Other Species / Isoforms
  IKKA (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
T23-p
EMRERLGtGGFGNVC
Upstream
Downstream
7 4
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, inhibited
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • Akt1 (human)
  • Akt2 (human)
Putative in vivo kinases:
  • Akt1 (human)
  • Akt2 (human)
Regulatory protein:
  • LKB1 (human)
  • RICTOR (human)
Treatment
  • Akt-I-1,2
  • IL-1a
  • LY294002
  • PP242
  • siRNA
  • skin aging
  • UVB
  • wortmannin
IKKA (human) EMRERLGtGGFGNVC T23-p
IKKA (mouse) EMRERLGtGGFGNVS T23-p
IKKA (rat) EMRERLGTGGFGNVS T23
K44-ub
LDLKIAIkSCRLELS
0 2
IKKA (human) LDLKIAIkSCRLELS K44-ub
IKKA (mouse) LDLKIAIKSCRLELS K44
IKKA (rat) LDLKIAIKSCRLELS K44
K53-ub
CRLELSTkNRERWCH
0 2
IKKA (human) CRLELSTkNRERWCH K53-ub
IKKA (mouse) CRLELSSKNRERWCH K53
IKKA (rat) CRLELSTKNRERWCH K53
K105-ub
CSGGDLRkLLNkPEN
0 2
IKKA (human) CSGGDLRkLLNkPEN K105-ub
IKKA (mouse) CSGGDLRKLLNKPEN K105
IKKA (rat) CSGGDLRKLLNKPEN K105
K109-ub
DLRkLLNkPENCCGL
0 2
IKKA (human) DLRkLLNkPENCCGL K109-ub
IKKA (mouse) DLRKLLNKPENCCGL K109
IKKA (rat) DLRKLLNKPENCCGL K109
K117-ub
PENCCGLkEsQILSL
0 1
IKKA (human) PENCCGLkEsQILSL K117-ub
IKKA (mouse) PENCCGLKESQILSL K117
IKKA (rat) PENCCGLKESQILSL K117
S119-ac
NCCGLkEsQILSLLS
1 0
IKKA (human) NCCGLkEsQILSLLS S119-ac
IKKA (mouse) NCCGLKESQILSLLS S119
IKKA (rat) NCCGLKESQILSLLS S119
K139-ub
IRYLHENkIIHRDLk
0 2
IKKA (human) IRYLHENkIIHRDLk K139-ub
IKKA (mouse) IRYLHENKIIHRDLK K139
IKKA (rat) IRYLHENKIIHRDLK K139
K146-ub
kIIHRDLkPENIVLQ
0 2
IKKA (human) kIIHRDLkPENIVLQ K146-ub
IKKA (mouse) KIIHRDLKPENIVLQ K146
IKKA (rat) KIIHRDLKPENIVLQ K146
K158-ub
VLQDVGGkIIHKIID
0 2
IKKA (human) VLQDVGGkIIHKIID K158-ub
IKKA (mouse) VLQDVGGKTIHKIID K158
IKKA (rat) VLQDVGGKIMHKIID K158
S176-p
AKDVDQGsLCtsFVG
Upstream
Downstream
23 1
IKKA (human)
S176-p
IKKA (mouse)
S176-p
IKKA (rat)
S176-p
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • Nik (human)
Putative in vivo kinases:
  • Nik (human)
Regulatory protein:
  • Akt1 (human)
  • CLASP1 (human)
  • EGFR (human)
  • IKKG (human)
  • LYN (human)
Treatment
  • angiotensin_2
  • anti-CD3/CD28
  • bortezomib
  • EGF
  • gomisin_A
  • gomisin_N
  • IL-1a
  • IL-1b
  • ionizing_radiation
  • ionomycin
  • LPS
  • LY294002
  • phorbol_ester
  • PIP3
  • seliciclib
  • TAK1_inhibitor
  • TNF
  • UVB
  • wortmannin
IKKA (human) AKDVDQGsLCtsFVG S176-p
IKKA (mouse) AKDVDQGsLCTsFVG S176-p
IKKA (rat) AKDVDQGSLCTsFVG S176
T179-ac
VDQGsLCtsFVGTLQ
1 0
IKKA (human) VDQGsLCtsFVGTLQ T179-ac
IKKA (mouse) VDQGsLCTsFVGTLQ T179
IKKA (rat) VDQGSLCTsFVGTLQ T179
S180-p
DQGsLCtsFVGTLQY
Upstream
Downstream
36 0
IKKA (human)
S180-p
IKKA (mouse)
S180-p
IKKA (rat)
S180-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
Effects on Biological Processes:
  • cell motility, altered
  • chromatin organization, altered
  • transcription, induced
Putative in vivo kinases:
  • Nik (human)
Regulatory protein:
  • CLASP1 (human)
  • EGFR (human)
  • HSP27 (human)
  • IKKG (human)
  • LYN (human)
  • MAPKAPK2 (human)
Treatment
  • anti-CD28
  • anti-CD3
  • anti-CD3/CD28
  • bortezomib
  • CCL5
  • contextual fear conditioning
  • DDTC
  • delphinidin
  • EGF
  • gomisin_A
  • gomisin_N
  • IL-1a
