Other Species / Isoforms
  APPL (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
P2-n-ub
______MpGIDkLPI
0 1
APPL (human) ______MpGIDkLPI P2-n-ub
APPL (mouse) ______MPGIDKLPI P2
APPL (rat) ______MPGIDKLPI P2
APPL (cow) ______MPGIDKLPI P2
K6-ub
__MpGIDkLPIEETL
0 2
APPL (human) __MpGIDkLPIEETL K6-ub
APPL (mouse) __MPGIDKLPIEETL K6
APPL (rat) __MPGIDKLPIEETL K6
APPL (cow) __MPGIDKLPIEETL K6
K63
AATHLTSKLLkEYEk
0 2
APPL (human) AATHLTSKLLkEYEk K63
APPL (mouse) AATHLTSkLLkEYEk K63-ac
APPL (rat) AATHLTSkLLKEYEK K63-ac
APPL (cow) AATHLTSKLLKEYEK K63
K63-ub
AATHLTSkLLkEYEk
0 3
APPL (human) AATHLTSkLLkEYEk K63-ub
APPL (mouse) AATHLTSkLLkEYEk K63-ub
APPL (rat) AATHLTSKLLKEYEK K63
APPL (cow) AATHLTSKLLKEYEK K63
K66-ub
HLTSkLLkEYEkQRF
0 10
APPL (human) HLTSkLLkEYEkQRF K66-ub
APPL (mouse) HLTSkLLkEYEkQRF K66-ub
APPL (rat) HLTSkLLKEYEKQRF K66
APPL (cow) HLTSKLLKEYEKQRF K66
K70-ub
kLLkEYEkQRFPLGG
0 3
APPL (human) kLLkEYEkQRFPLGG K70-ub
APPL (mouse) kLLkEYEkQRFPLGG K70-ub
APPL (rat) kLLKEYEKQRFPLGG K70
APPL (cow) KLLKEYEKQRFPLGG K70
S97-p
SKVIDELssCHAVLS
0 1
APPL (human) SKVIDELssCHAVLS S97-p
APPL (mouse) SKVIDELSSCHAVLS S97
APPL (rat) SKVIDELSSCHAVLS S97
APPL (cow) SKVIDELSSCHAVLS S97
S98-p
KVIDELssCHAVLST
0 1
APPL (human) KVIDELssCHAVLST S98-p
APPL (mouse) KVIDELSSCHAVLST S98
APPL (rat) KVIDELSSCHAVLST S98
APPL (cow) KVIDELSSCHAVLST S98
K124
QFKERDLKEILTLkE
0 1
APPL (human) QFKERDLKEILTLkE K124
APPL (mouse) QFKERDLKEILTLKE K124
APPL (rat) QFKERDLkEILTLKE K124-ac
APPL (cow) QFKERDLKEILTLKE K124
K124-ub
QFKERDLkEILTLkE
0 3
APPL (human) QFKERDLkEILTLkE K124-ub
APPL (mouse) QFKERDLKEILTLKE K124
APPL (rat) QFKERDLKEILTLKE K124
APPL (cow) QFKERDLKEILTLKE K124
K130-ub
LkEILTLkEVFQIAS
0 1
APPL (human) LkEILTLkEVFQIAS K130-ub
APPL (mouse) LKEILTLKEVFQIAS K130
APPL (rat) LkEILTLKEVFQIAS K130
APPL (cow) LKEILTLKEVFQIAS K130
K160-ub
KRENDKVkYEVTEDV
Upstream
Downstream
1 2
Effects on Modified Protein
  • intracellular localization
Treatment
  • insulin
APPL (human) KRENDKVkYEVTEDV K160-ub
APPL (mouse) KRENDKVKyEVTEDV K160
APPL (rat) KRENDKVKYEVTEDV K160
APPL (cow) KRENDKVKYEVTEDV K160
Y161
RENDKVkYEVTEDVY
0 2
APPL (human) RENDKVkYEVTEDVY Y161
APPL (mouse) RENDKVKyEVTEDVy Y161-p
APPL (rat) RENDKVKYEVTEDVY Y161
APPL (cow) RENDKVKYEVTEDVY Y161
Y168
YEVTEDVYTSRKKQH
0 2
APPL (human) YEVTEDVYTSRKKQH Y168
APPL (mouse) yEVTEDVyTSRKKQH Y168-p
APPL (rat) YEVTEDVYTSRKKQH Y168
APPL (cow) YEVTEDVYTSRKKQH Y168
