IKKB (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

S4-p

____MSWsPsLTTQT

IKKB (human)	____MSWsPsLTTQT	S4-p
IKKB (mouse)	____MSWSPSLPTQT	S4
IKKB (rat)	____MSWSPSLPTQT	S4

S6-p

__MSWsPsLTTQTCG

IKKB (human)	__MSWsPsLTTQTCG	S6-p
IKKB (mouse)	__MSWSPSLPTQTCG	S6
IKKB (rat)	__MSWSPSLPTQTCG	S6

T23-p

EMKERLGtGGFGNVI

IKKB (human)	EMKERLGtGGFGNVI	T23-p
IKKB (mouse)	EMKERLGTGGFGNVI	T23
IKKB (rat)	EMKERLGTGGFGNVI	T23

K44-ub

TGEQIAIkQCRQELS

IKKB (human)	TGEQIAIkQCRQELS	K44-ub
IKKB (mouse)	TGEQIAIKQCRQELS	K44
IKKB (rat)	TGEQIAIKQCRQELS	K44

K106-ub

CQGGDLRkYLNQFEN

IKKB (human)	CQGGDLRkYLNQFEN	K106-ub
IKKB (mouse)	CQGGDLRRYLNQFEN	R106
IKKB (rat)	CQGGDLRRYLNQFEN	R106

K147-ub

RIIHRDLkPENIVLQ

IKKB (human)	RIIHRDLkPENIVLQ	K147-ub
IKKB (mouse)	RIIHRDLKPENIVLQ	K147
IKKB (rat)	RIIHRDLKPENIVLQ	K147

K163-ub

GEQRLIHkIIDLGYA

IKKB (human)	GEQRLIHkIIDLGYA	K163-ub
IKKB (mouse)	GEKRLIHKIIDLGYA	K163
IKKB (rat)	GEKRLIHKIIDLGYA	K163

K171-ub

IIDLGYAkELDQGsL

IKKB (human)	IIDLGYAkELDQGsL	K171-ub
IKKB (mouse)	IIDLGYAKELDQGsL	K171
IKKB (rat)	IIDLGYAKELDQGsL	K171

S177-p

AkELDQGsLCtsFVG

Upstream

Downstream

IKKB (human)
S177-p

IKKB (mouse)
S177-p

IKKB (rat)
S177-p

Effects on Modified Protein

enzymatic activity, induced
intracellular localization
molecular association, regulation

Effects on Biological Processes:

transcription, induced

Kinase, in vitro:

AMPKA2 (human)
PKCA (human)
PKCZ (human)

Putative in vivo kinases:

AMPKA2 (human)
Nik (human)
PKCE (human)

Putative upstream phosphatases:

PPM1B (human)
PPPM1A (human)

Regulatory protein:

EGFR (human)
LYN (human)
MEKK3 (human)
PPP2CA (human)
Src (human)

Treatment

Akt-I-1
angiotensin_2
bortezomib
calyculin_A
EGF
herbimycin_A
HGF
IL-1b
ionomycin
L-glutamine_withdrawal
LPA
LPS
LY294002
MG132
PD98059
phorbol_ester
seliciclib
SP600125
TNF
vanadate

IKKB (human)	AkELDQGsLCtsFVG	S177-p
IKKB (mouse)	AKELDQGsLCTsFVG	S177-p
IKKB (rat)	AKELDQGsLCTsFVG	S177-p

T180-p

LDQGsLCtsFVGTLQ

IKKB (human)	LDQGsLCtsFVGTLQ	T180-p
IKKB (mouse)	LDQGsLCTsFVGTLQ	T180
IKKB (rat)	LDQGsLCTsFVGTLQ	T180

T180-ac

LDQGsLCtsFVGTLQ

IKKB (human)	LDQGsLCtsFVGTLQ	T180-ac
IKKB (mouse)	LDQGsLCTsFVGTLQ	T180
IKKB (rat)	LDQGsLCTsFVGTLQ	T180

S181-p

DQGsLCtsFVGTLQy

Upstream

Downstream

IKKB (human)
S181-p

IKKB (mouse)
S181-p

IKKB (rat)
S181-p

Effects on Modified Protein

activity, induced
enzymatic activity, induced
intracellular localization
molecular association, regulation
protein stabilization

