Other Species / Isoforms
  CASP8 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
-
gap
0 11
CASP8 (human) gap -
CASP8 iso2 (human) gap -
CASP8 iso4 (human) gap -
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) PGKGGADyILLPFKK Y52-p
CASP8 (mouse) gap -
CASP8 (rat) gap -
Y8
MDFSRNLYDIGEQLD
1 1
CASP8 (human) MDFSRNLYDIGEQLD Y8
CASP8 iso2 (human) MDFSRNLYDIGEQLD Y8
CASP8 iso4 (human) MDFSRNLyDIGEQLD Y8-p
CASP8 iso5 (human) MDFSRNLYDIGEQLD Y8
CASP8 iso6 (human) MDFSRNLYDIGEQLD Y8
CASP8 iso9 (human) MDFSRNLYDIGEQLD Y67
CASP8 (mouse) MDFQSCLYAIAEELG Y8
CASP8 (rat) MDFHSCLYDIAERLG Y8
S16-p
DIGEQLDsEDLASLk
0 1
CASP8 (human) DIGEQLDsEDLASLk S16-p
CASP8 iso2 (human) DIGEQLDSEDLASLK S16
CASP8 iso4 (human) DIGEQLDSEDLASLK S16
CASP8 iso5 (human) DIGEQLDSEDLASLK S16
CASP8 iso6 (human) DIGEQLDSEDLASLK S16
CASP8 iso9 (human) DIGEQLDSEDLASLK S75
CASP8 (mouse) AIAEELGSEDLAALK S16
CASP8 (rat) DIAERLGNEELAALK N16
K23-ub
sEDLASLkFLSLDYI
0 4
CASP8 (human) sEDLASLkFLSLDYI K23-ub
CASP8 iso2 (human) SEDLASLKFLSLDYI K23
CASP8 iso4 (human) SEDLASLKFLSLDYI K23
CASP8 iso5 (human) SEDLASLKFLSLDYI K23
CASP8 iso6 (human) SEDLASLKFLSLDYI K23
CASP8 iso9 (human) SEDLASLKFLSLDYI K82
CASP8 (mouse) SEDLAALKFLCLDYI K23
CASP8 (rat) NEELAALKFLCLDHI K23
K34-ub
LDYIPQRkQEPIkDA
0 1
CASP8 (human) LDYIPQRkQEPIkDA K34-ub
CASP8 iso2 (human) LDYIPQRKQEPIKDA K34
CASP8 iso4 (human) LDYIPQRKQEPIKDA K34
CASP8 iso5 (human) LDYIPQRKQEPIKDA K34
CASP8 iso6 (human) LDYIPQRKQEPIKDA K34
CASP8 iso9 (human) LDYIPQRKQEPIKDA K93
CASP8 (mouse) LDYIPHKKQETIEDA K34
CASP8 (rat) LDHIPQKKQESINDV K34
K39-ub
QRkQEPIkDALMLFQ
0 1
CASP8 (human) QRkQEPIkDALMLFQ K39-ub
CASP8 iso2 (human) QRKQEPIKDALMLFQ K39
CASP8 iso4 (human) QRKQEPIKDALMLFQ K39
CASP8 iso5 (human) QRKQEPIKDALMLFQ K39
CASP8 iso6 (human) QRKQEPIKDALMLFQ K39
CASP8 iso9 (human) QRKQEPIKDALMLFQ K98
CASP8 (mouse) HKKQETIEDAQKLFL E39
CASP8 (rat) QKKQESINDVLVLFQ N39
K63-ub
ESNLSFLkELLFRIN
0 10
CASP8 (human) ESNLSFLkELLFRIN K63-ub
CASP8 iso2 (human) ESNLSFLKELLFRIN K63
CASP8 iso4 (human) ESNLSFLKELLFRIN K63
CASP8 iso5 (human) ESNLSFLKELLFRIN K63
CASP8 iso6 (human) ESNLSFLKELLFRIN K63
CASP8 iso9 (human) ESNLSFLKELLFRIN K122
CASP8 (mouse) EGNLSFLKELLFHIS K63
CASP8 (rat) EDNLSFLKELLFHIS K63
S113-p
YQISEEVsRSELRSF
0 1
CASP8 (human) YQISEEVsRSELRSF S113-p
CASP8 iso2 (human) YQISEEVSRSELRSF S113
CASP8 iso4 (human) YQISEEVSRSELRSF S145
CASP8 iso5 (human) YQISEEVSRSELRSF S113
CASP8 iso6 (human) YQISEEVSRSELRSF S113
CASP8 iso9 (human) YQISEEVSRSELRSF S172
CASP8 (mouse) FKLSEEVSELELRSF S113
CASP8 (rat) FKLSEDMDKEDLKSF D113
K121-ub
RSELRSFkFLLQEEI
0 1
CASP8 (human) RSELRSFkFLLQEEI K121-ub
