Other Species / Isoforms
  cGAS (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K7-ac
_MQPWHGkAMQRAsE
1 2
cGAS (human) _MQPWHGkAMQRAsE K7-ac
cGAS (mouse) _MEDPRRRTTAPRAK R7
cGAS (rat) _MEDPRRRTTAPRAK R7
K7-m1
_MQPWHGkAMQRAsE
0 1
cGAS (human) _MQPWHGkAMQRAsE K7-m1
cGAS (mouse) _MEDPRRRTTAPRAK R7
cGAS (rat) _MEDPRRRTTAPRAK R7
S13-p
GkAMQRAsEAGATAP
0 3
cGAS (human) GkAMQRAsEAGATAP S13-p
cGAS (mouse) gap -
cGAS (rat) gap -
S37-p
APMDPTEsPAAPEAA
1 1
cGAS (human) APMDPTEsPAAPEAA S37-p
cGAS (mouse) APTQPSRTRAHAESC T28
cGAS (rat) APTRPSGTRATVSHA T28
K47-ac
APEAALPkAGkFGPA
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
Treatment
  • siRNA
  • virus infection
cGAS (human) APEAALPkAGkFGPA K47-ac
cGAS (mouse) QPSRTRAHAESCGPQ H31
cGAS (rat) GTRATVSHAGSCGPQ H34
K50-ac
AALPkAGkFGPARkS
3 4
cGAS (human) AALPkAGkFGPARkS K50-ac
cGAS (mouse) RTRAHAESCGPQRGA S34
cGAS (rat) ATVSHAGSCGPQRGA S37
K56-ac
GkFGPARkSGSRQkK
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
Treatment
  • siRNA
  • virus infection
cGAS (human) GkFGPARkSGSRQkK K56-ac
cGAS (mouse) ESCGPQRGARSRRAE G40
cGAS (rat) GSCGPQRGARSRRVE G43
K62-ac
RkSGSRQkKsAPDtQ
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
Treatment
  • siRNA
  • virus infection
cGAS (human) RkSGSRQkKsAPDtQ K62-ac
cGAS (mouse) RGARSRRAERDGDTT A46
cGAS (rat) RGARSRRVERDGDTT V49
S64-p
SGSRQkKsAPDtQER
0 3
cGAS (human) SGSRQkKsAPDtQER S64-p
cGAS (mouse) ARSRRAERDGDTTEK R48
cGAS (rat) ARSRRVERDGDTTEK R51
T68-p
QkKsAPDtQERPPVR
0 1
cGAS (human) QkKsAPDtQERPPVR T68-p
cGAS (mouse) RAERDGDTTEKPRAP T52
cGAS (rat) RVERDGDTTEKPHTP T55
K82-m1
RATGARAkkAPQRAQ
0 1
cGAS (human) RATGARAkkAPQRAQ K82-m1
cGAS (mouse) PGPRVHPARATELTK A66
cGAS (rat) PAPRVRPRRAAERTE R69
K83-ac
ATGARAkkAPQRAQD
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
Treatment
  • siRNA
  • virus infection
cGAS (human) ATGARAkkAPQRAQD K83-ac
cGAS (mouse) GPRVHPARATELTKD R67
cGAS (rat) APRVRPRRAAERTED R70
T91-p
APQRAQDtQPSDATS
0 1
cGAS (human) APQRAQDtQPSDATS T91-p
cGAS (mouse) ATELTKDAQPSAMDA A75
cGAS (rat) AAERTEDAQPLATDA A78
T97
DtQPSDATSAPGAEG
0 2
cGAS (human) DtQPSDATSAPGAEG T97
cGAS (mouse) DAAGATArPAVRVPQ R88-m1
cGAS (rat) DAAGASERPAVREPQ R91
R111-m2
GLEPPAArEPALsRA
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
cGAS (human) GLEPPAArEPALsRA R111-m2
cGAS (mouse) DPELPAVREPQPPAD R108
cGAS (rat) DPEPPAVPEPQAPED P111
S116-p
AArEPALsRAGsCRQ
1 2
cGAS (human) AArEPALsRAGsCRQ S116-p
cGAS (mouse) AVREPQPPADPEARK P113
cGAS (rat) AVPEPQAPEDPEAPT P116
S120-p
PALsRAGsCRQrGAR
0 1
cGAS (human) PALsRAGsCRQrGAR S120-p
cGAS (mouse) RKVVRGPSHRRGARS S126
cGAS (rat) PTVARGPVRRRGARS V129
