Other Species / Isoforms
  Rb (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
T5-p
___MPPKtPRKTAAT
1 0
Rb (human) ___MPPKtPRKTAAT T5-p
Rb (mouse) ___MPPKAPRRAAAA A5
Rb (rat) ___MPPKAPRRTAAA A5
S37-p
EEDPEQDsGPEDLPL
Upstream
0 43
Treatment
  • nocodazole
Rb (human) EEDPEQDsGPEDLPL S37-p
Rb (mouse) EDDPAQDsGPEELPL S31-p
Rb (rat) EDDPAQDsDPEELPL S30-p
K63-ub
DFTALCQkLkIPDHV
0 2
Rb (human) DFTALCQkLkIPDHV K63-ub
Rb (mouse) EFIALCQkLKVPDHV K57-ub
Rb (rat) EFIALCQKLKVPDHV K56
K65-ub
TALCQkLkIPDHVRE
0 3
Rb (human) TALCQkLkIPDHVRE K65-ub
Rb (mouse) IALCQkLKVPDHVRE K59
Rb (rat) IALCQKLKVPDHVRE K58
K94-ub
VLGGYIQkKKELWGI
0 1
Rb (human) VLGGYIQkKKELWGI K94-ub
Rb (mouse) ILEGYIQKKKELWGI K88
Rb (rat) ILEGYIQKKKELWGI K87
K136-ub
HKFFNLLkEIDtSTk
0 1
Rb (human) HKFFNLLkEIDtSTk K136-ub
Rb (mouse) YKFFDLLKEIDTSTK K130
Rb (rat) YKFFDLLKEIDTSTK K129
T140-p
NLLkEIDtSTkVDNA
0 1
Rb (human) NLLkEIDtSTkVDNA T140-p
Rb (mouse) DLLKEIDTSTKVDNA T134
Rb (rat) DLLKEIDTSTKVDNA T133
K143-ub
kEIDtSTkVDNAMsR
0 3
Rb (human) kEIDtSTkVDNAMsR K143-ub
Rb (mouse) KEIDTSTKVDNAMSR K137
Rb (rat) KEIDTSTKVDNAVSR K136
S149-p
TkVDNAMsRLLKKYD
0 2
Rb (human) TkVDNAMsRLLKKYD S149-p
Rb (mouse) TKVDNAMSRLLKKYN S143
Rb (rat) TKVDNAVSRLLKKYN S142
S163-p
DVLFALFsKLERTCE
0 1
Rb (human) DVLFALFsKLERTCE S163-p
Rb (mouse) NVLCALYSKLERTCE S157
Rb (rat) NVLCALYSKLERTCG S156
S230-p
LDYFIKLsPPMLLKE
2 0
Rb (human) LDYFIKLsPPMLLKE S230-p
Rb (mouse) VDYFIKFsPPALLRE S224-p
Rb (rat) LDYFIKLSPPALLRE S223
Y239-p
PMLLKEPyKtAVIPI
0 1
Rb (human) PMLLKEPyKtAVIPI Y239-p
Rb (mouse) PALLREPYKTAAIPI Y233
Rb (rat) PALLREPYKTAATPI Y232
T241-p
LLKEPyKtAVIPING
0 1
Rb (human) LLKEPyKtAVIPING T241-p
Rb (mouse) LLREPYKTAAIPING T235
Rb (rat) LLREPYKTAATPING T234
S249-p
AVIPINGsPRtPRRG
Upstream
Downstream
14 126
Effects on Modified Protein
  • activity, induced
  • activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
  • cell growth, induced
  • cell growth, inhibited
  • transcription, inhibited
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
  • P38A (human)
Phosphatases, in vitro:
  • PPP1CA (human)
  • PPP1CC (human)
Putative in vivo kinases:
  • CDK2 (human)
  • P38A (human)
Regulatory protein:
  • WT1 (human)
Treatment
  • butyrate
  • dasatinib
  • nocodazole
  • progestin_R5020
  • rapamycin
  • siRNA
  • TGF-beta
Rb (human) AVIPINGsPRtPRRG S249-p
Rb (mouse) AAIPINGsPRtPRRG S243-p
Rb (rat) AATPINGsPRtPRRG S242-p
T252-p
PINGsPRtPRRGQNR
Upstream
Downstream
16 87
Effects on Modified Protein
  • activity, induced
  • activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
  • cell growth, induced
  • cell growth, inhibited
  • transcription, inhibited
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
  • CDK4 (human)
  • P38A (human)
Putative in vivo kinases:
  • CDK2 (human)
  • P38A (human)
Regulatory protein:
  • WT1 (human)
Treatment
  • butyrate
  • progestin_R5020
  • rapamycin
  • siRNA
  • TGF-beta
Rb (human) PINGsPRtPRRGQNR T252-p
Rb (mouse) PINGsPRtPRRGQNR T246-p
Rb (rat) PINGsPRtPRRGQNR T245-p
K265-ub
NRSARIAkQLENDTR
0 4
Rb (human) NRSARIAkQLENDTR K265-ub
Rb (mouse) NRSARIAKQLENDTR K259
Rb (rat) NRSARIAKQLESDTR K258
K279-ub
RIIEVLCkEHECNID
0 3
Rb (human) RIIEVLCkEHECNID K279-ub
Rb (mouse) RIIEVLCKEHECNID K273
Rb (rat) RTIEVLCKEHECNVD K272
K289-ub
ECNIDEVkNVYFKNF
0 2
Rb (human) ECNIDEVkNVYFKNF K289-ub
Rb (mouse) ECNIDEVKNVYFKNF K283
Rb (rat) ECNVDEVKNVYFKNF K282
K319-ub
PEVENLSkRyEEIyL
0 1
Rb (human) PEVENLSkRyEEIyL K319-ub
Rb (mouse) PEVESLSKRYEEVYL K313
Rb (rat) PELESLSKRYEEVYL K312
Y321-p
VENLSkRyEEIyLkN
0 4
Rb (human) VENLSkRyEEIyLkN Y321-p
Rb (mouse) VESLSKRYEEVYLKN Y315
Rb (rat) LESLSKRYEEVYLKS Y314
Y325-p
SkRyEEIyLkNKDLD
0 4
Rb (human) SkRyEEIyLkNKDLD Y325-p
Rb (mouse) SKRYEEVYLKNKDLD Y319
Rb (rat) SKRYEEVYLKSKDLD Y318
K327-ub
RyEEIyLkNKDLDAR
0 1
Rb (human) RyEEIyLkNKDLDAR K327-ub
Rb (mouse) RYEEVYLKNKDLDAR K321
Rb (rat) RYEEVYLKSKDLDAR K320
K341-ub
RLFLDHDkTLQtdsI
0 1
Rb (human) RLFLDHDkTLQtdsI K341-ub
Rb (mouse) RLFLDHDKTLQTDPI K335
Rb (rat) RLFLDHDKTLQTDTI K334
T345-p
DHDkTLQtdsIDsFE
0 1
Rb (human) DHDkTLQtdsIDsFE T345-p
Rb (mouse) DHDKTLQTDPIDsFE T339
Rb (rat) DHDKTLQTDTIDSFE T338
D346-ca
HDkTLQtdsIDsFEt
0 1
Rb (human) HDkTLQtdsIDsFEt D346-ca
Rb (mouse) HDKTLQTDPIDsFET D340
Rb (rat) HDKTLQTDTIDSFET D339
S347-p
DkTLQtdsIDsFEtQ
1 4
Rb (human) DkTLQtdsIDsFEtQ S347-p
Rb (mouse) DKTLQTDPIDsFETE P341
Rb (rat) DKTLQTDTIDSFETE T340
S350-p
LQtdsIDsFEtQRtP
0 15
Rb (human) LQtdsIDsFEtQRtP S350-p
Rb (mouse) LQTDPIDsFETERtP S344-p
Rb (rat) LQTDTIDSFETERTP S343
T353-p
dsIDsFEtQRtPRks
0 14
Rb (human) dsIDsFEtQRtPRks T353-p
Rb (mouse) DPIDsFETERtPRKN T347
Rb (rat) DTIDSFETERTPRKS T346
T356-p
DsFEtQRtPRksNLD
Upstream
Downstream
12 53
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell growth, induced
Kinase, in vitro:
  • CDK2 (human)
  • CDK4 (human)
Phosphatases, in vitro:
  • PPP1CA (human)
  • PPP1CC (human)
Putative in vivo kinases:
  • UL97 (herpesvirus)
Regulatory protein:
  • CCNF (human)
  • NIPP-1 (human)
  • Oct4 (human)
Treatment
  • actinomycin_D
  • anti-CD3
  • butyrate
  • GW_8510
  • lapatinib
  • palbociclib
  • PD98059
  • SB218078
Rb (human) DsFEtQRtPRksNLD T356-p
Rb (mouse) DsFETERtPRKNNPD T350-p
Rb (rat) DSFETERTPRKSNPD T349
K359-ub
EtQRtPRksNLDEEV
0 1
Rb (human) EtQRtPRksNLDEEV K359-ub
Rb (mouse) ETERtPRKNNPDEEA K353
Rb (rat) ETERTPRKSNPDEEA K352
S360-p
tQRtPRksNLDEEVN
0 2
Rb (human) tQRtPRksNLDEEVN S360-p
Rb (mouse) TERtPRKNNPDEEAN N354
Rb (rat) TERTPRKSNPDEEAN S353
P370
DEEVNVIPPHtPVRT
1 6
Rb (human) DEEVNVIPPHtPVRT P370
