Rb (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

T5-p

___MPPKtPRKTAAT

Rb (human)	___MPPKtPRKTAAT	T5-p
Rb (mouse)	___MPPKAPRRAAAA	A5
Rb (rat)	___MPPKAPRRTAAA	A5

S37-p

EEDPEQDsGPEDLPL

Upstream

Treatment

nocodazole

Rb (human)	EEDPEQDsGPEDLPL	S37-p
Rb (mouse)	EDDPAQDsGPEELPL	S31-p
Rb (rat)	EDDPAQDsDPEELPL	S30-p

K63-ub

DFTALCQkLkIPDHV

Rb (human)	DFTALCQkLkIPDHV	K63-ub
Rb (mouse)	EFIALCQkLKVPDHV	K57-ub
Rb (rat)	EFIALCQKLKVPDHV	K56

K65-ub

TALCQkLkIPDHVRE

Rb (human)	TALCQkLkIPDHVRE	K65-ub
Rb (mouse)	IALCQkLKVPDHVRE	K59
Rb (rat)	IALCQKLKVPDHVRE	K58

K94-ub

VLGGYIQkKKELWGI

Rb (human)	VLGGYIQkKKELWGI	K94-ub
Rb (mouse)	ILEGYIQKKKELWGI	K88
Rb (rat)	ILEGYIQKKKELWGI	K87

K136-ub

HKFFNLLkEIDtSTk

Rb (human)	HKFFNLLkEIDtSTk	K136-ub
Rb (mouse)	YKFFDLLKEIDTSTK	K130
Rb (rat)	YKFFDLLKEIDTSTK	K129

T140-p

NLLkEIDtSTkVDNA

Rb (human)	NLLkEIDtSTkVDNA	T140-p
Rb (mouse)	DLLKEIDTSTKVDNA	T134
Rb (rat)	DLLKEIDTSTKVDNA	T133

K143-ub

kEIDtSTkVDNAMsR

Rb (human)	kEIDtSTkVDNAMsR	K143-ub
Rb (mouse)	KEIDTSTKVDNAMSR	K137
Rb (rat)	KEIDTSTKVDNAVSR	K136

S149-p

TkVDNAMsRLLKKYD

Rb (human)	TkVDNAMsRLLKKYD	S149-p
Rb (mouse)	TKVDNAMSRLLKKYN	S143
Rb (rat)	TKVDNAVSRLLKKYN	S142

S163-p

DVLFALFsKLERTCE

Rb (human)	DVLFALFsKLERTCE	S163-p
Rb (mouse)	NVLCALYSKLERTCE	S157
Rb (rat)	NVLCALYSKLERTCG	S156

S230-p

LDYFIKLsPPMLLKE

Rb (human)	LDYFIKLsPPMLLKE	S230-p
Rb (mouse)	VDYFIKFsPPALLRE	S224-p
Rb (rat)	LDYFIKLSPPALLRE	S223

Y239-p

PMLLKEPyKtAVIPI

Rb (human)	PMLLKEPyKtAVIPI	Y239-p
Rb (mouse)	PALLREPYKTAAIPI	Y233
Rb (rat)	PALLREPYKTAATPI	Y232

T241-p

LLKEPyKtAVIPING

Rb (human)	LLKEPyKtAVIPING	T241-p
Rb (mouse)	LLREPYKTAAIPING	T235
Rb (rat)	LLREPYKTAATPING	T234

S249-p

AVIPINGsPRtPRRG

Upstream

Downstream

126

Effects on Modified Protein

activity, induced
activity, inhibited
molecular association, regulation

Effects on Biological Processes:

apoptosis, inhibited
cell cycle regulation
cell growth, induced
cell growth, inhibited
transcription, inhibited

Kinase, in vitro:

CDK1 (human)
CDK2 (human)
P38A (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

CDK2 (human)
P38A (human)

Regulatory protein:

WT1 (human)

Treatment

butyrate
dasatinib
nocodazole
progestin_R5020
rapamycin
siRNA
TGF-beta

Rb (human)	AVIPINGsPRtPRRG	S249-p
Rb (mouse)	AAIPINGsPRtPRRG	S243-p
Rb (rat)	AATPINGsPRtPRRG	S242-p

T252-p

PINGsPRtPRRGQNR

Upstream

Downstream

Effects on Modified Protein

activity, induced
activity, inhibited
molecular association, regulation

Effects on Biological Processes:

apoptosis, inhibited
cell cycle regulation
cell growth, induced
cell growth, inhibited
transcription, inhibited

