Other Species / Isoforms
  Btk (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S21-p
SQQKKKTsPLNFKKR
Downstream
1 3
Effects on Modified Protein
  • molecular association, regulation
Btk (human) SQQKKKTsPLNFKKR S21-p
Btk iso2 (human) SQQKKKTSPLNFKKR S55
Btk (mouse) SQQKKKTsPLNFKKR S21-p
Btk (rat) SQQKKKTSPLNFKKR S21
Y40-p
TVHKLSYyEYDFERG
Upstream
0 26
Regulatory protein:
  • FCER1A (mouse)
Btk (human) TVHKLSYyEYDFERG Y40-p
Btk iso2 (human) TVHKLSYYEYDFERG Y74
Btk (mouse) TVHKLSYyEYDFERG Y40-p
Btk (rat) TVHKLSYYEYDFERG Y40
S51
FERGRRGSKKGSIDV
1 0
Btk (human) FERGRRGsKKGsIDV S51-p
Btk iso2 (human) FERGRRGSKKGSIDV S85
Btk (mouse) FERGRRGSKKGSIDV S51
Btk (rat) FERGRRGSKKGSIDV S51
S55
RRGSKKGSIDVEKIT
0 3
Btk (human) RRGsKKGsIDVEKIT S55-p
Btk iso2 (human) RRGSKKGSIDVEKIT S89
Btk (mouse) RRGSKKGSIDVEKIT S55
Btk (rat) RRGSKKGSIDVEKIT S55
S93
SSEMEQISIIERFPY
0 1
Btk (human) SSEMEQIsIIERFPY S93-p
Btk iso2 (human) SSEMEQISIIERFPY S127
Btk (mouse) SSEMEQISIIERFPY S93
Btk (rat) SSEMEQISIIERFPY S94
S115-p
EGPLYVFsPTEELRK
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
Btk (human) EGPLYVFSPTEELRK S115
Btk iso2 (human) EGPLYVFSPTEELRK S149
Btk (mouse) EGPLYVFsPTEELRK S115-p
Btk (rat) EGPLYVFSPTEELRK S116
Y134-p
QLKNVIRyNSDLVQK
0 1
Btk (human) QLKNVIRYNSDLVQK Y134
Btk iso2 (human) QLKNVIRYNSDLVQK Y168
Btk (mouse) QLKNVIRyNSDLVQK Y134-p
Btk (rat) QLKNVIRYNSDLVQK Y135
S174-p
ILENRNGsLKPGssH
0 1
Btk (human) ILENRNGSLKPGssH S174
Btk iso2 (human) ILENRNGSLKPGSSH S208
Btk (mouse) ILENRNGsLKPGssH S174-p
Btk (rat) ILENRNGSLKPGSSH S175
S179-p
NGsLKPGssHRKTKK
0 3
Btk (human) NGSLKPGssHRktKK S179-p
Btk iso2 (human) NGSLKPGSSHRKTKK S213
Btk (mouse) NGsLKPGssHRKTKK S179-p
Btk (rat) NGSLKPGSSHRKTKK S180
S180-p
GsLKPGssHRKTKKP
Upstream
Downstream
2 4
Btk (human)
S180-p
Btk (mouse)
S180-p
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
Putative in vivo kinases:
  • PKCB (mouse)
Treatment
  • IL-33
Btk (human) GSLKPGssHRktKKP S180-p
Btk iso2 (human) GSLKPGSSHRKTKKP S214
Btk (mouse) GsLKPGssHRKTKKP S180-p
Btk (rat) GSLKPGSSHRKTKKP S181
K183
KPGssHRKTKKPLPP
0 1
Btk (human) KPGssHRktKKPLPP K183-ac
Btk iso2 (human) KPGSSHRKTKKPLPP K217
Btk (mouse) KPGssHRKTKKPLPP K183
Btk (rat) KPGSSHRKTKKPLPP K184
T184
PGssHRKTKKPLPPt
0 1
Btk (human) PGssHRktKKPLPPt T184-p
Btk iso2 (human) PGSSHRKTKKPLPPT T218
Btk (mouse) PGssHRKTKKPLPPt T184
Btk (rat) PGSSHRKTKKPLPPT T185
T191-p
TKKPLPPtPEEDQIL
0 5
