Other Species / Isoforms
  SHARPIN (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
R29-m1
LAVHAAVrPLGAGPD
0 1
SHARPIN (human) LAVHAAVrPLGAGPD R29-m1
SHARPIN (mouse) LAVHAAVRPLGAGQD R28
SHARPIN (rat) LAVQAAVRLLGAGHE R28
R43
DAEAQLRRLQLSADP
1 1
SHARPIN (human) DAEAQLRRLQLSADP R43
SHARPIN (mouse) DAEAQPRkLQLIADP K42-ub
SHARPIN (rat) EDEAQLRKLQLKADP K42
S131-p
QNGSKSNsPPALGPE
Downstream
1 2
Effects on Modified Protein
  • molecular association, regulation
SHARPIN (human) QNGSKSNsPPALGPE S131-p
SHARPIN (mouse) QNGSGSPAPAPAPAM A130
SHARPIN (rat) QNGNDSTAPVPTPAM A130
S143-p
GPEACPVsLPsPPEA
0 1
SHARPIN (human) GPEACPVsLPsPPEA S143-p
SHARPIN (mouse) APAMCPISPPCSSMA S141
SHARPIN (rat) TPAMCPTSPPCSSVT S141
S146-p
ACPVsLPsPPEAStL
Upstream
Downstream
1 4
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell motility, induced
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
Putative in vivo kinases:
  • ERK1 (human)
  • ERK2 (human)
Treatment
  • ravoxertinib
SHARPIN (human) ACPVsLPsPPEAStL S146-p
SHARPIN (mouse) MCPISPPCSSMAQIP C144
SHARPIN (rat) MCPTSPPCSSVTPTP C144
T152-p
PsPPEAStLkGPPPE
0 1
SHARPIN (human) PsPPEAStLkGPPPE T152-p
SHARPIN (mouse) PCSSMAQIPKATQPE I150
SHARPIN (rat) PCSSVTPTPKATQPE T150
K154-ub
PPEAStLkGPPPEAD
0 1
SHARPIN (human) PPEAStLkGPPPEAD K154-ub
SHARPIN (mouse) SSMAQIPKATQPEVD K152
SHARPIN (rat) SSVTPTPKATQPEMD K152
S165-p
PEADLPRsPGNLtER
Upstream
Downstream
1 20
Effects on Modified Protein
  • intracellular localization
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
Putative in vivo kinases:
  • ERK1 (human)
Treatment
  • anisomycin
  • antibody
  • calyculin_A
  • ionomycin
  • LRRK2-IN-1
  • phorbol_ester
  • Ro31-7549
  • TNF
  • Trametinib
view more >
SHARPIN (human) PEADLPRsPGNLtER S165-p
SHARPIN (mouse) PEVDLPQSSGNFkkE S163
SHARPIN (rat) PEMDLPQGSGNLKKE G163
T170-p
PRsPGNLtEREELAG
0 1
SHARPIN (human) PRsPGNLtEREELAG T170-p
SHARPIN (mouse) gap -
SHARPIN (rat) gap -
E171
RsPGNLtEREELAGS
1 1
SHARPIN (human) RsPGNLtEREELAGS E171
SHARPIN (mouse) PQSSGNFkkEELATR K168-ub
SHARPIN (rat) PQGSGNLKKEELATH K168
R172
sPGNLtEREELAGSL
1 1
SHARPIN (human) sPGNLtEREELAGSL R172
SHARPIN (mouse) QSSGNFkkEELATRL K169-ub
SHARPIN (rat) QGSGNLKKEELATHL K169
K189-ub
AIAGGDEkGAAQVAA
0 30
SHARPIN (human) AIAGGDEkGAAQVAA K189-ub
SHARPIN (mouse) AIAGGDEkAAAQVAA K186-ub
SHARPIN (rat) AIAGGDEKAAAQVAA K186
T224-p
GPIRLQVtLEDAASA
0 2
SHARPIN (human) GPIRLQVtLEDAASA T224-p
SHARPIN (mouse) GPIRLQVTVEDATSV T221
SHARPIN (rat) GPIRLQVTVEDATSV T221
S282-p
CLCVPERsLASYGVR
0 1
SHARPIN (human) CLCVPERsLASYGVR S282-p
SHARPIN (mouse) CLCMPERSLASYGVS S279
SHARPIN (rat) CLCMPERSLASYGVS S279
S312-p
EAPAtGPsPQHPQkM
0 8
SHARPIN (human) EAPAtGPsPQHPQkM S312-p
SHARPIN (mouse) PREVSGQSLQNSkMD S307
SHARPIN (rat) PREVSGHSPQHSKMD S307
K318-ub
PsPQHPQkMDGELGR
1 8
SHARPIN (human) PsPQHPQkMDGELGR K318-ub
SHARPIN (mouse) GQSLQNSkMDRKLGL K312-ub
SHARPIN (rat) GHSPQHSKMDRKLGC K312
T309-p
APREAPAtGPsPQHP
Upstream
0 1
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
SHARPIN (human) APREAPAtGPsPQHP T309-p
SHARPIN (mouse) gap -
SHARPIN (rat) gap -