Other Species / Isoforms
  Kv2.1 (rat)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S12
MTKHGSRSTSsLPPE
0 1
Kv2.1 (human) MTKHGSRSTSsLPPE S12
Kv2.1 (mouse) MTKHGSRstSsLPPE S12-p
Kv2.1 (rat) MTKHGSRSTSsLPPE S12
T13
TKHGSRSTSsLPPEP
0 1
Kv2.1 (human) TKHGSRSTSsLPPEP T13
Kv2.1 (mouse) TKHGSRstSsLPPEP T13-p
Kv2.1 (rat) TKHGSRSTSsLPPEP T13
S15-p
HGSRSTSsLPPEPME
Upstream
Downstream
2 5
Effects on Modified Protein
  • activity, inhibited
Treatment
  • FK520
  • ionomycin
Kv2.1 (human) HGSRSTSsLPPEPME S15-p
Kv2.1 (mouse) HGSRstSsLPPEPME S15-p
Kv2.1 (rat) HGSRSTSsLPPEPME S15-p
S26
EPMEIVRSKACSRRV
0 1
Kv2.1 (human) EPMEIVRsKACSRRV S26-p
Kv2.1 (mouse) EPMEIVRSKACSRRV S26
Kv2.1 (rat) EPMEIVRSKACSRRV S26
Y128-p
YWGIDEIyLESCCQA
Upstream
Downstream
7 0
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, induced
  • signaling pathway regulation
Kinase, in vitro:
  • Src (chicken)
Putative in vivo kinases:
  • Src (human)
Regulatory protein:
  • Src (rat)
Treatment
  • PP2
  • vanadate
Kv2.1 (human) YWGIDEIyLESCCQA Y128-p
Kv2.1 (mouse) YWGIDEIyLESCCQA Y128-p
Kv2.1 (rat) YWGIDEIyLESCCQA Y128-p
T359
AEKDEDDTKFKSIPA
0 1
Kv2.1 (human) AEKDEDDtKFKSIPA T359-p
Kv2.1 (mouse) AEKDEDDTKFKSIPA T359
Kv2.1 (rat) AEKDEDDTKFKSIPA T359
T374
SFWWATITMTTVGYG
0 1
Kv2.1 (human) SFWWATItMTTVGYG T374-p
Kv2.1 (mouse) SFWWATITMTTVGYG T374
Kv2.1 (rat) SFWWATITMTTVGYG T374
S444-p
ERAKRNGsIVsMNMK
Upstream
Downstream
1 5
Effects on Modified Protein
  • activity, induced
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA2 (human)
Kv2.1 (human) ERAKRNGSIVSMNMK S444
Kv2.1 (mouse) ERAKRNGsIVsMNMk S444-p
Kv2.1 (rat) ERAKRNGsIVsMNMK S444-p
S447-p
KRNGsIVsMNMKDAF
0 2
Kv2.1 (human) KRNGSIVSMNMKDAF S447
Kv2.1 (mouse) KRNGsIVsMNMkDAF S447-p
Kv2.1 (rat) KRNGsIVsMNMKDAF S447-p
K451
sIVsMNMKDAFARsI
0 1
Kv2.1 (human) SIVSMNMKDAFARsI K451
Kv2.1 (mouse) sIVsMNMkDAFARsI K451-ub
Kv2.1 (rat) sIVsMNMKDAFARsI K451
S457-p
MKDAFARsIEMMDIV
Upstream
Downstream
4 6
Effects on Modified Protein
  • activity, inhibited
Treatment
  • FK520
  • ionomycin
Kv2.1 (human) MKDAFARsIEMMDIV S457-p
Kv2.1 (mouse) MkDAFARsIEMMDIV S457-p
Kv2.1 (rat) MKDAFARsIEMMDIV S457-p
K474-sm
KNGESIAkKDKVQDN
Downstream
1 1
Effects on Modified Protein
  • activity, inhibited
Kv2.1 (human) KNGENMGKKDKVQDN K474
Kv2.1 (mouse) KNGEGVAKKDKVQDN K474
Kv2.1 (rat) KNGESIAkKDKVQDN K474-sm
S484-p
