Other Species / Isoforms
  SMAD4 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
T9
DNMSITNTPTSNDAC
1 2
SMAD4 (human) DNMSITNtPTSNDAC T9-p
SMAD4 (mouse) DNMSITNTPTSNDAC T9
SMAD4 (rat) DNMSITNTPTSNDAC T9
S22
ACLSIVHSLMCHRQG
0 1
SMAD4 (human) ACLSIVHsLMCHRQG S22-p
SMAD4 (mouse) ACLSIVHSLMCHRQG S22
SMAD4 (rat) ACLSIVHSLMCHRQG S22
S32
CHRQGGESETFAKRA
0 1
SMAD4 (human) CHRQGGEsETFAkRA S32-p
SMAD4 (mouse) CHRQGGESETFAKRA S32
SMAD4 (rat) CHRQGGESETFAKRA S32
K37
GESETFAKRAIESLV
0 2
SMAD4 (human) GEsETFAkRAIESLV K37-ac
SMAD4 (mouse) GESETFAKRAIESLV K37
SMAD4 (rat) GESETFAKRAIESLV K37
K45
RAIESLVKkLkEKKD
0 3
SMAD4 (human) RAIESLVkKLkEKKD K45-ac
SMAD4 (mouse) RAIESLVKkLkEKKD K45
SMAD4 (rat) RAIESLVkKLKEKKD K45-ac
K45-ub
RAIESLVkkLkEKKD
0 2
SMAD4 (human) RAIESLVkKLkEKKD K45-ub
SMAD4 (mouse) RAIESLVkkLkEKKD K45-ub
SMAD4 (rat) RAIESLVKKLKEKKD K45
K46-ac
AIESLVkkLkEKKDE
0 1
SMAD4 (human) AIESLVkKLkEKKDE K46
SMAD4 (mouse) AIESLVkkLkEKKDE K46-ac
SMAD4 (rat) AIESLVkKLKEKKDE K46
K48-ac
ESLVkkLkEKKDELD
0 6
SMAD4 (human) ESLVkKLkEKKDELD K48-ac
SMAD4 (mouse) ESLVkkLkEKKDELD K48-ac
SMAD4 (rat) ESLVkKLKEKKDELD K48
K70
TNGAHPSKCVTIQRT
0 4
SMAD4 (human) TNGAHPSkCVTIQRt K70-ub
SMAD4 (mouse) TNGAHPSKCVTIQRT K70
SMAD4 (rat) TNGAHPSKCVTIQRT K70
T77
KCVTIQRTLDGRLQV
1 0
SMAD4 (human) kCVTIQRtLDGRLQV T77-p
SMAD4 (mouse) KCVTIQRTLDGRLQV T77
SMAD4 (rat) KCVTIQRTLDGRLQV T77
Y95
KGFPHVIYARLWRWP
0 1
SMAD4 (human) KGFPHVIyARLWRWP Y95-p
SMAD4 (mouse) KGFPHVIYARLWRWP Y95
SMAD4 (rat) KGFPHVIYARLWRWP Y95
K106
WRWPDLHKNELKHVk
0 1
SMAD4 (human) WRWPDLHkNELKHVk K106-ac
SMAD4 (mouse) WRWPDLHKNELKHVk K106
SMAD4 (rat) WRWPDLHKNELKHVK K106
K113-sm
KNELKHVkYCQYAFD
Upstream
Downstream
5 1
Effects on Biological Processes:
  • neural plasticity
  • transcription, induced
Treatment
  • siRNA
SMAD4 (human) kNELKHVkYCQYAFD K113-sm
SMAD4 (mouse) KNELKHVkYCQYAFD K113-sm
SMAD4 (rat) KNELKHVKYCQYAFD K113
K113-ub
KNELKHVkYCQYAFD
0 6
SMAD4 (human) kNELKHVkYCQYAFD K113-ub
SMAD4 (mouse) KNELKHVkYCQYAFD K113-ub
SMAD4 (rat) KNELKHVKYCQYAFD K113
K122
CQYAFDLKCDSVCVN
0 1
SMAD4 (human) CQYAFDLkCDSVCVN K122-ub
SMAD4 (mouse) CQYAFDLKCDSVCVN K122
SMAD4 (rat) CQYAFDLKCDSVCVN K122
S138
YHYERVVSPGIDLSG
1 2
SMAD4 (human) YHYERVVsPGIDLSG S138-p
SMAD4 (mouse) YHYERVVSPGIDLSG S138
SMAD4 (rat) YHYERVVSPGIDLSG S138
K158-sm
NAPSMLVkDEYVHDF
Upstream
Downstream
8 1
Effects on Biological Processes:
  • neural plasticity
  • transcription, induced
Treatment
  • siRNA
SMAD4 (human) APSSMMVkDEYVHDF K159-sm
SMAD4 (mouse) NAPSMLVkDEYVHDF K158-sm
SMAD4 (rat) APPSMLVKDEYVHDF K159
S177
SLPTEGHSIQTIQHP
0 1
SMAD4 (human) SLSTEGHsIQTIQHP S178-p
SMAD4 (mouse) SLPTEGHSIQTIQHP S177
SMAD4 (rat) SLPTEGHSIQTIQHP S178
Y194
NRASTETYSAPALLA
1 1
SMAD4 (human) NRASTETyStPALLA Y195-p
