Rb (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

T5-p

___MPPKtPRKTAAT

Rb (human)	___MPPKtPRKTAAT	T5-p
Rb (mouse)	___MPPKAPRRAAAA	A5
Rb (rat)	___MPPKAPRRTAAA	A5

S37-p

EEDPEQDsGPEDLPL

Upstream

Treatment

nocodazole

Rb (human)	EEDPEQDsGPEDLPL	S37-p
Rb (mouse)	EDDPAQDsGPEELPL	S31-p
Rb (rat)	EDDPAQDsDPEELPL	S30-p

K63-ub

DFTALCQkLkIPDHV

Rb (human)	DFTALCQkLkIPDHV	K63-ub
Rb (mouse)	EFIALCQkLKVPDHV	K57-ub
Rb (rat)	EFIALCQKLKVPDHV	K56

K65-ub

TALCQkLkIPDHVRE

Rb (human)	TALCQkLkIPDHVRE	K65-ub
Rb (mouse)	IALCQkLKVPDHVRE	K59
Rb (rat)	IALCQKLKVPDHVRE	K58

K94-ub

VLGGYIQkKKELWGI

Rb (human)	VLGGYIQkKKELWGI	K94-ub
Rb (mouse)	ILEGYIQKKKELWGI	K88
Rb (rat)	ILEGYIQKKKELWGI	K87

K136-ub

HKFFNLLkEIDtSTk

Rb (human)	HKFFNLLkEIDtSTk	K136-ub
Rb (mouse)	YKFFDLLKEIDTSTK	K130
Rb (rat)	YKFFDLLKEIDTSTK	K129

T140-p

NLLkEIDtSTkVDNA

Rb (human)	NLLkEIDtSTkVDNA	T140-p
Rb (mouse)	DLLKEIDTSTKVDNA	T134
Rb (rat)	DLLKEIDTSTKVDNA	T133

K143-ub

kEIDtSTkVDNAMsR

Rb (human)	kEIDtSTkVDNAMsR	K143-ub
Rb (mouse)	KEIDTSTKVDNAMSR	K137
Rb (rat)	KEIDTSTKVDNAVSR	K136

S149-p

TkVDNAMsRLLKKYD

Rb (human)	TkVDNAMsRLLKKYD	S149-p
Rb (mouse)	TKVDNAMSRLLKKYN	S143
Rb (rat)	TKVDNAVSRLLKKYN	S142

S163-p

DVLFALFsKLERTCE

Rb (human)	DVLFALFsKLERTCE	S163-p
Rb (mouse)	NVLCALYSKLERTCE	S157
Rb (rat)	NVLCALYSKLERTCG	S156

S230-p

LDYFIKLsPPMLLKE

Rb (human)	LDYFIKLsPPMLLKE	S230-p
Rb (mouse)	VDYFIKFsPPALLRE	S224-p
Rb (rat)	LDYFIKLSPPALLRE	S223

Y239-p

PMLLKEPyKtAVIPI

Rb (human)	PMLLKEPyKtAVIPI	Y239-p
Rb (mouse)	PALLREPYKTAAIPI	Y233
Rb (rat)	PALLREPYKTAATPI	Y232

T241-p

LLKEPyKtAVIPING

Rb (human)	LLKEPyKtAVIPING	T241-p
Rb (mouse)	LLREPYKTAAIPING	T235
Rb (rat)	LLREPYKTAATPING	T234

S249-p

AVIPINGsPRtPRRG

Upstream

Downstream

126

Effects on Modified Protein

acetylation
activity, induced
activity, inhibited
molecular association, regulation

Effects on Biological Processes:

apoptosis, inhibited
cell cycle regulation
cell growth, induced
cell growth, inhibited
transcription, induced
transcription, inhibited

Kinase, in vitro:

CDK1 (human)
CDK2 (human)
CDK4 (human)
P38A (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

CDK2 (human)
P38A (human)

Regulatory protein:

WT1 (human)

Treatment

butyrate
dasatinib
nocodazole
progestin_R5020
rapamycin
siRNA
TGF-beta

Rb (human)	AVIPINGsPRtPRRG	S249-p
Rb (mouse)	AAIPINGsPRtPRRG	S243-p
Rb (rat)	AATPINGsPRtPRRG	S242-p

T252-p

PINGsPRtPRRGQNR

Upstream

Downstream

Effects on Modified Protein

acetylation
activity, induced
activity, inhibited
molecular association, regulation

Effects on Biological Processes:

apoptosis, inhibited
cell cycle regulation
cell growth, induced
cell growth, inhibited
transcription, induced
transcription, inhibited

