Other Species / Isoforms
  Btk (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S21-p
SQQKKKTsPLNFKKR
1 3
Btk (human) SQQKKKTsPLNFKKR S21-p
Btk iso2 (human) SQQKKKTSPLNFKKR S55
Btk (mouse) SQQKKKTsPLNFKKR S21-p
Btk (rat) SQQKKKTSPLNFKKR S21
Y40-p
TVHKLSYyEYDFERG
0 26
Btk (human) TVHKLSYyEYDFERG Y40-p
Btk iso2 (human) TVHKLSYYEYDFERG Y74
Btk (mouse) TVHKLSYyEYDFERG Y40-p
Btk (rat) TVHKLSYYEYDFERG Y40
S51-p
FERGRRGsKKGsIDV
Upstream
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • signaling pathway regulation
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • anti-IgM
  • LY294002
Btk (human) FERGRRGsKKGsIDV S51-p
Btk iso2 (human) FERGRRGSKKGSIDV S85
Btk (mouse) FERGRRGSKKGSIDV S51
Btk (rat) FERGRRGSKKGSIDV S51
S55-p
RRGsKKGsIDVEKIT
0 3
Btk (human) RRGsKKGsIDVEKIT S55-p
Btk iso2 (human) RRGSKKGSIDVEKIT S89
Btk (mouse) RRGSKKGSIDVEKIT S55
Btk (rat) RRGSKKGSIDVEKIT S55
S93-p
SSEMEQIsIIERFPY
0 1
Btk (human) SSEMEQIsIIERFPY S93-p
Btk iso2 (human) SSEMEQISIIERFPY S127
Btk (mouse) SSEMEQISIIERFPY S93
Btk (rat) SSEMEQISIIERFPY S94
S115
EGPLYVFSPTEELRK
1 0
Btk (human) EGPLYVFSPTEELRK S115
Btk iso2 (human) EGPLYVFSPTEELRK S149
Btk (mouse) EGPLYVFsPTEELRK S115-p
Btk (rat) EGPLYVFSPTEELRK S116
Y134
QLKNVIRYNSDLVQK
0 1
Btk (human) QLKNVIRYNSDLVQK Y134
Btk iso2 (human) QLKNVIRYNSDLVQK Y168
Btk (mouse) QLKNVIRyNSDLVQK Y134-p
Btk (rat) QLKNVIRYNSDLVQK Y135
S174
ILENRNGSLKPGssH
0 1
Btk (human) ILENRNGSLKPGssH S174
Btk iso2 (human) ILENRNGSLKPGSSH S208
Btk (mouse) ILENRNGsLKPGssH S174-p
Btk (rat) ILENRNGSLKPGSSH S175
S179-p
NGSLKPGssHRktKK
0 3
Btk (human) NGSLKPGssHRktKK S179-p
Btk iso2 (human) NGSLKPGSSHRKTKK S213
Btk (mouse) NGsLKPGssHRKTKK S179-p
Btk (rat) NGSLKPGSSHRKTKK S180
S180-p
GSLKPGssHRktKKP
1 4
Btk (human)
S180-p
Btk (mouse)
S180-p
Btk (human) GSLKPGssHRktKKP S180-p
Btk iso2 (human) GSLKPGSSHRKTKKP S214
Btk (mouse) GsLKPGssHRKTKKP S180-p
Btk (rat) GSLKPGSSHRKTKKP S181
K183-ac
KPGssHRktKKPLPP
0 1
Btk (human) KPGssHRktKKPLPP K183-ac
Btk iso2 (human) KPGSSHRKTKKPLPP K217
Btk (mouse) KPGssHRKTKKPLPP K183
Btk (rat) KPGSSHRKTKKPLPP K184
T184-p
PGssHRktKKPLPPt
0 1
Btk (human) PGssHRktKKPLPPt T184-p
Btk iso2 (human) PGSSHRKTKKPLPPT T218
Btk (mouse) PGssHRKTKKPLPPt T184
Btk (rat) PGSSHRKTKKPLPPT T185
T191-p
tKKPLPPtPEEDQIL
0 5
Btk (human) tKKPLPPtPEEDQIL T191-p
Btk iso2 (human) TKKPLPPTPEEDQIL T225
Btk (mouse) TKKPLPPtPEEDQIL T191-p
Btk (rat) TKKPLPPTPEEDQIL T192
A207
