S69
|
KQVRLWVSPSGLRCE
|
|
|
0
|
2
|
|
|
TBC1D1 (human)
|
KQVRLCVsPSGLRCE
|
S69-p
|
TBC1D1 iso2 (human)
|
KQVRLCVSPSGLRCE
|
S69
|
TBC1D1 (mouse)
|
KQVRLWVSPSGLRCE
|
S69
|
TBC1D1 iso2 (mouse)
|
KQVRLWVSPSGLRCE
|
S69
|
TBC1D1 (rat)
|
KQVRLWVSPSGLRCE
|
S69
|
|
C90
|
QPWDPLICSSIFECK
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
QQWDPLIySSIFECK
|
Y90-p
|
TBC1D1 iso2 (human)
|
QQWDPLIYSSIFECK
|
Y90
|
TBC1D1 (mouse)
|
QPWDPLICSSIFECK
|
C90
|
TBC1D1 iso2 (mouse)
|
QPWDPLICSSIFECK
|
C90
|
TBC1D1 (rat)
|
QPWDPLICSSIFECK
|
C90
|
|
Y113-p
|
HNSHDPSyFACLIKE
|
|
|
0
|
11
|
|
|
TBC1D1 (human)
|
HNSHDPSyFACLIKE
|
Y113-p
|
TBC1D1 iso2 (human)
|
HNSHDPSYFACLIKE
|
Y113
|
TBC1D1 (mouse)
|
HNSHDPSyFACLIKE
|
Y113-p
|
TBC1D1 iso2 (mouse)
|
HNSHDPSYFACLIKE
|
Y113
|
TBC1D1 (rat)
|
HNSQDPSYFACLIKE
|
Y113
|
|
S145-p
|
TKVPEIIssIRQAGK
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
TKVPEIISSIRQAGK
|
S145
|
TBC1D1 iso2 (human)
|
TKVPEIISSIRQAGK
|
S145
|
TBC1D1 (mouse)
|
TKVPEIIssIRQAGK
|
S145-p
|
TBC1D1 iso2 (mouse)
|
TKVPEIISSIRQAGK
|
S145
|
TBC1D1 (rat)
|
TKVPEIISSIRQAGK
|
S145
|
|
S146-p
|
KVPEIIssIRQAGKI
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
KVPEIISSIRQAGKI
|
S146
|
TBC1D1 iso2 (human)
|
KVPEIISSIRQAGKI
|
S146
|
TBC1D1 (mouse)
|
KVPEIIssIRQAGKI
|
S146-p
|
TBC1D1 iso2 (mouse)
|
KVPEIISSIRQAGKI
|
S146
|
TBC1D1 (rat)
|
KVPEIISSIRQAGKI
|
S146
|
|
S163-p
|
QEELRCPsEFDDTFA
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
QEELHCPSEFDDTFS
|
S163
|
TBC1D1 iso2 (human)
|
QEELHCPSEFDDTFS
|
S163
|
TBC1D1 (mouse)
|
QEELRCPsEFDDTFA
|
S163-p
|
TBC1D1 iso2 (mouse)
|
QEELRCPSEFDDTFA
|
S163
|
TBC1D1 (rat)
|
QEELRCPSEFDDTFA
|
S163
|
|
K199
|
LIDECIEKFNHVSCG
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
LIDECIEkFNHVSGS
|
K199-ub
|
TBC1D1 iso2 (human)
|
LIDECIEKFNHVSGS
|
K199
|
TBC1D1 (mouse)
|
LIDECIEKFNHVSCG
|
K199
|
TBC1D1 iso2 (mouse)
|
LIDECIEKFNHVSCG
|
K199
|
TBC1D1 (rat)
|
LIDECIEKFNHVSCG
|
K199
|
|
-
|
gap
|
|
|
0
|
1
|
|
|
|
S229-p
|
GPRPMRKsFsQPGLR
|
|
|
1
|
3
|
|
|
TBC1D1 (human)
|
VRRPMRKsFsQPGLR
|
S235-p
|
TBC1D1 iso2 (human)
|
VRRPMRKSFSQPGLR
|
S235
|
TBC1D1 (mouse)
|
GPRPMRKsFsQPGLR
|
S229-p
|
TBC1D1 iso2 (mouse)
|
GPRPMRKSFSQPGLR
|
S229
|
TBC1D1 (rat)
|
GARPMRKSFsQPGLR
|
S229
|
|
S231-p
|
RPMRKsFsQPGLRSL
|
Upstream
|
Downstream
|
11
|
138
|
|
|
Effects on Biological Processes:
- signaling pathway regulation
- transcription, inhibited
|
|
Kinase, in vitro:
- Akt1 (human)
- AMPKA1 (human)
|