Kinase, in vitro:

CDK1 (human)
CDK2 (human)
CDK4 (human)
P38A (human)

Putative in vivo kinases:

CDK2 (human)
CDK4 (human)
P38A (human)

Regulatory protein:

WT1 (human)

Treatment

butyrate
flavopiridol
palbociclib
progestin_R5020
rapamycin
seliciclib
siRNA
TGF-beta

Rb (human)	PINGsPRtPRRGQNR	T252-p
Rb (mouse)	PINGsPRtPRRGQNR	T246-p
Rb (rat)	PINGsPRtPRRGQNR	T245-p

K265-ub

NRSARIAkQLENDTR

Rb (human)	NRSARIAkQLENDTR	K265-ub
Rb (mouse)	NRSARIAKQLENDTR	K259
Rb (rat)	NRSARIAKQLESDTR	K258

K279-ub

RIIEVLCkEHECNID

Rb (human)	RIIEVLCkEHECNID	K279-ub
Rb (mouse)	RIIEVLCKEHECNID	K273
Rb (rat)	RTIEVLCKEHECNVD	K272

K289-ub

ECNIDEVkNVYFKNF

Rb (human)	ECNIDEVkNVYFKNF	K289-ub
Rb (mouse)	ECNIDEVKNVYFKNF	K283
Rb (rat)	ECNVDEVKNVYFKNF	K282

K319-ub

PEVENLSkRyEEIyL

Rb (human)	PEVENLSkRyEEIyL	K319-ub
Rb (mouse)	PEVESLSKRYEEVYL	K313
Rb (rat)	PELESLSKRYEEVYL	K312

Y321-p

VENLSkRyEEIyLkN

Rb (human)	VENLSkRyEEIyLkN	Y321-p
Rb (mouse)	VESLSKRYEEVYLKN	Y315
Rb (rat)	LESLSKRYEEVYLKS	Y314

Y325-p

SkRyEEIyLkNKDLD

Rb (human)	SkRyEEIyLkNKDLD	Y325-p
Rb (mouse)	SKRYEEVYLKNKDLD	Y319
Rb (rat)	SKRYEEVYLKSKDLD	Y318

K327-ub

RyEEIyLkNKDLDAR

Rb (human)	RyEEIyLkNKDLDAR	K327-ub
Rb (mouse)	RYEEVYLKNKDLDAR	K321
Rb (rat)	RYEEVYLKSKDLDAR	K320

K341-ub

RLFLDHDkTLQtdsI

Rb (human)	RLFLDHDkTLQtdsI	K341-ub
Rb (mouse)	RLFLDHDKTLQTDPI	K335
Rb (rat)	RLFLDHDKTLQTDTI	K334

T345-p

DHDkTLQtdsIDsFE

Rb (human)	DHDkTLQtdsIDsFE	T345-p
Rb (mouse)	DHDKTLQTDPIDsFE	T339
Rb (rat)	DHDKTLQTDTIDSFE	T338

D346-ca

HDkTLQtdsIDsFEt

Rb (human)	HDkTLQtdsIDsFEt	D346-ca
Rb (mouse)	HDKTLQTDPIDsFET	D340
Rb (rat)	HDKTLQTDTIDSFET	D339

S347-p

DkTLQtdsIDsFEtQ

Rb (human)	DkTLQtdsIDsFEtQ	S347-p
Rb (mouse)	DKTLQTDPIDsFETE	P341
Rb (rat)	DKTLQTDTIDSFETE	T340

S350-p

LQtdsIDsFEtQRtP

Rb (human)	LQtdsIDsFEtQRtP	S350-p
Rb (mouse)	LQTDPIDsFETERtP	S344-p
Rb (rat)	LQTDTIDSFETERTP	S343

T353-p

dsIDsFEtQRtPRks

Rb (human)	dsIDsFEtQRtPRks	T353-p
Rb (mouse)	DPIDsFETERtPRKN	T347
Rb (rat)	DTIDSFETERTPRKS	T346

T356-p

DsFEtQRtPRksNLD

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

apoptosis, inhibited
carcinogenesis, induced
cell growth, induced

Kinase, in vitro:

CDK2 (human)
CDK4 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

UL97 (herpesvirus)

Regulatory protein:

CCNF (human)
NIPP-1 (human)
Oct4 (human)

Treatment

actinomycin_D
anti-CD3
butyrate
GW_8510
lapatinib
palbociclib
PD98059
SB218078

Rb (human)	DsFEtQRtPRksNLD	T356-p
Rb (mouse)	DsFETERtPRKNNPD	T350-p
Rb (rat)	DSFETERTPRKSNPD	T349

