CTNNB1 (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

K19-ac

MAMEPDRkAAVsHWQ

Downstream

Effects on Modified Protein

intracellular localization
protein stabilization

Effects on Biological Processes:

carcinogenesis, inhibited
cell motility, induced
transcription, induced

CTNNB1 (human)	MAMEPDRkAAVsHWQ	K19-ac
CTNNB1 (mouse)	MAMEPDRKAAVsHWQ	K19
CTNNB1 (rat)	MAMEPDRkAAVSHWQ	K19-ac
CTNNB1 (rabbit)	MAMEPDRKAAVSHWQ	K19

K19-ub

MAMEPDRkAAVsHWQ

Downstream

Effects on Modified Protein

protein degradation

Effects on Biological Processes:

carcinogenesis, inhibited
cell growth, inhibited
transcription, inhibited

CTNNB1 (human)	MAMEPDRkAAVsHWQ	K19-ub
CTNNB1 (mouse)	MAMEPDRkAAVsHWQ	K19-ub
CTNNB1 (rat)	MAMEPDRKAAVSHWQ	K19
CTNNB1 (rabbit)	MAMEPDRKAAVSHWQ	K19

S23-p

PDRkAAVsHWQQQsy

Upstream

Regulatory protein:

WNT1 (human)

Treatment

lithium

CTNNB1 (human)	PDRkAAVsHWQQQsy	S23-p
CTNNB1 (mouse)	PDRkAAVsHWQQQsY	S23-p
CTNNB1 (rat)	PDRkAAVSHWQQQSY	S23
CTNNB1 (rabbit)	PDRKAAVSHWQQQSY	S23

S23

PDRkAAVSHWQQQsy

CTNNB1 (human)	PDRkAAVSHWQQQsy	S23
CTNNB1 (mouse)	PDRkAAVsHWQQQsY	S23-gl
CTNNB1 (rat)	PDRkAAVSHWQQQSY	S23
CTNNB1 (rabbit)	PDRKAAVSHWQQQSY	S23

S29-p

VsHWQQQsyLDsGIH

Upstream

Downstream

Effects on Modified Protein

protein degradation

Effects on Biological Processes:

cell motility, altered

Kinase, in vitro:

CK2A2 (human)

Regulatory protein:

WNT1 (human)

Treatment

lithium

CTNNB1 (human)	VsHWQQQsyLDsGIH	S29-p
CTNNB1 (mouse)	VsHWQQQsYLDsGIH	S29-p
CTNNB1 (rat)	VSHWQQQSYLDsGIH	S29
CTNNB1 (rabbit)	VSHWQQQSYLDsGIH	S29

Y30-p

sHWQQQsyLDsGIHs

Upstream

Kinase, in vitro:

JAK3 (human)

Putative in vivo kinases:

JAK3 (human)

Treatment

Su11274

CTNNB1 (human)	sHWQQQsyLDsGIHs	Y30-p
CTNNB1 (mouse)	sHWQQQsYLDsGIHs	Y30
CTNNB1 (rat)	SHWQQQSYLDsGIHs	Y30
CTNNB1 (rabbit)	SHWQQQSYLDsGIHS	Y30

S33-p

QQQsyLDsGIHsGAT

Upstream

Downstream

113

CTNNB1 (human)
S33-p

CTNNB1 (mouse)
S33-p

CTNNB1 (rat)
S33-p

Effects on Modified Protein

activity, inhibited
intracellular localization
molecular association, regulation
neddylation
protein degradation
protein stabilization
ubiquitination

Effects on Biological Processes:

apoptosis, induced
carcinogenesis, induced
carcinogenesis, inhibited
cell adhesion, altered
cell cycle regulation
cell growth, altered
cell growth, inhibited
cell motility, inhibited
cytoskeletal reorganization
signaling pathway regulation
transcription, altered
transcription, induced
transcription, inhibited

Kinase, in vitro:

GSK3A (human)
GSK3B (human)
JNK1 (human)

Phosphatases, in vitro:

PPP2CA (human)

Putative in vivo kinases:

GSK3B (human)
IKKA (human)
JNK1 (human)

Regulatory protein:

ALK (human)
ANGPTL2 (human)
APC (human)
ARID1A (human)
ARMET (human)
AurA (human)
axin 1 (human)
CDH2 (human)
CTF2 (mouse)
CTNNA1 (human)
CTNNB1 (human)
DDX5 (human)
DKK1 (human)
DKK4 (human)
FAM83A (human)
GLIPR1 (human)
GRP78 (human)
GSKIP (human)
HORMAD1 (human)
IL24 (human)
MDFIC (human)
Merlin (human)
NDRG1 (human)
Notch 1 (human)
PPP2R2A (human)
PSEN1 (human)
Rb-like 2 (human)
ROCK1 (human)
Securin (human)
SFRP2 (human)
TRB2 (human)
WNT3A (human)
WNT5A (human)