Putative in vivo kinases:
- AMPKA1 (mouse)
- AMPKA2 (human)
|
Regulatory protein:
- RIPK3 (mouse)
- TLR9 (human)
|
Treatment
- acadesine
- electrical_stimulation
- exercise
- G-1
- high-fat diet
- insulin
- LPA
- LY294002
- MSH
- muscle contraction
- obesity-inducing diet
- PF739
|
|
TBC1D1 (human)
|
RPMRKsFsQPGLRSL
|
S237-p
|
TBC1D1 iso2 (human)
|
RPMRKSFSQPGLRSL
|
S237
|
TBC1D1 (mouse)
|
RPMRKsFsQPGLRSL
|
S231-p
|
TBC1D1 iso2 (mouse)
|
RPMRKSFSQPGLRSL
|
S231
|
TBC1D1 (rat)
|
RPMRKSFsQPGLRSL
|
S231-p
|
|
K242
|
LRSLAFRKEFQDASL
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
LRSLAFRkELQDGGL
|
K248-ub
|
TBC1D1 iso2 (human)
|
LRSLAFRKELQDGGL
|
K248
|
TBC1D1 (mouse)
|
LRSLAFRKEFQDASL
|
K242
|
TBC1D1 iso2 (mouse)
|
LRSLAFRKEFQDASL
|
K242
|
TBC1D1 (rat)
|
LRSLAFRKEFQDASL
|
K242
|
|
T253-p
|
DASLRSStFssFDND
|
Upstream
|
|
1
|
7
|
|
|
Kinase, in vitro:
- Akt1 (human)
- AMPKA1 (human)
|
Putative in vivo kinases:
|
Treatment
- acadesine
- insulin
- muscle contraction
|
|
TBC1D1 (human)
|
DGGLRSSGFFSsFEE
|
G259
|
TBC1D1 iso2 (human)
|
DGGLRSSGFFSSFEE
|
G259
|
TBC1D1 (mouse)
|
DASLRSStFssFDND
|
T253-p
|
TBC1D1 iso2 (mouse)
|
DASLRSSTFSSFDND
|
T253
|
TBC1D1 (rat)
|
DASLRSSTFSSFDND
|
T253
|
|
S255-p
|
SLRSStFssFDNDIE
|
|
|
0
|
2
|
|
|
TBC1D1 (human)
|
LRSSGFFSsFEESDI
|
S262
|
TBC1D1 iso2 (human)
|
LRSSGFFSSFEESDI
|
S262
|
TBC1D1 (mouse)
|
SLRSStFssFDNDIE
|
S255-p
|
TBC1D1 iso2 (mouse)
|
SLRSSTFSSFDNDIE
|
S255
|
TBC1D1 (rat)
|
SLRSSTFSSFDNDIE
|
S255
|
|
S256-p
|
LRSStFssFDNDIEN
|
|
|
0
|
15
|
|
|
TBC1D1 (human)
|
RSSGFFSsFEESDIE
|
S263-p
|
TBC1D1 iso2 (human)
|
RSSGFFSSFEESDIE
|
S263
|
TBC1D1 (mouse)
|
LRSStFssFDNDIEN
|
S256-p
|
TBC1D1 iso2 (mouse)
|
LRSSTFSSFDNDIEN
|
S256
|
TBC1D1 (rat)
|
LRSSTFSSFDNDIEN
|
S256
|
|
S332-p
|
GFICRECsGGGsGGF
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
GFICRESSGGGGFHF
|
S340
|
TBC1D1 iso2 (human)
|
GFICRESSGGGGFHF
|
S340
|
TBC1D1 (mouse)
|
GFICRECsGGGsGGF
|
S332-p
|
TBC1D1 iso2 (mouse)
|
GFICRECSGGGSGGF
|
S332
|
TBC1D1 (rat)
|
GFICRECSGGGGAGF
|
S332
|
|
S336-p
|
RECsGGGsGGFHFVC
|
|
|
0
|
1
|
|
|
|
S402
|
RIEGMNSSKTKLELQ
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
RIEGMNSsKtKLELQ
|
S408-p
|
TBC1D1 iso2 (human)
|
RIEGMNSSKTKLELQ
|
S408
|
TBC1D1 (mouse)
|
RIEGMNSSKTKLELQ
|
S402
|
TBC1D1 iso2 (mouse)
|
RIEGMNSSKTKLELQ
|
S402
|
TBC1D1 (rat)
|
RIEGMNSSKTKLELQ
|
S402
|
|
T404
|
EGMNSSKTKLELQKH
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
EGMNSsKtKLELQKH
|