CASP8 iso2 (human) RSELRSFKFLLQEEI K121
CASP8 iso4 (human) RSELRSFKFLLQEEI K153
CASP8 iso5 (human) RSELRSFKFLLQEEI K121
CASP8 iso6 (human) RSELRSFKFLLQEEI K121
CASP8 iso9 (human) RSELRSFKFLLQEEI K180
CASP8 (mouse) ELELRSFKFLLNNEI K121
CASP8 (rat) KEDLKSFKFLLITEI K121
K130-ub
LLQEEISkCKLDDDM
0 2
CASP8 (human) LLQEEISkCKLDDDM K130-ub
CASP8 iso2 (human) LLQEEISKCKLDDDM K130
CASP8 iso4 (human) LLQEEISKCKLDDDM K162
CASP8 iso5 (human) LLQEEISKCKLDDDM K130
CASP8 iso6 (human) LLQEEISKCKLDDDM K130
CASP8 iso9 (human) LLQEEISKCKLDDDM K189
CASP8 (mouse) LLNNEIPKCKLEDDL K130
CASP8 (rat) LLITEIPKCKLQDNS K130
K148-ub
DIFIEMEkRVILGEG
0 1
CASP8 (human) DIFIEMEkRVILGEG K148-ub
CASP8 iso2 (human) DIFIEMEKRVILGEG K148
CASP8 iso4 (human) DIFIEMEKRVILGEG K180
CASP8 iso5 (human) DIFIEMEKRVILGEG K148
CASP8 iso6 (human) DIFIEMEKRVILGEG K148
CASP8 iso9 (human) DIFIEMEKRVILGEG K207
CASP8 (mouse) EIFVEMEKRTMLAEN K148
CASP8 (rat) DIFVEMEKRTILAEN K148
K156-ub
RVILGEGkLDILKRV
1 2
CASP8 (human) RVILGEGkLDILKRV K156-ub
CASP8 iso2 (human) RVILGEGKLDILKRV K156
CASP8 iso4 (human) RVILGEGKLDILKRV K188
CASP8 iso5 (human) RVILGEGKLDILKRV K156
CASP8 iso6 (human) RVILGEGKLDILKRV K156
CASP8 iso9 (human) RVILGEGkLDILKRV K215-ub
CASP8 (mouse) RTMLAENNLETLKSI N156
CASP8 (rat) RTILAENNLVTLKSI N156
K156-sm
RVILGEGkLDILKRV
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
CASP8 (human) RVILGEGkLDILKRV K156-sm
CASP8 iso2 (human) RVILGEGKLDILKRV K156
CASP8 iso4 (human) RVILGEGKLDILKRV K188
CASP8 iso5 (human) RVILGEGKLDILKRV K156
CASP8 iso6 (human) RVILGEGKLDILKRV K156
CASP8 iso9 (human) RVILGEGKLDILKRV K215
CASP8 (mouse) RTMLAENNLETLKSI N156
CASP8 (rat) RTILAENNLVTLKSI N156
K169-ub
RVCAQINkSLLkIIN
0 2
CASP8 (human) RVCAQINkSLLkIIN K169-ub
CASP8 iso2 (human) RVCAQINKSLLKIIN K169
CASP8 iso4 (human) RVCAQINKSLLKIIN K201
CASP8 iso5 (human) RVCAQINKSLLKIIN K169
CASP8 iso6 (human) RVCAQINKSLLKIIN K169
CASP8 iso9 (human) RVCAQINKSLLKIIN K228
CASP8 (mouse) SICDQVNKSLLGKIE K169
CASP8 (rat) SICFRVNRSLLGRID R169
K173-ub
QINkSLLkIINDyEE
0 2
CASP8 (human) QINkSLLkIINDyEE K173-ub
CASP8 iso2 (human) QINKSLLKIINDYEE K173
CASP8 iso4 (human) QINKSLLKIINDYEE K205
CASP8 iso5 (human) QINKSLLKIINDYEE K173
CASP8 iso6 (human) QINKSLLKIINDYEE K173
CASP8 iso9 (human) QINKSLLKIINDYEE K232
CASP8 (mouse) QVNKSLLGKIEDYER G173
CASP8 (rat) RVNRSLLGRIDDYER G173
Y178-p
LLkIINDyEEFSkER
0 1
CASP8 (human) LLkIINDyEEFSkER Y178-p
CASP8 iso2 (human) LLKIINDYEEFSKGE Y178
CASP8 iso4 (human) LLKIINDYEEFSkGE Y210
CASP8 iso5 (human) LLKIINDYEEFSKER Y178
CASP8 iso6 (human) LLKIINDYEEFSkDF Y178
CASP8 iso9 (human) LLKIINDYEEFSKER Y237
CASP8 (mouse) LLGKIEDYERSSTER Y178
CASP8 (rat) LLGRIDDYERSSTER Y178