Kinase, in vitro:

CDK1 (human)
CDK2 (human)
CDK4 (human)
P38A (human)

Putative in vivo kinases:

CDK2 (human)
P38A (human)

Regulatory protein:

WT1 (human)

Treatment

butyrate
progestin_R5020
rapamycin
siRNA
TGF-beta

Rb (human)	PINGsPRtPRRGQNR	T252-p
Rb (mouse)	PINGsPRtPRRGQNR	T246-p
Rb (rat)	PINGsPRtPRRGQNR	T245-p

K265-ub

NRSARIAkQLENDTR

Rb (human)	NRSARIAkQLENDTR	K265-ub
Rb (mouse)	NRSARIAKQLENDTR	K259
Rb (rat)	NRSARIAKQLESDTR	K258

K279-ub

RIIEVLCkEHECNID

Rb (human)	RIIEVLCkEHECNID	K279-ub
Rb (mouse)	RIIEVLCKEHECNID	K273
Rb (rat)	RTIEVLCKEHECNVD	K272

K289-ub

ECNIDEVkNVYFKNF

Rb (human)	ECNIDEVkNVYFKNF	K289-ub
Rb (mouse)	ECNIDEVKNVYFKNF	K283
Rb (rat)	ECNVDEVKNVYFKNF	K282

K319-ub

PEVENLSkRyEEIyL

Rb (human)	PEVENLSkRyEEIyL	K319-ub
Rb (mouse)	PEVESLSKRYEEVYL	K313
Rb (rat)	PELESLSKRYEEVYL	K312

Y321-p

VENLSkRyEEIyLkN

Rb (human)	VENLSkRyEEIyLkN	Y321-p
Rb (mouse)	VESLSKRYEEVYLKN	Y315
Rb (rat)	LESLSKRYEEVYLKS	Y314

Y325-p

SkRyEEIyLkNKDLD

Rb (human)	SkRyEEIyLkNKDLD	Y325-p
Rb (mouse)	SKRYEEVYLKNKDLD	Y319
Rb (rat)	SKRYEEVYLKSKDLD	Y318

K327-ub

RyEEIyLkNKDLDAR

Rb (human)	RyEEIyLkNKDLDAR	K327-ub
Rb (mouse)	RYEEVYLKNKDLDAR	K321
Rb (rat)	RYEEVYLKSKDLDAR	K320

K341-ub

RLFLDHDkTLQtdsI

Rb (human)	RLFLDHDkTLQtdsI	K341-ub
Rb (mouse)	RLFLDHDKTLQTDPI	K335
Rb (rat)	RLFLDHDKTLQTDTI	K334

T345-p

DHDkTLQtdsIDsFE

Rb (human)	DHDkTLQtdsIDsFE	T345-p
Rb (mouse)	DHDKTLQTDPIDsFE	T339
Rb (rat)	DHDKTLQTDTIDSFE	T338

D346-ca

HDkTLQtdsIDsFEt

Rb (human)	HDkTLQtdsIDsFEt	D346-ca
Rb (mouse)	HDKTLQTDPIDsFET	D340
Rb (rat)	HDKTLQTDTIDSFET	D339

S347-p

DkTLQtdsIDsFEtQ

Rb (human)	DkTLQtdsIDsFEtQ	S347-p
Rb (mouse)	DKTLQTDPIDsFETE	P341
Rb (rat)	DKTLQTDTIDSFETE	T340

S350-p

LQtdsIDsFEtQRtP

Rb (human)	LQtdsIDsFEtQRtP	S350-p
Rb (mouse)	LQTDPIDsFETERtP	S344-p
Rb (rat)	LQTDTIDSFETERTP	S343

T353-p

dsIDsFEtQRtPRks

Rb (human)	dsIDsFEtQRtPRks	T353-p
Rb (mouse)	DPIDsFETERtPRKN	T347
Rb (rat)	DTIDSFETERTPRKS	T346

T356-p

DsFEtQRtPRksNLD

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

apoptosis, inhibited
carcinogenesis, induced
cell growth, induced

Kinase, in vitro:

CDK2 (human)
CDK4 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

UL97 (herpesvirus)

Regulatory protein:

CCNF (human)
NIPP-1 (human)
Oct4 (human)

Treatment

actinomycin_D
anti-CD3
butyrate
GW_8510
lapatinib
palbociclib
PD98059
SB218078

Rb (human)	DsFEtQRtPRksNLD	T356-p
Rb (mouse)	DsFETERtPRKNNPD	T350-p
Rb (rat)	DSFETERTPRKSNPD	T349