T410-p
|
TBC1D1 iso2 (human)
|
EGMNSSKTKLELQKH
|
T410
|
TBC1D1 (mouse)
|
EGMNSSKTKLELQKH
|
T404
|
TBC1D1 iso2 (mouse)
|
EGMNSSKTKLELQKH
|
T404
|
TBC1D1 (rat)
|
EGMNSSKTKLELQKH
|
T404
|
|
S489-p
|
ASRFRLDsLKNRAKR
|
Upstream
|
|
2
|
2
|
|
|
|
TBC1D1 (human)
|
ATRFRLDMLkNKAkR
|
M495
|
TBC1D1 iso2 (human)
|
ATRFRLDMLKNKAKR
|
M495
|
TBC1D1 (mouse)
|
ASRFRLDsLKNRAKR
|
S489-p
|
TBC1D1 iso2 (mouse)
|
ASRFRLDSLKNRAKR
|
S489
|
TBC1D1 (rat)
|
ASRFRLDsLKNRAKR
|
S489-p
|
|
K491
|
RFRLDsLKNRAKRsL
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
RFRLDMLkNKAkRsL
|
K497-ac
|
TBC1D1 iso2 (human)
|
RFRLDMLKNKAKRSL
|
K497
|
TBC1D1 (mouse)
|
RFRLDsLKNRAKRsL
|
K491
|
TBC1D1 iso2 (mouse)
|
RFRLDSLKNRAKRSL
|
K491
|
TBC1D1 (rat)
|
RFRLDsLKNRAKRsL
|
K491
|
|
K495
|
DsLKNRAKRsLtEsL
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
DMLkNKAkRsLtEsL
|
K501-ac
|
TBC1D1 iso2 (human)
|
DMLKNKAKRSLTESL
|
K501
|
TBC1D1 (mouse)
|
DsLKNRAKRsLtEsL
|
K495
|
TBC1D1 iso2 (mouse)
|
DSLKNRAKRSLTESL
|
K495
|
TBC1D1 (rat)
|
DsLKNRAKRsLtESL
|
K495
|
|
S497-p
|
LKNRAKRsLtEsLEs
|
|
|
0
|
14
|
|
|
TBC1D1 (human)
|
LkNKAkRsLtEsLES
|
S503-p
|
TBC1D1 iso2 (human)
|
LKNKAKRSLTESLES
|
S503
|
TBC1D1 (mouse)
|
LKNRAKRsLtEsLEs
|
S497-p
|
TBC1D1 iso2 (mouse)
|
LKNRAKRSLTESLES
|
S497
|
TBC1D1 (rat)
|
LKNRAKRsLtESLES
|
S497-p
|
|
T499-p
|
NRAKRsLtEsLEsIL
|
Upstream
|
Downstream
|
2
|
9
|
|
|
Effects on Modified Protein
|
|
Kinase, in vitro:
- Akt1 (human)
- AMPKA1 (human)
|
Putative in vivo kinases:
|
Treatment
|
|
TBC1D1 (human)
|
NKAkRsLtEsLESIL
|
T505-p
|
TBC1D1 iso2 (human)
|
NKAKRSLTESLESIL
|
T505
|
TBC1D1 (mouse)
|
NRAKRsLtEsLEsIL
|
T499-p
|
TBC1D1 iso2 (mouse)
|
NRAKRSLTESLESIL
|
T499
|
TBC1D1 (rat)
|
NRAKRsLtESLESIL
|
T499-p
|
|
S501-p
|
AKRsLtEsLEsILSR
|
Upstream
|
Downstream
|
1
|
12
|
|
|
Effects on Modified Protein
|
|
|
TBC1D1 (human)
|
AkRsLtEsLESILsR
|
S507-p
|
TBC1D1 iso2 (human)
|
AKRSLTESLESILSR
|
S507
|
TBC1D1 (mouse)
|
AKRsLtEsLEsILSR
|
S501-p
|
TBC1D1 iso2 (mouse)
|
AKRSLTESLESILSR
|
S501
|
TBC1D1 (rat)
|
AKRsLtESLESILSR
|
S501
|
|
S504-p
|
sLtEsLEsILSRGNK
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
sLtEsLESILsRGNK
|
S510
|
TBC1D1 iso2 (human)
|
SLTESLESILSRGNK
|
S510
|
TBC1D1 (mouse)
|
sLtEsLEsILSRGNK
|
S504-p
|
TBC1D1 iso2 (mouse)
|
SLTESLESILSRGNK
|
S504
|
TBC1D1 (rat)
|
sLtESLESILSRGNK
|
S504
|
|
S507
|
EsLEsILSRGNKARG
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
EsLESILsRGNKARG
|
S513-p
|
TBC1D1 iso2 (human)
