TRPV1 (rat)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

___MEQRAsLDSEES

TRPV1 (human)	___MKKWsstDLGAA	S5-p
TRPV1 (mouse)	___MEKWASLDSDES	A5
TRPV1 (rat)	___MEQRAsLDSEES	A5

S6-p

__MEQRAsLDSEESE

Upstream

Kinase, in vitro:

PKACA (cow)

TRPV1 (human)	__MKKWsstDLGAAA	S6-p
TRPV1 (mouse)	__MEKWASLDSDESE	S6
TRPV1 (rat)	__MEQRAsLDSEESE	S6-p

_MEQRAsLDSEESES

TRPV1 (human)	_MKKWsstDLGAAAD	T7-p
TRPV1 (mouse)	_MEKWASLDSDESEP	L7
TRPV1 (rat)	_MEQRAsLDSEESES	L7

S116-p

PRLYDRRsIFDAVAQ

Upstream

Downstream

Effects on Modified Protein

receptor desensitization, altered

Kinase, in vitro:

PKACA (cow)
PRKD1 (rat)

Putative in vivo kinases:

PKACA (cow)

Treatment

8-Br-AMP
H-89

TRPV1 (human)	LRLYDRRsIFEAVAQ	S117-p
TRPV1 (mouse)	PRLYDRRSIFDAVAQ	S117
TRPV1 (rat)	PRLYDRRsIFDAVAQ	S116-p

S131

SNCQELESLLPFLQR

TRPV1 (human)	NNCQDLEsLLLFLQK	S132-p
TRPV1 (mouse)	SNCQELESLLSFLQK	S132
TRPV1 (rat)	SNCQELESLLPFLQR	S131

S139

LLPFLQRSKKRLtDS

TRPV1 (human)	LLLFLQKsKKHLTDN	S140-p
TRPV1 (mouse)	LLSFLQKSKKRLtDS	S140
TRPV1 (rat)	LLPFLQRSKKRLtDS	S139

T144-p

QRSKKRLtDSEFKDP

Upstream

Kinase, in vitro:

PKACA (cow)
PKCA (human)

TRPV1 (human)	QKsKKHLTDNEFKDP	T145
TRPV1 (mouse)	QKSKKRLtDSEFKDP	T145-p
TRPV1 (rat)	QRSKKRLtDSEFKDP	T144-p

K160

TGKTCLLKAMLNLHN

TRPV1 (human)	TGKTCLLkAMLNLHD	K161-ac
TRPV1 (mouse)	TGKTCLLKAMLNLHN	K161
TRPV1 (rat)	TGKTCLLKAMLNLHN	K160

T195

QFVNASYTDSYyKGQ

TRPV1 (human)	ELVNASYtDSYyKGQ	T196-p
TRPV1 (mouse)	QFVNASYTDSYYKGQ	T196
TRPV1 (rat)	QFVNASYTDSYyKGQ	T195

Y199-p

ASYTDSYyKGQTALH

Downstream

Effects on Modified Protein

activity, induced

TRPV1 (human)	ASYtDSYyKGQTALH	Y200-p
TRPV1 (mouse)	ASYTDSYYKGQTALH	Y200
TRPV1 (rat)	ASYTDSYyKGQTALH	Y199-p

K265

TNQLAIVKFLLQNSW

TRPV1 (human)	TNQLGIVKFLLQNSW	K266
TRPV1 (mouse)	TNQLAIVkFLLQNSW	K266-ac
TRPV1 (rat)	TNQLAIVKFLLQNSW	K265

T329

TLKLEEITNRKGLTP

TRPV1 (human)	TLKLEELTNKKGMtP	T330
TRPV1 (mouse)	TLKLEELtNKKGLTP	T330-p
TRPV1 (rat)	TLKLEEITNRKGLTP	T329

T335

ITNRKGLTPLALAAS

TRPV1 (human)	LTNKKGMtPLALAAG	T336-p
TRPV1 (mouse)	LtNKKGLTPLALAAS	T336
TRPV1 (rat)	ITNRKGLTPLALAAS	T335

T370-p

RHLSRKFtEWAYGPV

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation
receptor desensitization, altered

Kinase, in vitro:

PKACA (cow)

Putative in vivo kinases:

PKACA (cow)

Treatment

8-Br-AMP
H-89

TRPV1 (human)	RHLSRKFTEWAYGPV	T371
TRPV1 (mouse)	RHLSRKFtEWAYGPV	T371-p
TRPV1 (rat)	RHLSRKFtEWAYGPV	T370-p

T406-p

IAYSSSEtPNRHDML

Upstream

Downstream

Effects on Modified Protein

activity, inhibited
intracellular localization
molecular association, regulation
phosphorylation
protein conformation
receptor desensitization, inhibited

Kinase, in vitro:

CDK5 (rat)

Putative in vivo kinases:

CDK5 (rat)

Treatment

peptide inhibitor
seliciclib

TRPV1 (human)	IAYSSSETPNRHDML	T407
TRPV1 (mouse)	IAYSSSEtPNRHDML	T407-p
TRPV1 (rat)	IAYSSSEtPNRHDML	T406-p

S502-p

YFLQRRPsLKSLFVD

Upstream

Downstream

Effects on Modified Protein

activity, induced
receptor desensitization, altered
receptor desensitization, inhibited

Kinase, in vitro:

PKACA (cow)
PKCA (human)
PKCE (rat)

Putative in vivo kinases:

CAMK2A (human)
PKCA (human)
PKCA (rat)
PKCE (no information)

Treatment

bisindolylmaleimide
calphostin_C
capsaicin
endothelin
epsilonV1-2
Go_6976
Ki16425
LPA
phorbol_ester

TRPV1 (human)	YFLQRRPsMKTLFVD	S502-p
TRPV1 (mouse)	YFLQRRPSLKSLFVD	S503
TRPV1 (rat)	YFLQRRPsLKSLFVD	S502-p

T704-p

WKLQRAItILDTEKS

Upstream

Downstream

Effects on Modified Protein

activity, induced
receptor desensitization, altered

Kinase, in vitro:

PKCA (human)

Putative in vivo kinases:

CAMK2A (human)
PKCE (no information)

Treatment

epsilonV1-2
Ki16425
LPA

TRPV1 (human)	WKLQRAItILDTEKS	T705-p
TRPV1 (mouse)	WKLQRAITILDTEKS	T705
TRPV1 (rat)	WKLQRAItILDTEKS	T704-p

T772

NCEGVKRTLsFSLRS

TRPV1 (human)	NCEGVKRtLsFSLRs	T773-p
TRPV1 (mouse)	NCEGVKRTLSFSLRS	T773
TRPV1 (rat)	NCEGVKRTLsFSLRS	T772

S774-p

EGVKRTLsFSLRSGR

Upstream

Kinase, in vitro:

PKACA (cow)
PKCA (human)

TRPV1 (human)	EGVKRtLsFSLRsSR	S775-p
TRPV1 (mouse)	EGVKRTLSFSLRSGR	S775
TRPV1 (rat)	EGVKRTLsFSLRSGR	S774-p

S779

TLsFSLRSGRVSGRN

TRPV1 (human)	tLsFSLRsSRVSGRH	S780-p
TRPV1 (mouse)	TLSFSLRSGRVSGRN	S780
TRPV1 (rat)	TLsFSLRSGRVSGRN	S779

S800-p

VPLLRDAsTRDRHAT

Upstream

Downstream

Effects on Modified Protein

activity, induced
molecular association, regulation
receptor desensitization, altered
receptor desensitization, inhibited

Effects on Biological Processes:

cytoskeletal reorganization

Kinase, in vitro:

PKCA (human)
PKCE (rat)

Putative in vivo kinases:

PKCA (human)
PKCA (rat)
PKCE (rat)

Regulatory protein:

AKAP5 (rat)
SUMO1 (human)

Treatment

bisindolylmaleimide
calphostin_C
capsaicin
DHPG
endothelin
estradiol
GF109203X
Go_6976
mono-iodoacetate (MIA)-induced joint pain model
NMDA
phorbol_ester

TRPV1 (human)	VPLLREAsARDRQsA	S801-p
TRPV1 (mouse)	VPLLRDAsTRDRHST	S801-p
TRPV1 (rat)	VPLLRDAsTRDRHAT	S800-p

A806

AsTRDRHATQQEEVQ

TRPV1 (human)	AsARDRQsAQPEEVy	S807-p
TRPV1 (mouse)	AsTRDRHSTQPEEVQ	S807
TRPV1 (rat)	AsTRDRHATQQEEVQ	A806

Q813

ATQQEEVQLKHYTGs

TRPV1 (human)	sAQPEEVyLRQFSGS	Y814-p
TRPV1 (mouse)	STQPEEVQLKHYTGS	Q814
TRPV1 (rat)	ATQQEEVQLKHYTGs	Q813

S820-p

QLKHYTGsLkPEDAE

Upstream

Kinase, in vitro:

PKACA (cow)
PKCA (human)

TRPV1 (human)	yLRQFSGSLKPEDAE	S821
TRPV1 (mouse)	QLKHYTGSLkPEDAE	S821
TRPV1 (rat)	QLKHYTGsLkPEDAE	S820-p

K822-sm

KHYTGsLkPEDAEVF

Downstream

Effects on Modified Protein

phosphorylation

TRPV1 (human)	RQFSGSLKPEDAEVF	K823
TRPV1 (mouse)	KHYTGSLkPEDAEVF	K823-sm
TRPV1 (rat)	KHYTGsLkPEDAEVF	K822-sm