Other Species / Isoforms
  AQP2 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K228
YLLFPSTKSLQERLA
1 0
AQP2 (human) YVLFPPAkSLSERLA K228-ub
AQP2 (mouse) YLLFPSTKSLQERLA K228
AQP2 (rat) YLLFPSAKSLQERLA K228
K238-ub
QERLAVLkGLEPDTD
0 1
AQP2 (human) SERLAVLKGLEPDTD K238
AQP2 (mouse) QERLAVLkGLEPDTD K238-ub
AQP2 (rat) QERLAVLKGLEPDTD K238
S256-p
REVRRRQsVELHsPQ
Upstream
Downstream
71 8
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
  • receptor internalization, inhibited
Effects on Biological Processes:
  • endocytosis, altered
  • exocytosis, altered
Regulatory protein:
  • ADCY6 (mouse)
Treatment
  • desmopressin
  • EGF
  • erlotinib
  • NH4Cl
  • vasopressin
AQP2 (human) REVRRRQsVELHsPQ S256-p
AQP2 (mouse) REVRRRQsVELHsPQ S256-p
AQP2 (rat) REVRRRQsVELHsPQ S256-p
S261-p
RQsVELHsPQsLPRG
Upstream
Downstream
36 8
Effects on Modified Protein
  • intracellular localization
  • ubiquitination
Putative in vivo kinases:
  • P38A (mouse)
Treatment
  • desmopressin
  • erlotinib
  • NH4Cl
  • NPS_2143
  • SB203580
AQP2 (human) RQsVELHsPQsLPRG S261-p
AQP2 (mouse) RQsVELHsPQsLPRG S261-p
AQP2 (rat) RQsVELHsPQsLPRG S261-p
S264-p
VELHsPQsLPRGskA
Downstream
19 7
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
AQP2 (human) VELHsPQsLPRGtkA S264-p
AQP2 (mouse) VELHsPQsLPRGskA S264-p
AQP2 (rat) VELHsPQsLPRGskA S264-p
S269-p
PQsLPRGskA_____
Upstream
Downstream
33 4
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • endocytosis, altered
  • endocytosis, inhibited
Regulatory protein:
  • ADCY6 (mouse)
Treatment
  • 8-CPT-2Me-cAMP
  • dDAVP
  • ddFSK
  • desmopressin
  • erlotinib
  • methyl-beta-cyclodextrin
  • oxytocin
  • vasopressin
AQP2 (human) PQsLPRGtkA_____ T269-p
AQP2 (mouse) PQsLPRGskA_____ S269-p
AQP2 (rat) PQsLPRGskA_____ S269-p
K270-ub
QsLPRGskA______
Downstream
6 0
Effects on Modified Protein
  • ubiquitination
AQP2 (human) QsLPRGtkA______ K270-ub
AQP2 (mouse) QsLPRGskA______ K270-ub
AQP2 (rat) QsLPRGskA______ K270-ub