S258-p
IEDLEVAsDPLYVPD
0 1
APPL (human) IEDLEVAsDPLYVPD S258-p
APPL (mouse) IEDLEVASDPLYLPD S258
APPL (rat) IEDLEVASDPLYLPD S258
APPL (cow) IEDLEVASDPLYVPD S258
K280-ub
VNRNLTRkAGYLNAR
0 2
APPL (human) VNRNLTRkAGYLNAR K280-ub
APPL (mouse) INRNLTRKAGYLNAR K280
APPL (rat) VNRNLTRKAGYLNAR K280
APPL (cow) VHRNLTRKAGYLNAR K280
K289-ub
GYLNARNkTGLVSST
0 1
APPL (human) GYLNARNkTGLVSST K289-ub
APPL (mouse) GYLNARNKTGLVSST K289
APPL (rat) GYLNARNKTGLVSST K289
APPL (cow) GYLNARNKTGLVSST K289
K350-ac
QITSFDGkksSILQA
0 1
APPL (human) QITSFDGkksSILQA K350-ac
APPL (mouse) QITSFDGKKSSILQA K350
APPL (rat) QITSFDGKKSSILQA K350
APPL (cow) QITSFDGKKSSILQA K350
K350-ub
QITSFDGkksSILQA
0 1
APPL (human) QITSFDGkksSILQA K350-ub
APPL (mouse) QITSFDGKKSSILQA K350
APPL (rat) QITSFDGKKSSILQA K350
APPL (cow) QITSFDGKKSSILQA K350
K351-ub
ITSFDGkksSILQAE
0 4
APPL (human) ITSFDGkksSILQAE K351-ub
APPL (mouse) ITSFDGKKSSILQAE K351
APPL (rat) ITSFDGKKSSILQAE K351
APPL (cow) ITSFDGKKSSILQAE K351
S352-p
TSFDGkksSILQAES
0 1
APPL (human) TSFDGkksSILQAES S352-p
APPL (mouse) TSFDGKKSSILQAES S352
APPL (rat) TSFDGKKSSILQAES S352
APPL (cow) TSFDGKKSSILQAES S352
K360-ub
SILQAESkkDHEEWI
0 1
APPL (human) SILQAESkkDHEEWI K360-ub
APPL (mouse) SILQAESKKDHEEWI K360
APPL (rat) SILQAESKKDHEEWI K360
APPL (cow) SILQAESKKDHEEWI K360
K361-ub
ILQAESkkDHEEWIC
0 2
APPL (human) ILQAESkkDHEEWIC K361-ub
APPL (mouse) ILQAESKKDHEEWIC K361
APPL (rat) ILQAESKKDHEEWIC K361
APPL (cow) ILQAESKKDHEEWIC K361
S374-p
ICTINNIskQIyLSE
0 1
APPL (human) ICTINNIskQIyLSE S374-p
APPL (mouse) ICTINNISKQIYLSE S374
APPL (rat) ICTINNISKQIYLSE S374
APPL (cow) ICTINNISKQIYLSE S374
K375-ub
CTINNIskQIyLSEN
0 2
APPL (human) CTINNIskQIyLSEN K375-ub
APPL (mouse) CTINNISKQIYLSEN K375
APPL (rat) CTINNISKQIYLSEN K375
APPL (cow) CTINNISKQIYLSEN K375
Y378-p
NNIskQIyLSENPEE
0 7
APPL (human) NNIskQIyLSENPEE Y378-p
APPL (mouse) NNISKQIYLSENPEE Y378
APPL (rat) NNISKQIYLSENPEE Y378
APPL (cow) NNISKQIYLSENPEE Y378
S393-p
TAARVNQsALEAVtP
0 1
APPL (human) TAARVNQsALEAVtP S393-p
APPL (mouse) TAARVNQSALEAVtP S393
APPL (rat) TAARVNQSALEAVtP S393
APPL (cow) IAARVNQSALEAVTP S393
T399-p
QsALEAVtPsPsFQQ
Upstream
0 14
Treatment
  • ischemia
APPL (human) QsALEAVtPsPsFQQ T399-p
APPL (mouse) QSALEAVtPsPsFQQ T399-p
APPL (rat) QSALEAVtPsPsFQQ T399-p
APPL (cow) QSALEAVTPSPSFQQ T399
S401-p
ALEAVtPsPsFQQRH
Upstream
Downstream
2 41
Effects on Biological Processes:
  • signaling pathway regulation
Treatment
  • ischemia
  • nocodazole
APPL (human) ALEAVtPsPsFQQRH S401-p
APPL (mouse) ALEAVtPsPsFQQRH S401-p
APPL (rat) ALEAVtPsPsFQQRH S401-p
APPL (cow) ALEAVTPSPSFQQRH S401
S403-p
EAVtPsPsFQQRHEs
1 5
APPL (human) EAVtPsPsFQQRHEs S403-p
APPL (mouse) EAVtPsPsFQQRHEs S403-p
APPL (rat) EAVtPsPsFQQRHES S403-p
APPL (cow) EAVTPSPSFQQRHES S403
S410-p
sFQQRHEsLRPAAGQ
Upstream
Downstream
2 3
Effects on Modified Protein
  • molecular association, regulation
  • receptor recycling, altered
  • receptor recycling, induced
Effects on Biological Processes:
  • endocytosis, inhibited
Kinase, in vitro:
  • PKACA (human)
Treatment
  • ischemia
  • KT5720
  • LH
view more >
APPL (human) sFQQRHEsLRPAAGQ S410-p
APPL (mouse) sFQQRHEsLRPGGQS S410-p
APPL (rat) sFQQRHESLRPGGQS S410
APPL (cow) SFQQRHESLRPAGQS S410
T422-p
AGQSRPPtARTSssG
0 1
APPL (human) AGQSRPPtARTSssG T422-p
APPL (mouse) GGQSRPPTARTSSSG T421
APPL (rat) GGQSRPPTARTSSSG T421
APPL (cow) AGQSRPPTARTSSSG T421
S427-p
PPtARTSssGsLGSE
0 1
APPL (human) PPtARTSssGsLGSE S427-p
APPL (mouse) PPTARTSSSGsLGSE S426
APPL (rat) PPTARTSSSGSLGSE S426
APPL (cow) PPTARTSSSGSLGSE S426
S428-p
PtARTSssGsLGSES
0 1
APPL (human) PtARTSssGsLGSES S428-p
APPL (mouse) PTARTSSSGsLGSES S427
APPL (rat) PTARTSSSGSLGSES S427
APPL (cow) PTARTSSSGSLGSES S427
S430-p
ARTSssGsLGSESTN
Upstream
Downstream
1 2
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • PKCA (mouse)
Putative in vivo kinases:
  • PKCA (human)
Treatment
  • Go_6976
  • Go_6983
  • high-fat diet
  • phorbol_ester
  • siRNA
  • thapsigargin
view more >
APPL (human) ARTSssGsLGSESTN S430-p
APPL (mouse) ARTSSSGsLGSESTN S429-p
APPL (rat) ARTSSSGSLGSESTN S429
APPL (cow) ARTSSSGSLGSESTN S429
S459-p
PIQFDIIsPVCEDQP
0 1
APPL (human) PIQFDIIsPVCEDQP S459-p
APPL (mouse) PIQFDIISPVCEDQP S458
APPL (rat) PIQFDIISPVCEDQP S458
APPL (cow) PIQFDIISPVCEDQS S458
T479-p
FGQGGRRtNPFGESG
0 8
APPL (human) FGQGGRRtNPFGESG T479-p
APPL (mouse) FGQGGRRTNPFGESG T478
APPL (rat) FGQGGRRTNPFGESG T478
APPL (cow) SGQGGRRTNPFGESG T478
K490-ub
GESGGSTksETEDSI
0 2
APPL (human) GESGGSTksETEDSI K490-ub
APPL (mouse) GESGGSTKSETEDSI K489
APPL (rat) GESGGSTKSETEDSI K489
APPL (cow) GESGGGTKSETEESI K489
S491-p
ESGGSTksETEDSIL
0 1
APPL (human) ESGGSTksETEDSIL S491-p
APPL (mouse) ESGGSTKSETEDSIL S490
APPL (rat) ESGGSTKSETEDSIL S490
APPL (cow) ESGGGTKSETEESIL S490
S509-p
FIVRFLGsMEVksDD
0 1
APPL (human) FIVRFLGsMEVksDD S509-p
