Other Species / Isoforms
  PKM (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
-
gap
0 1
PKM (human) gap -
PKM iso2 (human) gap -
PKM iso3 (human) ______MsPEAQPQR S2-p
PKM (mouse) ______MPkPHSEAG P2
PKM iso2 (mouse) ______MPKPHSEAG P2
PKM (rat) ______MPKPDSEAG P2
PKM iso2 (rat) ______MPKPDSEAG P2
S2-p
______MskPHsEAG
0 1
PKM (human) ______MskPHsEAG S2-p
PKM iso2 (human) ______MSkPHSEAG S2
PKM iso3 (human) gap -
PKM (mouse) gap -
PKM iso2 (mouse) gap -
PKM (rat) gap -
PKM iso2 (rat) gap -
K3-ac
_____MskPHsEAGT
0 43
PKM (human) _____MskPHsEAGT K3-ac
PKM iso2 (human) _____MSkPHSEAGT K3-ac
PKM iso3 (human) gap -
PKM (mouse) _____MPKPHSEAGT K3
PKM iso2 (mouse) _____MPKPHSEAGT K3
PKM (rat) _____MPKPDSEAGT K3
PKM iso2 (rat) _____MPKPDSEAGT K3
K3-ub
_____MskPHsEAGT
0 5
PKM (human) _____MskPHsEAGT K3-ub
PKM iso2 (human) _____MSKPHSEAGT K3
PKM iso3 (human) gap -
PKM (mouse) _____MPkPHSEAGT K3-ub
PKM iso2 (mouse) _____MPKPHSEAGT K3
PKM (rat) _____MPKPDSEAGT K3
PKM iso2 (rat) _____MPKPDSEAGT K3
K3-m3
_____MskPHsEAGT
0 3
PKM (human) _____MskPHsEAGT K3-m3
PKM iso2 (human) _____MSKPHSEAGT K3
PKM iso3 (human) gap -
PKM (mouse) _____MPKPHSEAGT K3
PKM iso2 (mouse) _____MPKPHSEAGT K3
PKM (rat) _____MPKPDSEAGT K3
PKM iso2 (rat) _____MPKPDSEAGT K3
S6-p
__MskPHsEAGTAFI
Upstream
0 3
Treatment
  • ischemia
PKM (human) __MskPHsEAGTAFI S6-p
PKM iso2 (human) __MSkPHSEAGTAFI S6
PKM iso3 (human) gap -
PKM (mouse) __MPkPHSEAGTAFI S6
PKM iso2 (mouse) __MPKPHSEAGTAFI S6
PKM (rat) __MPKPDSEAGTAFI S6
PKM iso2 (rat) __MPKPDSEAGTAFI S6
T25-p
LHAAMADtFLEHMCR
0 1
PKM (human) LHAAMADtFLEHMCR T25-p
PKM iso2 (human) LHAAMADTFLEHMCR T25
PKM iso3 (human) gap -
PKM (mouse) LHAAMADTFLEHMCR T25
PKM iso2 (mouse) LHAAMADTFLEHMCR T25
PKM (rat) LHAAMADTFLEHMCR T25
PKM iso2 (rat) LHAAMADTFLEHMCR T25
S37-p
MCRLDIDsPPItARN
Upstream
Downstream
8 66
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • Akt1 (human)
  • ERK2 (human)
Putative in vivo kinases:
  • ERK1 (human)
  • ERK2 (human)
Putative upstream phosphatases:
  • CDC25A (human)
Regulatory protein:
  • ECM1 (human)
Treatment
  • ascorbic_acid
  • EGF
  • metastatic potential
  • nocodazole
  • PUGNAc
  • U0126
PKM (human) MCRLDIDsPPItARN S37-p
PKM iso2 (human) MCRLDIDsPPITARN S37-p
PKM iso3 (human) gap -
PKM (mouse) MCRLDIDsAPItARN S37-p
PKM iso2 (mouse) MCRLDIDSAPITARN S37
PKM (rat) MCRLDIDSAPItARN S37
PKM iso2 (rat) MCRLDIDSAPITARN S37
T41-p
DIDsPPItARNtGII
0 15
PKM (human) DIDsPPItARNtGII T41-p
