Other Species / Isoforms
  APE1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K3-ac
_____MPkRGkkGAV
1 0
APE1 (human) _____MPkRGkkGAV K3-ac
APE1 (mouse) _____MPKRGKKAAA K3
APE1 (rat) _____MPKRGKRAAA K3
K6-ac
__MPkRGkkGAVAED
Upstream
Downstream
5 2
Effects on Modified Protein
  • enzymatic activity, induced
  • enzymatic activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • DNA repair, induced
  • DNA repair, inhibited
  • cell growth, induced
  • transcription, inhibited
Treatment
  • Ca(2+)
  • H2O2
  • MMS
  • nicotinamide
  • resveratrol
  • siRNA
  • trichostatin_A
view more >
APE1 (human) __MPkRGkkGAVAED K6-ac
APE1 (mouse) __MPKRGKKAAADDG K6
APE1 (rat) __MPKRGKRAAAEDG K6
K6-m1
__MPkRGkkGAVAED
0 1
APE1 (human) __MPkRGkkGAVAED K6-m1
APE1 (mouse) __MPKRGKKAAADDG K6
APE1 (rat) __MPKRGKRAAAEDG K6
K7-ac
_MPkRGkkGAVAEDG
Upstream
Downstream
5 2
Effects on Modified Protein
  • enzymatic activity, induced
  • enzymatic activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • DNA repair, induced
  • DNA repair, inhibited
  • cell growth, induced
  • transcription, inhibited
Treatment
  • Ca(2+)
  • H2O2
  • MMS
  • nicotinamide
  • resveratrol
  • siRNA
  • trichostatin_A
view more >
APE1 (human) _MPkRGkkGAVAEDG K7-ac
APE1 (mouse) _MPKRGKKAAADDGE K7
APE1 (rat) _MPKRGKRAAAEDGE R7
K7-ub
_MPkRGkkGAVAEDG
0 1
APE1 (human) _MPkRGkkGAVAEDG K7-ub
APE1 (mouse) _MPKRGKKAAADDGE K7
APE1 (rat) _MPKRGKRAAAEDGE R7
R18-m1
AEDGDELrtEPEAkk
1 1
APE1 (human) AEDGDELrtEPEAkk R18-m1
APE1 (mouse) ADDGEEPKsEPEtKK K17
APE1 (rat) AEDGEEPKsEPEtKK K17
T19-p
EDGDELrtEPEAkkS
0 24
APE1 (human) EDGDELrtEPEAkkS T19-p
APE1 (mouse) DDGEEPKsEPEtKKS S18-p
APE1 (rat) EDGEEPKsEPEtKKS S18-p
A23
ELrtEPEAkkSkTAA
0 5
APE1 (human) ELrtEPEAkkSkTAA A23
APE1 (mouse) EPKsEPEtKKSKGAA T22-p
APE1 (rat) EPKsEPEtKKSKGAA T22-p
K24-ac
LrtEPEAkkSkTAAk
0 17
APE1 (human) LrtEPEAkkSkTAAk K24-ac
APE1 (mouse) PKsEPEtKKSKGAAK K23
APE1 (rat) PKsEPEtKKSKGAAK K23
K24-ub
LrtEPEAkkSkTAAk
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, altered
  • protein degradation
Regulatory protein:
  • p53 (human)
Treatment
  • nutlin-3
APE1 (human) LrtEPEAkkSkTAAk K24-ub
APE1 (mouse) PKsEPEtKKSKGAAK K23
APE1 (rat) PKsEPEtKKSKGAAK K23
K24-sc
LrtEPEAkkSkTAAk
0 1
APE1 (human) LrtEPEAkkSkTAAk K24-sc
APE1 (mouse) PKsEPEtKKSKGAAK K23
APE1 (rat) PKsEPEtKKSKGAAK K23
K25-ac
rtEPEAkkSkTAAkk
0 2
APE1 (human) rtEPEAkkSkTAAkk K25-ac
APE1 (mouse) KsEPEtKKSKGAAKK K24
APE1 (rat) KsEPEtKKSKGAAKK K24
K25-ub
rtEPEAkkSkTAAkk
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, altered
  • protein degradation
Regulatory protein:
  • p53 (human)
Treatment
  • nutlin-3
APE1 (human) rtEPEAkkSkTAAkk K25-ub
APE1 (mouse) KsEPEtKKSKGAAKK K24
APE1 (rat) KsEPEtKKSKGAAKK K24
K27-ac
EPEAkkSkTAAkkND
Upstream
Downstream
4 2
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • DNA repair, induced
  • cell growth, induced
  • cell growth, inhibited