Rb (mouse) DEEANVVtPHtPVRT T364-p
Rb (rat) DEEANMVtPHtPVRT T363-p
T373-p
VNVIPPHtPVRTVMN
Upstream
Downstream
9 85
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
  • CDK4 (human)
Putative in vivo kinases:
  • UL97 (herpesvirus)
Regulatory protein:
  • VHL (human)
Treatment
  • anti-CD3
  • cytokines
  • EGF
  • GW_8510
  • phytohemagglutinin
Rb (human) VNVIPPHtPVRTVMN T373-p
Rb (mouse) ANVVtPHtPVRTVMN T367-p
Rb (rat) ANMVtPHtPVRTVMN T366-p
K420-ub
ESILKRVkDIGYIFk
0 2
Rb (human) ESILKRVkDIGYIFk K420-ub
Rb (mouse) ENILKRVKDVGHIFK K414
Rb (rat) ENILKRVKDVGHIFK K413
K427-ac
kDIGYIFkEKFAkAV
0 1
Rb (human) kDIGYIFkEKFAkAV K427-ac
Rb (mouse) KDVGHIFKEKFANAV K421
Rb (rat) KDVGHIFKEKFASAV K420
K427-ub
kDIGYIFkEKFAkAV
0 1
Rb (human) kDIGYIFkEKFAkAV K427-ub
Rb (mouse) KDVGHIFKEKFANAV K421
Rb (rat) KDVGHIFKEKFASAV K420
K432-ub
IFkEKFAkAVGQGCV
0 1
Rb (human) IFkEKFAkAVGQGCV K432-ub
Rb (mouse) IFKEKFANAVGQGCV N426
Rb (rat) IFKEKFASAVGQGCI S425
Y446
VEIGSQRYKLGVRLY
0 1
Rb (human) VEIGSQRYKLGVRLY Y446
Rb (mouse) VDIGVQRyKLGVRLY Y440-p
Rb (rat) IDIGAQRYKLGVRLY Y439
Y454-p
KLGVRLYyRVMESML
0 1
Rb (human) KLGVRLYyRVMESML Y454-p
Rb (mouse) KLGVRLYYRVMESML Y448
Rb (rat) KLGVRLYYRVMESML Y447
K537-ub
KVIESFIkAEGNLTR
0 1
Rb (human) KVIESFIkAEGNLTR K537-ub
Rb (mouse) KVIESFIKVEANLTR K531
Rb (rat) KVIESFIKVEANLTR K530
K548-ac
NLTREMIkHLERCEH
Upstream
0 1
Treatment
  • MS275
Rb (human) NLTREMIkHLERCEH K548-ac
Rb (mouse) NLTREMIKHLERCEH K542
Rb (rat) NLTREMIKHLERCEH K541
S567-p
SLAWLSDsPLFDLIk
Upstream
Downstream
6 0
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • apoptosis, induced
  • apoptosis, inhibited
  • cell growth, induced
Kinase, in vitro:
  • CDK2 (human)
  • P38A (human)
Putative in vivo kinases:
  • P38A (human)
Regulatory protein:
  • MKK3 (human)
  • P38A (human)
  • P38B (human)
Treatment
  • 3MCIC
  • butyrate
  • etoposide
  • SB203580
  • seliciclib
Rb (human) SLAWLSDsPLFDLIk S567-p
Rb (mouse) SLAWLSDsPLFDLIK S561-p
Rb (rat) SLAWLSDSPLFDLIK S560
K574-ub
sPLFDLIkQSKDREG
0 1
Rb (human) sPLFDLIkQSKDREG K574-ub
Rb (mouse) sPLFDLIKQSKDGEG K568
Rb (rat) SPLFDLIKQSKDGEG K567
T583-p
SKDREGPtDHLEsAC
0 1
Rb (human) SKDREGPtDHLEsAC T583-p
Rb (mouse) gap -
Rb (rat) gap -
S588-p
GPtDHLEsACPLNLP
0 2
Rb (human) GPtDHLEsACPLNLP S588-p
Rb (mouse) EGPDNLEPACPLSLP P581
Rb (rat) EGPDHLESACSLSLP S580
T601-p
LPLQNNHtAADMyLs
0 12
Rb (human) LPLQNNHtAADMyLs T601-p
Rb (mouse) LPLQGNHtAADMyLs T594-p
Rb (rat) LPLQSNHTAADMYLs T593
Y606-p
NHtAADMyLsPVRsP
0 12
Rb (human) NHtAADMyLsPVRsP Y606-p
Rb (mouse) NHtAADMyLsPLRsP Y599-p
Rb (rat) NHTAADMYLsPIRSP Y598
S608-p
tAADMyLsPVRsPKK
Upstream
Downstream
11 39
Rb (human)
S608-p
Rb (mouse)
S601-p
Rb (rat)
S600-p
Effects on Modified Protein
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