Effects on Biological Processes:

cell motility, altered
transcription, altered
transcription, induced

Kinase, in vitro:

AMPKA2 (human)
PKCA (human)
PKCZ (human)
SGK1 (human)

Putative in vivo kinases:

AMPKA2 (human)
Nik (human)

Putative upstream phosphatases:

PPM1B (human)
PPPM1A (human)

Regulatory protein:

Akt1 (human)
EGFR (human)
HSP27 (human)
IKKB (human)
LYN (human)
MAPKAPK2 (human)
MEKK3 (human)
PPP2CA (human)
SGK1 (human)
Src (human)

Treatment

Akt-I-1
anti-CD28
anti-CD3
bortezomib
calyculin_A
CCL5
DTT
EGF
herbimycin_A
IGF-1
IL-1b
ionomycin
LBH-589
LPA
LPS
LY294002
MG132
PAR1-activating_peptide
PAR3-activating_peptide
PAR4-activating_peptide
PD98059
PEITC
phorbol_ester
PIP3
salicylate
SB202190
SB203580
SC-514
seliciclib
siRNA
SP600125
sulforaphane
TAK1_inhibitor
thrombin
TNF
U0126
UV
UVB
vanadate
vorinostat
withaferin_A

IKKB (human)	DQGsLCtsFVGTLQy	S181-p
IKKB (mouse)	DQGsLCTsFVGTLQy	S181-p
IKKB (rat)	DQGsLCTsFVGTLQY	S181-p

Y188-p

sFVGTLQyLAPELLE

Upstream

Downstream

Effects on Modified Protein

activity, induced

Effects on Biological Processes:

transcription, altered

Putative in vivo kinases:

LYN (human)
Src (human)

Treatment

phorbol_ester
PP2
TNF

IKKB (human)	sFVGTLQyLAPELLE	Y188-p
IKKB (mouse)	sFVGTLQyLAPELLE	Y188-p
IKKB (rat)	sFVGTLQYLAPELLE	Y188

Y199-p

ELLEQQKyTVTVDYW

Upstream

Downstream

Effects on Modified Protein

activity, induced
molecular association, regulation

Effects on Biological Processes:

transcription, altered

Putative in vivo kinases:

LYN (human)
Src (human)

Regulatory protein:

LYN (human)

Treatment

BAPTA-AM
phorbol_ester
PP2
SCF
TNF
U73122

IKKB (human)	ELLEQQKyTVTVDYW	Y199-p
IKKB (mouse)	ELLEQQKyTVTVDYW	Y199-p
IKKB (rat)	ELLEQQKYTVTVDYW	Y199

S239-p

HSKVRQKsEVDIVVs

IKKB (human)	HSKVRQKsEVDIVVs	S239-p
IKKB (mouse)	HSKVRQKSEVDIVVS	S239
IKKB (rat)	HSKVRQKSEVDIVVS	S239

S246-p

sEVDIVVsEDLNGTV

IKKB (human)	sEVDIVVsEDLNGTV	S246-p
IKKB (mouse)	SEVDIVVSEDLNGAV	S246
IKKB (rat)	SEVDIVVSEDLNGTV	S246

S256-p

LNGTVKFsssLPyPN

IKKB (human)	LNGTVKFsssLPyPN	S256-p
IKKB (mouse)	LNGAVKFSSSLPFPN	S256
IKKB (rat)	LNGTVKFSSSSPFPN	S256

S257-p

NGTVKFsssLPyPNN

IKKB (human)	NGTVKFsssLPyPNN	S257-p
IKKB (mouse)	NGAVKFSSSLPFPNN	S257
IKKB (rat)	NGTVKFSSSSPFPNN	S257

S258-p

GTVKFsssLPyPNNL

IKKB (human)	GTVKFsssLPyPNNL	S258-p
IKKB (mouse)	GAVKFSSSLPFPNNL	S258
IKKB (rat)	GTVKFSSSSPFPNNL	S258