K359-ub

EtQRtPRksNLDEEV

Rb (human)	EtQRtPRksNLDEEV	K359-ub
Rb (mouse)	ETERtPRKNNPDEEA	K353
Rb (rat)	ETERTPRKSNPDEEA	K352

S360-p

tQRtPRksNLDEEVN

Rb (human)	tQRtPRksNLDEEVN	S360-p
Rb (mouse)	TERtPRKNNPDEEAN	N354
Rb (rat)	TERTPRKSNPDEEAN	S353

P370

DEEVNVIPPHtPVRT

Rb (human)	DEEVNVIPPHtPVRT	P370
Rb (mouse)	DEEANVVtPHtPVRT	T364-p
Rb (rat)	DEEANMVtPHtPVRT	T363-p

T373-p

VNVIPPHtPVRTVMN

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Kinase, in vitro:

CDK1 (human)
CDK2 (human)
CDK4 (human)

Putative in vivo kinases:

UL97 (herpesvirus)

Regulatory protein:

VHL (human)

Treatment

anti-CD3
cytokines
EGF
GW_8510
phytohemagglutinin

Rb (human)	VNVIPPHtPVRTVMN	T373-p
Rb (mouse)	ANVVtPHtPVRTVMN	T367-p
Rb (rat)	ANMVtPHtPVRTVMN	T366-p

K420-ub

ESILKRVkDIGYIFk

Rb (human)	ESILKRVkDIGYIFk	K420-ub
Rb (mouse)	ENILKRVKDVGHIFK	K414
Rb (rat)	ENILKRVKDVGHIFK	K413

K427-ac

kDIGYIFkEKFAkAV

Rb (human)	kDIGYIFkEKFAkAV	K427-ac
Rb (mouse)	KDVGHIFKEKFANAV	K421
Rb (rat)	KDVGHIFKEKFASAV	K420

K427-ub

kDIGYIFkEKFAkAV

Rb (human)	kDIGYIFkEKFAkAV	K427-ub
Rb (mouse)	KDVGHIFKEKFANAV	K421
Rb (rat)	KDVGHIFKEKFASAV	K420

K432-ub

IFkEKFAkAVGQGCV

Rb (human)	IFkEKFAkAVGQGCV	K432-ub
Rb (mouse)	IFKEKFANAVGQGCV	N426
Rb (rat)	IFKEKFASAVGQGCI	S425

Y446

VEIGSQRYKLGVRLY

Rb (human)	VEIGSQRYKLGVRLY	Y446
Rb (mouse)	VDIGVQRyKLGVRLY	Y440-p
Rb (rat)	IDIGAQRYKLGVRLY	Y439

Y454-p

KLGVRLYyRVMESML

Rb (human)	KLGVRLYyRVMESML	Y454-p
Rb (mouse)	KLGVRLYYRVMESML	Y448
Rb (rat)	KLGVRLYYRVMESML	Y447

K537-ub

KVIESFIkAEGNLTR

Rb (human)	KVIESFIkAEGNLTR	K537-ub
Rb (mouse)	KVIESFIKVEANLTR	K531
Rb (rat)	KVIESFIKVEANLTR	K530

K548-ac

NLTREMIkHLERCEH

Upstream

Treatment

MS275

Rb (human)	NLTREMIkHLERCEH	K548-ac
Rb (mouse)	NLTREMIKHLERCEH	K542
Rb (rat)	NLTREMIKHLERCEH	K541

S567-p

SLAWLSDsPLFDLIk

Upstream

Downstream

Effects on Modified Protein

activity, inhibited
molecular association, regulation
protein degradation

Effects on Biological Processes:

apoptosis, induced
apoptosis, inhibited
cell growth, induced

Kinase, in vitro:

CDK2 (human)
P38A (human)

Putative in vivo kinases:

P38A (human)

Regulatory protein:

MKK3 (human)
P38A (human)
P38B (human)

Treatment

3MCIC
butyrate
etoposide
SB203580
seliciclib

Rb (human)	SLAWLSDsPLFDLIk	S567-p
Rb (mouse)	SLAWLSDsPLFDLIK	S561-p
Rb (rat)	SLAWLSDSPLFDLIK	S560