KPLPPEPAAAPVSTS
0 1
Btk (human) KPLPPEPAAAPVSTS A207
Btk iso2 (human) KPLPPEPAAAPVSTS A241
Btk (mouse) KPLPPEPtAAPISTt T207-p
Btk (rat) KPLPPEPTAAPISTS T208
S214
AAAPVSTSELKKVVA
0 1
Btk (human) AAAPVSTSELKKVVA S214
Btk iso2 (human) AAAPVSTSELKKVVA S248
Btk (mouse) tAAPISTtELKKVVA T214-p
Btk (rat) TAAPISTSELKKVVA S215
Y223-p
LKKVVALyDyMPMNA
Upstream
Downstream
19 262
Btk (human)
Y223-p
Btk (mouse)
Y223-p
Btk (rat)
Y224-p
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • Btk (human)
  • Btk (mouse)
  • ITK (human)
  • TEC (human)
Putative in vivo kinases:
  • Abl (human)
  • Btk (human)
  • LYN (human)
Regulatory protein:
  • LYN (human)
  • Syk (human)
Treatment
  • anti-IgM
  • cGMP_analog
  • convulxin
  • CpG
  • CXCL12
  • DMXAA
  • FGF2
  • ibrutinib
  • IgE
  • IL-5
  • LPS
  • PLS-123
  • resiquimod
  • ristocetin
  • serum
  • single-stranded_RNA
  • von_Willebrand_factor
  • wortmannin
Btk (human) LKKVVALyDyMPMNA Y223-p
Btk iso2 (human) LKKVVALYDYMPMNA Y257
Btk (mouse) LKKVVALyDyMPMNA Y223-p
Btk (rat) LKKVVALYDYMPMNA Y224
Y225-p
KVVALyDyMPMNAND
0 91
Btk (human) KVVALyDyMPMNAND Y225-p
Btk iso2 (human) KVVALYDYMPMNAND Y259
Btk (mouse) KVVALyDyMPMNAND Y225-p
Btk (rat) KVVALYDYMPMNAND Y226
Y263-p
DKNGQEGyIPSNYVT
0 1
Btk (human) DKNGQEGyIPSNYVT Y263-p
Btk iso2 (human) DKNGQEGYIPSNYVT Y297
Btk (mouse) DKNGQEGYIPSNYIT Y263
Btk (rat) DKNGQEGYIPSNYVT Y264
Y279-p
AEDSIEMyEWYSKHM
0 1
Btk (human) AEDSIEMyEWYSKHM Y279-p
Btk iso2 (human) AEDSIEMYEWYSKHM Y313
Btk (mouse) AEDSIEMYEWYSKHM Y279
Btk (rat) AEDSIEMYEWYSKHM Y280
K300-ub
QLLKQEGkEGGFIVR
0 1
Btk (human) QLLKQEGkEGGFIVR K300-ub
Btk iso2 (human) QLLKQEGKEGGFIVR K334
Btk (mouse) QLLKQEGKEGGFIVR K300
Btk (rat) QLLKQEGKEGGFIVR K301
S318-p
KAGKYTVsVFAkSTG
0 1
Btk (human) KAGKYTVsVFAkSTG S318-p
Btk iso2 (human) KAGKYTVSVFAKSTG S352
Btk (mouse) KAGKYTVSVFAKSTG S318
Btk (rat) KAGKYTVSVFAKSTG S319
K322-ub
YTVsVFAkSTGDPQG
0 6
Btk (human) YTVsVFAkSTGDPQG K322-ub
Btk iso2 (human) YTVSVFAKSTGDPQG K356
Btk (mouse) YTVSVFAKSTGEPQG K322
Btk (rat) YTVSVFAKSTGEPQG K323
Y334-p
PQGVIRHyVVCSTPQ
0 7
Btk (human) PQGVIRHyVVCSTPQ Y334-p
Btk iso2 (human) PQGVIRHYVVCSTPQ Y368
Btk (mouse) PQGVIRHyVVCSTPQ Y334-p
Btk (rat) PQGVIRHYVVCSTPQ Y335
S342-p
VVCSTPQsQyyLAEK
0 1
Btk (human) VVCSTPQsQyyLAEK S342-p
Btk iso2 (human) VVCSTPQSQYYLAEK S376
Btk (mouse) VVCSTPQSQyyLAEK S342
Btk (rat) VVCSTPQSQYYLAEK S343
Y344-p
CSTPQsQyyLAEKHL
0 189