R124-m2
RAGsCRQrGARCsTK
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Treatment
  • EPZ015666
cGAS (human) RAGsCRQrGARCsTK R124-m2
cGAS (mouse) VRGPSHRRGARSTGQ R129
cGAS (rat) ARGPVRRRGARSIRQ R132
S129-p
RQrGARCsTKPrPPP
Upstream
0 1
Treatment
  • BI2536
  • MLN8054
cGAS (human) RQrGARCsTKPrPPP S129-p
cGAS (mouse) HRRGARSTGQPRAPR T134
cGAS (rat) RRRGARSIRQPRASQ I137
R133-m2
ARCsTKPrPPPGPWD
Downstream
1 0
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, inhibited
cGAS (human) ARCsTKPrPPPGPWD R133-m2
cGAS (mouse) ARSTGQPRAPRGSRK R138
cGAS (rat) ARSIRQPRASQGSRK R141
S143-p
PGPWDVPsPGLPVSA
Upstream
0 6
Treatment
  • AZD1152
  • BI2536
  • MLN8054
  • ZM447439
view more >
cGAS (human) PGPWDVPsPGLPVSA S143-p
cGAS (mouse) gap -
cGAS (rat) gap -
K164-ub
DAAPGASkLRAVLEK
0 1
cGAS (human) DAAPGASkLRAVLEK K164-ub
cGAS (mouse) GSRKEPDKLKKVLDK K149
cGAS (rat) GSRKEPDKLKKVLDK K152
K173-ub
RAVLEKLkLsRDDIS
0 1
cGAS (human) RAVLEKLkLsRDDIS K173-ub
cGAS (mouse) KKVLDKLRLKRKDIS R158
cGAS (rat) KKVLDKLRLKRKEIS R161
S175-p
VLEKLkLsRDDIStA
0 1
cGAS (human) VLEKLkLsRDDIStA S175-p
cGAS (mouse) VLDKLRLKRKDISEA K160
cGAS (rat) VLDKLRLKRKEISAA K163
T181-p
LsRDDIStAAGMVKG
0 1
cGAS (human) LsRDDIStAAGMVKG T181-p
cGAS (mouse) LKRKDISEAAEtVNK E166
cGAS (rat) LKRKEISAAAETVNK A169
M185
DIStAAGMVKGVVDH
0 1
cGAS (human) DIStAAGMVKGVVDH M185
cGAS (mouse) DISEAAEtVNKVVER T170-p
cGAS (rat) EISAAAETVNKVVDQ T173
K198-ac
DHLLLRLkCDsAFRG
Upstream
Downstream
1 1
Effects on Biological Processes:
  • transcription, induced
Treatment
  • virus infection
cGAS (human) DHLLLRLkCDsAFRG K198-ac
cGAS (mouse) RLLRRMQKRESEFKG K184
cGAS (rat) QLLRRMQRRESEFKG R187
K198-ub
DHLLLRLkCDsAFRG
0 1
cGAS (human) DHLLLRLkCDsAFRG K198-ub
cGAS (mouse) RLLRRMQKRESEFKG K184
cGAS (rat) QLLRRMQRRESEFKG R187
S201-p
LLRLkCDsAFRGVGL
1 1
cGAS (human) LLRLkCDsAFRGVGL S201-p
cGAS (mouse) RRMQKRESEFKGVEQ S187
cGAS (rat) RRMQRRESEFKGVEQ S190
Y214-p
GLLNTGSyyEHVKIs
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Putative in vivo kinases:
  • Syk (human)
cGAS (human) GLLNTGSyyEHVKIs Y214-p
cGAS (mouse) EQLNTGSyyEHVKIS Y200-p
cGAS (rat) EQLNTGSYYEHVKIS Y203
Y215-p
LLNTGSyyEHVKIsA
Upstream
Downstream
3 1
Effects on Modified Protein
  • enzymatic activity, induced
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • DNA repair, induced
  • DNA repair, inhibited
  • chromatin organization, altered
Putative in vivo kinases:
  • BLK (human)
  • Syk (human)
Treatment
  • etoposide
  • vanadate
cGAS (human) LLNTGSyyEHVKIsA Y215-p
cGAS (mouse) QLNTGSyyEHVKISA Y201-p
cGAS (rat) QLNTGSYYEHVKISA Y204
S221-p
yyEHVKIsAPNEFDV
