Other Species / Isoforms
  WWOX (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y6-p
__MAALRyAGLDDtD
0 5
WWOX (human) __MAALRyAGLDDtD Y6-p
WWOX (mouse) __MAALRyAGLDDtD Y6-p
T12-p
RyAGLDDtDsEDELP
0 29
WWOX (human) RyAGLDDtDsEDELP T12-p
WWOX (mouse) RyAGLDDtDsEDELP T12-p
S14-p
AGLDDtDsEDELPPG
Upstream
Downstream
2 31
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
  • signaling pathway regulation
Treatment
  • ceritinib
WWOX (human) AGLDDtDsEDELPPG S14-p
WWOX (mouse) AGLDDtDsEDELPPG S14-p
K28-ub
GWEERTTkDGWVyYA
0 2
WWOX (human) GWEERTTkDGWVyYA K28-ub
WWOX (mouse) GWEERTTKDGWVyYA K28
Y33-p
TTkDGWVyYANHTEE
Upstream
Downstream
21 1
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • carcinogenesis, inhibited
  • cell growth, induced
  • cell growth, inhibited
  • cell motility, inhibited
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • Src (human)
Putative in vivo kinases:
  • Src (human)
Regulatory protein:
  • FAM189B (human)
  • WWOX (human)
Treatment
  • androsterone
  • anisomycin
  • ceritinib
  • estradiol
  • light
  • MPP+
  • siRNA
  • UV
WWOX (human) TTkDGWVyYANHTEE Y33-p
WWOX (mouse) TTKDGWVyYANHTEE Y33-p
K48-ub
KTQWEHPkTGKRKRV
0 1
WWOX (human) KTQWEHPkTGKRKRV K48-ub
WWOX (mouse) KTQWEHPKTGKRKRV K48
K100-ub
TVDDNPTkPTTRQRY
0 4
WWOX (human) TVDDNPTkPTTRQRY K100-ub
WWOX (mouse) TVDDNPTKPTTRQRY K100
T111-p
RQRYDGStTAMEILQ
0 1
WWOX (human) RQRYDGStTAMEILQ T111-p
WWOX (mouse) RQRYDGSTTAMEILQ T111
S134-p
VVVTGANsGIGFETA
0 1
WWOX (human) VVVTGANsGIGFETA S134-p
WWOX (mouse) VLVTGANSGIGFETA S134
S162-p
CRNMARAsEAVSRIL
0 1
WWOX (human) CRNMARAsEAVSRIL S162-p
WWOX (mouse) CRNLSRASEAVSRIL S162
K274-ub
DINDSLGkLDFSRLS
Upstream
Downstream
1 3
Effects on Modified Protein
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • DNA repair, induced
  • cell cycle regulation
Treatment
  • hydroxyurea
  • UVC
WWOX (human) DINDSLGkLDFSRLS K274-ub
WWOX (mouse) DINDSSGKLDLsRLS K274
S278
SLGkLDFSRLSPTKN
0 1
WWOX (human) SLGkLDFSRLSPTKN S278
WWOX (mouse) SSGKLDLsRLSPPRS S278-p
Y287-p
LSPTKNDyWAMLAYN
Upstream
Downstream
4 0
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • cell cycle regulation
Putative in vivo kinases:
  • Ack (human)
Regulatory protein:
  • FAM189B (human)
WWOX (human) LSPTKNDyWAMLAYN Y287-p
WWOX (mouse) LSPPRSDyWAMLAYN Y287-p
S312-p
NELHRRLsPRGVTSN
0 1
WWOX (human) NELHRRLsPRGVTSN S312-p
WWOX (mouse) NELHRRLSPRGVTSN S312
S411
LIQERLGSQSG____
0 2
WWOX (human) LIQERLGSQSG____ S411
WWOX (mouse) LIQDRLGsPSS____ S411-p