhibited
- transcription, altered
- transcription, induced
|
|
Kinase, in vitro:
- Akt1 (human)
- Akt2 (human)
|
Putative in vivo kinases:
- Akt1 (human)
- Akt2 (human)
|
Regulatory protein:
- LKB1 (human)
- RICTOR (human)
|
Treatment
- Akt-I-1,2
- IL-1a
- LY294000
- LY294002
- PP242
- siRNA
- skin aging
- UVB
- wortmannin
|
|
IKKA (human)
|
EMRERLGtGGFGNVC
|
T23-p
|
IKKA (mouse)
|
EMRERLGtGGFGNVS
|
T23-p
|
IKKA (rat)
|
EMRERLGTGGFGNVS
|
T23
|
|
K44-ub
|
LDLKIAIkSCRLELS
|
|
|
0
|
2
|
|
|
IKKA (human)
|
LDLKIAIkSCRLELS
|
K44-ub
|
IKKA (mouse)
|
LDLKIAIKSCRLELS
|
K44
|
IKKA (rat)
|
LDLKIAIKSCRLELS
|
K44
|
|
K53-ub
|
CRLELSTkNRERWCH
|
|
|
0
|
2
|
|
|
IKKA (human)
|
CRLELSTkNRERWCH
|
K53-ub
|
IKKA (mouse)
|
CRLELSSKNRERWCH
|
K53
|
IKKA (rat)
|
CRLELSTKNRERWCH
|
K53
|
|
K105-ub
|
CSGGDLRkLLNkPEN
|
|
|
0
|
2
|
|
|
IKKA (human)
|
CSGGDLRkLLNkPEN
|
K105-ub
|
IKKA (mouse)
|
CSGGDLRKLLNKPEN
|
K105
|
IKKA (rat)
|
CSGGDLRKLLNKPEN
|
K105
|
|
K109-ub
|
DLRkLLNkPENCCGL
|
|
|
0
|
2
|
|
|
IKKA (human)
|
DLRkLLNkPENCCGL
|
K109-ub
|
IKKA (mouse)
|
DLRKLLNKPENCCGL
|
K109
|
IKKA (rat)
|
DLRKLLNKPENCCGL
|
K109
|
|
K117-ub
|
PENCCGLkEsQILSL
|
|
|
0
|
1
|
|
|
IKKA (human)
|
PENCCGLkEsQILSL
|
K117-ub
|
IKKA (mouse)
|
PENCCGLKESQILSL
|
K117
|
IKKA (rat)
|
PENCCGLKESQILSL
|
K117
|
|
S119-ac
|
NCCGLkEsQILSLLS
|
|
|
1
|
0
|
|
|
IKKA (human)
|
NCCGLkEsQILSLLS
|
S119-ac
|
IKKA (mouse)
|
NCCGLKESQILSLLS
|
S119
|
IKKA (rat)
|
NCCGLKESQILSLLS
|
S119
|
|
K139-ub
|
IRYLHENkIIHRDLk
|
|
|
0
|
2
|
|
|
IKKA (human)
|
IRYLHENkIIHRDLk
|
K139-ub
|
IKKA (mouse)
|
IRYLHENKIIHRDLK
|
K139
|
IKKA (rat)
|
IRYLHENKIIHRDLK
|
K139
|
|
K146-ub
|
kIIHRDLkPENIVLQ
|
|
|
0
|
2
|
|
|
IKKA (human)
|
kIIHRDLkPENIVLQ
|
K146-ub
|
IKKA (mouse)
|
KIIHRDLKPENIVLQ
|
K146
|
IKKA (rat)
|
KIIHRDLKPENIVLQ
|
K146
|
|
K158-ub
|
VLQDVGGkIIHKIID
|
|
|
0
|
2
|
|
|
IKKA (human)
|
VLQDVGGkIIHKIID
|
K158-ub
|
IKKA (mouse)
|
VLQDVGGKTIHKIID
|
K158
|
IKKA (rat)
|
VLQDVGGKIMHKIID
|
K158
|
|
S176-p
|
AKDVDQGsLCtsFVG
|
Upstream
|
Downstream
|
34
|
1
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
|
Effects on Biological Processes:
- signaling pathway regulation
- transcription, induced
|
|
Kinase, in vitro:
|
Putative in vivo kinases:
|
Regulatory protein:
- Akt1 (human)
- CLASP1 (human)
- DUSP14 (human)
- EGFR (human)
- FN1 (human)
- IKKG (human)
- LYN (human)
- TAB1 (human)
- UBL4A (human)
|
Treatment
- angiotensin_2
- antibody
- bortezomib
- EGF
- gomisin_A
- gomisin_N
- GSK467
- IL-1a
- IL-1b
- ionizing_radiation
- ionomycin
- LPS
- LY294002
- phorbol_ester
- PIP3