Btk (human) tKKPLPPtPEEDQIL T191-p
Btk iso2 (human) TKKPLPPTPEEDQIL T225
Btk (mouse) TKKPLPPtPEEDQIL T191-p
Btk (rat) TKKPLPPTPEEDQIL T192
T207-p
KPLPPEPtAAPISTt
0 1
Btk (human) KPLPPEPAAAPVSTS A207
Btk iso2 (human) KPLPPEPAAAPVSTS A241
Btk (mouse) KPLPPEPtAAPISTt T207-p
Btk (rat) KPLPPEPTAAPISTS T208
T214-p
tAAPISTtELKKVVA
0 1
Btk (human) AAAPVSTSELKKVVA S214
Btk iso2 (human) AAAPVSTSELKKVVA S248
Btk (mouse) tAAPISTtELKKVVA T214-p
Btk (rat) TAAPISTSELKKVVA S215
Y223-p
LKKVVALyDyMPMNA
Upstream
Downstream
42 264
Btk (human)
Y223-p
Btk (mouse)
Y223-p
Btk (rat)
Y224-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • palmitoylation
Effects on Biological Processes:
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell growth, altered
  • signaling pathway regulation
Putative in vivo kinases:
  • Btk (human)
  • PIK3CD (mouse)
Regulatory protein:
  • Akt1 (human)
  • Kit (human)
Treatment
  • bafetinib
  • dasatinib
  • ibrutinib
  • IL-13
  • IL-4
  • JAK_inhibitor_I
  • KS151
  • LFM-A13
  • M3814
  • piceatannol
  • PP1
  • PP2
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Btk (human) LKKVVALyDyMPMNA Y223-p
Btk iso2 (human) LKKVVALYDYMPMNA Y257
Btk (mouse) LKKVVALyDyMPMNA Y223-p
Btk (rat) LKKVVALYDYMPMNA Y224
Y225-p
KVVALyDyMPMNAND
0 91
Btk (human) KVVALyDyMPMNAND Y225-p
Btk iso2 (human) KVVALYDYMPMNAND Y259
Btk (mouse) KVVALyDyMPMNAND Y225-p
Btk (rat) KVVALYDYMPMNAND Y226
Y263
DKNGQEGYIPSNYIT
0 1
Btk (human) DKNGQEGyIPSNYVT Y263-p
Btk iso2 (human) DKNGQEGYIPSNYVT Y297
Btk (mouse) DKNGQEGYIPSNYIT Y263
Btk (rat) DKNGQEGYIPSNYVT Y264
Y279
AEDSIEMYEWYSKHM
0 1
Btk (human) AEDSIEMyEWYSKHM Y279-p
Btk iso2 (human) AEDSIEMYEWYSKHM Y313
Btk (mouse) AEDSIEMYEWYSKHM Y279
Btk (rat) AEDSIEMYEWYSKHM Y280
K300
QLLKQEGKEGGFIVR
0 1
Btk (human) QLLKQEGkEGGFIVR K300-ub
Btk iso2 (human) QLLKQEGKEGGFIVR K334
Btk (mouse) QLLKQEGKEGGFIVR K300
Btk (rat) QLLKQEGKEGGFIVR K301
S318
KAGKYTVSVFAKSTG
0 1
Btk (human) KAGKYTVsVFAkSTG S318-p
Btk iso2 (human) KAGKYTVSVFAKSTG S352
Btk (mouse) KAGKYTVSVFAKSTG S318
Btk (rat) KAGKYTVSVFAKSTG S319
K322
YTVSVFAKSTGEPQG
0 6
Btk (human) YTVsVFAkSTGDPQG K322-ub
Btk iso2 (human) YTVSVFAKSTGDPQG K356
Btk (mouse) YTVSVFAKSTGEPQG K322
Btk (rat) YTVSVFAKSTGEPQG K323
Y334-p
PQGVIRHyVVCSTPQ
0 7
Btk (human) PQGVIRHyVVCSTPQ Y334-p
Btk iso2 (human) PQGVIRHYVVCSTPQ Y368
Btk (mouse) PQGVIRHyVVCSTPQ Y334-p
Btk (rat) PQGVIRHYVVCSTPQ Y335
S342
VVCSTPQSQyyLAEK
0 1
