Other Species / Isoforms
  SIRT6 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S303-p
KLEPKEEsPtRINGs
1 18
SIRT6 (human) KLEPKEEsPtRINGs S303-p
SIRT6 iso2 (human) KLEPKEESPTRINGS S276
SIRT6 (mouse) gap -
SIRT6 (rat) gap -
S326-p
PCAQHNGsEPAsPKR
0 2
SIRT6 (human) PCAQHNGsEPAsPKR S326-p
SIRT6 iso2 (human) PCAQHNGSEPASPKR S299
SIRT6 (mouse) gap -
SIRT6 (rat) gap -
S330-p
HNGsEPAsPKRERPt
1 14
SIRT6 (human) HNGsEPAsPKRERPt S330-p
SIRT6 iso2 (human) HNGSEPASPKRERPT S303
SIRT6 (mouse) gap -
SIRT6 (rat) gap -
S10-p
VNYAAGLsPYADKGk
Upstream
Downstream
2 9
Effects on Biological Processes:
  • DNA repair, induced
Kinase, in vitro:
  • JNK1 (human)
Putative in vivo kinases:
  • JNK1 (human)
SIRT6 (human) VNYAAGLsPYADKGk S10-p
SIRT6 iso2 (human) VNYAAGLSPYADKGK S10
SIRT6 (mouse) VNYAAGLsPYADKGK S10-p
SIRT6 (rat) VNYAAGLSPYADKGK S10
K17-ub
sPYADKGkCGLPEIF
0 1
SIRT6 (human) sPYADKGkCGLPEIF K17-ub
SIRT6 iso2 (human) SPYADKGKCGLPEIF K17
SIRT6 (mouse) sPYADKGKCGLPEIF K17
SIRT6 (rat) SPYADKGKCGLPEIF K17
K33-ac
PPEELERkVWELARL
Downstream
1 0
Effects on Biological Processes:
  • DNA repair, inhibited
  • cell growth, inhibited
  • chromatin organization, altered
SIRT6 (human) PPEELERkVWELARL K33-ac
SIRT6 iso2 (human) PPEELERKVWELARL K33
SIRT6 (mouse) PPEELERKVWELARL K33
SIRT6 (rat) PPEELECKVWELARL K33
K33-ub
PPEELERkVWELARL
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • carcinogenesis, induced
SIRT6 (human) PPEELERkVWELARL K33-ub
SIRT6 iso2 (human) PPEELERKVWELARL K33
SIRT6 (mouse) PPEELERKVWELARL K33
SIRT6 (rat) PPEELECKVWELARL K33
K81-ub
EERGLAPkFDTTFES
0 1
SIRT6 (human) EERGLAPkFDTTFES K81-ub
SIRT6 iso2 (human) EERGLAPKFDTTFES K81
SIRT6 (mouse) EERGLAPKFDTTFEN K81
SIRT6 (rat) EERGLAPKFDITFEN K81
K128-ac
RSGFPRDkLAELHGN
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • transcription, induced
SIRT6 (human) RSGFPRDkLAELHGN K128-ac
SIRT6 iso2 (human) RSGFPRDKLAELHGN K128
SIRT6 (mouse) RSGFPRDKLAELHGN K128
SIRT6 (rat) RSGFPRDKLAELHGN K128
K128-ub
RSGFPRDkLAELHGN
Downstream
1 1
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • carcinogenesis, induced
SIRT6 (human) RSGFPRDkLAELHGN K128-ub
SIRT6 iso2 (human) RSGFPRDKLAELHGN K128
SIRT6 (mouse) RSGFPRDKLAELHGN K128
SIRT6 (rat) RSGFPRDKLAELHGN K128
T146-p
EECAKCKtQyVRDTV
0 1
SIRT6 (human) EECAKCKtQyVRDTV T146-p
SIRT6 iso2 (human) EECAKCKTQYVRDTV T146
SIRT6 (mouse) EECPKCKTQYVRDTV T146
SIRT6 (rat) EECPKCKTQYVRDTV T146
Y148-p
CAKCKtQyVRDTVVG
0 1
SIRT6 (human) CAKCKtQyVRDTVVG Y148-p
SIRT6 iso2 (human) CAKCKTQYVRDTVVG Y148
SIRT6 (mouse) CPKCKTQYVRDTVVG Y148
SIRT6 (rat) CPKCKTQYVRDTVVG Y148
K160-ac
VVGTMGLkAtGRLCT
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • transcription, induced