K574-ub

sPLFDLIkQSKDREG

Rb (human)	sPLFDLIkQSKDREG	K574-ub
Rb (mouse)	sPLFDLIKQSKDGEG	K568
Rb (rat)	SPLFDLIKQSKDGEG	K567

T583-p

SKDREGPtDHLEsAC

Rb (human)	SKDREGPtDHLEsAC	T583-p
Rb (mouse)	gap	-
Rb (rat)	gap	-

S588-p

GPtDHLEsACPLNLP

Rb (human)	GPtDHLEsACPLNLP	S588-p
Rb (mouse)	EGPDNLEPACPLSLP	P581
Rb (rat)	EGPDHLESACSLSLP	S580

T601-p

LPLQNNHtAADMyLs

Rb (human)	LPLQNNHtAADMyLs	T601-p
Rb (mouse)	LPLQGNHtAADMyLs	T594-p
Rb (rat)	LPLQSNHTAADMYLs	T593

Y606-p

NHtAADMyLsPVRsP

Rb (human)	NHtAADMyLsPVRsP	Y606-p
Rb (mouse)	NHtAADMyLsPLRsP	Y599-p
Rb (rat)	NHTAADMYLsPIRSP	Y598

S608-p

tAADMyLsPVRsPKK

Upstream

Downstream

Rb (human)
S608-p

Rb (mouse)
S601-p

2181 : Phospho-Rb (Ser608) Antibody

Rb (rat)
S600-p

2181 : Phospho-Rb (Ser608) Antibody

Effects on Modified Protein

molecular association, regulation
protein conformation

Effects on Biological Processes:

apoptosis, inhibited
cell cycle regulation
cell growth, induced

Kinase, in vitro:

CDK2 (human)
CDK4 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

UL97 (herpesvirus)

Regulatory protein:

EGFR (human)

Treatment

butyrate
retinoic_acid
RRD-251
seliciclib

Rb (human)	tAADMyLsPVRsPKK	S608-p
Rb (mouse)	tAADMyLsPLRsPKK	S601-p
Rb (rat)	TAADMYLsPIRSPKK	S600-p

S612-p

MyLsPVRsPKKKGsT

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation
protein conformation

Effects on Biological Processes:

apoptosis, induced
cell differentiation, induced
transcription, altered

Kinase, in vitro:

CDK2 (human)
CDK4 (human)
CDK6 (human)
Chk1 (human)
Chk2 (human)

Putative in vivo kinases:

Chk2 (human)
UL97 (herpesvirus)

Regulatory protein:

ATM (human)
Chk1 (human)
Chk2 (human)
EGFR (human)

Treatment

actinomycin_D
caffeine
Chk2_inhibitor_II
differentiation
etoposide
GW_8510
HPR
ionizing_radiation
KU-55933
phorbol_ester
SB218078
siRNA
UV

Rb (human)	MyLsPVRsPKKKGsT	S612-p
Rb (mouse)	MyLsPLRsPKKRTST	S605-p
Rb (rat)	MYLsPIRSPKKRTST	S604

S618-p

RsPKKKGsTTRVNst

Rb (human)	RsPKKKGsTTRVNst	S618-p
Rb (mouse)	RsPKKRTSTTRVNsA	S611
Rb (rat)	RSPKKRTSTTRVNSA	S610

S624-p

GsTTRVNstANAETQ

Rb (human)	GsTTRVNstANAETQ	S624-p
Rb (mouse)	TSTTRVNsAANTETQ	S617-p
Rb (rat)	TSTTRVNSAANTETQ	S616

T625-p

sTTRVNstANAETQA

Rb (human)	sTTRVNstANAETQA	T625-p
Rb (mouse)	STTRVNsAANTETQA	A618
Rb (rat)	STTRVNSAANTETQA	A617

K640-ub

TSAFQTQkPLKSTSL

Rb (human)	TSAFQTQkPLKSTSL	K640-ub
Rb (mouse)	ASAFHTQKPLKSTSL	K633
Rb (rat)	ASAFHTQKPLKSTSL	K632

K720-sm

KVKNIDLkFKIIVTA

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation
protein stabilization

Effects on Biological Processes:

cell growth, induced
transcription, inhibited

Regulatory protein:

SENP1 (human)

Rb (human)	KVKNIDLkFKIIVTA	K720-sm
Rb (mouse)	KVKNIDLkFKIIVTA	K713-sm
Rb (rat)	KVKNIDLKFKIIVTA	K712