|
ESLESILSRGNKARG
|
S513
|
TBC1D1 (mouse)
|
EsLEsILSRGNKARG
|
S507
|
TBC1D1 iso2 (mouse)
|
ESLESILSRGNKARG
|
S507
|
TBC1D1 (rat)
|
ESLESILSRGNKARG
|
S507
|
|
S519-p
|
ARGLQDHsAsVDLDS
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
ARGLQEHSIsVDLDS
|
S525
|
TBC1D1 iso2 (human)
|
ARGLQEHSISVDLDS
|
S525
|
TBC1D1 (mouse)
|
ARGLQDHsAsVDLDS
|
S519-p
|
TBC1D1 iso2 (mouse)
|
ARGLQDHSASVDLDS
|
S519
|
TBC1D1 (rat)
|
ARGLQDHSASVDLDS
|
S519
|
|
S521-p
|
GLQDHsAsVDLDSST
|
|
|
0
|
3
|
|
|
TBC1D1 (human)
|
GLQEHSIsVDLDSSL
|
S527-p
|
TBC1D1 iso2 (human)
|
GLQEHSISVDLDSSL
|
S527
|
TBC1D1 (mouse)
|
GLQDHsAsVDLDSST
|
S521-p
|
TBC1D1 iso2 (mouse)
|
GLQDHSASVDLDSST
|
S521
|
TBC1D1 (rat)
|
GLQDHSASVDLDSST
|
S521
|
|
S550
|
DKEAFPVSETSFKLL
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
EKEALPISESsFKLL
|
S556
|
TBC1D1 iso2 (human)
|
EKEALPISESSFKLL
|
S556
|
TBC1D1 (mouse)
|
DKEAFPVSETSFKLL
|
S550
|
TBC1D1 iso2 (mouse)
|
DKEAFPVSETSFKLL
|
S550
|
TBC1D1 (rat)
|
DKEALPIsESsFKLL
|
S550-p
|
|
S553
|
AFPVSETSFKLLGss
|
|
|
0
|
4
|
|
|
TBC1D1 (human)
|
ALPISESsFKLLGss
|
S559-p
|
TBC1D1 iso2 (human)
|
ALPISESSFKLLGSS
|
S559
|
TBC1D1 (mouse)
|
AFPVSETSFKLLGss
|
S553
|
TBC1D1 iso2 (mouse)
|
AFPVSETSFKLLGSS
|
S553
|
TBC1D1 (rat)
|
ALPIsESsFKLLGSS
|
S553-p
|
|
S559-p
|
TSFKLLGssDDLssD
|
|
|
2
|
24
|
|
|
TBC1D1 (human)
|
SsFKLLGssEDLssD
|
S565-p
|
TBC1D1 iso2 (human)
|
SSFKLLGSSEDLSSD
|
S565
|
TBC1D1 (mouse)
|
TSFKLLGssDDLssD
|
S559-p
|
TBC1D1 iso2 (mouse)
|
TSFKLLGSSDDLSSD
|
S559
|
TBC1D1 (rat)
|
SsFKLLGSSDDLSSD
|
S559
|
|
S560-p
|
SFKLLGssDDLssDs
|
|
|
1
|
21
|
|
|
TBC1D1 (human)
|
sFKLLGssEDLssDs
|
S566-p
|
TBC1D1 iso2 (human)
|
SFKLLGSSEDLSSDS
|
S566
|
TBC1D1 (mouse)
|
SFKLLGssDDLssDs
|
S560-p
|
TBC1D1 iso2 (mouse)
|
SFKLLGSSDDLSSDS
|
S560
|
TBC1D1 (rat)
|
sFKLLGSSDDLSSDS
|
S560
|
|
S564-p
|
LGssDDLssDsEGHI
|
|
|
0
|
16
|
|
|
TBC1D1 (human)
|
LGssEDLssDsEsHL
|
S570-p
|
TBC1D1 iso2 (human)
|
LGSSEDLSSDSESHL
|
S570
|
TBC1D1 (mouse)
|
LGssDDLssDsEGHI
|
S564-p
|
TBC1D1 iso2 (mouse)
|
LGSSDDLSSDSEGHI
|
S564
|
TBC1D1 (rat)
|
LGSSDDLSSDSESHI
|
S564
|
|
S565-p
|
GssDDLssDsEGHIA
|
|
|
0
|
24
|
|
|
TBC1D1 (human)
|
GssEDLssDsEsHLP
|
S571-p
|
TBC1D1 iso2 (human)
|
GSSEDLSSDSESHLP
|
S571
|
TBC1D1 (mouse)
|
GssDDLssDsEGHIA
|
S565-p
|
TBC1D1 iso2 (mouse)
|
GSSDDLSSDSEGHIA
|
S565
|
TBC1D1 (rat)
|
GSSDDLSSDSESHIA
|
S565
|
|
S567-p
|
sDDLssDsEGHIAEE
|
|
|
0
|
15
|
|
|
TBC1D1 (human)
|
sEDLssDsEsHLPEE
|
S573-p
|
TBC1D1 iso2 (human)
|