Y261-p

KFsssLPyPNNLNsV

IKKB (human)	KFsssLPyPNNLNsV	Y261-p
IKKB (mouse)	KFSSSLPFPNNLNSV	F261
IKKB (rat)	KFSSSSPFPNNLNSV	F261

S267-p

PyPNNLNsVLAERLE

IKKB (human)	PyPNNLNsVLAERLE	S267-p
IKKB (mouse)	PFPNNLNSVLAERLE	S267
IKKB (rat)	PFPNNLNSVLAERLE	S267

K301-ub

YGPNGCFkALDDILN

IKKB (human)	YGPNGCFkALDDILN	K301-ub
IKKB (mouse)	YGPNGCFRALDDILN	R301
IKKB (rat)	YGPNGCFRALDDILN	R301

T324-p

MVTGTIHtyPVTEDE

IKKB (human)	MVTGTIHtyPVTEDE	T324-p
IKKB (mouse)	MVTGTVHTYPVTEDE	T324
IKKB (rat)	MVTGTIHTYPVMEDE	T324

Y325-p

VTGTIHtyPVTEDEs

IKKB (human)	VTGTIHtyPVTEDEs	Y325-p
IKKB (mouse)	VTGTVHTYPVTEDES	Y325
IKKB (rat)	VTGTIHTYPVMEDES	Y325

S332-p

yPVTEDEsLQsLkAR

IKKB (human)	yPVTEDEsLQsLkAR	S332-p
IKKB (mouse)	YPVTEDESLQSLKTR	S332
IKKB (rat)	YPVMEDESLQSLKTR	S332

S335-p

TEDEsLQsLkARIQQ

IKKB (human)	TEDEsLQsLkARIQQ	S335-p
IKKB (mouse)	TEDESLQSLKTRIQE	S335
IKKB (rat)	MEDESLQSLKTRIRE	S335

K337-ub

DEsLQsLkARIQQDt

IKKB (human)	DEsLQsLkARIQQDt	K337-ub
IKKB (mouse)	DESLQSLKTRIQENT	K337
IKKB (rat)	DESLQSLKTRIREDT	K337

T344-p

kARIQQDtGIPEEDQ

IKKB (human)	kARIQQDtGIPEEDQ	T344-p
IKKB (mouse)	KTRIQENTGILETDQ	T344
IKKB (rat)	KTRIREDTGILETDQ	T344

K365-ub

GLALIPDkPAtQCIS

IKKB (human)	GLALIPDkPAtQCIS	K365-ub
IKKB (mouse)	GLVLLPDKPATQCIS	K365
IKKB (rat)	GLVLLPDKPATQCIS	K365

T368-p

LIPDkPAtQCISDGK

IKKB (human)	LIPDkPAtQCISDGK	T368-p
IKKB (mouse)	LLPDKPATQCISDSK	T368
IKKB (rat)	LLPDKPATQCISDSK	T368

S393-p

LVFLFDNsKItyEtQ

IKKB (human)	LVFLFDNsKItyEtQ	S393-p
IKKB (mouse)	LVFLLDNSKINYETQ	S393
IKKB (rat)	LVFLFDNSKMSYETQ	S393

T396-p

LFDNsKItyEtQIsP

IKKB (human)	LFDNsKItyEtQIsP	T396-p
IKKB (mouse)	LLDNSKINYETQITP	N396
IKKB (rat)	LFDNSKMSYETQITP	S396

Y397-p

FDNsKItyEtQIsPR

IKKB (human)	FDNsKItyEtQIsPR	Y397-p
IKKB (mouse)	LDNSKINYETQITPR	Y397
IKKB (rat)	FDNSKMSYETQITPR	Y397

T399-p

NsKItyEtQIsPRPQ

IKKB (human)	NsKItyEtQIsPRPQ	T399-p
IKKB (mouse)	NSKINYETQITPRPP	T399
IKKB (rat)	NSKMSYETQITPRPQ	T399

S402-p

ItyEtQIsPRPQPEs

IKKB (human)	ItyEtQIsPRPQPEs	S402-p
IKKB (mouse)	INYETQITPRPPPES	T402
IKKB (rat)	MSYETQITPRPQPES	T402