T766-p

VFMQRLKtNILQyAs

Rb (human)	VFMQRLKtNILQyAs	T766-p
Rb (mouse)	VFMQRLKTNILQYAS	T759
Rb (rat)	VFMQRLKTNILQYAS	T758

Y771-p

LKtNILQyAstrPPt

Rb (human)	LKtNILQyAstrPPt	Y771-p
Rb (mouse)	LKTNILQYASTRPPt	Y764
Rb (rat)	LKTNILQYASTRPPT	Y763

S773-p

tNILQyAstrPPtLs

Rb (human)	tNILQyAstrPPtLs	S773-p
Rb (mouse)	TNILQYASTRPPtLs	S766
Rb (rat)	TNILQYASTRPPTLs	S765

T774-p

NILQyAstrPPtLsP

Rb (human)	NILQyAstrPPtLsP	T774-p
Rb (mouse)	NILQYASTRPPtLsP	T767
Rb (rat)	NILQYASTRPPTLsP	T766

R775-m2

ILQyAstrPPtLsPI

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

cell cycle regulation
transcription, inhibited

Rb (human)	ILQyAstrPPtLsPI	R775-m2
Rb (mouse)	ILQYASTRPPtLsPI	R768
Rb (rat)	ILQYASTRPPTLsPI	R767

T778-p

yAstrPPtLsPIPHI

Upstream

Treatment

imatinib

Rb (human)	yAstrPPtLsPIPHI	T778-p
Rb (mouse)	YASTRPPtLsPIPHI	T771-p
Rb (rat)	YASTRPPTLsPIPHI	T770

S780-p

strPPtLsPIPHIPr

Upstream

Downstream

141

Rb (human)
S780-p

Rb (mouse)
S773-p

Rb (rat)
S772-p

Effects on Modified Protein

activity, inhibited
molecular association, regulation
protein degradation

Effects on Biological Processes:

apoptosis, inhibited
cell cycle regulation
cell growth, altered
cell growth, induced
transcription, altered
transcription, induced

Kinase, in vitro:

AurB (human)
CDK4 (human)
CDK6 (human)

Putative in vivo kinases:

CDK4 (human)
CDK6 (human)
PKACA (human)
UL97 (herpesvirus)

Regulatory protein:

Akt1 (human)
ATR (human)
Bcl-2 (human)
CCNE1 (human)
CDC25A (human)
CDC37 (human)
GNL2 (human)
HRas (human)
ID1 (human)
KAP (mouse)
MDM2 (human)
Myc (human)
NOX4 (human)
RPL23A (human)
RPLP0 (human)
SHIP (human)
small T antigen (polyomavirus)
TR-beta1 (human)

Treatment

2-deoxyglucose
alvocidib
apigenin
arsenite
BIM-23120
butyrate
Bz-423
caffeine
cAMP_analog
CVT-313
cytokines
GSK2334470
GW_8510
HPR
IGF-1
ionizing_radiation
IP(6)
LY294002
metribolone
miRNA
palbociclib
PD0332991
PDGF
phytohemagglutinin
PRL
radicicol
rapamycin
resibufogenin
ribociclib
riviciclib
seliciclib
serum
siRNA
somatostatin
TGF-beta
UV
wounding
Y27632

Rb (human)	strPPtLsPIPHIPr	S780-p
Rb (mouse)	STRPPtLsPIPHIPR	S773-p
Rb (rat)	STRPPTLsPIPHIPR	S772-p

R787-m2

sPIPHIPrsPykFPs

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

cell cycle regulation
transcription, inhibited

Rb (human)	sPIPHIPrsPykFPs	R787-m2
Rb (mouse)	sPIPHIPRsPyKFss	R780
Rb (rat)	sPIPHIPRsPYKFSS	R779

S788-p

PIPHIPrsPykFPss

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell growth, altered

Kinase, in vitro:

CDK4 (human)
CDK6 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

UL97 (herpesvirus)

Regulatory protein:

VHL (human)

Treatment

CXCL12
imatinib

Rb (human)	PIPHIPrsPykFPss	S788-p
Rb (mouse)	PIPHIPRsPyKFsss	S781-p
Rb (rat)	PIPHIPRsPYKFSSs	S780-p

Y790-p

PHIPrsPykFPssPL

Rb (human)	PHIPrsPykFPssPL	Y790-p
Rb (mouse)	PHIPRsPyKFsssPL	Y783-p
Rb (rat)	PHIPRsPYKFSSsPL	Y782