K359-ub

EtQRtPRksNLDEEV

Rb (human)	EtQRtPRksNLDEEV	K359-ub
Rb (mouse)	ETERtPRKNNPDEEA	K353
Rb (rat)	ETERTPRKSNPDEEA	K352

S360-p

tQRtPRksNLDEEVN

Rb (human)	tQRtPRksNLDEEVN	S360-p
Rb (mouse)	TERtPRKNNPDEEAN	N354
Rb (rat)	TERTPRKSNPDEEAN	S353

P370

DEEVNVIPPHtPVRT

Rb (human)	DEEVNVIPPHtPVRT	P370
Rb (mouse)	DEEANVVtPHtPVRT	T364-p
Rb (rat)	DEEANMVtPHtPVRT	T363-p

T373-p

VNVIPPHtPVRTVMN

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Kinase, in vitro:

CDK1 (human)
CDK2 (human)
CDK4 (human)

Putative in vivo kinases:

UL97 (herpesvirus)

Regulatory protein:

VHL (human)

Treatment

anti-CD3
cytokines
EGF
GW_8510
phytohemagglutinin

Rb (human)	VNVIPPHtPVRTVMN	T373-p
Rb (mouse)	ANVVtPHtPVRTVMN	T367-p
Rb (rat)	ANMVtPHtPVRTVMN	T366-p

K420-ub

ESILKRVkDIGYIFk

Rb (human)	ESILKRVkDIGYIFk	K420-ub
Rb (mouse)	ENILKRVKDVGHIFK	K414
Rb (rat)	ENILKRVKDVGHIFK	K413

K427-ac

kDIGYIFkEKFAkAV

Rb (human)	kDIGYIFkEKFAkAV	K427-ac
Rb (mouse)	KDVGHIFKEKFANAV	K421
Rb (rat)	KDVGHIFKEKFASAV	K420

K427-ub

kDIGYIFkEKFAkAV

Rb (human)	kDIGYIFkEKFAkAV	K427-ub
Rb (mouse)	KDVGHIFKEKFANAV	K421
Rb (rat)	KDVGHIFKEKFASAV	K420

K432-ub

IFkEKFAkAVGQGCV

Rb (human)	IFkEKFAkAVGQGCV	K432-ub
Rb (mouse)	IFKEKFANAVGQGCV	N426
Rb (rat)	IFKEKFASAVGQGCI	S425

Y446

VEIGSQRYKLGVRLY

Rb (human)	VEIGSQRYKLGVRLY	Y446
Rb (mouse)	VDIGVQRyKLGVRLY	Y440-p
Rb (rat)	IDIGAQRYKLGVRLY	Y439

Y454-p

KLGVRLYyRVMESML

Rb (human)	KLGVRLYyRVMESML	Y454-p
Rb (mouse)	KLGVRLYYRVMESML	Y448
Rb (rat)	KLGVRLYYRVMESML	Y447

K537-ub

KVIESFIkAEGNLTR

Rb (human)	KVIESFIkAEGNLTR	K537-ub
Rb (mouse)	KVIESFIKVEANLTR	K531
Rb (rat)	KVIESFIKVEANLTR	K530

K548-ac

NLTREMIkHLERCEH

Upstream

Treatment

MS275

Rb (human)	NLTREMIkHLERCEH	K548-ac
Rb (mouse)	NLTREMIKHLERCEH	K542
Rb (rat)	NLTREMIKHLERCEH	K541

S567-p

SLAWLSDsPLFDLIk

Upstream

Downstream

Effects on Modified Protein

activity, inhibited
molecular association, regulation
protein degradation

Effects on Biological Processes:

apoptosis, induced
apoptosis, inhibited
cell growth, induced

Kinase, in vitro:

CDK2 (human)
P38A (human)

Putative in vivo kinases:

P38A (human)

Regulatory protein:

MKK3 (human)
P38A (human)
P38B (human)

Treatment

3MCIC
butyrate
etoposide
SB203580
seliciclib

Rb (human)	SLAWLSDsPLFDLIk	S567-p
Rb (mouse)	SLAWLSDsPLFDLIK	S561-p
Rb (rat)	SLAWLSDSPLFDLIK	S560

K574-ub

sPLFDLIkQSKDREG

Rb (human)	sPLFDLIkQSKDREG	K574-ub
Rb (mouse)	sPLFDLIKQSKDGEG	K568
Rb (rat)	SPLFDLIKQSKDGEG	K567