SEDLSSDSESHLPEE
|
S573
|
TBC1D1 (mouse)
|
sDDLssDsEGHIAEE
|
S567-p
|
TBC1D1 iso2 (mouse)
|
SDDLSSDSEGHIAEE
|
S567
|
TBC1D1 (rat)
|
SDDLSSDSESHIAEE
|
S567
|
|
G569
|
DLssDsEGHIAEEsA
|
|
|
0
|
6
|
|
|
TBC1D1 (human)
|
DLssDsEsHLPEEPA
|
S575-p
|
TBC1D1 iso2 (human)
|
DLSSDSESHLPEEPA
|
S575
|
TBC1D1 (mouse)
|
DLssDsEGHIAEEsA
|
G569
|
TBC1D1 iso2 (mouse)
|
DLSSDSEGHIAEESA
|
G569
|
TBC1D1 (rat)
|
DLSSDSESHIAEESA
|
S569
|
|
S575-p
|
EGHIAEEsALLsPQQ
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
EsHLPEEPAPLsPQQ
|
P581
|
TBC1D1 iso2 (human)
|
ESHLPEEPAPLSPQQ
|
P581
|
TBC1D1 (mouse)
|
EGHIAEEsALLsPQQ
|
S575-p
|
TBC1D1 iso2 (mouse)
|
EGHIAEESALLSPQQ
|
S575
|
TBC1D1 (rat)
|
ESHIAEESALLSPQQ
|
S575
|
|
S579-p
|
AEEsALLsPQQAFRR
|
|
|
0
|
41
|
|
|
TBC1D1 (human)
|
PEEPAPLsPQQAFRR
|
S585-p
|
TBC1D1 iso2 (human)
|
PEEPAPLSPQQAFRR
|
S585
|
TBC1D1 (mouse)
|
AEEsALLsPQQAFRR
|
S579-p
|
TBC1D1 iso2 (mouse)
|
AEESALLSPQQAFRR
|
S579
|
TBC1D1 (rat)
|
AEESALLSPQQAFRR
|
S579
|
|
T590-p
|
AFRRRANtLsHFPVE
|
Upstream
|
Downstream
|
11
|
150
|
|
|
Effects on Modified Protein
- activity, inhibited
- phosphorylation
|
|
Kinase, in vitro:
- Akt1 (human)
- AMPKA1 (human)
|
Putative in vivo kinases:
- Akt1 (mouse)
- AMPKA1 (mouse)
|
Regulatory protein:
|
Treatment
- acadesine
- insulin
- MSH
- muscle contraction
|
|
TBC1D1 (human)
|
AFRRRANtLsHFPIE
|
T596-p
|
TBC1D1 iso2 (human)
|
AFRRRANTLSHFPIE
|
T596
|
TBC1D1 (mouse)
|
AFRRRANtLsHFPVE
|
T590-p
|
TBC1D1 iso2 (mouse)
|
AFRRRANTLSHFPVE
|
T590
|
TBC1D1 (rat)
|
AFRRRANtLSHFPVE
|
T590-p
|
|
S592-p
|
RRRANtLsHFPVECP
|
|
|
0
|
43
|
|
|
TBC1D1 (human)
|
RRRANtLsHFPIECQ
|
S598-p
|
TBC1D1 iso2 (human)
|
RRRANTLSHFPIECQ
|
S598
|
TBC1D1 (mouse)
|
RRRANtLsHFPVECP
|
S592-p
|
TBC1D1 iso2 (mouse)
|
RRRANTLSHFPVECP
|
S592
|
TBC1D1 (rat)
|
RRRANtLSHFPVECP
|
S592
|
|
S607-p
|
APPEPAQssPGVsQR
|
|
|
0
|
11
|
|
|
TBC1D1 (human)
|
EPPQPARGsPGVsQR
|
G613
|
TBC1D1 iso2 (human)
|
EPPQPARGSPGVSQR
|
G613
|
TBC1D1 (mouse)
|
APPEPAQssPGVsQR
|
S607-p
|
TBC1D1 iso2 (mouse)
|
APPEPAQSSPGVSQR
|
S607
|
TBC1D1 (rat)
|
APPEPAQTSPGVSQR
|
T607
|
|
S608-p
|
PPEPAQssPGVsQRK
|
|
|
0
|
54
|
|
|
TBC1D1 (human)
|
PPQPARGsPGVsQRK
|
S614-p
|
TBC1D1 iso2 (human)
|
PPQPARGSPGVSQRK
|
S614
|
TBC1D1 (mouse)
|
PPEPAQssPGVsQRK
|
S608-p
|
TBC1D1 iso2 (mouse)
|
PPEPAQSSPGVSQRK
|
S608
|
TBC1D1 (rat)
|
PPEPAQTSPGVSQRK
|
S608
|
|
S612-p
|
AQssPGVsQRKLMRY
|
|
|
0
|
5
|
|
|
TBC1D1 (human)
|
ARGsPGVsQRKLMRY
|
S618-p
|
TBC1D1 iso2 (human)
|