  • cell growth, induced
Kinase, in vitro:
  • CDK2 (human)
  • CDK4 (human)
Phosphatases, in vitro:
  • PPP1CA (human)
  • PPP1CC (human)
Putative in vivo kinases:
  • UL97 (herpesvirus)
Regulatory protein:
  • EGFR (human)
Treatment
  • butyrate
  • retinoic_acid
  • RRD-251
  • seliciclib
Rb (human) tAADMyLsPVRsPKK S608-p
Rb (mouse) tAADMyLsPLRsPKK S601-p
Rb (rat) TAADMYLsPIRSPKK S600-p
S612-p
MyLsPVRsPKKKGsT
Upstream
Downstream
11 51
Effects on Modified Protein
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • apoptosis, induced
  • cell differentiation, induced
  • transcription, altered
Kinase, in vitro:
  • CDK2 (human)
  • CDK4 (human)
  • CDK6 (human)
  • Chk1 (human)
  • Chk2 (human)
Putative in vivo kinases:
  • Chk2 (human)
  • UL97 (herpesvirus)
Regulatory protein:
  • ATM (human)
  • Chk1 (human)
  • Chk2 (human)
  • EGFR (human)
Treatment
  • actinomycin_D
  • caffeine
  • Chk2_inhibitor_II
  • differentiation
  • etoposide
  • GW_8510
  • HPR
  • ionizing_radiation
  • KU-55933
  • phorbol_ester
  • SB218078
  • siRNA
  • UV
Rb (human) MyLsPVRsPKKKGsT S612-p
Rb (mouse) MyLsPLRsPKKRTST S605-p
Rb (rat) MYLsPIRSPKKRTST S604
S618-p
RsPKKKGsTTRVNst
0 1
Rb (human) RsPKKKGsTTRVNst S618-p
Rb (mouse) RsPKKRTSTTRVNsA S611
Rb (rat) RSPKKRTSTTRVNSA S610
S624-p
GsTTRVNstANAETQ
0 48
Rb (human) GsTTRVNstANAETQ S624-p
Rb (mouse) TSTTRVNsAANTETQ S617-p
Rb (rat) TSTTRVNSAANTETQ S616
T625-p
sTTRVNstANAETQA
0 5
Rb (human) sTTRVNstANAETQA T625-p
Rb (mouse) STTRVNsAANTETQA A618
Rb (rat) STTRVNSAANTETQA A617
K640-ub
TSAFQTQkPLKSTSL
0 3
Rb (human) TSAFQTQkPLKSTSL K640-ub
Rb (mouse) ASAFHTQKPLKSTSL K633
Rb (rat) ASAFHTQKPLKSTSL K632
K720-sm
KVKNIDLkFKIIVTA
Upstream
Downstream
2 0
Effects on Modified Protein
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • cell growth, induced
  • transcription, inhibited
Regulatory protein:
  • SENP1 (human)
Rb (human) KVKNIDLkFKIIVTA K720-sm
Rb (mouse) KVKNIDLkFKIIVTA K713-sm
Rb (rat) KVKNIDLKFKIIVTA K712
T766-p
VFMQRLKtNILQyAs
0 1
Rb (human) VFMQRLKtNILQyAs T766-p
Rb (mouse) VFMQRLKTNILQYAS T759
Rb (rat) VFMQRLKTNILQYAS T758
Y771-p
LKtNILQyAstrPPt
0 3
Rb (human) LKtNILQyAstrPPt Y771-p
Rb (mouse) LKTNILQYASTRPPt Y764
Rb (rat) LKTNILQYASTRPPT Y763
S773-p
tNILQyAstrPPtLs
0 8
Rb (human) tNILQyAstrPPtLs S773-p
Rb (mouse) TNILQYASTRPPtLs S766
Rb (rat) TNILQYASTRPPTLs S765
T774-p
NILQyAstrPPtLsP
0 10
Rb (human) NILQyAstrPPtLsP T774-p
Rb (mouse) NILQYASTRPPtLsP T767
Rb (rat) NILQYASTRPPTLsP T766
R775-m2
ILQyAstrPPtLsPI
Downstream
1 0
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • cell cycle regulation
  • transcription, inhibited
Rb (human) ILQyAstrPPtLsPI R775-m2
Rb (mouse) ILQYASTRPPtLsPI R768
Rb (rat) ILQYASTRPPTLsPI R767
T778-p