T583-p

SKDREGPtDHLEsAC

Rb (human)	SKDREGPtDHLEsAC	T583-p
Rb (mouse)	gap	-
Rb (rat)	gap	-

S588-p

GPtDHLEsACPLNLP

Rb (human)	GPtDHLEsACPLNLP	S588-p
Rb (mouse)	EGPDNLEPACPLSLP	P581
Rb (rat)	EGPDHLESACSLSLP	S580

T601-p

LPLQNNHtAADMyLs

Rb (human)	LPLQNNHtAADMyLs	T601-p
Rb (mouse)	LPLQGNHtAADMyLs	T594-p
Rb (rat)	LPLQSNHTAADMYLs	T593

Y606-p

NHtAADMyLsPVRsP

Rb (human)	NHtAADMyLsPVRsP	Y606-p
Rb (mouse)	NHtAADMyLsPLRsP	Y599-p
Rb (rat)	NHTAADMYLsPIRSP	Y598

S608-p

tAADMyLsPVRsPKK

Upstream

Downstream

Rb (human)
S608-p

Rb (mouse)
S601-p

2181 : Phospho-Rb (Ser608) Antibody

Rb (rat)
S600-p

2181 : Phospho-Rb (Ser608) Antibody

Effects on Modified Protein

molecular association, regulation
protein conformation

Effects on Biological Processes:

apoptosis, inhibited
cell cycle regulation
cell growth, induced

Kinase, in vitro:

CDK2 (human)
CDK4 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

UL97 (herpesvirus)

Regulatory protein:

EGFR (human)

Treatment

butyrate
retinoic_acid
RRD-251
seliciclib

Rb (human)	tAADMyLsPVRsPKK	S608-p
Rb (mouse)	tAADMyLsPLRsPKK	S601-p
Rb (rat)	TAADMYLsPIRSPKK	S600-p

S612-p

MyLsPVRsPKKKGsT

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation
protein conformation

Effects on Biological Processes:

apoptosis, induced
cell differentiation, induced
transcription, altered

Kinase, in vitro:

CDK2 (human)
CDK4 (human)
CDK6 (human)
Chk1 (human)
Chk2 (human)

Putative in vivo kinases:

Chk2 (human)
UL97 (herpesvirus)

Regulatory protein:

ATM (human)
Chk1 (human)
Chk2 (human)
EGFR (human)

Treatment

actinomycin_D
caffeine
Chk2_inhibitor_II
differentiation
etoposide
GW_8510
HPR
ionizing_radiation
KU-55933
phorbol_ester
SB218078
siRNA
UV

Rb (human)	MyLsPVRsPKKKGsT	S612-p
Rb (mouse)	MyLsPLRsPKKRTST	S605-p
Rb (rat)	MYLsPIRSPKKRTST	S604

S618-p

RsPKKKGsTTRVNst

Rb (human)	RsPKKKGsTTRVNst	S618-p
Rb (mouse)	RsPKKRTSTTRVNsA	S611
Rb (rat)	RSPKKRTSTTRVNSA	S610

S624-p

GsTTRVNstANAETQ

Rb (human)	GsTTRVNstANAETQ	S624-p
Rb (mouse)	TSTTRVNsAANTETQ	S617-p
Rb (rat)	TSTTRVNSAANTETQ	S616

T625-p

sTTRVNstANAETQA

Rb (human)	sTTRVNstANAETQA	T625-p
Rb (mouse)	STTRVNsAANTETQA	A618
Rb (rat)	STTRVNSAANTETQA	A617

K640-ub

TSAFQTQkPLKSTSL

Rb (human)	TSAFQTQkPLKSTSL	K640-ub
Rb (mouse)	ASAFHTQKPLKSTSL	K633
Rb (rat)	ASAFHTQKPLKSTSL	K632

K720-sm

KVKNIDLkFKIIVTA

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation
protein stabilization

Effects on Biological Processes:

cell growth, induced
transcription, inhibited

Regulatory protein:

SENP1 (human)

Rb (human)	KVKNIDLkFKIIVTA	K720-sm
Rb (mouse)	KVKNIDLkFKIIVTA	K713-sm
Rb (rat)	KVKNIDLKFKIIVTA	K712

T766-p

VFMQRLKtNILQyAs

Rb (human)	VFMQRLKtNILQyAs	T766-p
Rb (mouse)	VFMQRLKTNILQYAS	T759
Rb (rat)	VFMQRLKTNILQYAS	T758

Y771-p

LKtNILQyAstrPPt

Rb (human)	LKtNILQyAstrPPt	Y771-p
Rb (mouse)	LKTNILQYASTRPPt	Y764
Rb (rat)	LKTNILQYASTRPPT	Y763