Treatment

ACY1215
antibody
BMX
calyculin_A
cAMP_analog
CHIR99021
CK1-7
colforsin
conditioned medium
CTGF
Dp44mT
DpC
FGF2
gemcitabine
H-89
KY1022
lithium
lncRNAs
LY2090314
LY294002
Matrine
MG132
MLN4924
okadaic_acid
olaparib
PLX4032
RNA aptamer
SB216763
SB415286
siRNA
SP600125
TMZ
vemurafenib
virus infection
Wnt
Wnt-C59
Wnt3a
XAV939
Y27632
Z-Ajoene

CTNNB1 (human)	QQQsyLDsGIHsGAT	S33-p
CTNNB1 (mouse)	QQQsYLDsGIHsGAT	S33-p
CTNNB1 (rat)	QQQSYLDsGIHsGAT	S33-p
CTNNB1 (rabbit)	QQQSYLDsGIHSGAT	S33-p

S37-p

yLDsGIHsGATtTAP

Upstream

Downstream

110

CTNNB1 (human)
S37-p

CTNNB1 (mouse)
S37-p

CTNNB1 (rat)
S37-p

Effects on Modified Protein

activity, inhibited
intracellular localization
molecular association, regulation
neddylation
protein degradation
protein stabilization
ubiquitination

Effects on Biological Processes:

apoptosis, induced
carcinogenesis, induced
carcinogenesis, inhibited
cell adhesion, altered
cell cycle regulation
cell growth, altered
cell growth, inhibited
cell motility, inhibited
cytoskeletal reorganization
signaling pathway regulation
transcription, altered
transcription, induced
transcription, inhibited

Kinase, in vitro:

GSK3A (human)
GSK3B (human)
JNK1 (human)

Phosphatases, in vitro:

PPP2CA (human)

Putative in vivo kinases:

GSK3B (human)
IKKA (human)
JNK1 (human)

Regulatory protein:

ALK (human)
ANGPTL2 (human)
ARID1A (human)
ARMET (human)
AurA (human)
axin 1 (human)
CDH2 (human)
CTF2 (mouse)
CTNNB1 (human)
DDX5 (human)
DKK1 (human)
DKK4 (human)
FAM83A (human)
GLIPR1 (human)
GRP78 (human)
GSKIP (human)
HORMAD1 (human)
IL24 (human)
MDFIC (human)
Merlin (human)
NDRG1 (human)
Notch 1 (human)
PPP2R2A (human)
PSEN1 (human)
ROCK1 (human)
Securin (human)
SFRP2 (human)
TAT (human)
TRB2 (human)
WNT3A (human)
WNT5A (human)

Treatment

ACY1215
antibody
BMX
calyculin_A
cAMP_analog
CHIR99021
CK1-7
colforsin
conditioned medium
CTGF
Dp44mT
DpC
FGF2
gemcitabine
H-89
IWR-1
KN-92
KN-93
KY1022
lithium
LLnL
lncRNAs
LY2090314
LY294002
Matrine
MG132
MLN4924
morphine
okadaic_acid
olaparib
PLX4032
SB216763
siRNA
SP600125
TMZ
vemurafenib
virus infection
W-5
W-7
Wnt
Wnt-C59
Wnt3a
XAV939
Y27632
Z-Ajoene

CTNNB1 (human)	yLDsGIHsGATtTAP	S37-p
CTNNB1 (mouse)	YLDsGIHsGATtTAP	S37-p
CTNNB1 (rat)	YLDsGIHsGATtTAP	S37-p
CTNNB1 (rabbit)	YLDsGIHSGATTTAP	S37

T41-p

GIHsGATtTAPsLsG

Upstream

Downstream

103

CTNNB1 (human)
T41-p

CTNNB1 (mouse)
T41-p

CTNNB1 (rat)
T41-p

Effects on Modified Protein

activity, inhibited
intracellular localization
molecular association, regulation
neddylation
protein degradation
protein stabilization
ubiquitination

Effects on Biological Processes:

apoptosis, induced
carcinogenesis, induced
carcinogenesis, inhibited
cell adhesion, altered
cell cycle regulation
cell growth, altered
cell growth, inhibited
cell motility, inhibited
cytoskeletal reorganization
signaling pathway regulation
transcription, altered
transcription, induced
transcription, inhibited

Kinase, in vitro:

GSK3A (human)
GSK3B (human)
JNK1 (human)

Putative in vivo kinases:

GSK3B (human)
IKKA (human)
JNK1 (human)
PKACA (human)

Putative upstream phosphatases:

PPP1CC (human)

Regulatory protein:

ALK (human)
ANGPTL2 (human)
ARID1A (human)
ARMET (human)
AurA (human)
axin 1 (human)
CTF2 (mouse)
CTNNB1 (human)
DDX5 (human)
DKK4 (human)
FAM83A (human)
G-alpha(s) (human)
GLIPR1 (human)
GRP78 (human)
GSKIP (human)
HORMAD1 (human)
IL24 (human)
JNK1 (human)
JNK2 (human)
MDFIC (human)
Merlin (human)
NDRG1 (human)
Notch 1 (human)
PPP2R2A (human)
PSEN1 (human)
ROCK1 (human)
Securin (human)
SFRP2 (human)
SMPD3 (human)
TAT (human)
TRB2 (human)
WNT3A (human)
WNT5A (human)