S409-p

sPRPQPEsVsCILQE

IKKB (human)	sPRPQPEsVsCILQE	S409-p
IKKB (mouse)	TPRPPPESVSCILQE	S409
IKKB (rat)	TPRPQPESVSCVLQE	S409

S411-p

RPQPEsVsCILQEPk

IKKB (human)	RPQPEsVsCILQEPk	S411-p
IKKB (mouse)	RPPPESVSCILQEPK	S411
IKKB (rat)	RPQPESVSCVLQEPK	S411

K418-ub

sCILQEPkRNLAFFQ

IKKB (human)	sCILQEPkRNLAFFQ	K418-ub
IKKB (mouse)	SCILQEPKRNLSFFQ	K418
IKKB (rat)	SCVLQEPKRNLSFFQ	K418

S466

LRNNSCLSkMKNsMA

IKKB (human)	LRNNSCLSkMKNsMA	S466
IKKB (mouse)	LRNNSCLsKMKNAMA	S466-p
IKKB (rat)	LRNNSCLSKMKNAMA	S466

K467-ub

RNNSCLSkMKNsMAs

IKKB (human)	RNNSCLSkMKNsMAs	K467-ub
IKKB (mouse)	RNNSCLsKMKNAMAS	K467
IKKB (rat)	RNNSCLSKMKNAMAS	K467

S471-p

CLSkMKNsMAsMsQQ

IKKB (human)	CLSkMKNsMAsMsQQ	S471-p
IKKB (mouse)	CLsKMKNAMASTAQQ	A471
IKKB (rat)	CLSKMKNAMASTAQQ	A471

S474-p

kMKNsMAsMsQQLKA

IKKB (human)	kMKNsMAsMsQQLKA	S474-p
IKKB (mouse)	KMKNAMASTAQQLKA	S474
IKKB (rat)	KMKNAMASTAQQLKA	S474

S476-p

KNsMAsMsQQLKAKL

IKKB (human)	KNsMAsMsQQLKAKL	S476-p
IKKB (mouse)	KNAMASTAQQLKAKL	A476
IKKB (rat)	KNAMASTAQQLKAKL	A476

T488-p

AKLDFFKtsIQIDLE

IKKB (human)	AKLDFFKtsIQIDLE	T488-p
IKKB (mouse)	AKLDFFKTSIQIDLE	T488
IKKB (rat)	AKLDFFKTSIQIDLE	T488

S489-p

KLDFFKtsIQIDLEK

IKKB (human)	KLDFFKtsIQIDLEK	S489-p
IKKB (mouse)	KLDFFKTSIQIDLEK	S489
IKKB (rat)	KLDFFKTSIQIDLEK	S489

S498

QIDLEKYSEQTEFGI

IKKB (human)	QIDLEKYSEQTEFGI	S498
IKKB (mouse)	QIDLEKYkEQtEFGI	K498-ub
IKKB (rat)	QIDLEKYREQTEFGI	R498

T501

LEKYSEQTEFGITsD

IKKB (human)	LEKYSEQTEFGITsD	T501
IKKB (mouse)	LEKYkEQtEFGITSD	T501-p
IKKB (rat)	LEKYREQTEFGITSD	T501

S507-p

QTEFGITsDkLLLAW

IKKB (human)	QTEFGITsDkLLLAW	S507-p
IKKB (mouse)	QtEFGITSDKLLLAW	S507
IKKB (rat)	QTEFGITSDKLLLAW	S507

K509-ub

EFGITsDkLLLAWRE

IKKB (human)	EFGITsDkLLLAWRE	K509-ub
IKKB (mouse)	EFGITSDKLLLAWRE	K509
IKKB (rat)	EFGITSDKLLLAWRE	K509

S550-p

DIVDLQRsPMGRkQG

IKKB (human)	DIVDLQRsPMGRkQG	S550-p
IKKB (mouse)	DIVDLQRSPMGRkQG	S550
IKKB (rat)	DIVDLQRSPMGRKQG	S550

K555-ub

QRsPMGRkQGGtLDD

IKKB (human)	QRsPMGRkQGGtLDD	K555-ub
IKKB (mouse)	QRSPMGRkQGGTLDD	K555-ub
IKKB (rat)	QRSPMGRKQGGTLDD	K555