SMAD4 (mouse) NRASTETYSAPALLA Y194
SMAD4 (rat) NRASTETYSAPALLA Y195
A196
ASTETYSAPALLAPA
1 0
SMAD4 (human) ASTETyStPALLAPS T197-p
SMAD4 (mouse) ASTETYSAPALLAPA A196
SMAD4 (rat) ASTETYSAPALLAPS A197
T264
ATYHHNSTTTWTGSR
1 0
SMAD4 (human) ATYHHNStTTWtGSR T265-p
SMAD4 (mouse) ATYHHNSTTTWTGSR T264
SMAD4 (rat) ATYHHNSTTTWTGSR T265
T268
HNSTTTWTGSRTAPY
1 0
SMAD4 (human) HNStTTWtGSRtAPY T269-p
SMAD4 (mouse) HNSTTTWTGSRTAPY T268
SMAD4 (rat) HNSTTTWTGSRTAPY T269
T272
TTWTGSRTAPYtPNL
1 0
SMAD4 (human) TTWtGSRtAPYtPNL T273-p
SMAD4 (mouse) TTWTGSRTAPYtPNL T272
SMAD4 (rat) TTWTGSRTAPYTPNL T273
T276-p
GSRTAPYtPNLPHHQ
Upstream
Downstream
3 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • ERK2 (mouse)
Putative in vivo kinases:
  • ERK2 (mouse)
Treatment
  • TGF-beta
  • U0126
SMAD4 (human) GSRtAPYtPNLPHHQ T277-p
SMAD4 (mouse) GSRTAPYtPNLPHHQ T276-p
SMAD4 (rat) GSRTAPYTPNLPHHQ T277
Y300
MPPHPGHYWPVHNEL
1 1
SMAD4 (human) MPPHPGHyWPVHNEL Y301-p
SMAD4 (mouse) MPPHPGHYWPVHNEL Y300
SMAD4 (rat) MPPHPGHYWPVHNEL Y301
Y321
SNHPAPEYWCSIAYF
1 1
SMAD4 (human) SNHPAPEyWCSIAYF Y322-p
SMAD4 (mouse) SNHPAPEYWCSIAYF Y321
SMAD4 (rat) SNHPAPEYWCSIAYF Y322
S342-p
GETFKVPsSCPVVTV
Downstream
2 0
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, induced
  • signaling pathway regulation
  • transcription, induced
SMAD4 (human) GETFKVPsSCPIVTV S343-p
SMAD4 (mouse) GETFKVPsSCPVVTV S342-p
SMAD4 (rat) GETFKVPSSCPIVTV S343
S367-p
RFCLGQLsNVHRTEA
Upstream
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • carcinogenesis, inhibited
Kinase, in vitro:
  • ERK2 (human)
Putative in vivo kinases:
  • ERK2 (human)
Regulatory protein:
  • MEK1 (human)
Treatment
  • antibody
  • SCH772984
SMAD4 (human) RFCLGQLSNVHRTEA S368
SMAD4 (mouse) RFCLGQLsNVHRTEA S367-p
SMAD4 (rat) RFCLGQLSNVHRTEA S368
K384
RARLHIGKGVQLECK
0 4
SMAD4 (human) RARLHIGkGVQLECK K385-ub
SMAD4 (mouse) RARLHIGKGVQLECK K384
SMAD4 (rat) RARLHIGKGVQLECK K385
K427
APGDAVHKIYPSAYI
0 4
SMAD4 (human) APGDAVHkIYPSAYI K428-ac
SMAD4 (mouse) APGDAVHKIYPSAYI K427
SMAD4 (rat) APGDAVHkIYPSAYI K428-ac
S503
RLCILRMSFVKGWGP
0 2
SMAD4 (human) RLCILRMsFVkGWGP S504-p
SMAD4 (mouse) RLCILRMSFVKGWGP S503
SMAD4 (rat) RLCILRMSFVKGWGP S504
K506
ILRMSFVKGWGPDYP
0 2
SMAD4 (human) ILRMsFVkGWGPDyP K507-ac
SMAD4 (mouse) ILRMSFVKGWGPDYP K506
SMAD4 (rat) ILRMSFVKGWGPDYP K507
K506
ILRMSFVKGWGPDYP
1 1
SMAD4 (human) ILRMsFVkGWGPDyP K507-ub
SMAD4 (mouse) ILRMSFVKGWGPDYP K506
SMAD4 (rat) ILRMSFVKGWGPDYP K507
Y512
VKGWGPDYPRQSIKE
0 1
SMAD4 (human) VkGWGPDyPRQSIkE Y513-p
SMAD4 (mouse) VKGWGPDYPRQSIKE Y512
SMAD4 (rat) VKGWGPDYPRQSIKE Y513
K518
DYPRQSIKETPCWIE
2 3
SMAD4 (human) DyPRQSIkETPCWIE K519-ub
SMAD4 (mouse) DYPRQSIKETPCWIE K518
SMAD4 (rat) DYPRQSIKETPCWIE K519