K183-ub
NDyEEFSkERSSSLE
1 3
CASP8 (human) NDyEEFSkERSSSLE K183-ub
CASP8 iso2 (human) NDYEEFSKGEELCGV K183
CASP8 iso4 (human) NDYEEFSkGEELCGV K215-ub
CASP8 iso5 (human) NDYEEFSKERSSSLE K183
CASP8 iso6 (human) NDYEEFSkDFGQSLP K183-ub
CASP8 iso9 (human) NDYEEFSKERSSSLE K242
CASP8 (mouse) EDYERSSTERRMsLE T183
CASP8 (rat) DDYERSSTERRMstE T183
S188
FSkERSSSLEGsPDE
0 24
CASP8 (human) FSkERSSSLEGsPDE S188
CASP8 iso2 (human) gap -
CASP8 iso4 (human) gap -
CASP8 iso5 (human) FSKERSSSLEGSPDE S188
CASP8 iso6 (human) gap -
CASP8 iso9 (human) FSKERSSSLEGSPDE S247
CASP8 (mouse) SSTERRMsLEGREEL S188-p
CASP8 (rat) SSTERRMstEGGEEL S188-p
L189
SkERSSSLEGsPDEF
0 1
CASP8 (human) SkERSSSLEGsPDEF L189
CASP8 iso2 (human) gap -
CASP8 iso4 (human) gap -
CASP8 iso5 (human) SKERSSSLEGSPDEF L189
CASP8 iso6 (human) gap -
CASP8 iso9 (human) SKERSSSLEGSPDEF L248
CASP8 (mouse) STERRMsLEGREELP L189
CASP8 (rat) STERRMstEGGEELP T189-p
S192-p
RSSSLEGsPDEFSNG
0 1
CASP8 (human) RSSSLEGsPDEFSNG S192-p
CASP8 iso2 (human) gap -
CASP8 iso4 (human) gap -
CASP8 iso5 (human) RSSSLEGSPDEFSND S192
CASP8 iso6 (human) gap -
CASP8 iso9 (human) RSSSLEGSPDEFSNG S251
CASP8 (mouse) RRMsLEGREELPPsV R192
CASP8 (rat) RRMstEGGEELPVSV G192
E195
SLEGsPDEFSNGEEL
0 2
CASP8 (human) SLEGsPDEFSNGEEL E195
CASP8 iso2 (human) gap -
CASP8 iso4 (human) gap -
CASP8 iso5 (human) SLEGSPDEFSNDFGQ E195
CASP8 iso6 (human) gap -
CASP8 iso9 (human) SLEGSPDEFSNGEEL E254
CASP8 (mouse) GREELPPsVLDEMSL S198-p
CASP8 (rat) GGEELPVSVLDEVTI S198
S209-p
LCGVMTIsDsPREQD
0 1
CASP8 (human) LCGVMTIsDsPREQD S209-p
CASP8 iso2 (human) LCGVMTISDSPREQD S194
CASP8 iso4 (human) LCGVMTISDsPREQD S226
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) LCGVMTISDSPREQD S268
CASP8 (mouse) SLKMAELCDsPREQD C211
CASP8 (rat) TIKMQDMWDSPGEQE W211
S211-p
GVMTIsDsPREQDSE
0 10
CASP8 (human) GVMTIsDsPREQDSE S211-p
CASP8 iso2 (human) GVMTISDSPREQDSE S196
CASP8 iso4 (human) GVMTISDsPREQDSE S228-p
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) GVMTISDSPREQDSE S270
CASP8 (mouse) KMAELCDsPREQDSE S213-p
CASP8 (rat) KMQDMWDSPGEQESE S213
S219-p
PREQDSEsQTLDkVY
0 1
CASP8 (human) PREQDSEsQTLDkVY S219-p
CASP8 iso2 (human) PREQDSESQTLDKVY S204
CASP8 iso4 (human) PREQDSESQTLDKVy S236
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) PREQDSESQTLDKVY S278
CASP8 (mouse) PREQDSESRTSDkVY S221
CASP8 (rat) PGEQESESLNSDNVY S221
K224
SEsQTLDKVYQMkSK
0 1
CASP8 (human) SEsQTLDKVYQMkSK K224
CASP8 iso2 (human) SESQTLDKVYQMKSK K209
CASP8 iso4 (human) SESQTLDKVyQMKSK K241
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) SESQTLDKVYQMKSK K283
CASP8 (mouse) SESRTSDkVYQMKNK K226-ac
CASP8 (rat) SESLNSDNVYQMKSK N226