KVQDNHLsPNKWKWT
Upstream
Downstream
1 11
Effects on Modified Protein
  • activity, inhibited
Treatment
  • ionomycin
Kv2.1 (human) KVQDNHLSPNKWKWT S484
Kv2.1 (mouse) KVQDNHLsPNkWKWt S484-p
Kv2.1 (rat) KVQDNHLsPNKWKWT S484-p
K487
DNHLsPNKWKWTKRA
0 1
Kv2.1 (human) DNHLSPNKWKWTKRT K487
Kv2.1 (mouse) DNHLsPNkWKWtkRA K487-ub
Kv2.1 (rat) DNHLsPNKWKWTKRA K487
T491
sPNKWKWTKRALsET
0 1
Kv2.1 (human) SPNKWKWTKRTLSET T491
Kv2.1 (mouse) sPNkWKWtkRALsET T491-p
Kv2.1 (rat) sPNKWKWTKRALsET T491
K492
PNKWKWTKRALsETS
0 1
Kv2.1 (human) PNKWKWTKRTLSETs K492
Kv2.1 (mouse) PNkWKWtkRALsETS K492-ub
Kv2.1 (rat) PNKWKWTKRALsETS K492
S496-p
KWTKRALsETSSSKs
1 5
Kv2.1 (human) KWTKRTLSETssSKS S496
Kv2.1 (mouse) KWtkRALsETSSSKS S496-p
Kv2.1 (rat) KWTKRALsETSSSKs S496-p
S499
KRALsETSSSKsFET
0 1
Kv2.1 (human) KRTLSETssSKSFET S499-p
Kv2.1 (mouse) kRALsETSSSKSFET S499
Kv2.1 (rat) KRALsETSSSKsFET S499
S500
RALsETSSSKsFETK
0 1
Kv2.1 (human) RTLSETssSKSFETK S500-p
Kv2.1 (mouse) RALsETSSSKSFETK S500
Kv2.1 (rat) RALsETSSSKsFETK S500
S503-p
sETSSSKsFETKEQG
1 2
Kv2.1 (human) SETssSKSFETKEQG S503
Kv2.1 (mouse) sETSSSKSFETKEQG S503
Kv2.1 (rat) sETSSSKsFETKEQG S503-p
S511-p
FETKEQGsPEKARSS
0 1
Kv2.1 (human) FETKEQGSPEKARSS S511
Kv2.1 (mouse) FETKEQGSPEKARSS S511
Kv2.1 (rat) FETKEQGsPEKARSS S511-p
S519-p
PEKARSSssPQHLNV
0 1
Kv2.1 (human) PEKARSSSSPQHLNV S519
Kv2.1 (mouse) PEKARSSSsPQHLNV S519
Kv2.1 (rat) PEKARSSssPQHLNV S519-p
S520-p
EKARSSssPQHLNVQ
Upstream
1 6
Kinase, in vitro:
  • CDK5 (human)
Kv2.1 (human) EKARSSSSPQHLNVQ S520
Kv2.1 (mouse) EKARSSSsPQHLNVQ S520-p
Kv2.1 (rat) EKARSSssPQHLNVQ S520-p
S541-p
SKMAKTQsQPILNTK
Upstream
Downstream
3 7
Effects on Modified Protein
  • activity, inhibited
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA2 (human)
Treatment
  • A-769662
  • FK520
  • ionomycin
Kv2.1 (human) NKMAKTQsQPILNTK S541-p
Kv2.1 (mouse) SKMAKTQsQPILNTK S541-p
Kv2.1 (rat) SKMAKTQsQPILNTK S541-p
S564
PEELEMSSMPsPVAP
0 2
Kv2.1 (human) KEELEMESIPSPVAP S564
Kv2.1 (mouse) QEELEMGsMPsPVAP S564-p
Kv2.1 (rat) PEELEMSSMPsPVAP S564
S567-p
LEMSSMPsPVAPLPA
Upstream
Downstream
6 6
Effects on Modified Protein
  • activity, inhibited
Treatment
  • calcineurin
  • colchicine
  • FK520
  • glutamic acid
  • ionomycin
  • ischemia
  • kainic_acid
  • pentobarbital
Kv2.1 (human) LEMESIPSPVAPLPT S567
Kv2.1 (mouse) LEMGsMPsPVAPLPT S567-p