PKM iso2 (human) DIDsPPITARNTGII T41
PKM iso3 (human) gap -
PKM (mouse) DIDsAPItARNTGII T41-p
PKM iso2 (mouse) DIDSAPITARNTGII T41
PKM (rat) DIDSAPItARNTGII T41-p
PKM iso2 (rat) DIDSAPITARNTGII T41
T45-p
PPItARNtGIICtIG
Upstream
Downstream
1 6
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell cycle regulation
  • cell growth, induced
Kinase, in vitro:
  • AurB (human)
Putative in vivo kinases:
  • AurB (human)
Regulatory protein:
  • BRAF (human)
  • EGFR (human)
  • KRas (human)
Treatment
  • AZD1152
  • doxycycline
  • ML-7
  • Y27632
PKM (human) PPItARNtGIICtIG T45-p
PKM iso2 (human) PPITARNTGIICTIG T45
PKM iso3 (human) gap -
PKM (mouse) APItARNTGIICtIG T45
PKM iso2 (mouse) APITARNTGIICTIG T45
PKM (rat) APItARNTGIICTIG T45
PKM iso2 (rat) APITARNTGIICTIG T45
T50-p
RNtGIICtIGPAsRs
0 8
PKM (human) RNtGIICtIGPAsRs T50-p
PKM iso2 (human) RNTGIICTIGPASRS T50
PKM iso3 (human) gap -
PKM (mouse) RNTGIICtIGPAsRs T50-p
PKM iso2 (mouse) RNTGIICTIGPASRS T50
PKM (rat) RNTGIICTIGPASRs T50
PKM iso2 (rat) RNTGIICTIGPASRS T50
S55-p
ICtIGPAsRsVEtLk
0 11
PKM (human) ICtIGPAsRsVEtLk S55-p
PKM iso2 (human) ICTIGPASRSVETLK S55
PKM iso3 (human) gap -
PKM (mouse) ICtIGPAsRsVEMLk S55-p
PKM iso2 (mouse) ICTIGPASRSVEMLK S55
PKM (rat) ICTIGPASRsVEMLk S55
PKM iso2 (rat) ICTIGPASRSVEMLK S55
S57-p
tIGPAsRsVEtLkEM
0 8
PKM (human) tIGPAsRsVEtLkEM S57-p
PKM iso2 (human) TIGPASRSVETLKEM S57
PKM iso3 (human) gap -
PKM (mouse) tIGPAsRsVEMLkEM S57-p
PKM iso2 (mouse) TIGPASRSVEMLKEM S57
PKM (rat) TIGPASRsVEMLkEM S57-p
PKM iso2 (rat) TIGPASRSVEMLKEM S57
T60-p
PAsRsVEtLkEMIkS
0 4
PKM (human) PAsRsVEtLkEMIkS T60-p
PKM iso2 (human) PASRSVETLKEMIKS T60
PKM iso3 (human) gap -
PKM (mouse) PAsRsVEMLkEMIkS M60
PKM iso2 (mouse) PASRSVEMLKEMIKS M60
PKM (rat) PASRsVEMLkEMIkS M60
PKM iso2 (rat) PASRSVEMLKEMIKS M60
K62-ub
sRsVEtLkEMIkSGM
0 18
PKM (human) sRsVEtLkEMIkSGM K62-ub
PKM iso2 (human) SRSVETLKEMIKSGM K62
PKM iso3 (human) gap -
PKM (mouse) sRsVEMLkEMIkSGM K62-ub
PKM iso2 (mouse) SRSVEMLKEMIKSGM K62
PKM (rat) SRsVEMLKEMIkSGM K62
PKM iso2 (rat) SRSVEMLKEMIKSGM K62
K62-ac
sRsVEtLkEMIkSGM
1 6
PKM (human) sRsVEtLkEMIkSGM K62-ac
PKM iso2 (human) SRSVETLKEMIKSGM K62
PKM iso3 (human) gap -
PKM (mouse) sRsVEMLKEMIkSGM K62
PKM iso2 (mouse) SRSVEMLKEMIKSGM K62
PKM (rat) SRsVEMLkEMIkSGM K62-ac
PKM iso2 (rat) SRSVEMLKEMIKSGM K62
K62-sc
sRsVEtLkEMIkSGM
0 1
PKM (human) sRsVEtLkEMIkSGM K62-sc
PKM iso2 (human) SRSVETLKEMIKSGM K62
PKM iso3 (human) gap -
PKM (mouse) sRsVEMLKEMIkSGM K62