yAstrPPtLsPIPHI
Upstream
0 75
Treatment
  • imatinib
Rb (human) yAstrPPtLsPIPHI T778-p
Rb (mouse) YASTRPPtLsPIPHI T771-p
Rb (rat) YASTRPPTLsPIPHI T770
S780-p
strPPtLsPIPHIPr
Upstream
Downstream
76 141
Rb (human)
S780-p
Rb (mouse)
S773-p
Rb (rat)
S772-p
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
  • cell growth, altered
  • cell growth, induced
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • AurB (human)
  • CDK4 (human)
  • CDK6 (human)
Putative in vivo kinases:
  • CDK4 (human)
  • CDK6 (human)
  • PKACA (human)
  • UL97 (herpesvirus)
Regulatory protein:
  • Akt1 (human)
  • ATR (human)
  • Bcl-2 (human)
  • CCNE1 (human)
  • CDC25A (human)
  • CDC37 (human)
  • GNL2 (human)
  • HRas (human)
  • ID1 (human)
  • KAP (mouse)
  • MDM2 (human)
  • Myc (human)
  • NOX4 (human)
  • RPL23A (human)
  • RPLP0 (human)
  • SHIP (human)
  • small T antigen (polyomavirus)
  • TR-beta1 (human)
Treatment
  • 2-deoxyglucose
  • alvocidib
  • apigenin
  • arsenite
  • BIM-23120
  • butyrate
  • Bz-423
  • caffeine
  • cAMP_analog
  • CVT-313
  • cytokines
  • GSK2334470
  • GW_8510
  • HPR
  • IGF-1
  • ionizing_radiation
  • IP(6)
  • LY294002
  • metribolone
  • miRNA
  • palbociclib
  • PD0332991
  • PDGF
  • phytohemagglutinin
  • PRL
  • radicicol
  • rapamycin
  • resibufogenin
  • ribociclib
  • riviciclib
  • seliciclib
  • serum
  • siRNA
  • somatostatin
  • TGF-beta
  • UV
  • wounding
  • Y27632
Rb (human) strPPtLsPIPHIPr S780-p
Rb (mouse) STRPPtLsPIPHIPR S773-p
Rb (rat) STRPPTLsPIPHIPR S772-p
R787-m2
sPIPHIPrsPykFPs
Downstream
1 0
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • cell cycle regulation
  • transcription, inhibited
Rb (human) sPIPHIPrsPykFPs R787-m2
Rb (mouse) sPIPHIPRsPyKFss R780
Rb (rat) sPIPHIPRsPYKFSS R779
S788-p
PIPHIPrsPykFPss
Upstream
Downstream
11 95
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • CDK4 (human)
  • CDK6 (human)
Phosphatases, in vitro:
  • PPP1CA (human)
  • PPP1CC (human)
Putative in vivo kinases:
  • UL97 (herpesvirus)
Regulatory protein:
  • VHL (human)
Treatment
  • CXCL12
  • imatinib
Rb (human) PIPHIPrsPykFPss S788-p
Rb (mouse) PIPHIPRsPyKFsss S781-p
Rb (rat) PIPHIPRsPYKFSSs S780-p
Y790-p
PHIPrsPykFPssPL
0 35
Rb (human) PHIPrsPykFPssPL Y790-p
Rb (mouse) PHIPRsPyKFsssPL Y783-p
Rb (rat) PHIPRsPYKFSSsPL Y782
K791-ub
HIPrsPykFPssPLr
0 3
Rb (human) HIPrsPykFPssPLr K791-ub
Rb (mouse) HIPRsPyKFsssPLR K784
Rb (rat) HIPRsPYKFSSsPLR K783
P793
PrsPykFPssPLrIP
1 1
Rb (human) PrsPykFPssPLrIP P793
Rb (mouse) PRsPyKFsssPLRIP S786-p
Rb (rat) PRsPYKFSSsPLRIP S785
S794-p
rsPykFPssPLrIPG
1 74
Rb (human) rsPykFPssPLrIPG S794-p
Rb (mouse) RsPyKFsssPLRIPG S787-p
Rb (rat) RsPYKFSSsPLRIPG S786
S795-p
sPykFPssPLrIPGG
Upstream
Downstream
45 109
Rb (human)