K224-ub
SEsQTLDkVYQMkSK
0 2
CASP8 (human) SEsQTLDkVYQMkSK K224-ub
CASP8 iso2 (human) SESQTLDKVYQMKSK K209
CASP8 iso4 (human) SESQTLDKVyQMKSK K241
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) SESQTLDKVYQMKSK K283
CASP8 (mouse) SESRTSDKVYQMKNK K226
CASP8 (rat) SESLNSDNVYQMKSK N226
Y226
sQTLDkVYQMkSKPR
1 1
CASP8 (human) sQTLDkVYQMkSKPR Y226
CASP8 iso2 (human) SQTLDKVYQMKSKPR Y211
CASP8 iso4 (human) SQTLDKVyQMKSKPR Y243-p
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) SQTLDKVYQMKSKPR Y285
CASP8 (mouse) SRTSDkVYQMKNKPR Y228
CASP8 (rat) SLNSDNVYQMKSKPR Y228
K229-ub
LDkVYQMkSKPRGyC
0 1
CASP8 (human) LDkVYQMkSKPRGyC K229-ub
CASP8 iso2 (human) LDKVYQMKSKPRGYC K214
CASP8 iso4 (human) LDKVyQMKSKPRGYC K246
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) LDKVYQMKSKPRGYC K288
CASP8 (mouse) SDkVYQMKNKPRGYC K231
CASP8 (rat) SDNVYQMKSKPRGYC K231
Y235-p
MkSKPRGyCLIINNH
0 1
CASP8 (human) MkSKPRGyCLIINNH Y235-p
CASP8 iso2 (human) MKSKPRGYCLIINNH Y220
CASP8 iso4 (human) MKSKPRGYCLIINNH Y252
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) MKSKPRGYCLIINNH Y294
CASP8 (mouse) MKNKPRGYCLIINNH Y237
CASP8 (rat) MKSKPRGYCLIFNNN Y237
K253-ub
KAREKVPkLHSIRDR
0 1
CASP8 (human) KAREKVPkLHSIRDR K253-ub
CASP8 iso2 (human) KAREKVPKLHSIRDR K238
CASP8 iso4 (human) KAREKVPKLHSIRDR K270
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) KAREKVPKLHSIRDR K312
CASP8 (mouse) KAREDITQLRKMKDR Q255
CASP8 (rat) KAREDIPKLSNMRDR K255
T263-p
SIRDRNGtHLDAGAL
Upstream
Downstream
2 1
Effects on Modified Protein
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
Kinase, in vitro:
  • RSK2 (human)
Putative in vivo kinases:
  • RSK2 (human)
Treatment
  • kaempferol
  • siRNA
CASP8 (human) SIRDRNGtHLDAGAL T263-p
CASP8 iso2 (human) SIRDRNGTHLDAGAL T248
CASP8 iso4 (human) SIRDRNGTHLDAGAL T280
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) SIRDRNGTHLDAGAL T322
CASP8 (mouse) KMKDRKGtDCDKEAL T265-p
CASP8 (rat) NMRDRKGTNYDEEAL T265
T273-p
DAGALTTtFEELHFE
Upstream
Downstream
4 0
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • PLK3 (human)
Putative in vivo kinases:
  • PLK3 (human)
Treatment
  • Fas
  • TRAIL
CASP8 (human) DAGALTTtFEELHFE T273-p
CASP8 iso2 (human) DAGALTTTFEELHFE T258
CASP8 iso4 (human) DAGALTTTFEELHFE T290
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) DAGALTTTFEELHFE T332
CASP8 (mouse) DKEALSKTFKELHFE T275
CASP8 (rat) DEEALSKTFKELHFE T275
S305-p
IYQLMDHsNMDCFIC
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein processing
Effects on Biological Processes:
  • apoptosis, inhibited
Kinase, in vitro:
  • PLK1 (human)
Putative in vivo kinases:
  • PLK1 (human)