1 1
cGAS (human) yyEHVKIsAPNEFDV S221-p
cGAS (mouse) yyEHVKISAPNEFDV S207
cGAS (rat) YYEHVKISAPNEFDV S210
K231-sm
NEFDVMFkLEVPRIQ
Downstream
1 0
Effects on Modified Protein
  • protein stabilization
cGAS (human) NEFDVMFkLEVPRIQ K231-sm
cGAS (mouse) NEFDVMFkLEVPRIE K217-sm
cGAS (rat) NEFDVMFKLEVPRIE K220
Y248-p
EYSNTRAyYFVKFKR
Upstream
Downstream
1 11
Effects on Biological Processes:
  • carcinogenesis, altered
  • signaling pathway regulation
Putative in vivo kinases:
  • Src (human)
cGAS (human) EYSNTRAyYFVKFKR Y248-p
cGAS (mouse) EYYETGAFYLVKFKR F234
cGAS (rat) EYYETGAFYRVKFKR F237
S263-p
NPKENPLsQFLEGEI
1 1
cGAS (human) NPKENPLsQFLEGEI S263-p
cGAS (mouse) IPRGNPLSHFLEGEV S249
cGAS (rat) IPRGNPLSHFLEGEV S252
K279-ub
SASKMLSkFRkIIkE
1 0
cGAS (human) SASKMLSkFRkIIkE K279-ub
cGAS (mouse) SATKMLSkFRKIIkE K265-ub
cGAS (rat) SATKVLSKFRELIKE K268
K282-ub
KMLSkFRkIIkEEIN
0 1
cGAS (human) KMLSkFRkIIkEEIN K282-ub
cGAS (mouse) KMLSkFRKIIkEEVK K268
cGAS (rat) KVLSKFRELIKEEVK E271
K285-ac
SkFRkIIkEEINDIk
1 1
cGAS (human) SkFRkIIkEEINDIk K285-ac
cGAS (mouse) SkFRKIIKEEVKEIk K271
cGAS (rat) SKFRELIKEEVKEIK K274
K285-ub
SkFRkIIkEEINDIk
2 1
cGAS (human) SkFRkIIkEEINDIk K285-ub
cGAS (mouse) SkFRKIIkEEVKEIk K271-ub
cGAS (rat) SKFRELIKEEVKEIK K274
K285-sm
SkFRkIIkEEINDIk
0 1
cGAS (human) SkFRkIIkEEINDIk K285-sm
cGAS (mouse) SkFRKIIKEEVKEIk K271
cGAS (rat) SKFRELIKEEVKEIK K274
K292-ac
kEEINDIkDtDVIMK
1 1
cGAS (human) kEEINDIkDtDVIMK K292-ac
cGAS (mouse) kEEVKEIKDIDVSVE K278
cGAS (rat) KEEVKEIKDTDVTVE K281
K292-ub
kEEINDIkDtDVIMK
1 2
cGAS (human) kEEINDIkDtDVIMK K292-ub
cGAS (mouse) kEEVKEIkDIDVSVE K278-ub
cGAS (rat) KEEVKEIKDTDVTVE K281
T294-p
EINDIkDtDVIMKRk
0 1
cGAS (human) EINDIkDtDVIMKRk T294-p
cGAS (mouse) EVKEIkDIDVSVEKE I280
cGAS (rat) EVKEIKDTDVTVEEE T283
K301-m1
tDVIMKRkRGGsPAV
0 1
cGAS (human) tDVIMKRkRGGsPAV K301-m1
cGAS (mouse) IDVSVEKEKPGsPAV E287
cGAS (rat) TDVTVEEEKPGSPAV E290
S305-p
MKRkRGGsPAVTLLI
Upstream
Downstream
3 2
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • apoptosis, inhibited
Kinase, in vitro:
  • CDK1 (human)
Treatment
  • nocodazole
  • taxol
cGAS (human) MKRkRGGsPAVTLLI S305-p
cGAS (mouse) VEKEKPGsPAVTLLI S291-p
cGAS (rat) VEEEKPGSPAVTLLI S294
K347-ub
IQNWLSAkVRKQLRL
2 3
cGAS (human) IQNWLSAkVRKQLRL K347-ub
cGAS (mouse) IQGWLGTkVRTNLRR K335-ub
cGAS (rat) IQDWLGTKVRTNLRR K338
K355-ac
VRKQLRLkPFYLVPk
1 1
cGAS (human) VRKQLRLkPFYLVPk K355-ac
cGAS (mouse) VRTNLRREPFYLVPK E343
cGAS (rat) VRTNLRREPFYLVPK E346
K355-ub
VRKQLRLkPFYLVPk
Upstream
0 2
Treatment
  • MG132
cGAS (human) VRKQLRLkPFYLVPk K355-ub
cGAS (mouse) VRTNLRREPFYLVPK E343