S773-p

tNILQyAstrPPtLs

Rb (human)	tNILQyAstrPPtLs	S773-p
Rb (mouse)	TNILQYASTRPPtLs	S766
Rb (rat)	TNILQYASTRPPTLs	S765

T774-p

NILQyAstrPPtLsP

Rb (human)	NILQyAstrPPtLsP	T774-p
Rb (mouse)	NILQYASTRPPtLsP	T767
Rb (rat)	NILQYASTRPPTLsP	T766

R775-m2

ILQyAstrPPtLsPI

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

cell cycle regulation
transcription, inhibited

Rb (human)	ILQyAstrPPtLsPI	R775-m2
Rb (mouse)	ILQYASTRPPtLsPI	R768
Rb (rat)	ILQYASTRPPTLsPI	R767

T778-p

yAstrPPtLsPIPHI

Upstream

Treatment

imatinib

Rb (human)	yAstrPPtLsPIPHI	T778-p
Rb (mouse)	YASTRPPtLsPIPHI	T771-p
Rb (rat)	YASTRPPTLsPIPHI	T770

S780-p

strPPtLsPIPHIPr

Upstream

Downstream

141

Rb (human)
S780-p

Rb (mouse)
S773-p

Rb (rat)
S772-p

Effects on Modified Protein

activity, inhibited
molecular association, regulation
protein degradation

Effects on Biological Processes:

apoptosis, inhibited
carcinogenesis, induced
cell cycle regulation
cell growth, altered
cell growth, induced
transcription, altered
transcription, induced

Kinase, in vitro:

AurB (human)
CDK4 (human)
CDK6 (human)

Putative in vivo kinases:

CDK4 (human)
CDK6 (human)
CDK7 (human)
PKACA (human)
UL97 (herpesvirus)

Regulatory protein:

Akt1 (human)
ATR (human)
Bcl-2 (human)
CCNE1 (human)
CDC25A (human)
CDC37 (human)
GNL2 (human)
HRas (human)
ID1 (human)
KAP (mouse)
MDM2 (human)
Myc (human)
NOX4 (human)
p27Kip1 (human)
PARP14 (human)
RPL23A (human)
RPLP0 (human)
SHIP (human)
small T antigen (polyomavirus)
TR-beta1 (human)

Treatment

2-deoxyglucose
abemaciclib
alvocidib
apigenin
arsenite
BIM-23120
butyrate
Bz-423
caffeine
cAMP_analog
CVT-313
cytokines
GBE
GSK2334470
GW_8510
HPR
IGF-1
ionizing_radiation
IP(6)
LY294002
metribolone
miRNA
palbociclib
PD0332991
PDGF
phytohemagglutinin
PLX3397
PRL
radicicol
rapamycin
resibufogenin
ribociclib
riviciclib
seliciclib
serum
siRNA
somatostatin
TGF-beta
UV
virus infection
VP1
wounding
Y27632

Rb (human)	strPPtLsPIPHIPr	S780-p
Rb (mouse)	STRPPtLsPIPHIPR	S773-p
Rb (rat)	STRPPTLsPIPHIPR	S772-p

R787-m2

sPIPHIPrsPykFPs

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

cell cycle regulation
transcription, inhibited

Rb (human)	sPIPHIPrsPykFPs	R787-m2
Rb (mouse)	sPIPHIPRsPyKFss	R780
Rb (rat)	sPIPHIPRsPYKFSS	R779

S788-p

PIPHIPrsPykFPss

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell growth, altered

Kinase, in vitro:

CDK4 (human)
CDK6 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

UL97 (herpesvirus)

Regulatory protein:

VHL (human)

Treatment

CXCL12
imatinib

Rb (human)	PIPHIPrsPykFPss	S788-p
Rb (mouse)	PIPHIPRsPyKFsss	S781-p
Rb (rat)	PIPHIPRsPYKFSSs	S780-p

Y790-p

PHIPrsPykFPssPL

Rb (human)	PHIPrsPykFPssPL	Y790-p
Rb (mouse)	PHIPRsPyKFsssPL	Y783-p
Rb (rat)	PHIPRsPYKFSSsPL	Y782

K791-ub

HIPrsPykFPssPLr

Rb (human)	HIPrsPykFPssPLr	K791-ub
Rb (mouse)	HIPRsPyKFsssPLR	K784
Rb (rat)	HIPRsPYKFSSsPLR	K783