PKM iso2 (mouse) SRSVEMLKEMIKSGM K62
PKM (rat) SRsVEMLKEMIkSGM K62
PKM iso2 (rat) SRSVEMLKEMIKSGM K62
K66-ub
EtLkEMIkSGMNVAR
0 15
PKM (human) EtLkEMIkSGMNVAR K66-ub
PKM iso2 (human) ETLKEMIKSGMNVAR K66
PKM iso3 (human) gap -
PKM (mouse) EMLkEMIkSGMNVAR K66-ub
PKM iso2 (mouse) EMLKEMIKSGMNVAR K66
PKM (rat) EMLkEMIKSGMNVAR K66
PKM iso2 (rat) EMLKEMIKSGMNVAR K66
K66-ac
EtLkEMIkSGMNVAR
0 4
PKM (human) EtLkEMIkSGMNVAR K66-ac
PKM iso2 (human) ETLKEMIKSGMNVAR K66
PKM iso3 (human) gap -
PKM (mouse) EMLkEMIKSGMNVAR K66
PKM iso2 (mouse) EMLKEMIKSGMNVAR K66
PKM (rat) EMLkEMIkSGMNVAR K66-ac
PKM iso2 (rat) EMLKEMIKSGMNVAR K66
S77-p
NVARLNFsHGtHEyH
0 31
PKM (human) NVARLNFsHGtHEyH S77-p
PKM iso2 (human) NVARLNFSHGTHEyH S77
PKM iso3 (human) gap -
PKM (mouse) NVARLNFsHGtHEyH S77-p
PKM iso2 (mouse) NVARLNFSHGTHEYH S77
PKM (rat) NVARLNFsHGTHEyH S77-p
PKM iso2 (rat) NVARLNFSHGTHEYH S77
T80-p
RLNFsHGtHEyHAEt
0 2
PKM (human) RLNFsHGtHEyHAEt T80-p
PKM iso2 (human) RLNFSHGTHEyHAET T80
PKM iso3 (human) gap -
PKM (mouse) RLNFsHGtHEyHAET T80-p
PKM iso2 (mouse) RLNFSHGTHEYHAET T80
PKM (rat) RLNFsHGTHEyHAET T80
PKM iso2 (rat) RLNFSHGTHEYHAET T80
Y83-p
FsHGtHEyHAEtIkN
1 242
PKM (human) FsHGtHEyHAEtIkN Y83-p
PKM iso2 (human) FSHGTHEyHAETIKN Y83-p
PKM iso3 (human) LASSVPLYHAETIKN Y68
PKM (mouse) FsHGtHEyHAETIkN Y83-p
PKM iso2 (mouse) FSHGTHEYHAETIKN Y83
PKM (rat) FsHGTHEyHAETIkN Y83-p
PKM iso2 (rat) FSHGTHEYHAETIKN Y83
T87-p
tHEyHAEtIkNVrtA
0 2
PKM (human) tHEyHAEtIkNVrtA T87-p
PKM iso2 (human) THEyHAETIKNVRTA T87
PKM iso3 (human) VPLYHAETIKNVRTA T72
PKM (mouse) tHEyHAETIkNVREA T87
PKM iso2 (mouse) THEYHAETIKNVREA T87
PKM (rat) THEyHAETIkNVRAA T87
PKM iso2 (rat) THEYHAETIKNVRAA T87
K89-ub
EyHAEtIkNVrtAtE
Upstream
0 20
Treatment
  • MG132
PKM (human) EyHAEtIkNVrtAtE K89-ub
PKM iso2 (human) EyHAETIKNVRTATE K89
PKM iso3 (human) LYHAETIKNVRTATE K74
PKM (mouse) EyHAETIkNVREAtE K89-ub
PKM iso2 (mouse) EYHAETIKNVREATE K89
PKM (rat) EyHAETIKNVRAATE K89
PKM iso2 (rat) EYHAETIKNVRAATE K89
K89-ac
EyHAEtIkNVrtAtE
0 5
PKM (human) EyHAEtIkNVrtAtE K89-ac
PKM iso2 (human) EyHAETIKNVRTATE K89
PKM iso3 (human) LYHAETIKNVRTATE K74
PKM (mouse) EyHAETIKNVREAtE K89
PKM iso2 (mouse) EYHAETIKNVREATE K89
PKM (rat) EyHAETIkNVRAATE K89-ac
PKM iso2 (rat) EYHAETIKNVRAATE K89
K89-sc
EyHAEtIkNVrtAtE
0 1
PKM (human) EyHAEtIkNVrtAtE K89-sc
PKM iso2 (human) EyHAETIKNVRTATE K89
PKM iso3 (human) LYHAETIKNVRTATE K74
PKM (mouse) EyHAETIKNVREAtE K89
PKM iso2 (mouse) EYHAETIKNVREATE K89