Treatment
  • MMS
APE1 (human) EPEAkkSkTAAkkND K27-ac
APE1 (mouse) EPEtKKSKGAAKKTE K26
APE1 (rat) EPEtKKSKGAAKKTE K26
K27-ub
EPEAkkSkTAAkkND
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, altered
  • protein degradation
Regulatory protein:
  • p53 (human)
Treatment
  • nutlin-3
APE1 (human) EPEAkkSkTAAkkND K27-ub
APE1 (mouse) EPEtKKSKGAAKKTE K26
APE1 (rat) EPEtKKSKGAAKKTE K26
K31-ac
kkSkTAAkkNDkEAA
Upstream
Downstream
4 2
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • DNA repair, induced
  • cell growth, induced
  • cell growth, inhibited
Treatment
  • MMS
APE1 (human) kkSkTAAkkNDkEAA K31-ac
APE1 (mouse) KKSKGAAKKTEKEAA K30
APE1 (rat) KKSKGAAKKTEKEAA K30
K32-ac
kSkTAAkkNDkEAAG
Upstream
Downstream
4 3
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • DNA repair, induced
  • cell growth, induced
  • cell growth, inhibited
Treatment
  • MMS
APE1 (human) kSkTAAkkNDkEAAG K32-ac
APE1 (mouse) KSKGAAKKTEKEAAG K31
APE1 (rat) KSKGAAKKTEKEAAG K31
K35-ac
TAAkkNDkEAAGEGP
Upstream
Downstream
2 4
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • DNA repair, induced
  • cell growth, inhibited
Treatment
  • MMS
APE1 (human) TAAkkNDkEAAGEGP K35-ac
APE1 (mouse) GAAKKTEKEAAGEGP K34
APE1 (rat) GAAKKTEKEAAGEGP K34
Y45-p
AGEGPALyEDPPDQk
0 10
APE1 (human) AGEGPALyEDPPDQk Y45-p
APE1 (mouse) AGEGPVLYEDPPDQK Y44
APE1 (rat) AGEGPVLYEDPPDQK Y44
K52-ub
yEDPPDQkTsPsGkP
0 1
APE1 (human) yEDPPDQkTsPsGkP K52-ub
APE1 (mouse) YEDPPDQKTSPSGKS K51
APE1 (rat) YEDPPDQKTSASGKS K51
K52-sm
yEDPPDQkTsPsGkP
0 2
APE1 (human) yEDPPDQkTsPsGkP K52-sm
APE1 (mouse) YEDPPDQKTSPSGKS K51
APE1 (rat) YEDPPDQKTSASGKS K51
S54-p
DPPDQkTsPsGkPAT
0 4
APE1 (human) DPPDQkTsPsGkPAT S54-p
APE1 (mouse) DPPDQKTSPSGKSAT S53
APE1 (rat) DPPDQKTSASGKSAT S53
S56-p
PDQkTsPsGkPATLk
0 1
APE1 (human) PDQkTsPsGkPATLk S56-p
APE1 (mouse) PDQKTSPSGKSATLK S55
APE1 (rat) PDQKTSASGKSATLK S55
K58-m2
QkTsPsGkPATLkIC
0 1
APE1 (human) QkTsPsGkPATLkIC K58-m2
APE1 (mouse) QKTSPSGKSATLKIC K57
APE1 (rat) QKTSASGKSATLKIC K57
K58-ub
QkTsPsGkPATLkIC
0 2
APE1 (human) QkTsPsGkPATLkIC K58-ub
APE1 (mouse) QKTSPSGKSATLKIC K57
APE1 (rat) QKTSASGKSATLKIC K57
K63-m2
sGkPATLkICsWNVD
0 1
APE1 (human) sGkPATLkICsWNVD K63-m2
APE1 (mouse) SGKSATLKICSWNVD K62
APE1 (rat) SGKSATLKICSWNVD K62
S66-p
PATLkICsWNVDGLr
0 1
APE1 (human) PATLkICsWNVDGLr S66-p
APE1 (mouse) SATLKICSWNVDGLR S65
APE1 (rat) SATLKICSWNVDGLR S65
R73-m1
sWNVDGLrAWIKKkG
0 1
APE1 (human) sWNVDGLrAWIKKkG R73-m1
APE1 (mouse) SWNVDGLRAWIKKKG R72
APE1 (rat) SWNVDGLRAWIKKKG R72
K79-ub
LrAWIKKkGLDWVkE
0 1
APE1 (human) LrAWIKKkGLDWVkE K79-ub
APE1 (mouse) LRAWIKKKGLDWVKE K78
APE1 (rat) LRAWIKKKGLDWVKE K78
K85-ac
KkGLDWVkEEAPDIL
0 1
APE1 (human) KkGLDWVkEEAPDIL K85-ac
APE1 (mouse) KKGLDWVKEEAPDIL K84
APE1 (rat) KKGLDWVKEEAPDIL K84
K85-ub
KkGLDWVkEEAPDIL
0 2
APE1 (human) KkGLDWVkEEAPDIL K85-ub
APE1 (mouse) KKGLDWVKEEAPDIL K84
APE1 (rat) KKGLDWVKEEAPDIL K84