Treatment

ACY1215
antibody
BMX
C6-ceramide
calyculin_A
cAMP_analog
CHIR99021
CK1-7
colforsin
conditioned medium
Dp44mT
DpC
FGF2
gemcitabine
H-89
high_cell_density
IWR-1
lithium
LLnL
lncRNAs
LY2090314
LY294002
Matrine
MG132
MLN4924
morphine
NKH_477
okadaic_acid
olaparib
PLX4032
RNA aptamer
SB216763
SB415286
siRNA
SP600125
TMZ
vemurafenib
virus infection
Wnt
Wnt-C59
Wnt3a
XAV939
Y27632
Z-Ajoene

CTNNB1 (human)	GIHsGATtTAPsLsG	T41-p
CTNNB1 (mouse)	GIHsGATtTAPsLsG	T41-p
CTNNB1 (rat)	GIHsGATtTAPsLSG	T41-p
CTNNB1 (rabbit)	GIHSGATTTAPSLSG	T41

S45-p

GATtTAPsLsGkGNP

Upstream

Downstream

CTNNB1 (human)
S45-p

CTNNB1 (mouse)
S45-p

CTNNB1 (rat)
S45-p

Effects on Modified Protein

activity, inhibited
intracellular localization
molecular association, regulation
neddylation
phosphorylation
protein degradation
protein stabilization
ubiquitination

Effects on Biological Processes:

carcinogenesis, altered
carcinogenesis, induced
carcinogenesis, inhibited
cell adhesion, altered
cell cycle regulation
cell differentiation, induced
cell growth, inhibited
cell motility, altered
signaling pathway regulation
transcription, induced
transcription, inhibited

Kinase, in vitro:

CK1A (human)
CK1D (human)
GSK3B (human)
PKACA (human)
PKCZ (human)

Putative in vivo kinases:

CK1A (human)
CK1A (rat)
CK1E (human)
IKKA (human)
PKACA (human)

Putative upstream phosphatases:

PPP1CC (human)

Regulatory protein:

axin 1 (human)
CK1A (human)
G-alpha(s) (human)
HDAC6 (human)
HDAC7 (human)
JNK1 (human)
JNK2 (human)
MCPIP1 (human)
PSEN1 (human)
SMPD3 (human)
WNT5A (human)
ZNF326 (human)

Treatment

ACY1215
antibody
C6-ceramide
calyculin_A
cAMP_analog
CBL0137
CK1-7
CKI-7
D4476
H-89
high_cell_density
lithium
lncRNAs
low_Ca(2+)
MG132
MLN4924
mutation
NKH_477
okadaic_acid
olaparib
pyrvinium pamoate
RNA aptamer
siRNA
SP600125
Wnt
Wnt3a
Z-Ajoene

CTNNB1 (human)	GATtTAPsLsGkGNP	S45-p
CTNNB1 (mouse)	GATtTAPsLsGkGNP	S45-p
CTNNB1 (rat)	GATtTAPsLSGkGNP	S45-p
CTNNB1 (rabbit)	GATTTAPSLSGKGNP	S45

S47-p

TtTAPsLsGkGNPEE

CTNNB1 (human)	TtTAPsLsGkGNPEE	S47-p
CTNNB1 (mouse)	TtTAPsLsGkGNPEE	S47-p
CTNNB1 (rat)	TtTAPsLSGkGNPEE	S47
CTNNB1 (rabbit)	TTTAPSLSGKGNPEE	S47

K49-ac

TAPsLsGkGNPEEED

Upstream

Downstream

CTNNB1 (human)
K49-ac

CTNNB1 (mouse)
K49-ac

CTNNB1 (rat)
K49-ac

Effects on Modified Protein

acetylation
intracellular localization
molecular association, regulation
phosphorylation
protein stabilization
ubiquitination

Effects on Biological Processes:

apoptosis, inhibited
carcinogenesis, induced
carcinogenesis, inhibited
cell differentiation, induced
cell growth, induced
cell motility, induced
transcription, induced
transcription, inhibited

Regulatory protein:

Bcl-3 (human)
DBC1 (human)
HDAC6 (human)
HDAC7 (human)
PKCA (human)
ROCK1 (human)
ZNF326 (human)

Treatment

ACY1215
anacardic acid
BG-45
CI994
CPD-60
crebinostat
EGF
siRNA
trichostatin_A
tubacin
Tubastatin A
virus infection
vorinostat
Wnt3a
Y27632

CTNNB1 (human)	TAPsLsGkGNPEEED	K49-ac
CTNNB1 (mouse)	TAPsLsGkGNPEEED	K49-ac
CTNNB1 (rat)	TAPsLSGkGNPEEED	K49-ac
CTNNB1 (rabbit)	TAPSLSGKGNPEEED	K49

K49-me

TAPsLsGkGNPEEED

Upstream

Downstream

Effects on Modified Protein

intracellular localization
methylation
molecular association, regulation

Effects on Biological Processes:

transcription, induced

Regulatory protein:

PTEN (human)

Treatment

H2O2

CTNNB1 (human)	TAPsLsGkGNPEEED	K49-me
CTNNB1 (mouse)	TAPsLsGKGNPEEED	K49
CTNNB1 (rat)	TAPsLSGKGNPEEED	K49
CTNNB1 (rabbit)	TAPSLSGKGNPEEED	K49