K791-ub

HIPrsPykFPssPLr

Rb (human)	HIPrsPykFPssPLr	K791-ub
Rb (mouse)	HIPRsPyKFsssPLR	K784
Rb (rat)	HIPRsPYKFSSsPLR	K783

P793

PrsPykFPssPLrIP

Rb (human)	PrsPykFPssPLrIP	P793
Rb (mouse)	PRsPyKFsssPLRIP	S786-p
Rb (rat)	PRsPYKFSSsPLRIP	S785

S794-p

rsPykFPssPLrIPG

Rb (human)	rsPykFPssPLrIPG	S794-p
Rb (mouse)	RsPyKFsssPLRIPG	S787-p
Rb (rat)	RsPYKFSSsPLRIPG	S786

S795-p

sPykFPssPLrIPGG

Upstream

Downstream

109

Rb (human)
S795-p

9301 : Phospho-Rb (Ser795) Antibody

Rb (rat)
S787-p

9301 : Phospho-Rb (Ser795) Antibody

Effects on Modified Protein

activity, inhibited
molecular association, regulation

Effects on Biological Processes:

cell cycle regulation
cell growth, altered
cell growth, induced

Kinase, in vitro:

CDK18 (human)
CDK4 (human)
CDK5 (human)
CDK6 (human)
CDK9 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

CDK2 (mouse)
UL97 (herpesvirus)

Regulatory protein:

ARF1 (human)
Bcl-2 (human)
CCNE1 (human)
CDC37 (human)
CDK20 (human)
DYNLT1 (human)
KAP (mouse)

Treatment

Bz-423
Chk2_inhibitor_II
cytokines
eflornithine
eusynstyelamide B
GW_8510
HPR
ischemia
LY294002
metribolone
phorbol_ester
phytohemagglutinin
rapamycin
sardomozide
serum
Y27632

Rb (human)	sPykFPssPLrIPGG	S795-p
Rb (mouse)	sPyKFsssPLRIPGG	S788-p
Rb (rat)	sPYKFSSsPLRIPGG	S787-p

R798-m2

kFPssPLrIPGGNIy

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

cell cycle regulation
transcription, inhibited

Rb (human)	kFPssPLrIPGGNIy	R798-m2
Rb (mouse)	KFsssPLRIPGGNIy	R791
Rb (rat)	KFSSsPLRIPGGNIY	R790

Y805-p

rIPGGNIyIsPLksP

Upstream

Kinase, in vitro:

Abl (human)

Putative in vivo kinases:

Abl (human)

Treatment

imatinib
metastatic potential

Rb (human)	rIPGGNIyIsPLksP	Y805-p
Rb (mouse)	RIPGGNIyIsPLksP	Y798-p
Rb (rat)	RIPGGNIYIsPLKsP	Y797

S807-p

PGGNIyIsPLksPyk

Upstream

Downstream

152

Rb (human)
S807-p

Rb (mouse)
S800-p

Rb (rat)
S799-p

Effects on Modified Protein

molecular association, regulation
phosphorylation

Effects on Biological Processes:

cell cycle regulation
cell growth, altered
transcription, altered

Kinase, in vitro:

CDK1 (human)
CDK18 (human)
CDK2 (human)
CDK4 (human)
CDK5 (human)
CDK6 (human)
CDK9 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

CDK3 (human)
UL97 (herpesvirus)

Regulatory protein:

Akt1 (human)
Bcl-2 (human)
CCNE1 (human)
DYNLT1 (human)
HRas (human)
JMJD3 (human)
KAP (mouse)
MLK3 (human)
NOX4 (human)
p57Kip2 (human)
p73 (human)
PPP1R1C (human)
VHL (human)

Treatment

3-Methyladenine
anti-CD3
bicyclol
Bz-423
caffeine
catalase
DOI
eflornithine
estradiol
eusynstyelamide B
faslodex
FGF2
fluvastatin
GW_8510
insulin
IP(6)
lovastatin
LRRK2-IN-1
LY294002
metastatic potential
mevastatin
PD98059
phytohemagglutinin
pravastatin
psoralen
rapamycin
resibufogenin
resveratrol
retinoic_acid
sardomozide
serum
simvastatin
siRNA
TGF-beta
UV
Y27632

Rb (human)	PGGNIyIsPLksPyk	S807-p
Rb (mouse)	PGGNIyIsPLksPyK	S800-p
Rb (rat)	PGGNIYIsPLKsPYK	S799-p

