Other Species / Isoforms
  SIK (rat)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K20
GTGQGQQKPLRVGFY
0 1
SIK (human) GQGQGQQkPLRVGFY K20-sm
SIK (mouse) GTGQGQQKPLRVGFY K20
SIK (rat) GTGQGQQKPLRVGFY K20
K20
GTGQGQQKPLRVGFY
0 2
SIK (human) GQGQGQQkPLRVGFY K20-ub
SIK (mouse) GTGQGQQKPLRVGFY K20
SIK (rat) GTGQGQQKPLRVGFY K20
T32
GFYDVERTLGKGNFA
0 1
SIK (human) GFYDIERtLGKGNFA T32-p
SIK (mouse) GFYDVERTLGKGNFA T32
SIK (rat) GFYDVERTLGKGNFA T32
K175
FGFGNFYKPGEPLSt
0 1
SIK (human) FGFGNFYkSGEPLSt K175-sm
SIK (mouse) FGFGNFYKPGEPLSt K175
SIK (rat) FGFGNFYKPGEPLSt K175
T182-p
KPGEPLStWCGsPPY
Upstream
5 0
Kinase, in vitro:
  • GSK3B (human)
  • GSK3B (rat)
Putative in vivo kinases:
  • GSK3B (rat)
  • LKB1 (human)
Treatment
  • acadesine
  • BDNF
  • bisindolylmaleimide
  • H-89
  • Hypericin
  • indirubin
  • KN-93
  • LY294002
  • PD98059
  • Ro31-8220
  • SB203580
  • serum
  • staurosporine
  • STO-609
  • wortmannin
SIK (human) kSGEPLStWCGSPPY T182-p
SIK (mouse) KPGEPLStWCGSPPY T182-p
SIK (rat) KPGEPLStWCGsPPY T182-p
S186-p
PLStWCGsPPYAAPE
Upstream
Downstream
2 0
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Kinase, in vitro:
  • GSK3B (rat)
  • SIK (rat)
Treatment
  • acadesine
  • bisindolylmaleimide
  • H-89
  • Hypericin
  • indirubin
  • KN-93
  • LY294002
  • PD98059
  • Ro31-8220
  • SB203580
  • serum
  • staurosporine
  • STO-609
  • wortmannin
SIK (human) PLStWCGSPPYAAPE S186
SIK (mouse) PLStWCGSPPYAAPE S186
SIK (rat) PLStWCGsPPYAAPE S186-p
T322-p
LGIDRQRtVESLQNS
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • CAMK1A (human)
SIK (human) LGVDRQRTVESLQNS T322
SIK (mouse) LGIDRQRTIESLQNS T322
SIK (rat) LGIDRQRtVESLQNS T322-p
S373
QLRNSDLSSLEVPQE
0 1
SIK (human) RPRSSDLsGLEVPQE S370-p
SIK (mouse) QLRSSDLSSLEVPQE S373
SIK (rat) QLRNSDLSSLEVPQE S373
S437
VFRHRSISPSSLLDT
1 14
SIK (human) VFRPRPVsPsSLLDT S435-p
SIK (mouse) VFRHRSIsPSSLLDT S437-p
SIK (rat) VFRHRSISPSSLLDT S437
S439
RHRSISPSSLLDTAI
0 2
SIK (human) RPRPVsPsSLLDTAI S437-p
SIK (mouse) RHRSIsPSSLLDTAI S439
SIK (rat) RHRSISPSSLLDTAI S439
V462
SLEEEQEVQEPLPGS
0 1
SIK (human) GLEEEQDtQESLPSS T460-p
SIK (mouse) SLEEEQEVQEPLPGS V462
SIK (rat) SLEEEQEVQEPLPGS V462
T475-p
GSTGRRHtLAEVSTH
1 5
SIK (human) SSTGRRHtLAEVStR T473-p
SIK (mouse) GSTGRRHtLAEVSTH T475-p
SIK (rat) GSTGRRHtLAEVSTH T475-p
T481
HtLAEVSTHFSPLNP
0 1
SIK (human) HtLAEVStRLSPLTA T479-p
SIK (mouse) HtLAEVSTHFSPLNP T481
SIK (rat) HtLAEVSTHFSPLNP T481
G518
LPFSASEGPAGLGGG
0 1
SIK (human) LTFSASKsPAGLSGT S516-p
SIK (mouse) LPFSASEGPAGLGSG G518
SIK (rat) LPFSASEGPAGLGGG G518
S536
PGLLGTSSPVRLASP
0 2
SIK (human) QGLLGACsPVRLASP S534-p
SIK (mouse) PGLLGTSSPVRLASP S536
SIK (rat) PGLLGTSSPVRLASP S536
S577-p
FQEGRRAsDTSLTQG
Upstream
Downstream
9 24
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Putative in vivo kinases:
  • PKACA (human)
  • PKACA (mouse)
Treatment
  • ACTH
  • cAMP_analog
SIK (human) FQEGRRAsDtSLTQG S575-p
SIK (mouse) FQEGRRAsDTSLTQG S577-p
SIK (rat) FQEGRRAsDTSLTQG S577-p
T579
EGRRAsDTSLTQGLK
0 1
SIK (human) EGRRAsDtSLTQGLk T577-p
SIK (mouse) EGRRAsDTSLTQGLK T579
SIK (rat) EGRRAsDTSLTQGLK T579
K586
TSLTQGLKAFRQQLR
0 1
SIK (human) tSLTQGLkAFRQQLR K584-sm
SIK (mouse) TSLTQGLKAFRQQLR K586
SIK (rat) TSLTQGLKAFRQQLR K586
K606
KGFLGLNKIKGLARQ
0 1
SIK (human) KGFLGLNkIKGLARQ K604-sm
SIK (mouse) KGFLGLNKIKGLARQ K606
SIK (rat) KGFLGLNKIKGLARQ K606
S627
RGSRGGMSTFHTPAP
0 3
SIK (human) RASRGGLsPFHAPAQ S626-p
SIK (mouse) RTPRGGMSTFHTPAP S627
SIK (rat) RGSRGGMSTFHTPAP S627
S635
TFHTPAPSSGLQGCT
0 2
SIK (human) PFHAPAQsPGLHGGA S634-p
SIK (mouse) TFHTPAPSSGLQGCT S635
SIK (rat) TFHTPAPSSGLQGCT S635
S645
LQGCTASSREGRSLL
0 1
SIK (human) LHGGAAGsREGWSLL S644-p
SIK (mouse) LQGCTTSNREGRSLL N645
SIK (rat) LQGCTASSREGRSLL S645