K49-m3

TAPsLsGkGNPEEED

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell differentiation, induced
transcription, inhibited

Treatment

CHIR99021
GSK343

CTNNB1 (human)	TAPsLsGkGNPEEED	K49-m3
CTNNB1 (mouse)	TAPsLsGKGNPEEED	K49
CTNNB1 (rat)	TAPsLSGKGNPEEED	K49
CTNNB1 (rabbit)	TAPSLSGKGNPEEED	K49

K49-ub

TAPsLsGkGNPEEED

Downstream

Effects on Modified Protein

protein degradation

Effects on Biological Processes:

carcinogenesis, inhibited
cell growth, inhibited
transcription, inhibited

CTNNB1 (human)	TAPsLsGkGNPEEED	K49-ub
CTNNB1 (mouse)	TAPsLsGKGNPEEED	K49
CTNNB1 (rat)	TAPsLSGKGNPEEED	K49
CTNNB1 (rabbit)	TAPSLSGKGNPEEED	K49

S60-p

EEEDVDTsQVLyEWE

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell cycle regulation

Kinase, in vitro:

PLK1 (human)

Putative in vivo kinases:

PLK1 (human)

Treatment

BI2536
siRNA

CTNNB1 (human)	EEEDVDTsQVLyEWE	S60-p
CTNNB1 (mouse)	EEEDVDTsQVLYEWE	S60-p
CTNNB1 (rat)	EEEDVDTSQVLYEWE	S60
CTNNB1 (rabbit)	EEEDVDTSQVLYEWE	S60

Y64-p

VDTsQVLyEWEQGFS

Upstream

Kinase, in vitro:

Brk (human)
JAK3 (human)

Putative in vivo kinases:

Brk (mouse)
JAK3 (human)

CTNNB1 (human)	VDTsQVLyEWEQGFS	Y64-p
CTNNB1 (mouse)	VDTsQVLYEWEQGFS	Y64
CTNNB1 (rat)	VDTSQVLYEWEQGFS	Y64
CTNNB1 (rabbit)	VDTSQVLYEWEQGFS	Y64

S73-p

WEQGFSQsFTQEQVA

CTNNB1 (human)	WEQGFSQsFTQEQVA	S73-p
CTNNB1 (mouse)	WEQGFSQSFTQEQVA	S73
CTNNB1 (rat)	WEQGFSQSFTQEQVA	S73
CTNNB1 (rabbit)	WEQGFSQSFTQEQVA	S73

Y86-p

VADIDGQyAMTRAQR

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation
protein stabilization
ubiquitination

Effects on Biological Processes:

carcinogenesis, induced
cell growth, altered
cell growth, induced
transcription, altered
transcription, induced

Kinase, in vitro:

Abl (human)
JAK3 (human)

Putative in vivo kinases:

Abl (human)
JAK3 (human)
Src (human)

Putative upstream phosphatases:

SHP-1 (mouse)

Regulatory protein:

CAPN2 (human)
Src (human)

Treatment

dasatinib
imatinib
SB216763
siRNA
SKI-606
Su11274
U0126

CTNNB1 (human)	VADIDGQyAMTRAQR	Y86-p
CTNNB1 (mouse)	VADIDGQyAMTRAQR	Y86-p
CTNNB1 (rat)	VADIDGQYAMTRAQR	Y86
CTNNB1 (rabbit)	VADIDGQYAMTRAQR	Y86

T102-p

RAAMFPEtLDEGMQI

Upstream

Downstream

Effects on Modified Protein

protein degradation

Effects on Biological Processes:

cell motility, altered

Kinase, in vitro:

CK2A2 (human)

CTNNB1 (human)	RAAMFPEtLDEGMQI	T102-p
CTNNB1 (mouse)	RAAMFPETLDEGMQI	T102
CTNNB1 (rat)	RAAMFPETLDEGMQI	T102
CTNNB1 (rabbit)	RAAMFPETLDEGMQI	T102

S111-p

DEGMQIPstQFdAAH

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

signaling pathway regulation
transcription, induced

Kinase, in vitro:

P38A (human)

Putative in vivo kinases:

P38A (human)

Treatment

ralimetinib

CTNNB1 (human)	DEGMQIPstQFdAAH	S111-p
CTNNB1 (mouse)	DEGMQIPSTQFDAAH	S111
CTNNB1 (rat)	DEGMQIPSTQFDAAH	S111
CTNNB1 (rabbit)	DEGMQIPSTQFDAAH	S111

T112-p

EGMQIPstQFdAAHP

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation
protein degradation

Effects on Biological Processes:

cell growth, inhibited
cell motility, altered
cell motility, inhibited
signaling pathway regulation
transcription, induced

Kinase, in vitro:

CK2A2 (human)
P38A (human)
PRKD1 (human)

Putative in vivo kinases:

P38A (human)
PRKD1 (human)