cGAS (rat) VRTNLRREPFYLVPK E346
K362-m1
kPFYLVPkHAkEGNG
0 1
cGAS (human) kPFYLVPkHAkEGNG K362-m1
cGAS (mouse) EPFYLVPKNAkDGNS K350
cGAS (rat) EPFYLVPKNAKDGNR K353
K365-ub
YLVPkHAkEGNGFQE
1 2
cGAS (human) YLVPkHAkEGNGFQE K365-ub
cGAS (mouse) YLVPKNAkDGNSFQG K353-ub
cGAS (rat) YLVPKNAKDGNRFQG K356
S378
QEETWRLSFSHIEkE
0 1
cGAS (human) QEETWRLSFSHIEkE S378
cGAS (mouse) QGETWRLsFsHtEkY S366-p
cGAS (rat) QGETWRLSFSHTEKY S369
S380
ETWRLSFSHIEkEIL
0 1
cGAS (human) ETWRLSFSHIEkEIL S380
cGAS (mouse) ETWRLsFsHtEkYIL S368-p
cGAS (rat) ETWRLSFSHTEKYIL S371
I382
WRLSFSHIEkEILNN
0 1
cGAS (human) WRLSFSHIEkEILNN I382
cGAS (mouse) WRLsFsHtEkYILNN T370-p
cGAS (rat) WRLSFSHTEKYILNN T373
K384-ac
LSFSHIEkEILNNHG
Upstream
Downstream
4 3
Effects on Modified Protein
  • activity, inhibited
  • enzymatic activity, inhibited
  • protein conformation
Effects on Biological Processes:
  • apoptosis, inhibited
Regulatory protein:
  • Tip60 (human)
Treatment
  • aspirin
  • HT-DNA
  • virus infection
view more >
cGAS (human) LSFSHIEkEILNNHG K384-ac
cGAS (mouse) LsFsHtEKYILNNHG K372
cGAS (rat) LSFSHTEKYILNNHG K375
K384-ub
LSFSHIEkEILNNHG
Downstream
1 2
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • autophagy, induced
cGAS (human) LSFSHIEkEILNNHG K384-ub
cGAS (mouse) LsFsHtEKYILNNHG K372
cGAS (rat) LSFSHTEKYILNNHG K375
K384-sm
LSFSHIEkEILNNHG
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, inhibited
cGAS (human) LSFSHIEkEILNNHG K384-sm
cGAS (mouse) LsFsHtEkYILNNHG K372-sm
cGAS (rat) LSFSHTEKYILNNHG K375
K392-ac
EILNNHGkSkTCCEN
1 2
cGAS (human) EILNNHGkSkTCCEN K392-ac
cGAS (mouse) YILNNHGIEkTCCES I380
cGAS (rat) YILNNHGIGKTCCES I383
K392-ub
EILNNHGkSkTCCEN
0 1
cGAS (human) EILNNHGkSkTCCEN K392-ub
cGAS (mouse) YILNNHGIEkTCCES I380
cGAS (rat) YILNNHGIGKTCCES I383
K394-ac
LNNHGkSkTCCENKE
Upstream
Downstream
3 2
Effects on Modified Protein
  • activity, inhibited
  • enzymatic activity, inhibited
  • protein conformation
Regulatory protein:
  • Tip60 (human)
Treatment
  • aspirin
  • HT-DNA
  • virus infection
view more >
cGAS (human) LNNHGkSkTCCENKE K394-ac
cGAS (mouse) LNNHGIEKTCCESSG K382
cGAS (rat) LNNHGIGKTCCESSG K385
K394-sm
LNNHGkSkTCCENKE
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, inhibited
cGAS (human) LNNHGkSkTCCENKE K394-sm
cGAS (mouse) LNNHGIEkTCCESSG K382-sm
cGAS (rat) LNNHGIGKTCCESSG K385
K411-ub
CCRKDCLkLMkyLLE
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, inhibited
  • molecular association, regulation
cGAS (human) CCRKDCLkLMkyLLE K411-ub
cGAS (mouse) CCRKECLKLMkYLLE K399
cGAS (rat) CCRKECLKLMKYLLE K402
K414-ac
KDCLkLMkyLLEQLk
Upstream
Downstream