P793

PrsPykFPssPLrIP

Rb (human)	PrsPykFPssPLrIP	P793
Rb (mouse)	PRsPyKFsssPLRIP	S786-p
Rb (rat)	PRsPYKFSSsPLRIP	S785

S794-p

rsPykFPssPLrIPG

Rb (human)	rsPykFPssPLrIPG	S794-p
Rb (mouse)	RsPyKFsssPLRIPG	S787-p
Rb (rat)	RsPYKFSSsPLRIPG	S786

S795-p

sPykFPssPLrIPGG

Upstream

Downstream

109

Rb (human)
S795-p

9301 : Phospho-Rb (Ser795) Antibody

Rb (rat)
S787-p

9301 : Phospho-Rb (Ser795) Antibody

Effects on Modified Protein

activity, inhibited
molecular association, regulation

Effects on Biological Processes:

carcinogenesis, induced
cell cycle regulation
cell growth, altered
cell growth, induced

Kinase, in vitro:

CDK18 (human)
CDK4 (human)
CDK5 (human)
CDK6 (human)
CDK9 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

CDK2 (mouse)
UL97 (herpesvirus)

Regulatory protein:

ARF1 (human)
Bcl-2 (human)
CCNE1 (human)
CDC37 (human)
CDK20 (human)
CDK7 (human)
DYNLT1 (human)
KAP (mouse)

Treatment

Bz-423
Chk2_inhibitor_II
cytokines
DCA
eflornithine
eusynstyelamide B
GW_8510
HPR
ischemia
LY294002
metribolone
phorbol_ester
phytohemagglutinin
PX-478
rapamycin
sardomozide
serum
VP1
Y27632

Rb (human)	sPykFPssPLrIPGG	S795-p
Rb (mouse)	sPyKFsssPLRIPGG	S788-p
Rb (rat)	sPYKFSSsPLRIPGG	S787-p

R798-m2

kFPssPLrIPGGNIy

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

cell cycle regulation
transcription, inhibited

Rb (human)	kFPssPLrIPGGNIy	R798-m2
Rb (mouse)	KFsssPLRIPGGNIy	R791
Rb (rat)	KFSSsPLRIPGGNIY	R790

Y805-p

rIPGGNIyIsPLksP

Upstream

Kinase, in vitro:

Abl (human)

Putative in vivo kinases:

Abl (human)

Treatment

imatinib
metastatic potential

Rb (human)	rIPGGNIyIsPLksP	Y805-p
Rb (mouse)	RIPGGNIyIsPLksP	Y798-p
Rb (rat)	RIPGGNIYIsPLKsP	Y797

S807-p

PGGNIyIsPLksPyk

Upstream

Downstream

152

Rb (human)
S807-p

Rb (mouse)
S800-p

Rb (rat)
S799-p

Effects on Modified Protein

molecular association, regulation
phosphorylation

Effects on Biological Processes:

carcinogenesis, induced
cell cycle regulation
cell growth, altered
cell growth, induced
transcription, altered

Kinase, in vitro:

CDK1 (human)
CDK18 (human)
CDK2 (human)
CDK4 (human)
CDK5 (human)
CDK6 (human)
CDK9 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

CDK2 (human)
CDK3 (human)
CDK4 (human)
CDK6 (human)
CDK7 (human)
UL97 (herpesvirus)

Regulatory protein:

Akt1 (human)
Bcl-2 (human)
CCNE1 (human)
Diaphanous-2 (human)
Diaphanous-3 (human)
DYNLT1 (human)
HRas (human)
JMJD3 (human)
KAP (mouse)
MLK3 (human)
NOX4 (human)
p57Kip2 (human)
p73 (human)
PIK3CA (human)
PPP1R1C (human)
VHL (human)

Treatment

3-Methyladenine
7rh
abemaciclib
anti-CD3
bicyclol
Bz-423
caffeine
catalase
DOI
eflornithine
estradiol
eusynstyelamide B
faslodex
FGF2
fluvastatin
GW_8510
insulin
IP(6)
lovastatin
LRRK2-IN-1
LY294002
metastatic potential
mevastatin
palbociclib
PD98059
phytohemagglutinin
pravastatin
psoralen
rapamycin
resibufogenin
resveratrol
retinoic_acid
sardomozide
serum
serum_starvation
simvastatin
siRNA
TGF-beta
UV
VP1
Y27632

Rb (human)	PGGNIyIsPLksPyk	S807-p
Rb (mouse)	PGGNIyIsPLksPyK	S800-p
Rb (rat)	PGGNIYIsPLKsPYK	S799-p