Treatment

ralimetinib

CTNNB1 (human)	EGMQIPstQFdAAHP	T112-p
CTNNB1 (mouse)	EGMQIPSTQFDAAHP	T112
CTNNB1 (rat)	EGMQIPSTQFDAAHP	T112
CTNNB1 (rabbit)	EGMQIPSTQFDAAHP	T112

D115-ca

QIPstQFdAAHPtNV

CTNNB1 (human)	QIPstQFdAAHPtNV	D115-ca
CTNNB1 (mouse)	QIPSTQFDAAHPtNV	D115
CTNNB1 (rat)	QIPSTQFDAAHPTNV	D115
CTNNB1 (rabbit)	QIPSTQFDAAHPTNV	D115

T120-p

QFdAAHPtNVQRLAE

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation
protein degradation

Effects on Biological Processes:

cell growth, inhibited
cell motility, inhibited
transcription, altered
transcription, induced
transcription, inhibited

Kinase, in vitro:

PRKD1 (human)

Putative in vivo kinases:

PRKD1 (human)

Treatment

3jc48-3
CID755673
MT-1
phosphorylated peptide
siRNA

CTNNB1 (human)	QFdAAHPtNVQRLAE	T120-p
CTNNB1 (mouse)	QFDAAHPtNVQRLAE	T120-p
CTNNB1 (rat)	QFDAAHPTNVQRLAE	T120
CTNNB1 (rabbit)	QFDAAHPTNVQRLAE	T120

S129-p

VQRLAEPsQMLkHAV

CTNNB1 (human)	VQRLAEPsQMLkHAV	S129-p
CTNNB1 (mouse)	VQRLAEPSQMLkHAV	S129
CTNNB1 (rat)	VQRLAEPSQMLKHAV	S129
CTNNB1 (rabbit)	VQRLAEPSQMLKHAV	S129

K133-m1

AEPsQMLkHAVVNLI

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

carcinogenesis, induced
cell growth, induced
signaling pathway regulation
transcription, induced

Treatment

LLY-507
siRNA

CTNNB1 (human)	AEPsQMLkHAVVNLI	K133-m1
CTNNB1 (mouse)	AEPSQMLKHAVVNLI	K133
CTNNB1 (rat)	AEPSQMLKHAVVNLI	K133
CTNNB1 (rabbit)	AEPSQMLKHAVVNLI	K133

K133-ub

AEPsQMLkHAVVNLI

CTNNB1 (human)	AEPsQMLkHAVVNLI	K133-ub
CTNNB1 (mouse)	AEPSQMLkHAVVNLI	K133-ub
CTNNB1 (rat)	AEPSQMLKHAVVNLI	K133
CTNNB1 (rabbit)	AEPSQMLKHAVVNLI	K133

Y142-p

AVVNLINyQDDAELA

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation
protein degradation

Effects on Biological Processes:

apoptosis, inhibited
carcinogenesis, induced
cell growth, induced
cell motility, induced
cytoskeletal reorganization
signaling pathway regulation
transcription, induced

Kinase, in vitro:

Brk (human)
EGFR (human)
FGFR2 (human)
FGFR3 (human)
TrkA (human)

Putative in vivo kinases:

EGFR (human)
FAK (human)
FGFR2 (human)
FGFR3 (human)
TrkA (human)
VEGFR1 (human)

Regulatory protein:

Fer (human)
Src (human)

Treatment

AGEs
Bioymifi
conditioned medium
CTGF
FGF2
HGF
imatinib
PF 573228
refametinib
SB216763
siRNA
SKI-606
sorafenib
U0126

CTNNB1 (human)	AVVNLINyQDDAELA	Y142-p
CTNNB1 (mouse)	AVVNLINyQDDAELA	Y142-p
CTNNB1 (rat)	AVVNLINyQDDAELA	Y142-p
CTNNB1 (rabbit)	AVVNLINYQDDAELA	Y142

K158-ub

RAIPELTkLLNDEDQ

CTNNB1 (human)	RAIPELTkLLNDEDQ	K158-ub
CTNNB1 (mouse)	RAIPELTkLLNDEDQ	K158-ub
CTNNB1 (rat)	RAIPELTKLLNDEDQ	K158
CTNNB1 (rabbit)	RAIPELTKLLNDEDQ	K158

K170-ub

EDQVVVNkAAVMVHQ

CTNNB1 (human)	EDQVVVNkAAVMVHQ	K170-ub
CTNNB1 (mouse)	EDQVVVNkAAVMVHQ	K170-ub
CTNNB1 (rat)	EDQVVVNKAAVMVHQ	K170
CTNNB1 (rabbit)	EDQVVVNKAAVMVHQ	K170

S179-p

AVMVHQLskKEAsRH

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Kinase, in vitro:

PKACA (human)

CTNNB1 (human)	AVMVHQLskKEAsRH	S179-p
CTNNB1 (mouse)	AVMVHQLsKKEASRH	S179-p
CTNNB1 (rat)	AVMVHQLSKKEASRH	S179
CTNNB1 (rabbit)	AVMVHQLSKKEASRH	S179