T559-p

MGRkQGGtLDDLEEQ

IKKB (human)	MGRkQGGtLDDLEEQ	T559-p
IKKB (mouse)	MGRkQGGTLDDLEEQ	T559
IKKB (rat)	MGRKQGGTLDDLEEQ	T559

T583-p

EKPRDQRtEGDsQEM

IKKB (human)	EKPRDQRtEGDsQEM	T583-p
IKKB (mouse)	EKPRDQRTEGDSQEM	T583
IKKB (rat)	EKPRDQRTEGDSQDM	T583

S587-p

DQRtEGDsQEMVRLL

IKKB (human)	DQRtEGDsQEMVRLL	S587-p
IKKB (mouse)	DQRTEGDSQEMVRLL	S587
IKKB (rat)	DQRTEGDSQDMVRLL	S587

S600-p

LLLQAIQsFEkKVRV

IKKB (human)	LLLQAIQsFEkKVRV	S600-p
IKKB (mouse)	LLLQAIQSFEKKVRV	S600
IKKB (rat)	LLLQAIQSFEKKVRV	S600

K603-ub

QAIQsFEkKVRVIyt

IKKB (human)	QAIQsFEkKVRVIyt	K603-ub
IKKB (mouse)	QAIQSFEKKVRVIYT	K603
IKKB (rat)	QAIQSFEKKVRVIYS	K603

Y609-p

EkKVRVIytQLSKTV

IKKB (human)	EkKVRVIytQLSKTV	Y609-p
IKKB (mouse)	EKKVRVIYTQLSKTV	Y609
IKKB (rat)	EKKVRVIYSQLSKTV	Y609

T610-p

kKVRVIytQLSKTVV

IKKB (human)	kKVRVIytQLSKTVV	T610-p
IKKB (mouse)	KKVRVIYTQLSKTVV	T610
IKKB (rat)	KKVRVIYSQLSKTVV	S610

K628-ub

KALELLPkVEEVVsL

IKKB (human)	KALELLPkVEEVVsL	K628-ub
IKKB (mouse)	KALELLPKVEEVVSL	K628
IKKB (rat)	KALELLPKVEEVVRL	K628

S634-p

PkVEEVVsLMNEDEK

IKKB (human)	PkVEEVVsLMNEDEK	S634-p
IKKB (mouse)	PKVEEVVSLMNEDER	S634
IKKB (rat)	PKVEEVVRLMNEDEK	R634

K652-ub

RLQEKRQkELWNLLk

IKKB (human)	RLQEKRQkELWNLLk	K652-ub
IKKB (mouse)	RLQEKRQKELWNLLK	K652
IKKB (rat)	RLQEKRQKELWNLLK	K652

K659-ac

kELWNLLkIACSkVR

IKKB (human)	kELWNLLkIACSkVR	K659-ac
IKKB (mouse)	KELWNLLKIACSKVR	K659
IKKB (rat)	KELWNLLKIACSKVR	K659

K664-ub

LLkIACSkVRGPVsG

IKKB (human)	LLkIACSkVRGPVsG	K664-ub
IKKB (mouse)	LLKIACSKVRGPVSG	K664
IKKB (rat)	LLKIACSKVRGPVSG	K664

S670-p

SkVRGPVsGsPDsMN

IKKB (human)	SkVRGPVsGsPDsMN	S670-p
IKKB (mouse)	SKVRGPVSGsPDsMN	S670
IKKB (rat)	SKVRGPVSGsPDSMN	S670

S672-p

VRGPVsGsPDsMNAs

Upstream

Treatment

MG132_withdrawal
nocodazole
thymidine

IKKB (human)	VRGPVsGsPDsMNAs	S672-p
IKKB (mouse)	VRGPVSGsPDsMNVs	S672-p
IKKB (rat)	VRGPVSGsPDSMNVS	S672-p

S675-p

PVsGsPDsMNAsRLs

IKKB (human)	PVsGsPDsMNAsRLs	S675-p
IKKB (mouse)	PVSGsPDsMNVsRLs	S675-p
IKKB (rat)	PVSGsPDSMNVSRLS	S675