PKM (rat) EyHAETIKNVRAATE K89
PKM iso2 (rat) EYHAETIKNVRAATE K89
R92-m1
AEtIkNVrtAtEsFA
0 1
PKM (human) AEtIkNVrtAtEsFA R92-m1
PKM iso2 (human) AETIKNVRTATESFA R92
PKM iso3 (human) AETIKNVRTATESFA R77
PKM (mouse) AETIkNVREAtESFA R92
PKM iso2 (mouse) AETIKNVREATESFA R92
PKM (rat) AETIkNVRAATEsFA R92
PKM iso2 (rat) AETIKNVRAATESFA R92
T93-p
EtIkNVrtAtEsFAs
0 2
PKM (human) EtIkNVrtAtEsFAs T93-p
PKM iso2 (human) ETIKNVRTATESFAS T93
PKM iso3 (human) ETIKNVRTATESFAS T78
PKM (mouse) ETIkNVREAtESFAs E93
PKM iso2 (mouse) ETIKNVREATESFAS E93
PKM (rat) ETIkNVRAATEsFAs A93
PKM iso2 (rat) ETIKNVRAATESFAS A93
T95-p
IkNVrtAtEsFAsDP
0 4
PKM (human) IkNVrtAtEsFAsDP T95-p
PKM iso2 (human) IKNVRTATESFASDP T95
PKM iso3 (human) IKNVRTATESFASDP T80
PKM (mouse) IkNVREAtESFAsDP T95-p
PKM iso2 (mouse) IKNVREATESFASDP T95
PKM (rat) IkNVRAATEsFAsDP T95
PKM iso2 (rat) IKNVRAATESFASDP T95
S97-p
NVrtAtEsFAsDPIL
Upstream
1 7
Kinase, in vitro:
  • Akt1 (human)
PKM (human) NVrtAtEsFAsDPIL S97-p
PKM iso2 (human) NVRTATESFASDPIL S97
PKM iso3 (human) NVRTATESFASDPIL S82
PKM (mouse) NVREAtESFAsDPIL S97
PKM iso2 (mouse) NVREATESFASDPIL S97
PKM (rat) NVRAATEsFAsDPIL S97-p
PKM iso2 (rat) NVRAATESFASDPIL S97
S100-p
tAtEsFAsDPILyRP
0 37
PKM (human) tAtEsFAsDPILyRP S100-p
PKM iso2 (human) TATESFASDPILyRP S100
PKM iso3 (human) TATESFASDPILYRP S85
PKM (mouse) EAtESFAsDPILyRP S100-p
PKM iso2 (mouse) EATESFASDPILYRP S100
PKM (rat) AATEsFAsDPILyRP S100-p
PKM iso2 (rat) AATESFASDPILYRP S100
Y105-p
FAsDPILyRPVAVAL
Upstream
Downstream
8 445
PKM (human)
Y105-p
PKM iso2 (human)
Y105-p
PKM (mouse)
Y105-p
PKM (rat)
Y105-p
Effects on Modified Protein
  • enzymatic activity, inhibited
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
Kinase, in vitro:
  • NPM-ALK (human)
Putative in vivo kinases:
  • NPM-ALK (human)
Regulatory protein:
  • CSFR (human)
  • EGFR (human)
  • HK2 (human)
Treatment
  • AP20187
  • crizotinib
  • erlotinib
  • PHA-665752
  • WZ4002
PKM (human) FAsDPILyRPVAVAL Y105-p
PKM iso2 (human) FASDPILyRPVAVAL Y105-p
PKM iso3 (human) FASDPILYRPVAVAL Y90
PKM (mouse) FAsDPILyRPVAVAL Y105-p
PKM iso2 (mouse) FASDPILYRPVAVAL Y105
PKM (rat) FAsDPILyRPVAVAL Y105-p
PKM iso2 (rat) FASDPILYRPVAVAL Y105
K115-ub
VAVALDTkGPEIRTG
Upstream
0 41
Treatment
  • vorinostat
PKM (human) VAVALDTkGPEIRTG K115-ub
PKM iso2 (human) VAVALDTKGPEIRTG K115
PKM iso3 (human) VAVALDTKGPEIRTG K100
PKM (mouse) VAVALDTkGPEIRTG K115-ub
PKM iso2 (mouse) VAVALDTKGPEIRTG K115