Treatment
  • BI2536
CASP8 (human) IYQLMDHsNMDCFIC S305-p
CASP8 iso2 (human) IYQLMDHSNMDCFIC S290
CASP8 iso4 (human) IYQLMDHSNMDCFIC S322
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) IYQLMDHSNMDCFIC S364
CASP8 (mouse) GYQSADHKNKDCFIC K307
CASP8 (rat) SYQSKDHKGKDCFIC K307
Y334-p
DGQEAPIyELTSQFT
1 13
CASP8 (human) DGQEAPIyELTSQFT Y334-p
CASP8 iso2 (human) DGQEAPIYELTSQFT Y319
CASP8 iso4 (human) DGQEAPIyELTSQFT Y351-p
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) DGQEAPIYELTSQFT Y393
CASP8 (mouse) DGKEASIYDLTSYFT Y336
CASP8 (rat) DGKEASIYELTSYFT Y336
K344-ub
TSQFTGLkCPsLAGk
0 2
CASP8 (human) TSQFTGLkCPsLAGk K344-ub
CASP8 iso2 (human) TSQFTGLKCPSLAGK K329
CASP8 iso4 (human) TSQFTGLKCPSLAGK K361
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) TSQFTGLKCPSLAGK K403
CASP8 (mouse) TSYFTGSKCPSLSGK K346
CASP8 (rat) TSYFTGSKCPSLAGK K346
S347-p
FTGLkCPsLAGkPkV
Upstream
Downstream
1 0
Effects on Modified Protein
  • activity, inhibited
Effects on Biological Processes:
  • apoptosis, inhibited
Kinase, in vitro:
  • P38A (human)
Putative in vivo kinases:
  • P38A (human)
CASP8 (human) FTGLkCPsLAGkPkV S347-p
CASP8 iso2 (human) FTGLKCPSLAGKPKV S332
CASP8 iso4 (human) FTGLKCPSLAGKPKV S364
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) FTGLKCPSLAGKPKV S406
CASP8 (mouse) FTGSKCPSLSGKPKI S349
CASP8 (rat) FTGSKCPSLAGKPKI S349
K351-ub
kCPsLAGkPkVFFIQ
0 2
CASP8 (human) kCPsLAGkPkVFFIQ K351-ub
CASP8 iso2 (human) KCPSLAGKPKVFFIQ K336
CASP8 iso4 (human) KCPSLAGKPKVFFIQ K368
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) KCPSLAGKPKVFFIQ K410
CASP8 (mouse) KCPSLSGKPKIFFIQ K353
CASP8 (rat) KCPSLAGKPKIFFIQ K353
K353-ub
PsLAGkPkVFFIQAC
0 1
CASP8 (human) PsLAGkPkVFFIQAC K353-ub
CASP8 iso2 (human) PSLAGKPKVFFIQAC K338
CASP8 iso4 (human) PSLAGKPKVFFIQAC K370
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) PSLAGKPKVFFIQAC K412
CASP8 (mouse) PSLSGKPKIFFIQAC K355
CASP8 (rat) PSLAGKPKIFFIQAC K355
T373-p
QKGIPVEtDsEEQPy
0 1
CASP8 (human) QKGIPVEtDsEEQPy T373-p
CASP8 iso2 (human) QKGIPVETDSEEQPY T358
CASP8 iso4 (human) QKGIPVETDSEEQPy T390
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) QKGIPVETDSEEQPY T432
CASP8 (mouse) QKGVPDEAGFEQQNH A375
CASP8 (rat) QKAVPVPDETGLEQE D375
S375-p
GIPVEtDsEEQPyLE
0 3
CASP8 (human) GIPVEtDsEEQPyLE S375-p
CASP8 iso2 (human) GIPVETDSEEQPYLE S360
CASP8 iso4 (human) GIPVETDSEEQPyLE S392
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) GIPVETDSEEQPYLE S434
CASP8 (mouse) GVPDEAGFEQQNHTL F377
CASP8 (rat) AVPVPDETGLEQEHV T377
Y380-p
tDsEEQPyLEMDLSs
Upstream
Downstream
10 38
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein processing