Kv2.1 (rat) LEMSSMPsPVAPLPA S567-p
S584-p
EGVIDMRsMSSIDsF
0 1
Kv2.1 (human) EGVIDMRSMSSIDSF S584
Kv2.1 (mouse) EGVIDMRSMSSIDSF S584
Kv2.1 (rat) EGVIDMRsMSSIDsF S584-p
S590-p
RsMSSIDsFIsCATD
1 1
Kv2.1 (human) RSMSSIDSFISCATD S590
Kv2.1 (mouse) RSMSSIDSFISCATD S590
Kv2.1 (rat) RsMSSIDsFIsCATD S590-p
S593-p
SSIDsFIsCATDFPE
0 1
Kv2.1 (human) SSIDSFISCATDFPE S593
Kv2.1 (mouse) SSIDSFISCATDFPE S593
Kv2.1 (rat) SSIDsFIsCATDFPE S593-p
S607-p
EATRFSHsPLASLsS
Upstream
Downstream
7 6
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
Effects on Biological Processes:
  • neural plasticity
Kinase, in vitro:
  • CDK5 (human)
Phosphatases, in vitro:
  • PPP1CA (human)
Putative in vivo kinases:
  • CDK5 (human)
Putative upstream phosphatases:
  • PPP1CA (human)
Regulatory protein:
  • CDK5R1 (human)
Treatment
  • calcineurin
  • colchicine
  • FK520
  • glutamic acid
  • ionomycin
  • ischemia
  • kainic_acid
  • okadaic_acid
  • pentobarbital
  • seliciclib
  • status epilepticus
  • TTX
Kv2.1 (human) EATRFSHSPLTSLPS S607
Kv2.1 (mouse) EATRFSHsPLAsLsG S607-p
Kv2.1 (rat) EATRFSHsPLASLsS S607-p
S611
FSHsPLASLsSKAGs
0 1
Kv2.1 (human) FSHSPLTSLPSKTGG S611
Kv2.1 (mouse) FSHsPLAsLsGKSGG S611-p
Kv2.1 (rat) FSHsPLASLsSKAGs S611
S613-p
HsPLASLsSKAGsST
0 2
Kv2.1 (human) HSPLTSLPSKTGGST P613
Kv2.1 (mouse) HsPLAsLsGKSGGST S613-p
Kv2.1 (rat) HsPLASLsSKAGsST S613-p
S618-p
SLsSKAGsSTAPEVG
0 1
Kv2.1 (human) SLPSKTGGSTAPEVG G618
Kv2.1 (mouse) sLsGKSGGSTAPEVG G618
Kv2.1 (rat) SLsSKAGsSTAPEVG S618-p
S649-p
PIPETSRsGFFVEsP
0 1
Kv2.1 (human) SPDASQHSSFFIESP S650
Kv2.1 (mouse) PIPEASRSGFFVEsP S649
Kv2.1 (rat) PIPETSRsGFFVEsP S649-p
S655-p
RsGFFVEsPRSSMKT
Upstream
2 16
Kinase, in vitro:
  • CDK5 (human)
Treatment
  • FK520
  • ionomycin
Kv2.1 (human) HSSFFIESPKSSMKT S656
Kv2.1 (mouse) RSGFFVEsPRSSMKT S655-p
Kv2.1 (rat) RsGFFVEsPRSSMKT S655-p
Y690-p
LLPSLGLyHDPLRNR
Upstream
Downstream
2 4
Effects on Modified Protein
  • intracellular localization
Putative in vivo kinases:
  • Src (human)
Treatment
  • carbachol
  • ionomycin
  • PP2
  • vanadate
Kv2.1 (human) LLPVLGMyHDPLRNR Y691-p
Kv2.1 (mouse) LLPALGLyHDPLRNR Y690-p
Kv2.1 (rat) LLPSLGLyHDPLRNR Y690-p
S719-p
LLDKPVLsPESSIYT
Upstream
Downstream
4 3
Effects on Modified Protein
  • activity, inhibited
Treatment
  • colchicine
  • FK520
  • ionomycin
Kv2.1 (human) LLDKAVLSPEsSIYT S720