4 3
Effects on Modified Protein
  • activity, inhibited
  • enzymatic activity, inhibited
  • protein conformation
Effects on Biological Processes:
  • apoptosis, inhibited
Regulatory protein:
  • Tip60 (human)
Treatment
  • aspirin
  • HT-DNA
  • virus infection
  • vorinostat
view more >
cGAS (human) KDCLkLMkyLLEQLk K414-ac
cGAS (mouse) KECLKLMKYLLEQLK K402
cGAS (rat) KECLKLMKYLLEQLK K405
K414-ub
KDCLkLMkyLLEQLk
Upstream
Downstream
2 7
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • autophagy, induced
  • signaling pathway regulation
Regulatory protein:
  • TRIM14 (human)
Treatment
  • bafilomycin_A
  • EBSS
cGAS (human) KDCLkLMkyLLEQLk K414-ub
cGAS (mouse) KECLKLMkYLLEQLK K402-ub
cGAS (rat) KECLKLMKYLLEQLK K405
Y415-p
DCLkLMkyLLEQLkE
0 1
cGAS (human) DCLkLMkyLLEQLkE Y415-p
cGAS (mouse) ECLKLMkYLLEQLKK Y403
cGAS (rat) ECLKLMKYLLEQLKR Y406
K421-ub
kyLLEQLkERFKDKK
0 1
cGAS (human) kyLLEQLkERFKDKK K421-ub
cGAS (mouse) kYLLEQLKKEFQELD K409
cGAS (rat) KYLLEQLKREFQELD K412
K432-ac
KDKKHLDkFSsYHVK
1 1
cGAS (human) KDKKHLDkFSsYHVK K432-ac
cGAS (mouse) KEFQELDAFCsYHVK A417
cGAS (rat) REFQELDAFCSYHVK A420
K432-ub
KDKKHLDkFSsYHVK
0 1
cGAS (human) KDKKHLDkFSsYHVK K432-ub
cGAS (mouse) KEFQELDAFCsYHVK A417
cGAS (rat) REFQELDAFCSYHVK A420
S435-p
KHLDkFSsYHVKTAF
Upstream
Downstream
2 0
Effects on Biological Processes:
  • carcinogenesis, altered
  • transcription, induced
Treatment
  • dsDNA
  • NU7441
cGAS (human) KHLDkFSsYHVKTAF S435-p
cGAS (mouse) QELDAFCsYHVKTAI S420-p
cGAS (rat) QELDAFCSYHVKTAI S423
K479-ac
LQCLRTEkLENyFIP
1 1
cGAS (human) LQCLRTEkLENyFIP K479-ac
cGAS (mouse) LECLRTEKLDHYFIP K464
cGAS (rat) LECLRTEKLDHYFIP K467
K479
LQCLRTEKLENyFIP
1 0
cGAS (human) LQCLRTEKLENyFIP K479
cGAS (mouse) LECLRTEkLDHYFIP K464-ub
cGAS (rat) LECLRTEKLDHYFIP K467
K479-sm
LQCLRTEkLENyFIP
Downstream
1 0
Effects on Modified Protein
  • activity, induced
  • protein stabilization
cGAS (human) LQCLRTEkLENyFIP K479-sm
cGAS (mouse) LECLRTEkLDHYFIP K464-sm
cGAS (rat) LECLRTEKLDHYFIP K467
Y483-p
RTEkLENyFIPEFNL
Upstream
1 1
Putative in vivo kinases:
  • Syk (human)
cGAS (human) RTEkLENyFIPEFNL Y483-p
cGAS (mouse) RTEkLDHYFIPKFNL Y468
cGAS (rat) RTEKLDHYFIPKFNL Y471
K501-ub
NLIDKRSkEFLTkQI
0 1
cGAS (human) NLIDKRSkEFLTkQI K501-ub
cGAS (mouse) ELIDRKSKEFLSkKI K486
cGAS (rat) ELIDKKSKEFLSEKI K489
K506
RSkEFLTKQIEYERN
1 0
cGAS (human) RSkEFLTKQIEYERN K506
cGAS (mouse) KSKEFLSkKIEYERN K491-m1
cGAS (rat) KSKEFLSEKIEYERN E494
K506-ub
RSkEFLTkQIEYERN
Upstream
0 2
Treatment
  • MG132
cGAS (human) RSkEFLTkQIEYERN K506-ub
cGAS (mouse) KSKEFLSKKIEYERN K491
cGAS (rat) KSKEFLSEKIEYERN E494