AQP2 (rat)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

K228

YLLFPSAKSLQERLA

AQP2 (human)	YVLFPPAkSLSERLA	K228-ub
AQP2 (mouse)	YLLFPSTKSLQERLA	K228
AQP2 (rat)	YLLFPSAKSLQERLA	K228

K238

QERLAVLKGLEPDTD

AQP2 (human)	SERLAVLKGLEPDTD	K238
AQP2 (mouse)	QERLAVLkGLEPDTD	K238-ub
AQP2 (rat)	QERLAVLKGLEPDTD	K238

S256-p

REVRRRQsVELHsPQ

Upstream

Downstream

Effects on Modified Protein

activity, induced
intracellular localization
molecular association, regulation

Effects on Biological Processes:

endocytosis, inhibited

Kinase, in vitro:

PKACA (human)
PKACA (rat)

Putative in vivo kinases:

PKACA (rat)

Regulatory protein:

ILK (rat)
PKD1 (human)
PPP2CA (human)

Treatment

4AD
acadesine
adrenomedullin
aldosterone
ANP
BUO
butaprost
calyculin_A
cAMP_analog
candesartan
CAY10580
chelerythrine
colforsin
compound_C
cpd22
dasatinib
dDAVP
desmopressin
FK506
GH
H-89
hypertonic_buffer
IBMX
ibuprofen
L-NAME
meloxicam
metformin
Mn(2+)
NH4Cl
NKH_477
okadaic_acid
osmotic_stress
PGE2
phorbol_ester
roflumilast N-oxide
rolipram
rottlerin
sanguinarine
seliciclib
streptozotocin
tolvaptan
U73122
V2_vasopressin_receptor_antagonist
vasopressin

AQP2 (human)	REVRRRQsVELHsPQ	S256-p
AQP2 (mouse)	REVRRRQsVELHsPQ	S256-p
AQP2 (rat)	REVRRRQsVELHsPQ	S256-p

S261-p

RQsVELHsPQsLPRG

Upstream

Downstream

Effects on Modified Protein

activity, inhibited
intracellular localization
molecular association, regulation
ubiquitination

Effects on Biological Processes:

endocytosis, inhibited
exocytosis, induced

Kinase, in vitro:

PKACA (rat)

Regulatory protein:

ILK (rat)
PKD1 (human)

Treatment

4AD
acadesine
adrenomedullin
aldosterone
BUO
calyculin_A
chelerythrine
ciclosporin
colforsin
compound_C
cpd22
dDAVP
desmopressin
FK506
hypertonic_buffer
IBMX
L-NAME
meloxicam
metformin
Mn(2+)
NH4Cl
NKH_477
okadaic_acid
PD98059
phorbol_ester
roflumilast
roflumilast N-oxide
rottlerin
sanguinarine
seliciclib
sulprostone
tolvaptan
U73122
vasopressin

AQP2 (human)	RQsVELHsPQsLPRG	S261-p
AQP2 (mouse)	RQsVELHsPQsLPRG	S261-p
AQP2 (rat)	RQsVELHsPQsLPRG	S261-p

S264-p

VELHsPQsLPRGskA

Upstream

Downstream

Effects on Modified Protein

activity, inhibited
intracellular localization
ubiquitination

Effects on Biological Processes:

endocytosis, inhibited
exocytosis, induced

Kinase, in vitro:

PKACA (rat)

Treatment

butaprost
calyculin_A
cAMP_analog
CAY10580
desmopressin
FK506
H-89
IBMX
ibuprofen
meloxicam
Mn(2+)
PGE2
roflumilast N-oxide
tolvaptan
vasopressin

AQP2 (human)	VELHsPQsLPRGtkA	S264-p
AQP2 (mouse)	VELHsPQsLPRGskA	S264-p
AQP2 (rat)	VELHsPQsLPRGskA	S264-p

S269-p

PQsLPRGskA_____

Upstream

Downstream

Effects on Modified Protein

intracellular localization

Effects on Biological Processes:

endocytosis, inhibited

Kinase, in vitro:

PKACA (rat)

Treatment

4AD
butaprost
calyculin_A
cAMP_analog
CAY10580
colforsin
dasatinib
desmopressin
FK506
H-89
IBMX
ibuprofen
Ipragliflozin
meloxicam
Mn(2+)
NKH_477
PGE2
roflumilast
roflumilast N-oxide
sulprostone
tolvaptan
vasopressin

AQP2 (human)	PQsLPRGtkA_____	T269-p
AQP2 (mouse)	PQsLPRGskA_____	S269-p
AQP2 (rat)	PQsLPRGskA_____	S269-p

K270-ub

QsLPRGskA______

Downstream

Effects on Modified Protein

intracellular localization

AQP2 (human)	QsLPRGtkA______	K270-ub
AQP2 (mouse)	QsLPRGskA______	K270-ub
AQP2 (rat)	QsLPRGskA______	K270-ub