Other Species / Isoforms
  SIK (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K20
GTGQGQQKPLRVGFY
0 1
SIK (human) GQGQGQQkPLRVGFY K20-sm
SIK (mouse) GTGQGQQKPLRVGFY K20
SIK (rat) GTGQGQQKPLRVGFY K20
K20
GTGQGQQKPLRVGFY
0 2
SIK (human) GQGQGQQkPLRVGFY K20-ub
SIK (mouse) GTGQGQQKPLRVGFY K20
SIK (rat) GTGQGQQKPLRVGFY K20
T32
GFYDVERTLGKGNFA
0 1
SIK (human) GFYDIERtLGKGNFA T32-p
SIK (mouse) GFYDVERTLGKGNFA T32
SIK (rat) GFYDVERTLGKGNFA T32
K175
FGFGNFYKPGEPLSt
0 1
SIK (human) FGFGNFYkSGEPLSt K175-sm
SIK (mouse) FGFGNFYKPGEPLSt K175
SIK (rat) FGFGNFYKPGEPLSt K175
T182-p
KPGEPLStWCGSPPY
Downstream
7 0
Effects on Modified Protein
  • enzymatic activity, induced
SIK (human) kSGEPLStWCGSPPY T182-p
SIK (mouse) KPGEPLStWCGSPPY T182-p
SIK (rat) KPGEPLStWCGsPPY T182-p
S186
PLStWCGSPPYAAPE
2 0
SIK (human) PLStWCGSPPYAAPE S186
SIK (mouse) PLStWCGSPPYAAPE S186
SIK (rat) PLStWCGsPPYAAPE S186-p
T322
LGIDRQRTIESLQNS
1 0
SIK (human) LGVDRQRTVESLQNS T322
SIK (mouse) LGIDRQRTIESLQNS T322
SIK (rat) LGIDRQRtVESLQNS T322-p
S373
QLRSSDLSSLEVPQE
0 1
SIK (human) RPRSSDLsGLEVPQE S370-p
SIK (mouse) QLRSSDLSSLEVPQE S373
SIK (rat) QLRNSDLSSLEVPQE S373
S437-p
VFRHRSIsPSSLLDT
1 14
SIK (human) VFRPRPVsPsSLLDT S435-p
SIK (mouse) VFRHRSIsPSSLLDT S437-p
SIK (rat) VFRHRSISPSSLLDT S437
S439
RHRSIsPSSLLDTAI
0 2
SIK (human) RPRPVsPsSLLDTAI S437-p
SIK (mouse) RHRSIsPSSLLDTAI S439
SIK (rat) RHRSISPSSLLDTAI S439
V462
SLEEEQEVQEPLPGS
0 1
SIK (human) GLEEEQDtQESLPSS T460-p
SIK (mouse) SLEEEQEVQEPLPGS V462
SIK (rat) SLEEEQEVQEPLPGS V462
T475-p
GSTGRRHtLAEVSTH
Upstream
Downstream
1 5
Effects on Modified Protein
  • intracellular localization
  • protein stabilization
Kinase, in vitro:
  • PKACA (human)
Regulatory protein:
  • PKACA (mouse)
Treatment
  • IBMX
  • NKH_477
SIK (human) SSTGRRHtLAEVStR T473-p
SIK (mouse) GSTGRRHtLAEVSTH T475-p
SIK (rat) GSTGRRHtLAEVSTH T475-p
T481
HtLAEVSTHFSPLNP
0 1
SIK (human) HtLAEVStRLSPLTA T479-p
SIK (mouse) HtLAEVSTHFSPLNP T481
SIK (rat) HtLAEVSTHFSPLNP T481
G518
LPFSASEGPAGLGSG
0 1
SIK (human) LTFSASKsPAGLSGT S516-p
SIK (mouse) LPFSASEGPAGLGSG G518
SIK (rat) LPFSASEGPAGLGGG G518
S536
PGLLGTSSPVRLASP
0 2
SIK (human) QGLLGACsPVRLASP S534-p
SIK (mouse) PGLLGTSSPVRLASP S536
SIK (rat) PGLLGTSSPVRLASP S536
S577-p
FQEGRRAsDTSLTQG
Upstream
Downstream
10 25
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • PKACA (cow)
Putative in vivo kinases:
  • PKACA (mouse)
  • PKCA (mouse)
Treatment
  • ACTH
  • IBMX
  • LPA
  • NKH_477
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SIK (human) FQEGRRAsDtSLTQG S575-p
SIK (mouse) FQEGRRAsDTSLTQG S577-p
SIK (rat) FQEGRRAsDTSLTQG S577-p
T579
EGRRAsDTSLTQGLK
0 1
SIK (human) EGRRAsDtSLTQGLk T577-p
SIK (mouse) EGRRAsDTSLTQGLK T579
SIK (rat) EGRRAsDTSLTQGLK T579
K586
TSLTQGLKAFRQQLR
0 1
SIK (human) tSLTQGLkAFRQQLR K584-sm
SIK (mouse) TSLTQGLKAFRQQLR K586
SIK (rat) TSLTQGLKAFRQQLR K586
K606
KGFLGLNKIKGLARQ
0 1
SIK (human) KGFLGLNkIKGLARQ K604-sm
SIK (mouse) KGFLGLNKIKGLARQ K606
SIK (rat) KGFLGLNKIKGLARQ K606
S627
RTPRGGMSTFHTPAP
0 3
SIK (human) RASRGGLsPFHAPAQ S626-p
SIK (mouse) RTPRGGMSTFHTPAP S627
SIK (rat) RGSRGGMSTFHTPAP S627
S635
TFHTPAPSSGLQGCT
0 2
SIK (human) PFHAPAQsPGLHGGA S634-p
SIK (mouse) TFHTPAPSSGLQGCT S635
SIK (rat) TFHTPAPSSGLQGCT S635
N645
LQGCTTSNREGRSLL
0 1
SIK (human) LHGGAAGsREGWSLL S644-p
SIK (mouse) LQGCTTSNREGRSLL N645
SIK (rat) LQGCTASSREGRSLL S645