- seliciclib
- TAK1_inhibitor
- TNF
- UVB
- virus infection
- wortmannin
|
|
IKKA (human)
|
AKDVDQGsLCtsFVG
|
S176-p
|
IKKA (mouse)
|
AKDVDQGsLCTsFVG
|
S176-p
|
IKKA (rat)
|
AKDVDQGSLCTsFVG
|
S176
|
|
T179-ac
|
VDQGsLCtsFVGTLQ
|
|
|
1
|
0
|
|
|
IKKA (human)
|
VDQGsLCtsFVGTLQ
|
T179-ac
|
IKKA (mouse)
|
VDQGsLCTsFVGTLQ
|
T179
|
IKKA (rat)
|
VDQGSLCTsFVGTLQ
|
T179
|
|
S180-p
|
DQGsLCtsFVGTLQY
|
Upstream
|
Downstream
|
44
|
0
|
|
|
|
Effects on Modified Protein
- activity, induced
- enzymatic activity, induced
|
Effects on Biological Processes:
- cell motility, altered
- chromatin organization, altered
- transcription, induced
|
|
Putative in vivo kinases:
|
Regulatory protein:
- CK2A1 (human)
- CLASP1 (human)
- DUSP14 (human)
- EGFR (human)
- HSP27 (human)
- IKKG (human)
- LYN (human)
- MAPKAPK2 (human)
- TAB1 (human)
- UBL4A (human)
|
Treatment
- 4miRs
- antibody
- bortezomib
- CCL5
- contextual fear conditioning
- DDTC
- delphinidin
- EGF
- gomisin_A
- gomisin_N
- GSK467
- Huanglianjiedu Decoction
- IL-1a
- IL-1b
- ionizing_radiation
- ionomycin
- LBH-589
- LPS
- LY294002
- PAR1-activating_peptide
- PAR3-activating_peptide
- PAR4-activating_peptide
- PEITC
- phorbol_ester
- salicylate
- SB202190
- SB203580
- SC-514
- seliciclib
- siRNA
- SP600125
- sulfasalazine
- sulforaphane
- thrombin
- TNF
- U0126
- UV
- virus infection
- vorinostat
- withaferin_A
- wortmannin
|
|
IKKA (human)
|
DQGsLCtsFVGTLQY
|
S180-p
|
IKKA (mouse)
|
DQGsLCTsFVGTLQY
|
S180-p
|
IKKA (rat)
|
DQGSLCTsFVGTLQY
|
S180-p
|
|
K296-ub
|
GPVDLTLkQPRCFVL
|
|
Downstream
|
1
|
4
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- intracellular localization
- protein stabilization
|
Effects on Biological Processes:
|
|
IKKA (human)
|
GPVDLTLkQPRCFVL
|
K296-ub
|
IKKA (mouse)
|
GPIDLTLKQPRCFAL
|
K296
|
IKKA (rat)
|
GPIDPPLKQPKCFVL
|
K296
|
|
K322-ac
|
ILNMTSAkIISFLLP
|
|
|
0
|
1
|
|
|
IKKA (human)
|
ILNMTSAkIISFLLP
|
K322-ac
|
IKKA (mouse)
|
ILNMTSAKIISFLLP
|
K322
|
IKKA (rat)
|
ILNMTSAKIISFLLP
|
K322
|
|
K366-ub
|
GISLDPRkPASQCVL
|
|
|
0
|
2
|
|
|
IKKA (human)
|
GISLDPRkPASQCVL
|
K366-ub
|
IKKA (mouse)
|
GISLDPRKPASQCVL
|
K366
|
IKKA (rat)
|
GISLDPRKPASQCVL
|
K366
|
|
K391-ub
|
VYLFDKSkTVYEGPF
|
|
|
0
|
1
|
|
|
IKKA (human)
|
VYLFDKSkTVYEGPF
|
K391-ub
|
IKKA (mouse)
|
VYLFDKSKTVYEGPF
|
K391
|
IKKA (rat)
|
VYLFDKSKTVYEGPF
|
K391
|
|
K415-ub
|
NYIVQDSkIQLPIIQ
|
|
|
0
|
1
|
|
|
IKKA (human)
|
NYIVQDSkIQLPIIQ
|
K415-ub
|
IKKA (mouse)
|
NYIVQDSKIQLPIIQ
|
K415
|
IKKA (rat)
|
NYIVQDSKIQLPVTQ
|
K415
|
|
K438-ac
|
VHYVSGLkEDYSRLF
|
|