Btk (human) CSTPQsQyyLAEKHL Y344-p
Btk iso2 (human) CSTPQSQYYLAEKHL Y378
Btk (mouse) CSTPQSQyyLAEKHL Y344-p
Btk (rat) CSTPQSQYYLAEKHL Y345
Y345-p
STPQsQyyLAEKHLF
0 8
Btk (human) STPQsQyyLAEKHLF Y345-p
Btk iso2 (human) STPQSQYYLAEKHLF Y379
Btk (mouse) STPQSQyyLAEKHLF Y345-p
Btk (rat) STPQSQYYLAEKHLF Y346
Y361-p
TIPELINyHQHNsAG
0 111
Btk (human) TIPELINyHQHNsAG Y361-p
Btk iso2 (human) TIPELINYHQHNSAG Y395
Btk (mouse) TIPELINyHQHNSAG Y361-p
Btk (rat) TIPELINYHQHNSAG Y362
S366-p
INyHQHNsAGLIsRL
0 3
Btk (human) INyHQHNsAGLIsRL S366-p
Btk iso2 (human) INYHQHNSAGLISRL S400
Btk (mouse) INyHQHNSAGLISRL S366
Btk (rat) INYHQHNSAGLISRL S367
S371-p
HNsAGLIsRLKyPVs
0 1
Btk (human) HNsAGLIsRLKyPVs S371-p
Btk iso2 (human) HNSAGLISRLKYPVS S405
Btk (mouse) HNSAGLISRLKyPVS S371
Btk (rat) HNSAGLISRLKYPVS S372
Y375-p
GLIsRLKyPVsQQNK
1 25
Btk (human) GLIsRLKyPVsQQNK Y375-p
Btk iso2 (human) GLISRLKYPVSQQNK Y409
Btk (mouse) GLISRLKyPVSKQNK Y375-p
Btk (rat) GLISRLKYPVSKQNK Y376
S378-p
sRLKyPVsQQNKNAP
0 2
Btk (human) sRLKyPVsQQNKNAP S378-p
Btk iso2 (human) SRLKYPVSQQNKNAP S412
Btk (mouse) SRLKyPVSKQNKNAP S378
Btk (rat) SRLKYPVSKQNKNAP S379
K406-ub
PKDLTFLkELGTGQF
0 13
Btk (human) PKDLTFLkELGTGQF K406-ub
Btk iso2 (human) PKDLTFLKELGTGQF K440
Btk (mouse) PKDLTFLKELGTGQF K406
Btk (rat) PKDLTFLKELGTGQF K407
Y425
YGKWRGQYDVAIKMI
0 1
Btk (human) YGKWRGQYDVAIKMI Y425
Btk iso2 (human) YGKWRGQYDVAIKMI Y459
Btk (mouse) YGKWRGQyDVAIKMI Y425-p
Btk (rat) YGKWRGQYDVAIKMI Y426
S436
IKMIKEGSMSEDEFI
0 1
Btk (human) IKMIKEGSMSEDEFI S436
Btk iso2 (human) IKMIKEGSMSEDEFI S470
Btk (mouse) IKMIREGsMSEDEFI S436-p
Btk (rat) IKMIREGSMSEDEFI S437
Y461-p
HEKLVQLyGVCTkQR
0 15
Btk (human) HEKLVQLyGVCTkQR Y461-p
Btk iso2 (human) HEKLVQLYGVCTKQR Y495
Btk (mouse) HEKLVQLyGVCTKQR Y461-p
Btk (rat) HEKLVQLyGVCTKQR Y462-p
K466-ub
QLyGVCTkQRPIFII
0 3
Btk (human) QLyGVCTkQRPIFII K466-ub
Btk iso2 (human) QLYGVCTKQRPIFII K500
Btk (mouse) QLyGVCTKQRPIFII K466
Btk (rat) QLyGVCTKQRPIFII K467
T495-p
EMRHRFQtQQLLEMC
Upstream
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • signaling pathway regulation
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • anti-IgM
  • LY294002
Btk (human) EMRHRFQtQQLLEMC T495-p
Btk iso2 (human) EMRHRFQTQQLLEMC T529
Btk (mouse) EMRHRFQTQQLLEMC T495
Btk (rat) EMRHRFQTQQLLEMC T496
K536-ub
VNDQGVVkVSDFGLs
0 5
Btk (human) VNDQGVVkVSDFGLs K536-ub
Btk iso2 (human) VNDQGVVKVSDFGLS K570
Btk (mouse) VNDQGVVKVSDFGLs K536