Btk (human) VVCSTPQsQyyLAEK S342-p
Btk iso2 (human) VVCSTPQSQYYLAEK S376
Btk (mouse) VVCSTPQSQyyLAEK S342
Btk (rat) VVCSTPQSQYYLAEK S343
Y344-p
CSTPQSQyyLAEKHL
Upstream
0 189
Regulatory protein:
  • FCER1A (mouse)
Btk (human) CSTPQsQyyLAEKHL Y344-p
Btk iso2 (human) CSTPQSQYYLAEKHL Y378
Btk (mouse) CSTPQSQyyLAEKHL Y344-p
Btk (rat) CSTPQSQYYLAEKHL Y345
Y345-p
STPQSQyyLAEKHLF
0 8
Btk (human) STPQsQyyLAEKHLF Y345-p
Btk iso2 (human) STPQSQYYLAEKHLF Y379
Btk (mouse) STPQSQyyLAEKHLF Y345-p
Btk (rat) STPQSQYYLAEKHLF Y346
Y361-p
TIPELINyHQHNSAG
0 112
Btk (human) TIPELINyHQHNsAG Y361-p
Btk iso2 (human) TIPELINYHQHNSAG Y395
Btk (mouse) TIPELINyHQHNSAG Y361-p
Btk (rat) TIPELINYHQHNSAG Y362
S366
INyHQHNSAGLISRL
0 3
Btk (human) INyHQHNsAGLIsRL S366-p
Btk iso2 (human) INYHQHNSAGLISRL S400
Btk (mouse) INyHQHNSAGLISRL S366
Btk (rat) INYHQHNSAGLISRL S367
S371
HNSAGLISRLKyPVS
0 1
Btk (human) HNsAGLIsRLKyPVs S371-p
Btk iso2 (human) HNSAGLISRLKYPVS S405
Btk (mouse) HNSAGLISRLKyPVS S371
Btk (rat) HNSAGLISRLKYPVS S372
Y375-p
GLISRLKyPVSKQNK
Upstream
Downstream
1 25
Effects on Modified Protein
  • not reported
Putative in vivo kinases:
  • Btk (mouse)
Btk (human) GLIsRLKyPVsQQNK Y375-p
Btk iso2 (human) GLISRLKYPVSQQNK Y409
Btk (mouse) GLISRLKyPVSKQNK Y375-p
Btk (rat) GLISRLKYPVSKQNK Y376
S378
SRLKyPVSKQNKNAP
0 2
Btk (human) sRLKyPVsQQNKNAP S378-p
Btk iso2 (human) SRLKYPVSQQNKNAP S412
Btk (mouse) SRLKyPVSKQNKNAP S378
Btk (rat) SRLKYPVSKQNKNAP S379
K406
PKDLTFLKELGTGQF
0 13
Btk (human) PKDLTFLkELGTGQF K406-ub
Btk iso2 (human) PKDLTFLKELGTGQF K440
Btk (mouse) PKDLTFLKELGTGQF K406
Btk (rat) PKDLTFLKELGTGQF K407
Y425-p
YGKWRGQyDVAIKMI
0 1
Btk (human) YGKWRGQYDVAIKMI Y425
Btk iso2 (human) YGKWRGQYDVAIKMI Y459
Btk (mouse) YGKWRGQyDVAIKMI Y425-p
Btk (rat) YGKWRGQYDVAIKMI Y426
S436-p
IKMIREGsMSEDEFI
0 1
Btk (human) IKMIKEGSMSEDEFI S436
Btk iso2 (human) IKMIKEGSMSEDEFI S470
Btk (mouse) IKMIREGsMSEDEFI S436-p
Btk (rat) IKMIREGSMSEDEFI S437
Y461-p
HEKLVQLyGVCTKQR
0 15
Btk (human) HEKLVQLyGVCTkQR Y461-p
Btk iso2 (human) HEKLVQLYGVCTKQR Y495
Btk (mouse) HEKLVQLyGVCTKQR Y461-p
Btk (rat) HEKLVQLyGVCTKQR Y462-p
K466
QLyGVCTKQRPIFII
0 3
Btk (human) QLyGVCTkQRPIFII K466-ub
Btk iso2 (human) QLYGVCTKQRPIFII K500
Btk (mouse) QLyGVCTKQRPIFII K466
Btk (rat) QLyGVCTKQRPIFII K467
T495
EMRHRFQTQQLLEMC
1 0
Btk (human) EMRHRFQtQQLLEMC T495-p
Btk iso2 (human) EMRHRFQTQQLLEMC T529
Btk (mouse) EMRHRFQTQQLLEMC T495
Btk (rat) EMRHRFQTQQLLEMC T496