APPL (mouse) FIVRFLGSMEVkSDD S508
APPL (rat) FIVRFLGSMEVKSDD S508
APPL (cow) FIVRFLGSMEVKSDD S508
K513-ub
FLGsMEVksDDHPDV
0 3
APPL (human) FLGsMEVksDDHPDV K513-ub
APPL (mouse) FLGSMEVkSDDHPDV K512-ub
APPL (rat) FLGSMEVKSDDHPDV K512
APPL (cow) FLGSMEVKSDDNPDV K512
S514-p
LGsMEVksDDHPDVV
0 1
APPL (human) LGsMEVksDDHPDVV S514-p
APPL (mouse) LGSMEVkSDDHPDVV S513
APPL (rat) LGSMEVKSDDHPDVV S513
APPL (cow) LGSMEVKSDDNPDVV S513
Y522-p
DDHPDVVyEtMRQIL
Upstream
0 6
Treatment
  • U0126
APPL (human) DDHPDVVyEtMRQIL Y522-p
APPL (mouse) DDHPDVVYETMRQIL Y521
APPL (rat) DDHPDVVYETMRQIL Y521
APPL (cow) DDNPDVVYETMRQIL Y521
T524-p
HPDVVyEtMRQILAA
0 1
APPL (human) HPDVVyEtMRQILAA T524-p
APPL (mouse) HPDVVYETMRQILAA T523
APPL (rat) HPDVVYETMRQILAA T523
APPL (cow) NPDVVYETMRQILAA T523
Y604-p
SNLSSVCyIFESNNE
0 1
APPL (human) SNLSSVCyIFESNNE Y604-p
APPL (mouse) SNLSSVCYIFESNNE Y603
APPL (rat) SNLSSVCYIFESNNE Y603
APPL (cow) SNLSSVCYIFESNNE Y603
K623-ub
CDSVGLAkQIALHAE
0 1
APPL (human) CDSVGLAkQIALHAE K623-ub
APPL (mouse) CDSVGLAKQIALHAE K622
APPL (rat) CDSVGLAKQIALHAE K622
APPL (cow) CDSVGLAKQIALHAE K622
S636-p
AELDRRAsEkQKEIE
0 7
APPL (human) AELDRRAsEkQKEIE S636-p
APPL (mouse) AELDRRASEKQKEIE S635
APPL (rat) AELDRRASEKQKEIE S635
APPL (cow) AELDRRASEKQKEIE S635
K638-ub
LDRRAsEkQKEIERV
0 1
APPL (human) LDRRAsEkQKEIERV K638-ub
APPL (mouse) LDRRASEKQKEIERV K637
APPL (rat) LDRRASEKQKEIERV K637
APPL (cow) LDRRASEKQKEIERV K637
K661-ub
NKQKQIEkDLEEQSR
0 1
APPL (human) NKQKQIEkDLEEQSR K661-ub
APPL (mouse) SKQKQIEKDLEEQSR K660
APPL (rat) SKQKEIEKDLEEQSR K660
APPL (cow) SKQKQIEKDLEEQSR K660
S689-p
EGQFVVLsSsQsEEs
0 2
APPL (human) EGQFVVLsSsQsEEs S689-p
APPL (mouse) SEGQLVLsSSQsEEs S687-p
APPL (rat) SEGQLVLSSSQSEES S687
APPL (cow) EGQFVVLSSSQSEES S688
S691-p
QFVVLsSsQsEEsDL
0 3
APPL (human) QFVVLsSsQsEEsDL S691-p
APPL (mouse) GQLVLsSSQsEEsDL S689
APPL (rat) GQLVLSSSQSEESDL S689
APPL (cow) QFVVLSSSQSEESDL S690
S693-p
VVLsSsQsEEsDLGE
0 3
APPL (human) VVLsSsQsEEsDLGE S693-p
APPL (mouse) LVLsSSQsEEsDLGE S691-p
APPL (rat) LVLSSSQSEESDLGE S691
APPL (cow) VVLSSSQSEESDLGE S692
S696-p
sSsQsEEsDLGEGGK
0 3
APPL (human) sSsQsEEsDLGEGGK S696-p
APPL (mouse) sSSQsEEsDLGEEGK S694-p
APPL (rat) SSSQSEESDLGEEGK S694
APPL (cow) SSSQSEESDLGEEGK S695
S707
EGGKKRESEA_____
1 0
APPL (human) EGGKKRESEA_____ S707
APPL (mouse) EEGKKRESEA_____ S705
APPL (rat) EEGKKREsEA_____ S705-p
APPL (cow) EEGKKRESEA_____ S706