Kv2.1 (mouse) LLDKPVLSPESSIYT S719
Kv2.1 (rat) LLDKPVLsPESSIYT S719-p
S722
KPVLsPESSIYTTAS
0 1
Kv2.1 (human) KAVLSPEsSIYTTAS S723-p
Kv2.1 (mouse) KPVLSPESSIYTTAS S722
Kv2.1 (rat) KPVLsPESSIYTTAS S722
S736
SARTPPRSPEKHTAI
0 1
Kv2.1 (human) SAKTPPRSPEKHTAI S737
Kv2.1 (mouse) SARTPPRsPEKHTAI S736-p
Kv2.1 (rat) SARTPPRSPEKHTAI S736
S771-p
QLLYSVDsSPPKSLH
Upstream
Downstream
1 0
Effects on Modified Protein
  • activity, inhibited
Treatment
  • ionomycin
Kv2.1 (human) QLLYSVDSSPPKSLP S772
Kv2.1 (mouse) QLLYSVDSSPPKSLH S771
Kv2.1 (rat) QLLYSVDsSPPKSLH S771-p
S782-p
KSLHGSTsPKFSTGA
1 1
Kv2.1 (human) KSLPGSTSPKFStGT S783
Kv2.1 (mouse) KSLHGSTSPKFSLGA S782
Kv2.1 (rat) KSLHGSTsPKFSTGA S782-p
T787
STsPKFSTGARTEKN
0 1
Kv2.1 (human) STSPKFStGTRSEKN T788-p
Kv2.1 (mouse) STSPKFSLGARTEKN L787
Kv2.1 (rat) STsPKFSTGARTEKN T787
S799-p
EKNHFESsPLPTsPK
Upstream
Downstream
5 3
Effects on Modified Protein
  • activity, induced
  • intracellular localization
Effects on Biological Processes:
  • apoptosis, induced
Putative in vivo kinases:
  • P38A (human)
Regulatory protein:
  • CXCL12 (human)
Treatment
  • ionomycin
  • SB203580
Kv2.1 (human) EKNHFESsPLPtsPK S800-p
Kv2.1 (mouse) EKNHFESSPLPtsPK S799
Kv2.1 (rat) EKNHFESsPLPTsPK S799-p
T803
FESsPLPTsPKFLRP
0 4
Kv2.1 (human) FESsPLPtsPKFLRQ T804-p
Kv2.1 (mouse) FESSPLPtsPKFLRP T803-p
Kv2.1 (rat) FESsPLPTsPKFLRP T803
S804-p
ESsPLPTsPKFLRPN
Upstream
Downstream
7 8
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, induced
  • signaling pathway regulation
Kinase, in vitro:
  • CDK5 (human)
  • P38A (human)
Putative in vivo kinases:
  • P38A (rat)
Regulatory protein:
  • Src (rat)
Treatment
  • ionomycin
  • SB239063
Kv2.1 (human) ESsPLPtsPKFLRQN S805-p
Kv2.1 (mouse) ESSPLPtsPKFLRPN S804-p
Kv2.1 (rat) ESsPLPTsPKFLRPN S804-p
Y814-p
FLRPNCVysSEGLTG
Upstream
Downstream
2 1
Effects on Modified Protein
  • intracellular localization
Putative in vivo kinases:
  • Src (human)
Treatment
  • carbachol
  • ionomycin
  • PP2
  • vanadate
Kv2.1 (human) FLRQNCIYsTEALTG Y815
Kv2.1 (mouse) FLRPNCVyASEGLPG Y814-p
Kv2.1 (rat) FLRPNCVysSEGLTG Y814-p
S815-p
LRPNCVysSEGLTGK
0 3
Kv2.1 (human) LRQNCIYsTEALTGK S816-p
Kv2.1 (mouse) LRPNCVyASEGLPGK A815
Kv2.1 (rat) LRPNCVysSEGLTGK S815-p
T836-p
KCKLENHtPPDVHML
1 3
Kv2.1 (human) KCKLENHISPDVRVL I837
Kv2.1 (mouse) KCKLENHTSPDVHML T836
Kv2.1 (rat) KCKLENHtPPDVHML T836-p