K536
VNDQGVVKVSDFGLs
0 5
Btk (human) VNDQGVVkVSDFGLs K536-ub
Btk iso2 (human) VNDQGVVKVSDFGLS K570
Btk (mouse) VNDQGVVKVSDFGLs K536
Btk (rat) VNDQGVVKVSDFGLS K537
S543-p
KVSDFGLsRYVLDDE
0 2
Btk (human) kVSDFGLsRYVLDDE S543-p
Btk iso2 (human) KVSDFGLSRYVLDDE S577
Btk (mouse) KVSDFGLsRYVLDDE S543-p
Btk (rat) KVSDFGLSRYVLDDE S544
Y551-p
RYVLDDEyTsSVGSK
Upstream
Downstream
35 149
Btk (human)
Y551-p
Btk iso2 (human)
Y585-p
Btk (mouse)
Y551-p
Btk (rat)
Y552-p
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • Btk (mouse)
Phosphatases, in vitro:
  • STS-1 (mouse)
Putative in vivo kinases:
  • LYN (human)
  • PIK3CD (mouse)
Putative upstream phosphatases:
  • STS-1 (mouse)
Regulatory protein:
  • FCER1A (mouse)
Treatment
  • convulxin
Btk (human) RYVLDDEytsSVGSk Y551-p
Btk iso2 (human) RYVLDDEYTSSVGSK Y585
Btk (mouse) RYVLDDEyTsSVGSK Y551-p
Btk (rat) RYVLDDEYTSSVGSK Y552
T552
YVLDDEyTsSVGSKF
0 9
Btk (human) YVLDDEytsSVGSkF T552-p
Btk iso2 (human) YVLDDEYTSSVGSKF T586
Btk (mouse) YVLDDEyTsSVGSKF T552
Btk (rat) YVLDDEYTSSVGSKF T553
S553-p
VLDDEyTsSVGSKFP
0 4
Btk (human) VLDDEytsSVGSkFP S553-p
Btk iso2 (human) VLDDEYTSSVGSKFP S587
Btk (mouse) VLDDEyTsSVGSKFP S553-p
Btk (rat) VLDDEYTSSVGSKFP S554
K558
yTsSVGSKFPVRWSP
0 12
Btk (human) ytsSVGSkFPVRWsP K558-ub
Btk iso2 (human) YTSSVGSKFPVRWSP K592
Btk (mouse) yTsSVGSKFPVRWSP K558
Btk (rat) YTSSVGSKFPVRWSP K559
S564
SKFPVRWSPPEVLMY
0 1
Btk (human) SkFPVRWsPPEVLMY S564-p
Btk iso2 (human) SKFPVRWSPPEVLMY S598
Btk (mouse) SKFPVRWSPPEVLMY S564
Btk (rat) SKFPVRWSPPEVLMY S565
T602
KMPYERFTNSETAEH
0 1
Btk (human) KMPYERFtNsETAEH T602-p
Btk iso2 (human) KMPYERFTNSETAEH T636
Btk (mouse) KMPYERFTNSETAEH T602
Btk (rat) KIPYERFTNSETAEH T603
S604
PYERFTNSETAEHIA
0 2
Btk (human) PYERFtNsETAEHIA S604-p
Btk iso2 (human) PYERFTNSETAEHIA S638
Btk (mouse) PYERFTNSETAEHIA S604
Btk (rat) PYERFTNSETAEHIA S605
Y617-p
IAQGLRLyRPHLAsE
Upstream
1 1
Putative in vivo kinases:
  • Btk (mouse)
Btk (human) IAQGLRLYRPHLASE Y617
Btk iso2 (human) IAQGLRLYRPHLASE Y651
Btk (mouse) IAQGLRLyRPHLAsE Y617-p
Btk (rat) IAQGLRLYRPHLASD Y618
S623-p
LyRPHLAsERVYTIM
0 1
Btk (human) LYRPHLASEKVYTIM S623
Btk iso2 (human) LYRPHLASEKVYTIM S657
Btk (mouse) LyRPHLAsERVYTIM S623-p
Btk (rat) LYRPHLASDRVYTIM S624
S659
LDVMDEES_______
0 1
Btk (human) LDVMDEEs_______ S659-p
Btk iso2 (human) LDVMDEES_______ S693
Btk (mouse) LDVMDEES_______ S659
Btk (rat) LDVMDEES_______ S660