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell adhesion, altered
  • cell growth, induced
  • cell motility, altered
  • cell motility, induced
  • transcription, induced
Kinase, in vitro:
  • Src (human)
Putative in vivo kinases:
  • LYN (human)
  • Src (human)
Putative upstream phosphatases:
  • SHP-1 (human)
Regulatory protein:
  • FAK (human)
Treatment
  • dasatinib
  • EGF
  • Fas
  • fibronectin
  • siRNA
view more >
CASP8 (human) tDsEEQPyLEMDLSs Y380-p
CASP8 iso2 (human) TDSEEQPYLEMDLSS Y365
CASP8 iso4 (human) TDSEEQPyLEMDLSS Y397-p
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) TDSEEQPYLEMDLSS Y439
CASP8 (mouse) AGFEQQNHTLEVDSS H382
CASP8 (rat) ETGLEQEHVLEEDSS H383
S387-p
yLEMDLSsPQTRYIP
Upstream
Downstream
5 2
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein conformation
  • protein processing
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, inhibited
  • carcinogenesis, altered
  • cell cycle regulation
Kinase, in vitro:
  • CDK1 (human)
  • ERK2 (human)
Putative in vivo kinases:
  • CDK1 (human)
  • ERK1 (human)
  • ERK2 (human)
view more >
Regulatory protein:
  • CCNB1 (human)
  • ERK1 (human)
  • ERK2 (human)
  • FasL (human)
view more >
Treatment
  • cycloheximide
  • dinaciclib
  • nocodazole
  • PD98059
  • RO-3306
  • TRAIL
view more >
CASP8 (human) yLEMDLSsPQTRYIP S387-p
CASP8 iso2 (human) YLEMDLSSPQTRYIP S372
CASP8 iso4 (human) yLEMDLSSPQTRYIP S404
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) YLEMDLSSPQTRYIP S446
CASP8 (mouse) HTLEVDSSSHKNYIP S389
CASP8 (rat) HVLEEDSSSYKNYIP S390
Y448-p
TILTEVNyEVSNKDD
Upstream
Downstream
2 1
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • apoptosis, altered
Putative in vivo kinases:
  • LYN (human)
Putative upstream phosphatases:
  • SHP-1 (human)
CASP8 (human) TILTEVNyEVSNKDD Y448-p
CASP8 iso2 (human) TILTEVNYEVSNKDD Y433
CASP8 iso4 (human) TILTEVNyEVSNKDD Y465-p
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) TILTEVNYEVSNKDD Y507
CASP8 (mouse) SILTGVNYDVSNKDD Y450
CASP8 (rat) SILTGVNYDVSNKDN Y451
K461-ub
DDKKNMGkQMPQPTF
0 3
CASP8 (human) DDKKNMGkQMPQPTF K461-ub
CASP8 iso2 (human) DDKKNMGKQMPQPTF K446
CASP8 iso4 (human) DDKKNMGKQMPQPTF K478
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) DDKKNMGKQMPQPTF K520
CASP8 (mouse) DDRRNKGKQMPQPTF K463
CASP8 (rat) DNPRNMGKQMPQPIF K464
K473-ub
PTFTLRKkLVFPSD_
0 1
CASP8 (human) PTFTLRKkLVFPSD_ K473-ub
CASP8 iso2 (human) PTFTLRKKLVFPSD_ K458
CASP8 iso4 (human) PTFTLRKKLVFPSD_ K490
CASP8 iso5 (human) gap -
CASP8 iso6 (human) gap -
CASP8 iso9 (human) PTFTLRKKLVFPSD_ K532
CASP8 (mouse) PTFTLRKKLFFPP__ K475
CASP8 (rat) PIFTLRKKLFFPPN_ K476