PKM (rat) VAVALDTKGPEIRtG K115
PKM iso2 (rat) VAVALDTKGPEIRTG K115
K115-ac
VAVALDTkGPEIRTG
0 3
PKM (human) VAVALDTkGPEIRTG K115-ac
PKM iso2 (human) VAVALDTKGPEIRTG K115
PKM iso3 (human) VAVALDTKGPEIRTG K100
PKM (mouse) VAVALDTKGPEIRTG K115
PKM iso2 (mouse) VAVALDTKGPEIRTG K115
PKM (rat) VAVALDTkGPEIRtG K115-ac
PKM iso2 (rat) VAVALDTKGPEIRTG K115
T121
TkGPEIRTGLIkGsG
0 1
PKM (human) TkGPEIRTGLIkGsG T121
PKM iso2 (human) TKGPEIRTGLIKGSG T121
PKM iso3 (human) TKGPEIRTGLIKGSG T106
PKM (mouse) TkGPEIRTGLIkGsG T121
PKM iso2 (mouse) TKGPEIRTGLIKGSG T121
PKM (rat) TkGPEIRtGLIKGsG T121-p
PKM iso2 (rat) TKGPEIRTGLIKGSG T121
K125-ub
EIRTGLIkGsGtAEV
0 8
PKM (human) EIRTGLIkGsGtAEV K125-ub
PKM iso2 (human) EIRTGLIKGSGTAEV K125
PKM iso3 (human) EIRTGLIKGSGTAEV K110
PKM (mouse) EIRTGLIkGsGtAEV K125-ub
PKM iso2 (mouse) EIRTGLIKGSGTAEV K125
PKM (rat) EIRtGLIKGsGtAEV K125
PKM iso2 (rat) EIRTGLIKGSGTAEV K125
S127-p
RTGLIkGsGtAEVEL
0 11
PKM (human) RTGLIkGsGtAEVEL S127-p
PKM iso2 (human) RTGLIKGSGTAEVEL S127
PKM iso3 (human) RTGLIKGSGTAEVEL S112
PKM (mouse) RTGLIkGsGtAEVEL S127-p
PKM iso2 (mouse) RTGLIKGSGTAEVEL S127
PKM (rat) RtGLIKGsGtAEVEL S127-p
PKM iso2 (rat) RTGLIKGSGTAEVEL S127
T129-p
GLIkGsGtAEVELkk
Upstream
Downstream
1 8
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • EEF2K (human)
Putative in vivo kinases:
  • EEF2K (human)
Treatment
  • A484954
  • siRNA
PKM (human) GLIkGsGtAEVELkk T129-p
PKM iso2 (human) GLIKGSGTAEVELkK T129
PKM iso3 (human) GLIKGSGTAEVELKK T114
PKM (mouse) GLIkGsGtAEVELkK T129-p
PKM iso2 (mouse) GLIKGSGTAEVELKK T129
PKM (rat) GLIKGsGtAEVELkK T129-p
PKM iso2 (rat) GLIKGSGTAEVELKK T129
K135-ac
GtAEVELkkGATLkI
0 45
PKM (human) GtAEVELkkGATLkI K135-ac
PKM iso2 (human) GTAEVELkKGATLKI K135-ac
PKM iso3 (human) GTAEVELKKGATLKI K120
PKM (mouse) GtAEVELkKGATLkI K135-ac
PKM iso2 (mouse) GTAEVELKKGATLKI K135
PKM (rat) GtAEVELkKGATLKI K135-ac
PKM iso2 (rat) GTAEVELKKGATLKI K135
K135-ub
GtAEVELkkGATLkI
0 24
PKM (human) GtAEVELkkGATLkI K135-ub
PKM iso2 (human) GTAEVELKKGATLKI K135
PKM iso3 (human) GTAEVELKKGATLKI K120
PKM (mouse) GtAEVELkKGATLkI K135-ub
PKM iso2 (mouse) GTAEVELKKGATLKI K135
PKM (rat) GtAEVELkKGATLKI K135-ub
PKM iso2 (rat) GTAEVELKKGATLKI K135
K135-sc
GtAEVELkkGATLkI
0 1
PKM (human) GtAEVELkkGATLkI K135-sc
PKM iso2 (human) GTAEVELKKGATLKI K135
PKM iso3 (human) GTAEVELKKGATLKI K120
PKM (mouse) GtAEVELKKGATLkI K135
PKM iso2 (mouse) GTAEVELKKGATLKI K135
PKM (rat) GtAEVELKKGATLKI K135