K810-ub

NIyIsPLksPykIsE

Rb (human)	NIyIsPLksPykIsE	K810-ub
Rb (mouse)	NIyIsPLksPyKIsE	K803-ub
Rb (rat)	NIYIsPLKsPYKISE	K802

K810-m1

NIyIsPLksPykIsE

Rb (human)	NIyIsPLksPykIsE	K810-m1
Rb (mouse)	NIyIsPLKsPyKIsE	K803
Rb (rat)	NIYIsPLKsPYKISE	K802

K810-m2

NIyIsPLksPykIsE

Rb (human)	NIyIsPLksPykIsE	K810-m2
Rb (mouse)	NIyIsPLKsPyKIsE	K803
Rb (rat)	NIYIsPLKsPYKISE	K802

S811-p

IyIsPLksPykIsEG

Upstream

Downstream

115

Rb (human)
S811-p

Rb (mouse)
S804-p

Rb (rat)
S803-p

Effects on Modified Protein

molecular association, regulation
phosphorylation

Effects on Biological Processes:

cell cycle regulation
cell growth, altered
transcription, altered

Kinase, in vitro:

CDK1 (human)
CDK18 (human)
CDK2 (human)
CDK4 (human)
CDK5 (human)
CDK6 (human)
CDK9 (human)

Putative in vivo kinases:

CDK3 (human)
UL97 (herpesvirus)

Regulatory protein:

Akt1 (human)
Bcl-2 (human)
CCNE1 (human)
DYNLT1 (human)
HRas (human)
JMJD3 (human)
KAP (mouse)
MLK3 (human)
NOX4 (human)
p57Kip2 (human)
p73 (human)
PPP1R1C (human)
VHL (human)

Treatment

3-Methyladenine
anti-CD3
Bz-423
caffeine
catalase
DOI
eflornithine
estradiol
eusynstyelamide B
faslodex
FGF2
fluvastatin
insulin
IP(6)
ischemia
lovastatin
LRRK2-IN-1
LY294002
metastatic potential
mevastatin
phytohemagglutinin
pravastatin
psoralen
rapamycin
resibufogenin
resveratrol
retinoic_acid
sardomozide
serum
simvastatin
siRNA
TGF-beta
UV
Y27632

Rb (human)	IyIsPLksPykIsEG	S811-p
Rb (mouse)	IyIsPLksPyKIsEG	S804-p
Rb (rat)	IYIsPLKsPYKISEG	S803-p

Y813-p

IsPLksPykIsEGLP

Rb (human)	IsPLksPykIsEGLP	Y813-p
Rb (mouse)	IsPLksPyKIsEGLP	Y806-p
Rb (rat)	IsPLKsPYKISEGLP	Y805

K814-ub

sPLksPykIsEGLPt

Rb (human)	sPLksPykIsEGLPt	K814-ub
Rb (mouse)	sPLksPyKIsEGLPt	K807
Rb (rat)	sPLKsPYKISEGLPt	K806

S816-p

LksPykIsEGLPtPt

Upstream

Regulatory protein:

VHL (human)

Rb (human)	LksPykIsEGLPtPt	S816-p
Rb (mouse)	LksPyKIsEGLPtPt	S809-p
Rb (rat)	LKsPYKISEGLPtPt	S808

T821-p

kIsEGLPtPtkMtPR

Upstream

Downstream

Effects on Modified Protein

activity, induced
molecular association, regulation

Effects on Biological Processes:

apoptosis, inhibited
cell growth, altered
cell growth, induced
transcription, induced

Kinase, in vitro:

CDK2 (human)
CDK6 (human)

Putative in vivo kinases:

CDK2 (human)
UL97 (herpesvirus)

Regulatory protein:

CCNE1 (human)
small T antigen (polyomavirus)
VHL (human)

Treatment

anti-CD3
CVT-313
dasatinib
GW_8510
HPR
IGF-1
ischemia
palbociclib
PD0332991
PDGF
radicicol
seliciclib
serum

Rb (human)	kIsEGLPtPtkMtPR	T821-p
Rb (mouse)	KIsEGLPtPtKMtPR	T814-p
Rb (rat)	KISEGLPtPtKMtPR	T813-p

T823-p

sEGLPtPtkMtPRsR

Rb (human)	sEGLPtPtkMtPRsR	T823-p
Rb (mouse)	sEGLPtPtKMtPRSR	T816-p
Rb (rat)	SEGLPtPtKMtPRSR	T815-p