S795-p
Rb (rat)
S787-p
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, altered
  • cell growth, induced
Kinase, in vitro:
  • CDK18 (human)
  • CDK4 (human)
  • CDK5 (human)
  • CDK6 (human)
  • CDK9 (human)
Phosphatases, in vitro:
  • PPP1CA (human)
  • PPP1CC (human)
Putative in vivo kinases:
  • CDK2 (mouse)
  • UL97 (herpesvirus)
Regulatory protein:
  • ARF1 (human)
  • Bcl-2 (human)
  • CCNE1 (human)
  • CDC37 (human)
  • CDK20 (human)
  • DYNLT1 (human)
  • KAP (mouse)
Treatment
  • Bz-423
  • Chk2_inhibitor_II
  • cytokines
  • eflornithine
  • eusynstyelamide B
  • GW_8510
  • HPR
  • ischemia
  • LY294002
  • metribolone
  • phorbol_ester
  • phytohemagglutinin
  • rapamycin
  • sardomozide
  • serum
  • Y27632
Rb (human) sPykFPssPLrIPGG S795-p
Rb (mouse) sPyKFsssPLRIPGG S788-p
Rb (rat) sPYKFSSsPLRIPGG S787-p
R798-m2
kFPssPLrIPGGNIy
Downstream
1 0
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • cell cycle regulation
  • transcription, inhibited
Rb (human) kFPssPLrIPGGNIy R798-m2
Rb (mouse) KFsssPLRIPGGNIy R791
Rb (rat) KFSSsPLRIPGGNIY R790
Y805-p
rIPGGNIyIsPLksP
Upstream
1 33
Kinase, in vitro:
  • Abl (human)
Putative in vivo kinases:
  • Abl (human)
Treatment
  • imatinib
  • metastatic potential
Rb (human) rIPGGNIyIsPLksP Y805-p
Rb (mouse) RIPGGNIyIsPLksP Y798-p
Rb (rat) RIPGGNIYIsPLKsP Y797
S807-p
PGGNIyIsPLksPyk
Upstream
Downstream
65 152
Rb (human)
S807-p
Rb (mouse)
S800-p
Rb (rat)
S799-p
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, altered
  • transcription, altered
Kinase, in vitro:
  • CDK1 (human)
  • CDK18 (human)
  • CDK2 (human)
  • CDK4 (human)
  • CDK5 (human)
  • CDK6 (human)
  • CDK9 (human)
Phosphatases, in vitro:
  • PPP1CA (human)
  • PPP1CC (human)
Putative in vivo kinases:
  • CDK3 (human)
  • UL97 (herpesvirus)
Regulatory protein:
  • Akt1 (human)
  • Bcl-2 (human)
  • CCNE1 (human)
  • DYNLT1 (human)
  • HRas (human)
  • JMJD3 (human)
  • KAP (mouse)
  • MLK3 (human)
  • NOX4 (human)
  • p57Kip2 (human)
  • p73 (human)
  • PPP1R1C (human)
  • VHL (human)
Treatment
  • 3-Methyladenine
  • anti-CD3
  • bicyclol
  • Bz-423
  • caffeine
  • catalase
  • DOI
  • eflornithine
  • estradiol
  • eusynstyelamide B
  • faslodex
  • FGF2
  • fluvastatin
  • GW_8510
  • insulin
  • IP(6)
  • lovastatin
  • LRRK2-IN-1
  • LY294002
  • metastatic potential
  • mevastatin
  • PD98059
  • phytohemagglutinin
  • pravastatin
  • psoralen
  • rapamycin
  • resibufogenin
  • resveratrol
  • retinoic_acid
  • sardomozide
  • serum
  • simvastatin
  • siRNA
  • TGF-beta
  • UV
  • Y27632
Rb (human) PGGNIyIsPLksPyk S807-p
Rb (mouse) PGGNIyIsPLksPyK S800-p
Rb (rat) PGGNIYIsPLKsPYK S799-p
K810-ub
NIyIsPLksPykIsE
0 6
Rb (human) NIyIsPLksPykIsE K810-ub