K810-ub

NIyIsPLksPykIsE

Rb (human)	NIyIsPLksPykIsE	K810-ub
Rb (mouse)	NIyIsPLksPyKIsE	K803-ub
Rb (rat)	NIYIsPLKsPYKISE	K802

K810-m1

NIyIsPLksPykIsE

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation
phosphorylation
protein conformation

Effects on Biological Processes:

DNA repair, induced
carcinogenesis, inhibited
cell cycle regulation
cell growth, inhibited
transcription, induced
transcription, inhibited

Treatment

etoposide
siRNA

Rb (human)	NIyIsPLksPykIsE	K810-m1
Rb (mouse)	NIyIsPLKsPyKIsE	K803
Rb (rat)	NIYIsPLKsPYKISE	K802

K810-m2

NIyIsPLksPykIsE

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

DNA repair, induced
carcinogenesis, inhibited
cell cycle regulation
cell growth, inhibited

Rb (human)	NIyIsPLksPykIsE	K810-m2
Rb (mouse)	NIyIsPLKsPyKIsE	K803
Rb (rat)	NIYIsPLKsPYKISE	K802

S811-p

IyIsPLksPykIsEG

Upstream

Downstream

115

Rb (human)
S811-p

Rb (mouse)
S804-p

Rb (rat)
S803-p

Effects on Modified Protein

molecular association, regulation
phosphorylation

Effects on Biological Processes:

carcinogenesis, induced
cell cycle regulation
cell growth, altered
cell growth, induced
transcription, altered

Kinase, in vitro:

CDK1 (human)
CDK18 (human)
CDK2 (human)
CDK4 (human)
CDK5 (human)
CDK6 (human)
CDK9 (human)

Putative in vivo kinases:

CDK2 (human)
CDK3 (human)
CDK4 (human)
CDK6 (human)
CDK7 (human)
UL97 (herpesvirus)

Regulatory protein:

Akt1 (human)
Bcl-2 (human)
CCNE1 (human)
DYNLT1 (human)
HRas (human)
JMJD3 (human)
KAP (mouse)
MLK3 (human)
NOX4 (human)
p57Kip2 (human)
p73 (human)
PIK3CA (human)
PPP1R1C (human)
VHL (human)

Treatment

3-Methyladenine
7rh
abemaciclib
anti-CD3
Bz-423
caffeine
catalase
DOI
eflornithine
estradiol
eusynstyelamide B
faslodex
FGF2
fluvastatin
insulin
IP(6)
ischemia
lovastatin
LRRK2-IN-1
LY294002
metastatic potential
mevastatin
palbociclib
phytohemagglutinin
pravastatin
psoralen
rapamycin
resibufogenin
resveratrol
retinoic_acid
sardomozide
serum
simvastatin
siRNA
TGF-beta
UV
VP1
Y27632

Rb (human)	IyIsPLksPykIsEG	S811-p
Rb (mouse)	IyIsPLksPyKIsEG	S804-p
Rb (rat)	IYIsPLKsPYKISEG	S803-p

Y813-p

IsPLksPykIsEGLP

Rb (human)	IsPLksPykIsEGLP	Y813-p
Rb (mouse)	IsPLksPyKIsEGLP	Y806-p
Rb (rat)	IsPLKsPYKISEGLP	Y805

K814-ub

sPLksPykIsEGLPt

Rb (human)	sPLksPykIsEGLPt	K814-ub
Rb (mouse)	sPLksPyKIsEGLPt	K807
Rb (rat)	sPLKsPYKISEGLPt	K806

S816-p

LksPykIsEGLPtPt

Upstream

Regulatory protein:

VHL (human)

Rb (human)	LksPykIsEGLPtPt	S816-p
Rb (mouse)	LksPyKIsEGLPtPt	S809-p
Rb (rat)	LKsPYKISEGLPtPt	S808

T821-p

kIsEGLPtPtkMtPR

Upstream

Downstream

Effects on Modified Protein

acetylation
activity, induced
molecular association, regulation

Effects on Biological Processes:

apoptosis, inhibited
cell cycle regulation
cell growth, altered
cell growth, induced
transcription, induced

Kinase, in vitro:

CDK2 (human)
CDK6 (human)

Putative in vivo kinases:

CDK2 (human)
UL97 (herpesvirus)

Regulatory protein:

CCND1 (human)
CCNE1 (human)
p21Cip1 (human)
p27Kip1 (human)
p53 (human)
PARP14 (human)
small T antigen (polyomavirus)
VHL (human)

Treatment

anti-CD3
CVT-313
dasatinib
flavopiridol
GW_8510
HPR
IGF-1
ischemia
palbociclib
PD0332991
PDGF
radicicol
seliciclib
serum