K180-ub

VMVHQLskKEAsRHA

CTNNB1 (human)	VMVHQLskKEAsRHA	K180-ub
CTNNB1 (mouse)	VMVHQLsKKEASRHA	K180
CTNNB1 (rat)	VMVHQLSKKEASRHA	K180
CTNNB1 (rabbit)	VMVHQLSKKEASRHA	K180

S184-p

QLskKEAsRHAIMRs

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation
phosphorylation
protein stabilization

Effects on Biological Processes:

carcinogenesis, induced
signaling pathway regulation
transcription, induced

Kinase, in vitro:

PMVK (human)

Putative in vivo kinases:

PMVK (human)

Treatment

methyl-beta-cyclodextrin
mevalonate 5-diphosphate
mevalonate 5-phosphate
PMVKi5

CTNNB1 (human)	QLskKEAsRHAIMRs	S184-p
CTNNB1 (mouse)	QLsKKEASRHAIMRs	S184
CTNNB1 (rat)	QLSKKEASRHAIMRs	S184
CTNNB1 (rabbit)	QLSKKEASRHAIMRS	S184

S191-p

sRHAIMRsPQMVsAI

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation
protein conformation
protein stabilization

Effects on Biological Processes:

transcription, induced

Kinase, in vitro:

CDK5 (human)

Treatment

LRRK2-IN-1

CTNNB1 (human)	sRHAIMRsPQMVsAI	S191-p
CTNNB1 (mouse)	SRHAIMRsPQMVSAI	S191-p
CTNNB1 (rat)	SRHAIMRsPQMVSAI	S191-p
CTNNB1 (rabbit)	SRHAIMRSPQMVSAI	S191

S196-p

MRsPQMVsAIVRTMQ

CTNNB1 (human)	MRsPQMVsAIVRTMQ	S196-p
CTNNB1 (mouse)	MRsPQMVSAIVRTMQ	S196
CTNNB1 (rat)	MRsPQMVSAIVRTMQ	S196
CTNNB1 (rabbit)	MRSPQMVSAIVRTMQ	S196

S222-p

AGTLHNLsHHREGLL

CTNNB1 (human)	AGTLHNLsHHREGLL	S222-p
CTNNB1 (mouse)	AGTLHNLsHHREGLL	S222-p
CTNNB1 (rat)	AGTLHNLSHHREGLL	S222
CTNNB1 (rabbit)	AGTLHNLSHHREGLL	S222

K233-ub

EGLLAIFkSGGIPAL

Upstream

Treatment

S1 wash out

CTNNB1 (human)	EGLLAIFkSGGIPAL	K233-ub
CTNNB1 (mouse)	EGLLAIFkSGGIPAL	K233-ub
CTNNB1 (rat)	EGLLAIFKSGGIPAL	K233
CTNNB1 (rabbit)	EGLLAIFKSGGIPAL	K233

K233

EGLLAIFKSGGIPAL

CTNNB1 (human)	EGLLAIFKSGGIPAL	K233
CTNNB1 (mouse)	EGLLAIFkSGGIPAL	K233-sm
CTNNB1 (rat)	EGLLAIFKSGGIPAL	K233
CTNNB1 (rabbit)	EGLLAIFKSGGIPAL	K233

S246-p

ALVKMLGsPVDSVLF

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation
protein conformation
protein stabilization

Effects on Biological Processes:

transcription, induced

Kinase, in vitro:

CDK5 (human)

CTNNB1 (human)	ALVKMLGsPVDSVLF	S246-p
CTNNB1 (mouse)	ALVKMLGSPVDSVLF	S246
CTNNB1 (rat)	ALVKMLGSPVDSVLF	S246
CTNNB1 (rabbit)	ALVKMLGSPVDSVLF	S246

K288-ub

KMVALLNkTNVKFLA

CTNNB1 (human)	KMVALLNkTNVKFLA	K288-ub
CTNNB1 (mouse)	KMVALLNKTNVKFLA	K288
CTNNB1 (rat)	KMVALLNKTNVKFLA	K288
CTNNB1 (rabbit)	KMVALLNKTNVKFLA	K288

T298-p

VKFLAITtDCLQILA

CTNNB1 (human)	VKFLAITtDCLQILA	T298-p
CTNNB1 (mouse)	VKFLAITTDCLQILA	T298
CTNNB1 (rat)	VKFLAITTDCLQILA	T298
CTNNB1 (rabbit)	VKFLAITTDCLQILA	T298

S311-p

LAYGNQEsKLIILAS

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation
protein stabilization

Effects on Biological Processes:

carcinogenesis, induced
cell growth, induced
cell motility, induced
signaling pathway regulation
transcription, altered

Kinase, in vitro:

PLK1 (human)

Putative in vivo kinases:

PLK1 (human)

CTNNB1 (human)	LAYGNQEsKLIILAS	S311-p
CTNNB1 (mouse)	LAYGNQESKLIILAS	S311
CTNNB1 (rat)	LAYGNQESKLIILAS	S311
CTNNB1 (rabbit)	LAYGNQESKLIILAS	S311

Y331-p

LVNIMRTytyEkLLW

Upstream

Kinase, in vitro:

Brk (human)