K85-sm
KkGLDWVkEEAPDIL
0 2
APE1 (human) KkGLDWVkEEAPDIL K85-sm
APE1 (mouse) KKGLDWVKEEAPDIL K84
APE1 (rat) KKGLDWVKEEAPDIL K84
K98-ub
ILCLQETkCSENkLP
0 1
APE1 (human) ILCLQETkCSENkLP K98-ub
APE1 (mouse) ILCLQETKCSENKLP K97
APE1 (rat) ILCLQETKCSENKLP K97
K103-ub
ETkCSENkLPAELQE
0 1
APE1 (human) ETkCSENkLPAELQE K103-ub
APE1 (mouse) ETKCSENKLPAELQE K102
APE1 (rat) ETKCSENKLPAELQE K102
S123-p
HQYWSAPsDkEGySG
0 1
APE1 (human) HQYWSAPsDkEGySG S123-p
APE1 (mouse) HQYWSAPSDkEGYSG S122
APE1 (rat) HQYWSAPSDKEGYSG S122
K125-ac
YWSAPsDkEGySGVG
0 1
APE1 (human) YWSAPsDkEGySGVG K125-ac
APE1 (mouse) YWSAPSDkEGYSGVG K124-ac
APE1 (rat) YWSAPSDKEGYSGVG K124
K125-ub
YWSAPsDkEGySGVG
0 2
APE1 (human) YWSAPsDkEGySGVG K125-ub
APE1 (mouse) YWSAPSDKEGYSGVG K124
APE1 (rat) YWSAPSDKEGYSGVG K124
Y128-p
APsDkEGySGVGLLS
0 2
APE1 (human) APsDkEGySGVGLLS Y128-p
APE1 (mouse) APSDkEGYSGVGLLS Y127
APE1 (rat) APSDKEGYSGVGLLS Y127
R136-m1
SGVGLLSrQCPLKVS
0 1
APE1 (human) SGVGLLSrQCPLKVS R136-m1
APE1 (mouse) SGVGLLSRQCPLKVS R135
APE1 (rat) SGVGLLSRQCPLKVS R135
R156-m1
EEHDQEGrVIVAEFD
1 1
APE1 (human) EEHDQEGrVIVAEFD R156-m1
APE1 (mouse) EEHDQEGRVIVAEFE R155
APE1 (rat) EEHDQEGRVIVAEFE R155
Y171-p
SFVLVTAyVPNAGRG
0 6
APE1 (human) SFVLVTAyVPNAGRG Y171-p
APE1 (mouse) SFVLVTAYVPNAGRG Y170
APE1 (rat) SFILVTAYVPNAGRG Y170
Y184-p
RGLVRLEyRQRWDEA
0 1
APE1 (human) RGLVRLEyRQRWDEA Y184-p
APE1 (mouse) RGLVRLEYRQRWDEA Y183
APE1 (rat) RGLVRLEYRQRWDEA Y183
K197-ac
EAFRKFLkGLASRKP
Upstream
0 1
Treatment
  • MS275
APE1 (human) EAFRKFLkGLASRKP K197-ac
APE1 (mouse) EAFRKFLKDLASRKP K196
APE1 (rat) EAFRKFLKDLASRKP K196
K197-ub
EAFRKFLkGLASRKP
0 3
APE1 (human) EAFRKFLkGLASRKP K197-ub
APE1 (mouse) EAFRKFLKDLASRKP K196
APE1 (rat) EAFRKFLKDLASRKP K196
K197-sc
EAFRKFLkGLASRKP
0 1
APE1 (human) EAFRKFLkGLASRKP K197-sc
APE1 (mouse) EAFRKFLKDLASRKP K196
APE1 (rat) EAFRKFLKDLASRKP K196
K228-ub
RNPKGNKkNAGFtPQ
0 3
APE1 (human) RNPKGNKkNAGFtPQ K228-ub
APE1 (mouse) RNPKGNKkNAGFtPQ K227-ub
APE1 (rat) RNPKGNKKNAGFTPQ K227
T233-p
NKkNAGFtPQERQGF
Upstream
Downstream
2 0
Effects on Modified Protein
  • activity, induced
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • transcription, inhibited
Putative in vivo kinases:
  • CDK5 (human)
APE1 (human) NKkNAGFtPQERQGF T233-p
APE1 (mouse) NKkNAGFtPQERQGF T232-p
APE1 (rat) NKKNAGFTPQERQGF T232
S252-p
QAVPLADsFRHLYPN
0 1
APE1 (human) QAVPLADsFRHLYPN S252-p
APE1 (mouse) QAVPLADSFRHLYPN S251
APE1 (rat) QAVPLADSFRHLYPN S251
Y262-p
HLYPNTPyAYTFWTY
0 2
APE1 (human) HLYPNTPyAYTFWTY Y262-p
APE1 (mouse) HLYPNTAYAYTFWTY Y261
APE1 (rat) HLYPNTAYAYTFWTY Y261
K276-sc
YMMNARSkNVGWRLD
0 1
APE1 (human) YMMNARSkNVGWRLD K276-sc
APE1 (mouse) YMMNARSKNVGWRLD K275
APE1 (rat) YMMNARSKNVGWRLD K275
R301-me
ALCDSKIrSKALGSD
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
Treatment
  • H2O2
APE1 (human) ALCDSKIrSKALGSD R301-me
APE1 (mouse) ALCDSKIRSKALGSD R300
APE1 (rat) ALCDSKIRSKALGSD R300