Rb (mouse) NIyIsPLksPyKIsE K803-ub
Rb (rat) NIYIsPLKsPYKISE K802
K810-m1
NIyIsPLksPykIsE
4 1
Rb (human) NIyIsPLksPykIsE K810-m1
Rb (mouse) NIyIsPLKsPyKIsE K803
Rb (rat) NIYIsPLKsPYKISE K802
K810-m2
NIyIsPLksPykIsE
2 0
Rb (human) NIyIsPLksPykIsE K810-m2
Rb (mouse) NIyIsPLKsPyKIsE K803
Rb (rat) NIYIsPLKsPYKISE K802
S811-p
IyIsPLksPykIsEG
Upstream
Downstream
64 115
Rb (human)
S811-p
Rb (mouse)
S804-p
Rb (rat)
S803-p
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, altered
  • transcription, altered
Kinase, in vitro:
  • CDK1 (human)
  • CDK18 (human)
  • CDK2 (human)
  • CDK4 (human)
  • CDK5 (human)
  • CDK6 (human)
  • CDK9 (human)
Putative in vivo kinases:
  • CDK3 (human)
  • UL97 (herpesvirus)
Regulatory protein:
  • Akt1 (human)
  • Bcl-2 (human)
  • CCNE1 (human)
  • DYNLT1 (human)
  • HRas (human)
  • JMJD3 (human)
  • KAP (mouse)
  • MLK3 (human)
  • NOX4 (human)
  • p57Kip2 (human)
  • p73 (human)
  • PPP1R1C (human)
  • VHL (human)
Treatment
  • 3-Methyladenine
  • anti-CD3
  • Bz-423
  • caffeine
  • catalase
  • DOI
  • eflornithine
  • estradiol
  • eusynstyelamide B
  • faslodex
  • FGF2
  • fluvastatin
  • insulin
  • IP(6)
  • ischemia
  • lovastatin
  • LRRK2-IN-1
  • LY294002
  • metastatic potential
  • mevastatin
  • phytohemagglutinin
  • pravastatin
  • psoralen
  • rapamycin
  • resibufogenin
  • resveratrol
  • retinoic_acid
  • sardomozide
  • serum
  • simvastatin
  • siRNA
  • TGF-beta
  • UV
  • Y27632
Rb (human) IyIsPLksPykIsEG S811-p
Rb (mouse) IyIsPLksPyKIsEG S804-p
Rb (rat) IYIsPLKsPYKISEG S803-p
Y813-p
IsPLksPykIsEGLP
0 12
Rb (human) IsPLksPykIsEGLP Y813-p
Rb (mouse) IsPLksPyKIsEGLP Y806-p
Rb (rat) IsPLKsPYKISEGLP Y805
K814-ub
sPLksPykIsEGLPt
0 3
Rb (human) sPLksPykIsEGLPt K814-ub
Rb (mouse) sPLksPyKIsEGLPt K807
Rb (rat) sPLKsPYKISEGLPt K806
S816-p
LksPykIsEGLPtPt
Upstream
0 11
Regulatory protein:
  • VHL (human)
Rb (human) LksPykIsEGLPtPt S816-p
Rb (mouse) LksPyKIsEGLPtPt S809-p
Rb (rat) LKsPYKISEGLPtPt S808
T821-p
kIsEGLPtPtkMtPR
Upstream
Downstream
21 99
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell growth, altered
  • cell growth, induced
  • transcription, induced
Kinase, in vitro:
  • CDK2 (human)
  • CDK6 (human)
Putative in vivo kinases:
  • CDK2 (human)
  • UL97 (herpesvirus)
Regulatory protein:
  • CCNE1 (human)
  • small T antigen (polyomavirus)
  • VHL (human)
Treatment
  • anti-CD3
  • CVT-313
  • dasatinib
  • GW_8510
  • HPR
  • IGF-1
  • ischemia
  • palbociclib
  • PD0332991
  • PDGF
  • radicicol
  • seliciclib
  • serum
Rb (human) kIsEGLPtPtkMtPR T821-p
Rb (mouse) KIsEGLPtPtKMtPR T814-p
Rb (rat) KISEGLPtPtKMtPR T813-p
T823-p
sEGLPtPtkMtPRsR
0 62
Rb (human) sEGLPtPtkMtPRsR T823-p
Rb (mouse) sEGLPtPtKMtPRSR T816-p
Rb (rat) SEGLPtPtKMtPRSR T815-p