SIRT6 (human) VVGTMGLkAtGRLCT K160-ac
SIRT6 iso2 (human) VVGTMGLKATGRLCT K160
SIRT6 (mouse) VVGTMGLKATGRLCT K160
SIRT6 (rat) VVGTMGLKATGRLCT K160
K160-ub
VVGTMGLkAtGRLCT
1 1
SIRT6 (human) VVGTMGLkAtGRLCT K160-ub
SIRT6 iso2 (human) VVGTMGLKATGRLCT K160
SIRT6 (mouse) VVGTMGLKATGRLCT K160
SIRT6 (rat) VVGTMGLKATGRLCT K160
T162-p
GTMGLkAtGRLCTVA
0 1
SIRT6 (human) GTMGLkAtGRLCTVA T162-p
SIRT6 iso2 (human) GTMGLKATGRLCTVA T162
SIRT6 (mouse) GTMGLKATGRLCTVA T162
SIRT6 (rat) GTMGLKATGRLCTVA T162
K170-ub
GRLCTVAkARGLRAC
Downstream
1 3
Effects on Modified Protein
  • protein stabilization
Effects on Biological Processes:
  • DNA repair, induced
  • transcription, inhibited
SIRT6 (human) GRLCTVAkARGLRAC K170-ub
SIRT6 iso2 (human) GRLCTVAKARGLRAC K170
SIRT6 (mouse) GRLCTVAKTRGLRAC K170
SIRT6 (rat) GRLCTVAKARGLRAC K170
K245-ub
IVNLQPTkHDRHADL
0 2
SIRT6 (human) IVNLQPTkHDRHADL K245-ub
SIRT6 iso2 (human) IVNLQPTKHDRHADL K218
SIRT6 (mouse) IVNLQPTKHDRQADL K245
SIRT6 (rat) IVNLQPTKHDRQADL K245
K267-ac
EVMTRLMkHLGLEIP
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • transcription, induced
SIRT6 (human) EVMTRLMkHLGLEIP K267-ac
SIRT6 iso2 (human) EVMTRLMKHLGLEIP K240
SIRT6 (mouse) EVMCRLMKHLGLEIP K267
SIRT6 (rat) EVMCKLMKHLGLEIP K267
K267-ub
EVMTRLMkHLGLEIP
0 2
SIRT6 (human) EVMTRLMkHLGLEIP K267-ub
SIRT6 iso2 (human) EVMTRLMKHLGLEIP K240
SIRT6 (mouse) EVMCRLMKHLGLEIP K267
SIRT6 (rat) EVMCKLMKHLGLEIP K267
T294-p
PPLPRPPtPKLEPKE
Upstream
1 77
Treatment
  • LRRK2-IN-1
SIRT6 (human) PPLPRPPtPKLEPKE T294-p
SIRT6 iso2 (human) PPLPRPPTPKLEPKE T267
SIRT6 (mouse) PPLPRPVALKAEPPV A294
SIRT6 (rat) PPLPRPVAPKAEPPV A294
T305-p
EPKEEsPtRINGsIP
0 1
SIRT6 (human) EPKEEsPtRINGsIP T305-p
SIRT6 iso2 (human) EPKEESPTRINGSIP T278
SIRT6 (mouse) ALKAEPPVHLNGAVH V301
SIRT6 (rat) APKAEPPVHLNGSYK V301
S310-p
sPtRINGsIPAGPKQ
0 4
SIRT6 (human) sPtRINGsIPAGPKQ S310-p
SIRT6 iso2 (human) SPTRINGSIPAGPKQ S283
SIRT6 (mouse) PPVHLNGAVHVSYKS A306
SIRT6 (rat) PPVHLNGSYKPKPDS S306
T337-p
sPKRERPtsPAPHRP
0 11
SIRT6 (human) sPKRERPtsPAPHRP T337-p
SIRT6 iso2 (human) SPKRERPTSPAPHRP T310
SIRT6 (mouse) VSYKSKPNSPILHRP N316
SIRT6 (rat) GSYKPKPDSPVPHRP D312
S338-p
PKRERPtsPAPHRPP
Upstream
Downstream
3 30
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein degradation
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell growth, induced
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
  • CK2A1 (human)
Treatment
  • adriamycin
  • emodin
  • siRNA
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SIRT6 (human) PKRERPtsPAPHRPP S338-p
SIRT6 iso2 (human) PKRERPTSPAPHRPP S311
SIRT6 (mouse) SYKSKPNSPILHRPP S317
SIRT6 (rat) SYKPKPDSPVPHRPP S313