Treatment

acetaldehyde

CTNNB1 (human)	LVNIMRTytyEkLLW	Y331-p
CTNNB1 (mouse)	LVNIMRTYTYEKLLW	Y331
CTNNB1 (rat)	LVNIMRTYTYEKLLW	Y331
CTNNB1 (rabbit)	LVNIMRTYTYEKLLW	Y331

T332-p

VNIMRTytyEkLLWT

Upstream

Downstream

Effects on Biological Processes:

apoptosis, induced
transcription, inhibited

Kinase, in vitro:

CAMK2A (human)

CTNNB1 (human)	VNIMRTytyEkLLWT	T332-p
CTNNB1 (mouse)	VNIMRTYTYEKLLWT	T332
CTNNB1 (rat)	VNIMRTYTYEKLLWT	T332
CTNNB1 (rabbit)	VNIMRTYTYEKLLWT	T332

Y333-p

NIMRTytyEkLLWTT

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation
protein stabilization
ubiquitination

Effects on Biological Processes:

carcinogenesis, induced
cell cycle regulation
cell growth, induced
transcription, induced

Kinase, in vitro:

Brk (human)
Src (human)

Putative in vivo kinases:

Src (human)

Regulatory protein:

CAPN2 (human)
FBXL7 (human)

Treatment

acetaldehyde
dasatinib
siRNA

CTNNB1 (human)	NIMRTytyEkLLWTT	Y333-p
CTNNB1 (mouse)	NIMRTYTYEKLLWTT	Y333
CTNNB1 (rat)	NIMRTYTYEKLLWTT	Y333
CTNNB1 (rabbit)	NIMRTYTYEKLLWTT	Y333

K335-ub

MRTytyEkLLWTTSR

CTNNB1 (human)	MRTytyEkLLWTTSR	K335-ub
CTNNB1 (mouse)	MRTYTYEKLLWTTSR	K335
CTNNB1 (rat)	MRTYTYEKLLWTTSR	K335
CTNNB1 (rabbit)	MRTYTYEKLLWTTSR	K335

K345-ac

WTTSRVLkVLSVCSs

Downstream

Effects on Modified Protein

activity, induced
molecular association, regulation

Effects on Biological Processes:

transcription, induced

CTNNB1 (human)	WTTSRVLkVLSVCSs	K345-ac
CTNNB1 (mouse)	WTTSRVLKVLSVCSS	K345
CTNNB1 (rat)	WTTSRVLKVLSVCSS	K345
CTNNB1 (rabbit)	WTTSRVLKVLSVCSS	K345

K345-ub

WTTSRVLkVLSVCSs

CTNNB1 (human)	WTTSRVLkVLSVCSs	K345-ub
CTNNB1 (mouse)	WTTSRVLKVLSVCSS	K345
CTNNB1 (rat)	WTTSRVLKVLSVCSS	K345
CTNNB1 (rabbit)	WTTSRVLKVLSVCSS	K345

S352-p

kVLSVCSsNkPAIVE

CTNNB1 (human)	kVLSVCSsNkPAIVE	S352-p
CTNNB1 (mouse)	KVLSVCSSNKPAIVE	S352
CTNNB1 (rat)	KVLSVCSSNKPAIVE	S352
CTNNB1 (rabbit)	KVLSVCSSNKPAIVE	S352

K354-ac

LSVCSsNkPAIVEAG

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

transcription, induced

Treatment

C646
glucose
lithium
nicotinamide
resveratrol

CTNNB1 (human)	LSVCSsNkPAIVEAG	K354-ac
CTNNB1 (mouse)	LSVCSSNKPAIVEAG	K354
CTNNB1 (rat)	LSVCSSNKPAIVEAG	K354
CTNNB1 (rabbit)	LSVCSSNKPAIVEAG	K354

K354-ub

LSVCSsNkPAIVEAG

CTNNB1 (human)	LSVCSsNkPAIVEAG	K354-ub
CTNNB1 (mouse)	LSVCSSNKPAIVEAG	K354
CTNNB1 (rat)	LSVCSSNKPAIVEAG	K354
CTNNB1 (rabbit)	LSVCSSNKPAIVEAG	K354

T371-p

QALGLHLtDPsQRLV

CTNNB1 (human)	QALGLHLtDPsQRLV	T371-p
CTNNB1 (mouse)	QALGLHLTDPSQRLV	T371
CTNNB1 (rat)	QALGPHLTDPSQRLV	T371
CTNNB1 (rabbit)	QALGLHLTDPSQRLV	T371

S374-p

GLHLtDPsQRLVQNC

CTNNB1 (human)	GLHLtDPsQRLVQNC	S374-p
CTNNB1 (mouse)	GLHLTDPSQRLVQNC	S374
CTNNB1 (rat)	GPHLTDPSQRLVQNC	S374
CTNNB1 (rabbit)	GLHLTDPSQRLVQNC	S374

T384-p

LVQNCLWtLRNLSDA

CTNNB1 (human)	LVQNCLWtLRNLSDA	T384-p
CTNNB1 (mouse)	LVQNCLWTLRNLSDA	T384
CTNNB1 (rat)	LVQNCLWTLRNLSDA	T384
CTNNB1 (rabbit)	LVQNCLWTLRNLSDA	T384