PKM iso2 (rat) GTAEVELKKGATLKI K135
K136-ub
tAEVELkkGATLkIt
0 3
PKM (human) tAEVELkkGATLkIt K136-ub
PKM iso2 (human) TAEVELkKGATLKIT K136
PKM iso3 (human) TAEVELKKGATLKIT K121
PKM (mouse) tAEVELkKGATLkIt K136
PKM iso2 (mouse) TAEVELKKGATLKIT K136
PKM (rat) tAEVELkKGATLKIt K136
PKM iso2 (rat) TAEVELKKGATLKIT K136
K141-ub
LkkGATLkItLDNAy
0 4
PKM (human) LkkGATLkItLDNAy K141-ub
PKM iso2 (human) LkKGATLKITLDNAy K141
PKM iso3 (human) LKKGATLKITLDNAY K126
PKM (mouse) LkKGATLkItLDNAy K141-ub
PKM iso2 (mouse) LKKGATLKITLDNAY K141
PKM (rat) LkKGATLKItLDNAy K141
PKM iso2 (rat) LKKGATLKITLDNAY K141
K141-ac
LkkGATLkItLDNAy
0 1
PKM (human) LkkGATLkItLDNAy K141-ac
PKM iso2 (human) LkKGATLKITLDNAy K141
PKM iso3 (human) LKKGATLKITLDNAY K126
PKM (mouse) LkKGATLKItLDNAy K141
PKM iso2 (mouse) LKKGATLKITLDNAY K141
PKM (rat) LkKGATLKItLDNAy K141
PKM iso2 (rat) LKKGATLKITLDNAY K141
T143-p
kGATLkItLDNAyME
0 4
PKM (human) kGATLkItLDNAyME T143-p
PKM iso2 (human) KGATLKITLDNAyME T143
PKM iso3 (human) KGATLKITLDNAYME T128
PKM (mouse) KGATLkItLDNAyME T143-p
PKM iso2 (mouse) KGATLKITLDNAYME T143
PKM (rat) KGATLKItLDNAyME T143-p
PKM iso2 (rat) KGATLKITLDNAYME T143
Y148-p
kItLDNAyMEkCDEN
Upstream
Downstream
3 346
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • cell growth, induced
Kinase, in vitro:
  • EGFR (human)
Putative in vivo kinases:
  • EGFR (human)
Regulatory protein:
  • EGFR (human)
Treatment
  • anti-CD28
  • anti-CD3
  • U0126
PKM (human) kItLDNAyMEkCDEN Y148-p
PKM iso2 (human) KITLDNAyMEKCDEN Y148-p
PKM iso3 (human) KITLDNAYMEKCDEN Y133
PKM (mouse) kItLDNAyMEkCDEN Y148-p
PKM iso2 (mouse) KITLDNAYMEKCDEN Y148
PKM (rat) KItLDNAyMEKCDEN Y148-p
PKM iso2 (rat) KITLDNAYMEKCDEN Y148
K151-ac
LDNAyMEkCDENILW
0 1
PKM (human) LDNAyMEkCDENILW K151-ac
PKM iso2 (human) LDNAyMEKCDENILW K151
PKM iso3 (human) LDNAYMEKCDENILW K136
PKM (mouse) LDNAyMEKCDENILW K151
PKM iso2 (mouse) LDNAYMEKCDENILW K151
PKM (rat) LDNAyMEKCDENILW K151
PKM iso2 (rat) LDNAYMEKCDENILW K151
K151-ub
LDNAyMEkCDENILW
0 33
PKM (human) LDNAyMEkCDENILW K151-ub
PKM iso2 (human) LDNAyMEKCDENILW K151
PKM iso3 (human) LDNAYMEKCDENILW K136
PKM (mouse) LDNAyMEkCDENILW K151-ub
PKM iso2 (mouse) LDNAYMEKCDENILW K151
PKM (rat) LDNAyMEKCDENILW K151
PKM iso2 (rat) LDNAYMEKCDENILW K151
Y161-p
ENILWLDykNICkVV
0 1
PKM (human) ENILWLDykNICkVV Y161-p
PKM iso2 (human) ENILWLDYKNICKVV Y161
PKM iso3 (human) ENILWLDYKNICKVV Y146
PKM (mouse) ENILWLDYkNICkVV Y161
PKM iso2 (mouse) ENILWLDYKNICKVV Y161