ARGSPGVSQRKLMRY
|
S618
|
TBC1D1 (mouse)
|
AQssPGVsQRKLMRY
|
S612-p
|
TBC1D1 iso2 (mouse)
|
AQSSPGVSQRKLMRY
|
S612
|
TBC1D1 (rat)
|
AQTSPGVSQRKLMRY
|
S612
|
|
S621-p
|
RKLMRYHsVstETPH
|
Upstream
|
|
1
|
56
|
|
|
Kinase, in vitro:
- Akt1 (human)
- AMPKA1 (human)
|
Putative in vivo kinases:
|
Treatment
- acadesine
- insulin
- LY294002
- muscle contraction
|
|
TBC1D1 (human)
|
RKLMRYHsVSTETPH
|
S627-p
|
TBC1D1 iso2 (human)
|
RKLMRYHSVSTETPH
|
S627
|
TBC1D1 (mouse)
|
RKLMRYHsVstETPH
|
S621-p
|
TBC1D1 iso2 (mouse)
|
RKLMRYHsVSTETPH
|
S621-p
|
TBC1D1 (rat)
|
RKLMRYHSVSTETPH
|
S621
|
|
S623-p
|
LMRYHsVstETPHER
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
LMRYHsVSTETPHER
|
S629
|
TBC1D1 iso2 (human)
|
LMRYHSVSTETPHER
|
S629
|
TBC1D1 (mouse)
|
LMRYHsVstETPHER
|
S623-p
|
TBC1D1 iso2 (mouse)
|
LMRYHsVSTETPHER
|
S623
|
TBC1D1 (rat)
|
LMRYHSVSTETPHER
|
S623
|
|
T624-p
|
MRYHsVstETPHERN
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
MRYHsVSTETPHERK
|
T630
|
TBC1D1 iso2 (human)
|
MRYHSVSTETPHERN
|
T630
|
TBC1D1 (mouse)
|
MRYHsVstETPHERN
|
T624-p
|
TBC1D1 iso2 (mouse)
|
MRYHsVSTETPHERK
|
T624
|
TBC1D1 (rat)
|
MRYHSVSTETPHERN
|
T624
|
|
S660-p
|
PRLNPSAssPNFFKY
|
Upstream
|
Downstream
|
3
|
8
|
|
|
|
Effects on Modified Protein
- molecular association, regulation
|
Effects on Biological Processes:
- carcinogenesis, induced
- cell growth, induced
- cell motility, induced
- signaling pathway regulation
- transcription, induced
|
|
Kinase, in vitro:
- Akt1 (human)
- AMPKA1 (human)
|
Putative in vivo kinases:
|
Regulatory protein:
|
Treatment
- acadesine
- cyclochalasin D
- exercise
- insulin
- muscle contraction
|
|
|
S661-p
|
RLNPSAssPNFFKYL
|
|
|
0
|
2
|
|
|
|
K669-m1
|
PNFFKYLkHNSSGEQ
|
|
|
0
|
1
|
|
|
|
S697-p
|
ALRKKLHssssVPNF
|
|
|
0
|
1
|
|
|
|
S698-p
|
LRKKLHssssVPNFL
|
|
|
0
|
1
|
|
|
|
S699-p
|
RKKLHssssVPNFLK
|
|
|
0
|
1
|
|
|
|
S700-p
|
KKLHssssVPNFLKF
|
Upstream
|
|
2
|
8
|
|
|
|
Kinase, in vitro:
- Akt1 (human)
- AMPKA1 (human)
|
Putative in vivo kinases:
|
Treatment
- acadesine
- exercise
- insulin
- muscle contraction
|
|
|
T736
|
KANHLGDTDGtPVKT
|
|
|
0
|
2
|
|
|
TBC1D1 (human)
|
KANHLGDsGGtPVKT
|
S649-p
|
TBC1D1 iso2 (human)
|
KANHLGDSGGTPVKT
|
S743
|
TBC1D1 (mouse)
|
KANHLGDTDGtPVKT
|
T736
|
TBC1D1 iso2 (mouse)
|
KANHLGDTDGtPVKT
|
T643
|
TBC1D1 (rat)
|
KANHLGDTDGtPVKA
|
T738
|
|
T739-p
|
HLGDTDGtPVKTRRH
|
|
|
0
|
15
|
|
|
|
S747-p
|
PVKTRRHsWRQQIFL
|
|
|
0
|
7
|
|
|
TBC1D1 (human)
|
