Other Species / Isoforms
  5-LO (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y21-p
WFAGTDDyIyLSLVG
0 1
5-LO (human) WFAGTDDyIyLSLVG Y21-p
5-LO (mouse) WFAGTDDYIYLSLIG Y21
5-LO (rat) WFAGTDDYIYLSLIG Y21
Y23-p
AGTDDyIyLSLVGSA
0 1
5-LO (human) AGTDDyIyLSLVGSA Y23-p
5-LO (mouse) AGTDDYIYLSLIGSA Y23
5-LO (rat) AGTDDYIYLSLIGSA Y23
Y43-p
HLLDKPFyNDFERGA
Upstream
0 1
Kinase, in vitro:
  • FGR (human)
  • Hck (human)
  • Yes (human)
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5-LO (human) HLLDKPFyNDFERGA Y43-p
5-LO (mouse) HLLDKAFYNDFERGA Y43
5-LO (rat) HLLDKAFYNDFERGG Y43
Y54-p
ERGAVDSyDVTVDEE
Upstream
0 1
Kinase, in vitro:
  • FGR (human)
  • Hck (human)
  • Yes (human)
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5-LO (human) ERGAVDSyDVTVDEE Y54-p
5-LO (mouse) ERGAVDSYDVTVDEE Y54
5-LO (rat) ERGGRDSYDVTVDEE Y54
Y75-p
VRIEKRKyWLNDDWY
0 1
5-LO (human) VRIEKRKyWLNDDWY Y75-p
5-LO (mouse) VKIEKRKYWLHDDWY Y75
5-LO (rat) VKIEKRKYRLHDDWY Y75
T87-p
DWYLKYItLKTPHGD
0 1
5-LO (human) DWYLKYItLKTPHGD T87-p
5-LO (mouse) DWYLKYITLKTPHGD T87
5-LO (rat) DWYLKYITLKTPHDY T87
Y95-p
LKTPHGDyIEFPCyR
Upstream
0 2
Kinase, in vitro:
  • Hck (human)
5-LO (human) LKTPHGDyIEFPCyR Y95-p
5-LO (mouse) LKTPHGDyIEFPCYR Y95-p
5-LO (rat) TLKTPHDYIEFPCYR Y94
Y101-p
DyIEFPCyRWItGDV
0 1
5-LO (human) DyIEFPCyRWItGDV Y101-p
5-LO (mouse) DyIEFPCYRWITGEG Y101
5-LO (rat) DYIEFPCYRWITGEG Y100
T105-p
FPCyRWItGDVEVVL
0 2
5-LO (human) FPCyRWItGDVEVVL T105-p
5-LO (mouse) FPCYRWITGEGEIVL T105
5-LO (rat) FPCYRWITGEGEIVL T104
Y182-p
GVDFVLNysKAMENL
0 1
5-LO (human) GVDFVLNysKAMENL Y182-p
5-LO (mouse) GVDFVLNYSKAMENL Y182
5-LO (rat) GVDFVLNYSKAMENL Y181
S183-p
VDFVLNysKAMENLF
0 1
5-LO (human) VDFVLNysKAMENLF S183-p
5-LO (mouse) VDFVLNYSKAMENLF S183
5-LO (rat) VDFVLNYSKAMENLF S182
T250-p
PVLIRRCtELPEKLP
0 1
5-LO (human) PVLIRRCtELPEKLP T250-p
5-LO (mouse) PVLIKRCTALPPKLP T250
5-LO (rat) PVLIKRCTELPKKLP T249
T259-p
LPEKLPVttEMVECs
1 0
5-LO (human) LPEKLPVttEMVECs T259-p
5-LO (mouse) LPPKLPVTTEMVECS T259
5-LO (rat) LPKKLPVTTEMVECS T258
T260-p
PEKLPVttEMVECsL
0 1
5-LO (human) PEKLPVttEMVECsL T260-p
5-LO (mouse) PPKLPVTTEMVECSL T260
5-LO (rat) PKKLPVTTEMVECSL T259
S266-p
ttEMVECsLERQLsL
0 1
5-LO (human) ttEMVECsLERQLsL S266-p
5-LO (mouse) TTEMVECSLERQLsL S266
5-LO (rat) TTEMVECSLERQLSL S265
S272-p
CsLERQLsLEQEVQQ
Upstream
Downstream
9 3
5-LO (human)
S272-p
5-LO (mouse)
S272-p
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
Kinase, in vitro:
  • CAMK2A (human)
  • MAPKAPK2 (human)
  • PKACA (human)