PKM (rat) ENILWLDYKNICkVV Y161
PKM iso2 (rat) ENILWLDYKNICKVV Y161
K162-ac
NILWLDykNICkVVE
0 6
PKM (human) NILWLDykNICkVVE K162-ac
PKM iso2 (human) NILWLDYKNICKVVE K162
PKM iso3 (human) NILWLDYKNICKVVE K147
PKM (mouse) NILWLDYKNICkVVE K162
PKM iso2 (mouse) NILWLDYKNICKVVE K162
PKM (rat) NILWLDYKNICkVVE K162
PKM iso2 (rat) NILWLDYKNICKVVE K162
K162-ub
NILWLDykNICkVVE
0 29
PKM (human) NILWLDykNICkVVE K162-ub
PKM iso2 (human) NILWLDYKNICKVVE K162
PKM iso3 (human) NILWLDYKNICKVVE K147
PKM (mouse) NILWLDYkNICkVVE K162-ub
PKM iso2 (mouse) NILWLDYKNICKVVE K162
PKM (rat) NILWLDYKNICkVVE K162
PKM iso2 (rat) NILWLDYKNICKVVE K162
K166-ub
LDykNICkVVEVGsK
0 103
PKM (human) LDykNICkVVEVGsK K166-ub
PKM iso2 (human) LDYKNICKVVEVGSK K166
PKM iso3 (human) LDYKNICKVVEVGSK K151
PKM (mouse) LDYkNICkVVEVGSK K166-ub
PKM iso2 (mouse) LDYKNICKVVEVGSK K166
PKM (rat) LDYKNICkVVEVGSK K166-ub
PKM iso2 (rat) LDYKNICKVVEVGSK K166
K166-ac
LDykNICkVVEVGsK
0 4
PKM (human) LDykNICkVVEVGsK K166-ac
PKM iso2 (human) LDYKNICKVVEVGSK K166
PKM iso3 (human) LDYKNICKVVEVGSK K151
PKM (mouse) LDYkNICKVVEVGSK K166
PKM iso2 (mouse) LDYKNICKVVEVGSK K166
PKM (rat) LDYKNICkVVEVGSK K166-ac
PKM iso2 (rat) LDYKNICKVVEVGSK K166
K166-sm
LDykNICkVVEVGsK
0 1
PKM (human) LDykNICkVVEVGsK K166-sm
PKM iso2 (human) LDYKNICKVVEVGSK K166
PKM iso3 (human) LDYKNICKVVEVGSK K151
PKM (mouse) LDYkNICKVVEVGSK K166
PKM iso2 (mouse) LDYKNICKVVEVGSK K166
PKM (rat) LDYKNICKVVEVGSK K166
PKM iso2 (rat) LDYKNICKVVEVGSK K166
S172-p
CkVVEVGsKIyVDDG
0 2
PKM (human) CkVVEVGsKIyVDDG S172-p
PKM iso2 (human) CKVVEVGSKIYVDDG S172
PKM iso3 (human) CKVVEVGSKIYVDDG S157
PKM (mouse) CkVVEVGSKIyVDDG S172
PKM iso2 (mouse) CKVVEVGSKIYVDDG S172
PKM (rat) CkVVEVGSKIyVDDG S172
PKM iso2 (rat) CKVVEVGSKIYVDDG S172
Y175-p
VEVGsKIyVDDGLIs
Upstream
1 34
Regulatory protein:
  • EGFR (human)
PKM (human) VEVGsKIyVDDGLIs Y175-p
PKM iso2 (human) VEVGSKIYVDDGLIS Y175
PKM iso3 (human) VEVGSKIYVDDGLIS Y160
PKM (mouse) VEVGSKIyVDDGLIS Y175-p
PKM iso2 (mouse) VEVGSKIYVDDGLIS Y175
PKM (rat) VEVGSKIyVDDGLIS Y175-p
PKM iso2 (rat) VEVGSKIYVDDGLIS Y175
S182-p
yVDDGLIsLQVkQkG
0 1
PKM (human) yVDDGLIsLQVkQkG S182-p
PKM iso2 (human) YVDDGLISLQVKQKG S182
PKM iso3 (human) YVDDGLISLQVKQKG S167
PKM (mouse) yVDDGLISLQVkEkG S182
PKM iso2 (mouse) YVDDGLISLQVKEKG S182
PKM (rat) yVDDGLISLQVKEkG S182
PKM iso2 (rat) YVDDGLISLQVKEKG S182
K186-ac
GLIsLQVkQkGADFL
0 2
PKM (human) GLIsLQVkQkGADFL K186-ac
PKM iso2 (human) GLISLQVKQKGADFL K186