S679-p

sPDsMNAsRLsQPGQ

Upstream

Treatment

BI2536

IKKB (human)	sPDsMNAsRLsQPGQ	S679-p
IKKB (mouse)	sPDsMNVsRLsHPGQ	S679-p
IKKB (rat)	sPDSMNVSRLSHPGH	S679

S682-p

sMNAsRLsQPGQLMS

IKKB (human)	sMNAsRLsQPGQLMS	S682-p
IKKB (mouse)	sMNVsRLsHPGQLMs	S682-p
IKKB (rat)	SMNVSRLSHPGHLMS	S682

S689

sQPGQLMSQPStAsN

IKKB (human)	sQPGQLMSQPStAsN	S689
IKKB (mouse)	sHPGQLMsQPsSACD	S689-p
IKKB (rat)	SHPGHLMSQPSSACD	S689

S692

GQLMSQPStAsNsLP

IKKB (human)	GQLMSQPStAsNsLP	S692
IKKB (mouse)	GQLMsQPsSACDsLP	S692-p
IKKB (rat)	GHLMSQPSSACDSLP	S692

T693-p

QLMSQPStAsNsLPE

IKKB (human)	QLMSQPStAsNsLPE	T693-p
IKKB (mouse)	QLMsQPsSACDsLPE	S693
IKKB (rat)	HLMSQPSSACDSLPD	S693

S695-p

MSQPStAsNsLPEPA

IKKB (human)	MSQPStAsNsLPEPA	S695-p
IKKB (mouse)	MsQPsSACDsLPEsD	C695
IKKB (rat)	MSQPSSACDSLPDSD	C695

S697-p

QPStAsNsLPEPAkK

IKKB (human)	QPStAsNsLPEPAkK	S697-p
IKKB (mouse)	QPsSACDsLPEsDKK	S697-p
IKKB (rat)	QPSSACDSLPDSDKK	S697

P701

AsNsLPEPAkKSEEL

IKKB (human)	AsNsLPEPAkKSEEL	P701
IKKB (mouse)	ACDsLPEsDKKsEEL	S701-p
IKKB (rat)	ACDSLPDSDKKSEEL	S701

K703-ub

NsLPEPAkKSEELVA

IKKB (human)	NsLPEPAkKSEELVA	K703-ub
IKKB (mouse)	DsLPEsDKKsEELVA	K703
IKKB (rat)	DSLPDSDKKSEELVA	K703

S705

LPEPAkKSEELVAEA

IKKB (human)	LPEPAkKSEELVAEA	S705
IKKB (mouse)	LPEsDKKsEELVAEA	S705-p
IKKB (rat)	LPDSDKKSEELVAEA	S705

S733-p

TVREQDQsFtALDWs

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Kinase, in vitro:

PLK1 (human)

IKKB (human)	TVREQDQsFtALDWs	S733-p
IKKB (mouse)	TVKEQDRSFTTLDWS	S733
IKKB (rat)	TVKQQDRSFTTLDWS	S733

S733-gl

TVREQDQsFtALDWs

IKKB (human)	TVREQDQsFtALDWs	S733-gl
IKKB (mouse)	TVKEQDRSFTTLDWS	S733
IKKB (rat)	TVKQQDRSFTTLDWS	S733

T735-p

REQDQsFtALDWsWL

IKKB (human)	REQDQsFtALDWsWL	T735-p
IKKB (mouse)	KEQDRSFTTLDWSWL	T735
IKKB (rat)	KQQDRSFTTLDWSWL	T735

S740-p

sFtALDWsWLQTEEE

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Kinase, in vitro:

PLK1 (human)

Putative in vivo kinases:

PLK1 (human)

Treatment

nocodazole
TNF

IKKB (human)	sFtALDWsWLQTEEE	S740-p
IKKB (mouse)	SFTTLDWSWLQMEDE	S740
IKKB (rat)	SFTTLDWSWLQMEDE	S740

S750-p

QTEEEEHsCLEQAS_

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Kinase, in vitro:

PLK1 (human)

IKKB (human)	QTEEEEHsCLEQAS_	S750-p
IKKB (mouse)	QMEDEERCSLEQACD	C750
IKKB (rat)	QMEDEERCGLEQACD	C750