T393-p

RNLSDAAtkQEGMEG

Upstream

Downstream

Effects on Modified Protein

activity, induced
molecular association, regulation
phosphorylation
protein stabilization

Effects on Biological Processes:

transcription, altered
transcription, induced

Kinase, in vitro:

CK2A1 (mouse)

Treatment

apigenin
wortmannin

CTNNB1 (human)	RNLSDAAtkQEGMEG	T393-p
CTNNB1 (mouse)	RNLSDAAtKQEGMEG	T393-p
CTNNB1 (rat)	RNLSDAATKQEGMEG	T393
CTNNB1 (rabbit)	RNLSDAATKQEGMEG	T393

K394-ub

NLSDAAtkQEGMEGL

Downstream

Effects on Modified Protein

protein stabilization

Effects on Biological Processes:

transcription, induced

CTNNB1 (human)	NLSDAAtkQEGMEGL	K394-ub
CTNNB1 (mouse)	NLSDAAtKQEGMEGL	K394
CTNNB1 (rat)	NLSDAATKQEGMEGL	K394
CTNNB1 (rabbit)	NLSDAATKQEGMEGL	K394

K435-ac

TCNNYKNkMMVCQVG

CTNNB1 (human)	TCNNYKNkMMVCQVG	K435-ac
CTNNB1 (mouse)	TCNNYKNKMMVCQVG	K435
CTNNB1 (rat)	TCNNYKNKMMVCQVG	K435
CTNNB1 (rabbit)	TCNNYKNKMMVCQVG	K435

K435-ub

TCNNYKNkMMVCQVG

CTNNB1 (human)	TCNNYKNkMMVCQVG	K435-ub
CTNNB1 (mouse)	TCNNYKNKMMVCQVG	K435
CTNNB1 (rat)	TCNNYKNKMMVCQVG	K435
CTNNB1 (rabbit)	TCNNYKNKMMVCQVG	K435

T461-p

AGDREDItEPAICAL

CTNNB1 (human)	AGDREDItEPAICAL	T461-p
CTNNB1 (mouse)	AGDREDItEPAICAL	T461-p
CTNNB1 (rat)	AGDREDITEPAICAL	T461
CTNNB1 (rabbit)	AGDREDITEPAICAL	T461

T472-p

ICALRHLtsRHQEAE

Upstream

Downstream

Effects on Biological Processes:

apoptosis, induced
transcription, inhibited

Kinase, in vitro:

CAMK2A (human)

CTNNB1 (human)	ICALRHLtsRHQEAE	T472-p
CTNNB1 (mouse)	ICALRHLTSRHQEAE	T472
CTNNB1 (rat)	ICALRHLTSRHQEAE	T472
CTNNB1 (rabbit)	ICALRHLTSRHQEAE	T472

S473-p

CALRHLtsRHQEAEM

CTNNB1 (human)	CALRHLtsRHQEAEM	S473-p
CTNNB1 (mouse)	CALRHLTSRHQEAEM	S473
CTNNB1 (rat)	CALRHLTSRHQEAEM	S473
CTNNB1 (rabbit)	CALRHLTSRHQEAEM	S473

Y489-p

QNAVRLHyGLPVVVk

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

transcription, induced

Kinase, in vitro:

Abl (human)

CTNNB1 (human)	QNAVRLHyGLPVVVk	Y489-p
CTNNB1 (mouse)	QNAVRLHyGLPVVVK	Y489-p
CTNNB1 (rat)	QNAVRLHyGLPVVVK	Y489-p
CTNNB1 (rabbit)	QNAVRLHYGLPVVVK	Y489

K496-ub

yGLPVVVkLLHPPSH

CTNNB1 (human)	yGLPVVVkLLHPPSH	K496-ub
CTNNB1 (mouse)	yGLPVVVKLLHPPSH	K496
CTNNB1 (rat)	yGLPVVVKLLHPPSH	K496
CTNNB1 (rabbit)	YGLPVVVKLLHPPSH	K496

K508-ub

PSHWPLIkAtVGLIR

CTNNB1 (human)	PSHWPLIkAtVGLIR	K508-ub
CTNNB1 (mouse)	PSHWPLIKATVGLIR	K508
CTNNB1 (rat)	PSHWPLIKATVGLIR	K508
CTNNB1 (rabbit)	PSHWPLIKATVGLIR	K508

T510-p

HWPLIkAtVGLIRNL

CTNNB1 (human)	HWPLIkAtVGLIRNL	T510-p
CTNNB1 (mouse)	HWPLIKATVGLIRNL	T510
CTNNB1 (rat)	HWPLIKATVGLIRNL	T510
CTNNB1 (rabbit)	HWPLIKATVGLIRNL	T510

T547-p

LVRAHQDtQRRtsMG

CTNNB1 (human)	LVRAHQDtQRRtsMG	T547-p
CTNNB1 (mouse)	LVRAHQDTQRRtsMG	T547
CTNNB1 (rat)	LVRAHQDTQRRtsMG	T547
CTNNB1 (rabbit)	LVRAHQDTQRRTsMG	T547

T551-p

HQDtQRRtsMGGtQQ

Upstream