PKM iso3 (human) GLISLQVKQKGADFL K171
PKM (mouse) GLISLQVKEkGADFL K186
PKM iso2 (mouse) GLISLQVKEKGADFL K186
PKM (rat) GLISLQVKEkGADyL K186
PKM iso2 (rat) GLISLQVKEKGADYL K186
K186-ub
GLIsLQVkQkGADFL
1 5
PKM (human) GLIsLQVkQkGADFL K186-ub
PKM iso2 (human) GLISLQVKQKGADFL K186
PKM iso3 (human) GLISLQVKQKGADFL K171
PKM (mouse) GLISLQVkEkGADFL K186-ub
PKM iso2 (mouse) GLISLQVKEKGADFL K186
PKM (rat) GLISLQVKEkGADyL K186
PKM iso2 (rat) GLISLQVKEKGADYL K186
K186-sc
GLIsLQVkQkGADFL
0 1
PKM (human) GLIsLQVkQkGADFL K186-sc
PKM iso2 (human) GLISLQVKQKGADFL K186
PKM iso3 (human) GLISLQVKQKGADFL K171
PKM (mouse) GLISLQVKEkGADFL K186
PKM iso2 (mouse) GLISLQVKEKGADFL K186
PKM (rat) GLISLQVKEkGADyL K186
PKM iso2 (rat) GLISLQVKEKGADYL K186
K188-ub
IsLQVkQkGADFLVt
0 7
PKM (human) IsLQVkQkGADFLVt K188-ub
PKM iso2 (human) ISLQVKQKGADFLVT K188
PKM iso3 (human) ISLQVKQKGADFLVT K173
PKM (mouse) ISLQVkEkGADFLVT K188-ub
PKM iso2 (mouse) ISLQVKEKGADFLVT K188
PKM (rat) ISLQVKEKGADyLVT K188
PKM iso2 (rat) ISLQVKEKGADYLVT K188
K188-ac
IsLQVkQkGADFLVt
0 3
PKM (human) IsLQVkQkGADFLVt K188-ac
PKM iso2 (human) ISLQVKQKGADFLVT K188
PKM iso3 (human) ISLQVKQKGADFLVT K173
PKM (mouse) ISLQVkEKGADFLVT K188
PKM iso2 (mouse) ISLQVKEKGADFLVT K188
PKM (rat) ISLQVKEkGADyLVT K188-ac
PKM iso2 (rat) ISLQVKEKGADYLVT K188
F192
VkQkGADFLVtEVEN
0 1
PKM (human) VkQkGADFLVtEVEN F192
PKM iso2 (human) VKQKGADFLVTEVEN F192
PKM iso3 (human) VKQKGADFLVTEVEN F177
PKM (mouse) VkEkGADFLVTEVEn F192
PKM iso2 (mouse) VKEKGADFLVTEVEN F192
PKM (rat) VKEkGADyLVTEVEN Y192-p
PKM iso2 (rat) VKEKGADYLVTEVEN Y192
T195-p
kGADFLVtEVENGGs
0 8
PKM (human) kGADFLVtEVENGGs T195-p
PKM iso2 (human) KGADFLVTEVENGGS T195
PKM iso3 (human) KGADFLVTEVENGGS T180
PKM (mouse) kGADFLVTEVEnGGs T195
PKM iso2 (mouse) KGADFLVTEVENGGS T195
PKM (rat) kGADyLVTEVENGGs T195
PKM iso2 (rat) KGADYLVTEVENGGS T195
N199
FLVtEVENGGsLGsk
0 1
PKM (human) FLVtEVENGGsLGsk N199
PKM iso2 (human) FLVTEVENGGSLGSk N199
PKM iso3 (human) FLVTEVENGGSLGSK N184
PKM (mouse) FLVTEVEnGGsLGSk N199-ng
PKM iso2 (mouse) FLVTEVENGGSLGSK N199
PKM (rat) yLVTEVENGGsLGSk N199
PKM iso2 (rat) YLVTEVENGGSLGSK N199
S202-p
tEVENGGsLGskkGV
Upstream
Downstream
1 7
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Kinase, in vitro:
  • Akt1 (human)
Treatment
  • IGF-1
PKM (human) tEVENGGsLGskkGV S202-p
PKM iso2 (human) TEVENGGSLGSkKGV S202
PKM iso3 (human) TEVENGGSLGSKKGV S187
PKM (mouse) TEVEnGGsLGSkkGV S202-p
PKM iso2 (mouse) TEVENGGSLGSKKGV S202
PKM (rat)