PVKTRRHsWRQQIFL
|
S660-p
|
TBC1D1 iso2 (human)
|
PVKTRRHSWRQQIFL
|
S754
|
TBC1D1 (mouse)
|
PVKTRRHsWRQQIFL
|
S747-p
|
TBC1D1 iso2 (mouse)
|
PVKTRRHSWRQQIFL
|
S654
|
TBC1D1 (rat)
|
PVKARRHSWRQQIFL
|
S749
|
|
T758
|
QIFLRVATPQKACDS
|
|
|
0
|
4
|
|
|
TBC1D1 (human)
|
QIFLRVAtPQKACDS
|
T671-p
|
TBC1D1 iso2 (human)
|
QIFLRVATPQKACDS
|
T765
|
TBC1D1 (mouse)
|
QIFLRVATPQKACDS
|
T758
|
TBC1D1 iso2 (mouse)
|
QIFLRVATPQKACDS
|
T665
|
TBC1D1 (rat)
|
QIFLRVATPQKACDS
|
T760
|
|
S782-p
|
LGELPPRsPLEPVCE
|
|
|
0
|
5
|
|
|
TBC1D1 (human)
|
LGELPPRsPLEPVCE
|
S695-p
|
TBC1D1 iso2 (human)
|
LGELPPRSPLEPVCE
|
S789
|
TBC1D1 (mouse)
|
LGELPPRsPLEPVCE
|
S782-p
|
TBC1D1 iso2 (mouse)
|
LGELPPRSPLEPVCE
|
S689
|
TBC1D1 (rat)
|
LGELPPRSPLEPVCE
|
S784
|
|
K830
|
RMEKENQKLQASEND
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
RMEKENQkLQASEND
|
K743-ub
|
TBC1D1 iso2 (human)
|
RMEKENQKLQASEND
|
K837
|
TBC1D1 (mouse)
|
RMEKENQKLQASEND
|
K830
|
TBC1D1 iso2 (mouse)
|
RMEKENQKLQASEND
|
K737
|
TBC1D1 (rat)
|
RMEKENQKLQASEND
|
K832
|
|
K841
|
SENDLLNKRLKLDYE
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
SENDLLNkRLKLDYE
|
K754-ub
|
TBC1D1 iso2 (human)
|
SENDLLNKRLKLDYE
|
K848
|
TBC1D1 (mouse)
|
SENDLLNKRLKLDYE
|
K841
|
TBC1D1 iso2 (mouse)
|
SENDLLNKRLKLDYE
|
K748
|
TBC1D1 (rat)
|
SENDLLNKRLKLDYE
|
K843
|
|
K855
|
EEITPCLKEVTTVWE
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
EEITPCLkEVTTVWE
|
K768-ub
|
TBC1D1 iso2 (human)
|
EEITPCLKEVTTVWE
|
K862
|
TBC1D1 (mouse)
|
EEITPCLKEVTTVWE
|
K855
|
TBC1D1 iso2 (mouse)
|
EEITPCLKEVTTVWE
|
K762
|
TBC1D1 (rat)
|
EEITPCLKEVTTVWE
|
K857
|
|
K913
|
LKHPFPSKQQPKDVP
|
|
|
0
|
2
|
|
|
TBC1D1 (human)
|
LKHQFPSkQQPKDVP
|
K826-ub
|
TBC1D1 iso2 (human)
|
LKHQFPSKQQPKDVP
|
K920
|
TBC1D1 (mouse)
|
LKHPFPSKQQPKDVP
|
K913
|
TBC1D1 iso2 (mouse)
|
LKHPFPSKQQPKDVP
|
K820
|
TBC1D1 (rat)
|
LKHPFPSkQQPkDVP
|
K915-ub
|
|
K917
|
FPSKQQPKDVPYKEL
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
FPSkQQPKDVPYkEL
|
K830
|
TBC1D1 iso2 (human)
|
FPSKQQPKDVPYKEL
|
K924
|
TBC1D1 (mouse)
|
FPSKQQPKDVPYKEL
|
K917
|
TBC1D1 iso2 (mouse)
|
FPSKQQPKDVPYKEL
|
K824
|
TBC1D1 (rat)
|
FPSkQQPkDVPYKEL
|
K919-ub
|
|
K922
|
QPKDVPYKELLKKLT
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
QPKDVPYkELLKQLT
|
K835-ub
|
TBC1D1 iso2 (human)
|
QPKDVPYKELLKQLT
|
K929
|
TBC1D1 (mouse)
|
QPKDVPYKELLKKLT
|
K922
|
TBC1D1 iso2 (mouse)
|
QPKDVPYKELLKKLT
|
K829
|
TBC1D1 (rat)
|
QPkDVPYKELLKKLT
|
K924
|
|
Y967
|
LYNILKAYSLLDQEV
