NPM-ALK (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y67-p
VEAEAMNyEGsPIKV
0 2
NPM-ALK (human) VEAEAMNyEGsPIKV Y67-p
S70-p
EAMNyEGsPIKVTLA
0 8
NPM-ALK (human) EAMNyEGsPIKVTLA S70-p
T95-p
SLGGFEItPPVVLRL
0 4
NPM-ALK (human) SLGGFEItPPVVLRL T95-p
S135-p
AMQMELQsPEyKLSK
Upstream
Downstream
1 1
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, altered
  • cell growth, altered
Treatment
  • PD98059
  • SB203580
  • SP600125
  • U0126
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NPM-ALK (human) AMQMELQsPEyKLSK S135-p
Y138-p
MELQsPEyKLSKLRT
0 5
NPM-ALK (human) MELQsPEyKLSKLRT Y138-p
Y152-p
TSTIMTDyNPNyCFA
0 3
NPM-ALK (human) TSTIMTDyNPNyCFA Y152-p
Y156-p
MTDyNPNyCFAGKTS
Downstream
3 5
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
NPM-ALK (human) MTDyNPNyCFAGKTS Y156-p
S164-p
CFAGKTSsISDLKEV
Upstream
Downstream
1 1
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, altered
  • cell growth, altered
Treatment
  • D4476
  • GSK-3_inhibitor_IX
NPM-ALK (human) CFAGKTSsISDLKEV S164-p
Y191-p
HGAFGEVyEGQVSGM
0 2
NPM-ALK (human) HGAFGEVyEGQVSGM Y191-p
Y338-p
FGMARDIyRASyyRK
Upstream
Downstream
3 6
Effects on Modified Protein
  • enzymatic activity, induced
Putative upstream phosphatases:
  • SHP-1 (human)
NPM-ALK (human) FGMARDIyRASyyRK Y338-p
Y342-p
RDIyRASyyRKGGCA
Upstream
Downstream
3 5
Effects on Modified Protein
  • enzymatic activity, induced
Putative upstream phosphatases:
  • SHP-1 (human)
NPM-ALK (human) RDIyRASyyRKGGCA Y342-p
Y343-p
DIyRASyyRKGGCAM
Downstream
4 5
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, altered
NPM-ALK (human) DIyRASyyRKGGCAM Y343-p
Y419-p
KNCPGPVyRIMTQCW
0 4
NPM-ALK (human) KNCPGPVyRIMTQCW Y419-p
S497-p
AKREEERsPAAPPPL
Upstream
Downstream
1 1
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, altered
  • cell growth, altered
Treatment
  • PD98059
  • SB203580
  • SP600125
  • U0126
view more >
NPM-ALK (human) AKREEERsPAAPPPL S497-p
Y567-p
TSLWNPTyGSWFTEK
Downstream
4 3
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
NPM-ALK (human) TSLWNPTyGSWFTEK Y567-p
Y644-p
FPCGNVNyGYQQQGL
0 3
NPM-ALK (human) FPCGNVNyGYQQQGL Y644-p
Y664-p
TAPGAGHyEDTILKS
Upstream
Downstream
4 4
Effects on Biological Processes:
  • cell growth, induced
  • transcription, induced
Putative upstream phosphatases:
  • SHP-1 (human)
Treatment
  • LY294002
  • SU6656
  • WHI-P154
view more >
NPM-ALK (human) TAPGAGHyEDTILKS Y664-p