K824-ub

EGLPtPtkMtPRsRI

Rb (human)	EGLPtPtkMtPRsRI	K824-ub
Rb (mouse)	EGLPtPtKMtPRSRI	K817
Rb (rat)	EGLPtPtKMtPRSRI	K816

T826-p

LPtPtkMtPRsRILV

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell growth, altered

Kinase, in vitro:

CDK2 (human)
CDK4 (human)
CDK6 (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP1CC (human)

Putative in vivo kinases:

UL97 (herpesvirus)

Regulatory protein:

CCNE1 (human)
CDC6 (human)
p16-INK4A (human)
small T antigen (polyomavirus)
VHL (human)

Treatment

anti-CD3
dasatinib
seliciclib
serum
siRNA

Rb (human)	LPtPtkMtPRsRILV	T826-p
Rb (mouse)	LPtPtKMtPRSRILV	T819-p
Rb (rat)	LPtPtKMtPRSRILV	T818-p

S829-p

PtkMtPRsRILVsIG

Rb (human)	PtkMtPRsRILVsIG	S829-p
Rb (mouse)	PtKMtPRSRILVSIG	S822
Rb (rat)	PtKMtPRSRILVsIG	S821

S834-p

PRsRILVsIGEsFGt

Rb (human)	PRsRILVsIGEsFGt	S834-p
Rb (mouse)	PRSRILVSIGESFGt	S827
Rb (rat)	PRSRILVsIGEsFGT	S826-p

S838-p

ILVsIGEsFGtsEkF

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell cycle regulation
chromatin organization, altered
signaling pathway regulation

Kinase, in vitro:

P38A (human)

Putative in vivo kinases:

P38A (human)

Treatment

calyculin_A
SB203580
vanadate

Rb (human)	ILVsIGEsFGtsEkF	S838-p
Rb (mouse)	ILVSIGESFGtSEKF	S831
Rb (rat)	ILVsIGEsFGTsEKF	S830-p

T841-p

sIGEsFGtsEkFQkI

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell cycle regulation
chromatin organization, altered
signaling pathway regulation

Kinase, in vitro:

P38A (human)

Putative in vivo kinases:

P38A (human)

Treatment

calyculin_A
ischemia
SB203580
vanadate

Rb (human)	sIGEsFGtsEkFQkI	T841-p
Rb (mouse)	SIGESFGtSEKFQKI	T834-p
Rb (rat)	sIGEsFGTsEKFQKI	T833

S842-p

IGEsFGtsEkFQkIN

Rb (human)	IGEsFGtsEkFQkIN	S842-p
Rb (mouse)	IGESFGtSEKFQKIN	S835
Rb (rat)	IGEsFGTsEKFQKIN	S834-p

K844-ub

EsFGtsEkFQkINQM

Rb (human)	EsFGtsEkFQkINQM	K844-ub
Rb (mouse)	ESFGtSEKFQKINQM	K837
Rb (rat)	EsFGTsEKFQKINQM	K836

K847-ub

GtsEkFQkINQMVCN

Rb (human)	GtsEkFQkINQMVCN	K847-ub
Rb (mouse)	GtSEKFQKINQMVCN	K840
Rb (rat)	GTsEKFQKINQMVCN	K839

S855-p

INQMVCNsDrVLkRs

Rb (human)	INQMVCNsDrVLkRs	S855-p
Rb (mouse)	INQMVCNsDRVLKRS	S848-p
Rb (rat)	INQMVCNSDRVLKRS	S847

R857-m1

QMVCNsDrVLkRsAE

Rb (human)	QMVCNsDrVLkRsAE	R857-m1
Rb (mouse)	QMVCNsDRVLKRSAE	R850
Rb (rat)	QMVCNSDRVLKRSAE	R849

K860-ub

CNsDrVLkRsAEGsN

Rb (human)	CNsDrVLkRsAEGsN	K860-ub
Rb (mouse)	CNsDRVLKRSAEGGN	K853
Rb (rat)	CNSDRVLKRSAEGGN	K852

S862-p

sDrVLkRsAEGsNPP

Rb (human)	sDrVLkRsAEGsNPP	S862-p
Rb (mouse)	sDRVLKRSAEGGNPP	S855
Rb (rat)	SDRVLKRSAEGGNPP	S854

S866-p

LkRsAEGsNPPkPLk

Rb (human)	LkRsAEGsNPPkPLk	S866-p
Rb (mouse)	LKRSAEGGNPPKPLK	G859
Rb (rat)	LKRSAEGGNPPKPLK	G858

K870-ub