Rb (human)	kIsEGLPtPtkMtPR	T821-p
Rb (mouse)	KIsEGLPtPtKMtPR	T814-p
Rb (rat)	KISEGLPtPtKMtPR	T813-p

T823-p

sEGLPtPtkMtPRsR

Rb (human)	sEGLPtPtkMtPRsR	T823-p
Rb (mouse)	sEGLPtPtKMtPRSR	T816-p
Rb (rat)	SEGLPtPtKMtPRSR	T815-p

K824-ub

EGLPtPtkMtPRsRI

Rb (human)	EGLPtPtkMtPRsRI	K824-ub
Rb (mouse)	EGLPtPtKMtPRSRI	K817
Rb (rat)	EGLPtPtKMtPRSRI	K816

T826-p

LPtPtkMtPRsRILV

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell cycle regulation
cell growth, altered
cell growth, induced
transcription, induced

Kinase, in vitro:

CDK2 (human)
CDK4 (human)
CDK6 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

UL97 (herpesvirus)

Regulatory protein:

CCND1 (human)
CCNE1 (human)
CDC6 (human)
p16-INK4A (human)
p21Cip1 (human)
p27Kip1 (human)
p53 (human)
PARP14 (human)
small T antigen (polyomavirus)
VHL (human)

Treatment

anti-CD3
dasatinib
seliciclib
serum
siRNA

Rb (human)	LPtPtkMtPRsRILV	T826-p
Rb (mouse)	LPtPtKMtPRSRILV	T819-p
Rb (rat)	LPtPtKMtPRSRILV	T818-p

S829-p

PtkMtPRsRILVsIG

Rb (human)	PtkMtPRsRILVsIG	S829-p
Rb (mouse)	PtKMtPRSRILVSIG	S822
Rb (rat)	PtKMtPRSRILVsIG	S821

S834-p

PRsRILVsIGEsFGt

Rb (human)	PRsRILVsIGEsFGt	S834-p
Rb (mouse)	PRSRILVSIGESFGt	S827
Rb (rat)	PRSRILVsIGEsFGT	S826-p

S838-p

ILVsIGEsFGtsEkF

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell cycle regulation
chromatin organization, altered
signaling pathway regulation

Kinase, in vitro:

P38A (human)

Putative in vivo kinases:

P38A (human)

Treatment

calyculin_A
SB203580
vanadate

Rb (human)	ILVsIGEsFGtsEkF	S838-p
Rb (mouse)	ILVSIGESFGtSEKF	S831
Rb (rat)	ILVsIGEsFGTsEKF	S830-p

T841-p

sIGEsFGtsEkFQkI

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell cycle regulation
chromatin organization, altered
signaling pathway regulation

Kinase, in vitro:

P38A (human)

Putative in vivo kinases:

P38A (human)

Treatment

calyculin_A
ischemia
SB203580
vanadate

Rb (human)	sIGEsFGtsEkFQkI	T841-p
Rb (mouse)	SIGESFGtSEKFQKI	T834-p
Rb (rat)	sIGEsFGTsEKFQKI	T833

S842-p

IGEsFGtsEkFQkIN

Rb (human)	IGEsFGtsEkFQkIN	S842-p
Rb (mouse)	IGESFGtSEKFQKIN	S835
Rb (rat)	IGEsFGTsEKFQKIN	S834-p

K844-ub

EsFGtsEkFQkINQM

Rb (human)	EsFGtsEkFQkINQM	K844-ub
Rb (mouse)	ESFGtSEKFQKINQM	K837
Rb (rat)	EsFGTsEKFQKINQM	K836

K847-ub

GtsEkFQkINQMVCN

Rb (human)	GtsEkFQkINQMVCN	K847-ub
Rb (mouse)	GtSEKFQKINQMVCN	K840
Rb (rat)	GTsEKFQKINQMVCN	K839

S855-p

INQMVCNsDrVLkRs

Rb (human)	INQMVCNsDrVLkRs	S855-p
Rb (mouse)	INQMVCNsDRVLKRS	S848-p
Rb (rat)	INQMVCNSDRVLKRS	S847

R857-m1

QMVCNsDrVLkRsAE

Rb (human)	QMVCNsDrVLkRsAE	R857-m1
Rb (mouse)	QMVCNsDRVLKRSAE	R850
Rb (rat)	QMVCNSDRVLKRSAE	R849

K860-ub

CNsDrVLkRsAEGsN

Rb (human)	CNsDrVLkRsAEGsN	K860-ub