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Treatment
  • A23187
  • fMLP
  • KN-93
  • SB203580
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5-LO (human) CsLERQLsLEQEVQQ S272-p
5-LO (mouse) CSLERQLsLEQEVQE S272-p
5-LO (rat) CSLERQLSLEQEVQE S271
T298
DGIDANKTDPCTLQF
0 1
5-LO (human) DGIDANKTDPCTLQF T298
5-LO (mouse) DGIDANKtDPCtHQF T298-p
5-LO (rat) DGIDANKTDPCTHQF T297
T302
ANKTDPCTLQFLAAP
0 1
5-LO (human) ANKTDPCTLQFLAAP T302
5-LO (mouse) ANKtDPCtHQFLAAP T302-p
5-LO (rat) ANKTDPCTHQFLAAP T301
T445-p
QRAMKDLtyAsLCFP
0 1
5-LO (human) QRAMKDLtyAsLCFP T445-p
5-LO (mouse) QRAVQDLTYSSLCFP T445
5-LO (rat) QRAVQDLTYSSLCFP T444
Y446-p
RAMKDLtyAsLCFPE
Upstream
0 1
Kinase, in vitro:
  • FGR (human)
  • Yes (human)
5-LO (human) RAMKDLtyAsLCFPE Y446-p
5-LO (mouse) RAVQDLTYSSLCFPE Y446
5-LO (rat) RAVQDLTYSSLCFPE Y445
S448-p
MKDLtyAsLCFPEAI
Upstream
0 1
Kinase, in vitro:
  • PKACA (human)
5-LO (human) MKDLtyAsLCFPEAI S448-p
5-LO (mouse) VQDLTYSSLCFPEAI S448
5-LO (rat) VQDLTYSSLCFPEAI S447
K456
LCFPEAIKARGMESK
0 1
5-LO (human) LCFPEAIKARGMESK K456
5-LO (mouse) LCFPEAIkARGMDST K456-ub
5-LO (rat) LCFPEAIKARGMDNT K455
T486-p
WEAIRTFtAEVVDIY
0 1
5-LO (human) WEAIRTFtAEVVDIY T486-p
5-LO (mouse) WEAIQSFTMEVVSIY T486
5-LO (rat) WEAIQSFTTEVVSIY T485
S524-p
GMRGRKSsGFPkSVK
Upstream
Downstream
6 1
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
Kinase, in vitro:
  • PKACA (human)
  • PKACA (mouse)
Putative in vivo kinases:
  • PKACA (human)
  • PKACA (mouse)
Treatment
  • cAMP_analog
  • colforsin
  • H-89
  • IBMX
  • PGE2
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5-LO (human) GMRGRKSsGFPkSVK S524-p
5-LO (mouse) GMRGKKASGFPKSIK S524
5-LO (rat) GMRGRKAsGFPKSIK S523-p
K528-ac
RKSsGFPkSVKsREQ
0 1
5-LO (human) RKSsGFPkSVKsREQ K528-ac
5-LO (mouse) KKASGFPKSIKSREK K528
5-LO (rat) RKAsGFPKSIKSREK K527
S532-p
GFPkSVKsREQLSEY
0 1
5-LO (human) GFPkSVKsREQLSEY S532-p
5-LO (mouse) GFPKSIKSREKLSEY S532
5-LO (rat) GFPKSIKSREKLSEY S531
S664-p
QLPYYYLsPDRIPNs
Upstream
Downstream
3 1
5-LO (human)
S664-p
5-LO (mouse)
S664-p
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • ERK2 (human)
Treatment
  • arachidonic_acid
  • linoleic_acid
  • oleic_acid
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5-LO (human) QLPYYYLsPDRIPNs S664-p
5-LO (mouse) KLPYYYLSPDRIPNS S664
5-LO (rat) KLPYYYLSPDRIPNS S663
S671-p
sPDRIPNsVAI____
Upstream
1 0
Kinase, in vitro:
  • PKACA (human)
5-LO (human) sPDRIPNsVAI____ S671-p
5-LO (mouse) SPDRIPNSVAI____ S671
5-LO (rat) SPDRIPNSVAI____ S670