  • IL-1b
  • ionizing_radiation
  • ionomycin
  • LBH-589
  • LPS
  • LY294002
  • PAR1-activating_peptide
  • PAR3-activating_peptide
  • PAR4-activating_peptide
  • PEITC
  • phorbol_ester
  • salicylate
  • SB202190
  • SB203580
  • SC-514
  • seliciclib
  • siRNA
  • SP600125
  • sulfasalazine
  • sulforaphane
  • thrombin
  • TNF
  • U0126
  • UV
  • vorinostat
  • withaferin_A
  • wortmannin
IKKA (human) DQGsLCtsFVGTLQY S180-p
IKKA (mouse) DQGsLCTsFVGTLQY S180-p
IKKA (rat) DQGSLCTsFVGTLQY S180-p
K296-ub
GPVDLTLkQPRCFVL
0 3
IKKA (human) GPVDLTLkQPRCFVL K296-ub
IKKA (mouse) GPIDLTLKQPRCFAL K296
IKKA (rat) GPIDPPLKQPKCFVL K296
K322-ac
ILNMTSAkIISFLLP
0 1
IKKA (human) ILNMTSAkIISFLLP K322-ac
IKKA (mouse) ILNMTSAKIISFLLP K322
IKKA (rat) ILNMTSAKIISFLLP K322
K366-ub
GISLDPRkPASQCVL
0 2
IKKA (human) GISLDPRkPASQCVL K366-ub
IKKA (mouse) GISLDPRKPASQCVL K366
IKKA (rat) GISLDPRKPASQCVL K366
K391-ub
VYLFDKSkTVYEGPF
0 1
IKKA (human) VYLFDKSkTVYEGPF K391-ub
IKKA (mouse) VYLFDKSKTVYEGPF K391
IKKA (rat) VYLFDKSKTVYEGPF K391
K415-ub
NYIVQDSkIQLPIIQ
0 1
IKKA (human) NYIVQDSkIQLPIIQ K415-ub
IKKA (mouse) NYIVQDSKIQLPIIQ K415
IKKA (rat) NYIVQDSKIQLPVTQ K415
K438-ac
VHYVSGLkEDYSRLF
0 1
IKKA (human) VHYVSGLkEDYSRLF K438-ac
IKKA (mouse) VHYVSGLKEDYSRLF K438
IKKA (rat) VHYVSGLKEDYSRLF K438
T463-p
LRYNANLtKMKNTLI
0 2
IKKA (human) LRYNANLtKMKNTLI T463-p
IKKA (mouse) LRYNANLTKMKNTLI T463
IKKA (rat) LRYNANLTKMKNTLI T463
S473-p
KNTLISAsQQLKAKL
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein stabilization
Kinase, in vitro:
  • ATM (human)
Treatment
  • cisplatin
IKKA (human) KNTLISAsQQLKAKL S473-p
IKKA (mouse) KNTLISASQQLKAKL S473
IKKA (rat) KNTLISASQQLKAKL S473
T499
ERYSEQMTyGISSEk
0 1
IKKA (human) ERYSEQMTyGISSEk T499
IKKA (mouse) ERYSEQMtYGISSEk T499-p
IKKA (rat) ERYSEQMTYGISSEK T499
Y500-p
RYSEQMTyGISSEkM
0 1
IKKA (human) RYSEQMTyGISSEkM Y500-p
IKKA (mouse) RYSEQMtYGISSEkM Y500
IKKA (rat) RYSEQMTYGISSEKM Y500
K506-ub
TyGISSEkMLKAWKE
0 2
IKKA (human) TyGISSEkMLKAWKE K506-ub
IKKA (mouse) tYGISSEkMLKAWKE K506-ub
IKKA (rat) TYGISSEKMLKAWKE K506
K569-ub
QRAIDLYkQLkHRPs
0 1
IKKA (human) QRAIDLYkQLkHRPs K569-ub
IKKA (mouse) QRAIDLYKQLKHRPP K569
IKKA (rat) QRAIDLYKQLKHRPT K569
K572-ub
IDLYkQLkHRPsDHS
0 1
IKKA (human) IDLYkQLkHRPsDHS K572-ub
IKKA (mouse) IDLYKQLKHRPPDHL K572
IKKA (rat) IDLYKQLKHRPTDHS K572
S576-p
kQLkHRPsDHSYSDS
0 1
IKKA (human) kQLkHRPsDHSYSDS S576-p
IKKA (mouse) KQLKHRPPDHLYSDS P576
IKKA (rat) KQLKHRPTDHSYSDS T576
T593-p
MVKIIVHtVQSQDRV
0 1
IKKA (human) MVKIIVHtVQSQDRV T593-p
IKKA (mouse) MVKIIVHTVQSQDRV T593
IKKA (rat) MVKIIVHTVQSQDRV T593
K602-ub
QSQDRVLkELFGHLS
0 1
IKKA (human) QSQDRVLkELFGHLS K602-ub
IKKA (mouse) QSQDRVLKELFGHLS K602
IKKA (rat) QSQDRVLKELFGHLS K602
K615-ub
LSKLLGCkQkIIDLL
0 1
IKKA (human) LSKLLGCkQkIIDLL K615-ub
IKKA (mouse) LSKLLGCKQKIIDLL K615
IKKA (rat) LSKLLGCKQKIIDLL K615
K617-ub
KLLGCkQkIIDLLPk
0 1
IKKA (human) KLLGCkQkIIDLLPk K617-ub
IKKA (mouse) KLLGCKQKIIDLLPK K617
IKKA (rat) KLLGCKQKIIDLLPK K617
K624-ub
kIIDLLPkVEVALSN
0 1
IKKA (human) kIIDLLPkVEVALSN K624-ub
IKKA (mouse) KIIDLLPKVEVALSN K624
IKKA (rat) KIIDLLPKVEVALSN K624
T722-ac
NCLGHLStIIHEANE
1 0
IKKA (human) NCLGHLStIIHEANE T722-ac
IKKA (mouse) NCLGHLSTIIREANE T722
IKKA (rat) gap -