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
LYNILKAySLLDQEV
|
Y880-p
|
TBC1D1 iso2 (human)
|
LYNILKAYSLLDQEV
|
Y974
|
TBC1D1 (mouse)
|
LYNILKAYSLLDQEV
|
Y967
|
TBC1D1 iso2 (mouse)
|
LYNILKAYSLLDQEV
|
Y874
|
TBC1D1 (rat)
|
LYNILKAYSLLDQEV
|
Y969
|
|
S1028-p
|
QIQMYQLsRLLHDYH
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
QIQMYQLSRLLHDYH
|
S941
|
TBC1D1 iso2 (human)
|
gap
|
-
|
TBC1D1 (mouse)
|
QIQMYQLsRLLHDYH
|
S1028-p
|
TBC1D1 iso2 (mouse)
|
QIQMYQLSRLLHDYH
|
S935
|
TBC1D1 (rat)
|
QIQMYQLSRLLHDYH
|
S1030
|
|
Y1039-p
|
HDYHRDLyNHLEEHE
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
HDYHRDLYNHLEEHE
|
Y952
|
TBC1D1 iso2 (human)
|
gap
|
-
|
TBC1D1 (mouse)
|
HDYHRDLyNHLEEHE
|
Y1039-p
|
TBC1D1 iso2 (mouse)
|
HDYHRDLYNHLEEHE
|
Y946
|
TBC1D1 (rat)
|
HDYHRDLYNHLEEYE
|
Y1041
|
|
K1179-ub
|
KTNSSLRkQNLDLLE
|
|
|
0
|
2
|
|
|
TBC1D1 (human)
|
KTNSSLRkQNLDLLE
|
K1092-ub
|
TBC1D1 iso2 (human)
|
KTNSSLRKQNLDLLE
|
K1083
|
TBC1D1 (mouse)
|
KTNSSLRkQNLDLLE
|
K1179-ub
|
TBC1D1 iso2 (mouse)
|
KTNSSLRKQNLDLLE
|
K1086
|
TBC1D1 (rat)
|
KTNSSLRKQNLDLLE
|
K1181
|
|
T1218-p
|
KLKQAALtLEVERSA
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
KLKQAMLTLELERsA
|
T1131
|
TBC1D1 iso2 (human)
|
KLKQAMLTLELERSA
|
T1122
|
TBC1D1 (mouse)
|
KLKQAALtLEVERSA
|
T1218-p
|
TBC1D1 iso2 (mouse)
|
KLKQAALTLEVERSA
|
T1125
|
TBC1D1 (rat)
|
KLKQAVLTLEMERSA
|
T1220
|
|
S1224
|
LtLEVERSALLQMVE
|
|
|
0
|
1
|
|
|
TBC1D1 (human)
|
LTLELERsALLQTVE
|
S1137-p
|
TBC1D1 iso2 (human)
|
LTLELERSALLQTVE
|
S1128
|
TBC1D1 (mouse)
|
LtLEVERSALLQMVE
|
S1224
|
TBC1D1 iso2 (mouse)
|
LTLEVERSALLQMVE
|
S1131
|
TBC1D1 (rat)
|
LTLEMERSALLQMVE
|
S1226
|
|
S1237-p
|
VEELRRQsARPstPE
|
|
|
0
|
3
|
|
|
TBC1D1 (human)
|
VEELRRRSAEPSDRE
|
S1150
|
TBC1D1 iso2 (human)
|
VEELRRRSAEPSDRE
|
S1141
|
TBC1D1 (mouse)
|
VEELRRQsARPstPE
|
S1237-p
|
TBC1D1 iso2 (mouse)
|
VEELRRQSARPSTPE
|
S1144
|
TBC1D1 (rat)
|
VEELRRQMAQPSTAE
|
M1239
|
|
S1241-p
|
RRQsARPstPEPDCT
|
|
|
0
|
4
|
|
|
TBC1D1 (human)
|
RRRSAEPSDREPECT
|
S1154
|
TBC1D1 iso2 (human)
|
RRRSAEPSDREPECT
|
S1145
|
TBC1D1 (mouse)
|
RRQsARPstPEPDCT
|
S1241-p
|
TBC1D1 iso2 (mouse)
|
RRQSARPSTPEPDCT
|
S1148
|
TBC1D1 (rat)
|
RRQMAQPSTAEPDCT
|
S1243
|
|
T1242-p
|
RQsARPstPEPDCTQ
|
|
|
0
|
6
|
|
|
TBC1D1 (human)
|
RRSAEPSDREPECTQ
|
D1155
|
TBC1D1 iso2 (human)
|
RRSAEPSDREPECTQ
|
D1146
|
TBC1D1 (mouse)
|
RQsARPstPEPDCTQ
|
T1242-p
|
TBC1D1 iso2 (mouse)
|
RQSARPSTPEPDCTQ
|
T1149
|
TBC1D1 (rat)
|
RQMAQPSTAEPDCTR
|
T1244
|
|