K824-ub
EGLPtPtkMtPRsRI
0 2
Rb (human) EGLPtPtkMtPRsRI K824-ub
Rb (mouse) EGLPtPtKMtPRSRI K817
Rb (rat) EGLPtPtKMtPRSRI K816
T826-p
LPtPtkMtPRsRILV
Upstream
Downstream
15 88
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • CDK2 (human)
  • CDK4 (human)
  • CDK6 (human)
Phosphatases, in vitro:
  • PPP1CA (human)
  • PPP1CC (human)
Putative in vivo kinases:
  • UL97 (herpesvirus)
Regulatory protein:
  • CCNE1 (human)
  • CDC6 (human)
  • p16-INK4A (human)
  • small T antigen (polyomavirus)
  • VHL (human)
Treatment
  • anti-CD3
  • dasatinib
  • seliciclib
  • serum
  • siRNA
Rb (human) LPtPtkMtPRsRILV T826-p
Rb (mouse) LPtPtKMtPRSRILV T819-p
Rb (rat) LPtPtKMtPRSRILV T818-p
S829-p
PtkMtPRsRILVsIG
0 1
Rb (human) PtkMtPRsRILVsIG S829-p
Rb (mouse) PtKMtPRSRILVSIG S822
Rb (rat) PtKMtPRSRILVsIG S821
S834-p
PRsRILVsIGEsFGt
0 4
Rb (human) PRsRILVsIGEsFGt S834-p
Rb (mouse) PRSRILVSIGESFGt S827
Rb (rat) PRSRILVsIGEsFGT S826-p
S838-p
ILVsIGEsFGtsEkF
Upstream
Downstream
1 3
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
  • chromatin organization, altered
  • signaling pathway regulation
Kinase, in vitro:
  • P38A (human)
Putative in vivo kinases:
  • P38A (human)
Treatment
  • calyculin_A
  • SB203580
  • vanadate
Rb (human) ILVsIGEsFGtsEkF S838-p
Rb (mouse) ILVSIGESFGtSEKF S831
Rb (rat) ILVsIGEsFGTsEKF S830-p
T841-p
sIGEsFGtsEkFQkI
Upstream
Downstream
1 15
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
  • chromatin organization, altered
  • signaling pathway regulation
Kinase, in vitro:
  • P38A (human)
Putative in vivo kinases:
  • P38A (human)
Treatment
  • calyculin_A
  • ischemia
  • SB203580
  • vanadate
Rb (human) sIGEsFGtsEkFQkI T841-p
Rb (mouse) SIGESFGtSEKFQKI T834-p
Rb (rat) sIGEsFGTsEKFQKI T833
S842-p
IGEsFGtsEkFQkIN
0 3
Rb (human) IGEsFGtsEkFQkIN S842-p
Rb (mouse) IGESFGtSEKFQKIN S835
Rb (rat) IGEsFGTsEKFQKIN S834-p
K844-ub
EsFGtsEkFQkINQM
0 1
Rb (human) EsFGtsEkFQkINQM K844-ub
Rb (mouse) ESFGtSEKFQKINQM K837
Rb (rat) EsFGTsEKFQKINQM K836
K847-ub
GtsEkFQkINQMVCN
0 4
Rb (human) GtsEkFQkINQMVCN K847-ub
Rb (mouse) GtSEKFQKINQMVCN K840
Rb (rat) GTsEKFQKINQMVCN K839
S855-p
INQMVCNsDrVLkRs
0 23
Rb (human) INQMVCNsDrVLkRs S855-p
Rb (mouse) INQMVCNsDRVLKRS S848-p
Rb (rat) INQMVCNSDRVLKRS S847
R857-m1
QMVCNsDrVLkRsAE
0 1
Rb (human) QMVCNsDrVLkRsAE R857-m1
Rb (mouse) QMVCNsDRVLKRSAE R850
Rb (rat) QMVCNSDRVLKRSAE R849
K860-ub
CNsDrVLkRsAEGsN
0 1
Rb (human) CNsDrVLkRsAEGsN K860-ub
Rb (mouse) CNsDRVLKRSAEGGN K853
Rb (rat) CNSDRVLKRSAEGGN K852
S862-p
sDrVLkRsAEGsNPP
0 1
Rb (human) sDrVLkRsAEGsNPP S862-p
Rb (mouse) sDRVLKRSAEGGNPP S855
Rb (rat) SDRVLKRSAEGGNPP S854
S866-p
LkRsAEGsNPPkPLk
0 1
Rb (human) LkRsAEGsNPPkPLk S866-p
Rb (mouse) LKRSAEGGNPPKPLK G859
Rb (rat) LKRSAEGGNPPKPLK G858
K870-ub