|
0
|
1
|
|
|
IKKA (human)
|
VHYVSGLkEDYSRLF
|
K438-ac
|
IKKA (mouse)
|
VHYVSGLKEDYSRLF
|
K438
|
IKKA (rat)
|
VHYVSGLKEDYSRLF
|
K438
|
|
T463-p
|
LRYNANLtKMKNTLI
|
|
|
0
|
2
|
|
|
IKKA (human)
|
LRYNANLtKMKNTLI
|
T463-p
|
IKKA (mouse)
|
LRYNANLTKMKNTLI
|
T463
|
IKKA (rat)
|
LRYNANLTKMKNTLI
|
T463
|
|
S473-p
|
KNTLISAsQQLKAKL
|
Upstream
|
Downstream
|
1
|
0
|
|
|
Effects on Modified Protein
|
|
Kinase, in vitro:
|
Treatment
|
|
IKKA (human)
|
KNTLISAsQQLKAKL
|
S473-p
|
IKKA (mouse)
|
KNTLISASQQLKAKL
|
S473
|
IKKA (rat)
|
KNTLISASQQLKAKL
|
S473
|
|
T499
|
ERYSEQMTyGISSEk
|
|
|
0
|
1
|
|
|
IKKA (human)
|
ERYSEQMTyGISSEk
|
T499
|
IKKA (mouse)
|
ERYSEQMtYGISSEk
|
T499-p
|
IKKA (rat)
|
ERYSEQMTYGISSEK
|
T499
|
|
Y500-p
|
RYSEQMTyGISSEkM
|
|
|
0
|
1
|
|
|
IKKA (human)
|
RYSEQMTyGISSEkM
|
Y500-p
|
IKKA (mouse)
|
RYSEQMtYGISSEkM
|
Y500
|
IKKA (rat)
|
RYSEQMTYGISSEKM
|
Y500
|
|
K506-ub
|
TyGISSEkMLKAWKE
|
|
|
0
|
2
|
|
|
IKKA (human)
|
TyGISSEkMLKAWKE
|
K506-ub
|
IKKA (mouse)
|
tYGISSEkMLKAWKE
|
K506-ub
|
IKKA (rat)
|
TYGISSEKMLKAWKE
|
K506
|
|
K569-ub
|
QRAIDLYkQLkHRPs
|
|
|
0
|
1
|
|
|
IKKA (human)
|
QRAIDLYkQLkHRPs
|
K569-ub
|
IKKA (mouse)
|
QRAIDLYKQLKHRPP
|
K569
|
IKKA (rat)
|
QRAIDLYKQLKHRPT
|
K569
|
|
K572-ub
|
IDLYkQLkHRPsDHS
|
|
|
0
|
1
|
|
|
IKKA (human)
|
IDLYkQLkHRPsDHS
|
K572-ub
|
IKKA (mouse)
|
IDLYKQLKHRPPDHL
|
K572
|
IKKA (rat)
|
IDLYKQLKHRPTDHS
|
K572
|
|
S576-p
|
kQLkHRPsDHSYSDS
|
|
|
0
|
1
|
|
|
IKKA (human)
|
kQLkHRPsDHSYSDS
|
S576-p
|
IKKA (mouse)
|
KQLKHRPPDHLYSDS
|
P576
|
IKKA (rat)
|
KQLKHRPTDHSYSDS
|
T576
|
|
T593-p
|
MVKIIVHtVQSQDRV
|
|
|
0
|
1
|
|
|
IKKA (human)
|
MVKIIVHtVQSQDRV
|
T593-p
|
IKKA (mouse)
|
MVKIIVHTVQSQDRV
|
T593
|
IKKA (rat)
|
MVKIIVHTVQSQDRV
|
T593
|
|
K602-ub
|
QSQDRVLkELFGHLS
|
|
|
0
|
1
|
|
|
IKKA (human)
|
QSQDRVLkELFGHLS
|
K602-ub
|
IKKA (mouse)
|
QSQDRVLKELFGHLS
|
K602
|
IKKA (rat)
|
QSQDRVLKELFGHLS
|
K602
|
|
K615-ub
|
LSKLLGCkQkIIDLL
|
|
|
0
|
1
|
|
|
IKKA (human)
|
LSKLLGCkQkIIDLL
|
K615-ub
|
IKKA (mouse)
|
LSKLLGCKQKIIDLL
|
K615
|
IKKA (rat)
|
LSKLLGCKQKIIDLL
|
K615
|
|
K617-ub
|
KLLGCkQkIIDLLPk
|
|
|
0
|
1
|
|
|
IKKA (human)
|
KLLGCkQkIIDLLPk
|
K617-ub
|
IKKA (mouse)
|
KLLGCKQKIIDLLPK
|
K617
|
IKKA (rat)
|
KLLGCKQKIIDLLPK
|
K617
|
|
K624-ub
|
kIIDLLPkVEVALSN
|
|
|
0
|
1
|
|
|
IKKA (human)
|
kIIDLLPkVEVALSN
|
K624-ub
|
IKKA (mouse)
|
KIIDLLPKVEVALSN
|
K624
|
IKKA (rat)
|
KIIDLLPKVEVALSN
|
K624
|
|
T722-ac
|
NCLGHLStIIHEANE
|
|
|
1
|
0
|
|
|
IKKA (human)
|
NCLGHLStIIHEANE
|
T722-ac
|
IKKA (mouse)
|
NCLGHLSTIIREANE
|
T722
|
IKKA (rat)
|
gap
|
-
|
|