Btk (rat) VNDQGVVKVSDFGLS K537
S543-p
kVSDFGLsRYVLDDE
0 2
Btk (human) kVSDFGLsRYVLDDE S543-p
Btk iso2 (human) KVSDFGLSRYVLDDE S577
Btk (mouse) KVSDFGLsRYVLDDE S543-p
Btk (rat) KVSDFGLSRYVLDDE S544
Y551-p
RYVLDDEytsSVGSk
Upstream
Downstream
24 149
Btk (human)
Y551-p
Btk iso2 (human)
Y585-p
Btk (mouse)
Y551-p
Btk (rat)
Y552-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • Btk (human)
  • Syk (human)
Putative in vivo kinases:
  • Btk (human)
  • LYN (human)
Regulatory protein:
  • BLNK (human)
  • IBTK (human)
  • LYN (human)
  • Syk (human)
  • TREM1 (human)
Treatment
  • anti-IgM
  • Bay61-3606
  • BV02
  • convulxin
  • erlotinib
  • FGF2
  • gefitinib
  • Go_6976
  • ibrutinib
  • IgE
  • IL-5
  • LPS
  • PLS-123
  • PP2
  • ristocetin
  • serum
  • von_Willebrand_factor
  • wortmannin
Btk (human) RYVLDDEytsSVGSk Y551-p
Btk iso2 (human) RYVLDDEYTSSVGSK Y585
Btk (mouse) RYVLDDEyTsSVGSK Y551-p
Btk (rat) RYVLDDEYTSSVGSK Y552
T552-p
YVLDDEytsSVGSkF
0 9
Btk (human) YVLDDEytsSVGSkF T552-p
Btk iso2 (human) YVLDDEYTSSVGSKF T586
Btk (mouse) YVLDDEyTsSVGSKF T552
Btk (rat) YVLDDEYTSSVGSKF T553
S553-p
VLDDEytsSVGSkFP
0 4
Btk (human) VLDDEytsSVGSkFP S553-p
Btk iso2 (human) VLDDEYTSSVGSKFP S587
Btk (mouse) VLDDEyTsSVGSKFP S553-p
Btk (rat) VLDDEYTSSVGSKFP S554
K558-ub
ytsSVGSkFPVRWsP
0 12
Btk (human) ytsSVGSkFPVRWsP K558-ub
Btk iso2 (human) YTSSVGSKFPVRWSP K592
Btk (mouse) yTsSVGSKFPVRWSP K558
Btk (rat) YTSSVGSKFPVRWSP K559
S564-p
SkFPVRWsPPEVLMY
0 1
Btk (human) SkFPVRWsPPEVLMY S564-p
Btk iso2 (human) SKFPVRWSPPEVLMY S598
Btk (mouse) SKFPVRWSPPEVLMY S564
Btk (rat) SKFPVRWSPPEVLMY S565
T602-p
KMPYERFtNsETAEH
0 1
Btk (human) KMPYERFtNsETAEH T602-p
Btk iso2 (human) KMPYERFTNSETAEH T636
Btk (mouse) KMPYERFTNSETAEH T602
Btk (rat) KIPYERFTNSETAEH T603
S604-p
PYERFtNsETAEHIA
0 2
Btk (human) PYERFtNsETAEHIA S604-p
Btk iso2 (human) PYERFTNSETAEHIA S638
Btk (mouse) PYERFTNSETAEHIA S604
Btk (rat) PYERFTNSETAEHIA S605
Y617
IAQGLRLYRPHLASE
1 1
Btk (human) IAQGLRLYRPHLASE Y617
Btk iso2 (human) IAQGLRLYRPHLASE Y651
Btk (mouse) IAQGLRLyRPHLAsE Y617-p
Btk (rat) IAQGLRLYRPHLASD Y618
S623
LYRPHLASEKVYTIM
0 1
Btk (human) LYRPHLASEKVYTIM S623
Btk iso2 (human) LYRPHLASEKVYTIM S657
Btk (mouse) LyRPHLAsERVYTIM S623-p
Btk (rat) LYRPHLASDRVYTIM S624
S659-p
LDVMDEEs_______
0 1
Btk (human) LDVMDEEs_______ S659-p
Btk iso2 (human) LDVMDEES_______ S693
Btk (mouse) LDVMDEES_______ S659
Btk (rat) LDVMDEES_______ S660