Other Species / Isoforms
  SHP-2 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S28
LTRGVDGSFLARPSK
0 1
SHP-2 (human) LTRGVDGsFLARPsK S28-p
SHP-2 iso1 (human) LTRGVDGSFLARPSK S28
SHP-2 (mouse) LTRGVDGSFLARPSK S28
SHP-2 (rat) LTRGVDGSFLARPSK S28
S34
GSFLARPSKsNPGDF
0 3
SHP-2 (human) GsFLARPsKsNPGDF S34-p
SHP-2 iso1 (human) GSFLARPSKSNPGDF S34
SHP-2 (mouse) GSFLARPSKsNPGDF S34
SHP-2 (rat) GSFLARPSKSNPGDF S34
S36-p
FLARPSKsNPGDFTL
0 2
SHP-2 (human) FLARPsKsNPGDFTL S36-p
SHP-2 iso1 (human) FLARPSKSNPGDFTL S36
SHP-2 (mouse) FLARPSKsNPGDFTL S36-p
SHP-2 (rat) FLARPSKSNPGDFTL S36
T59
THIKIQNTGDyyDLy
0 3
SHP-2 (human) THIKIQNtGDyyDLy T59-p
SHP-2 iso1 (human) THIKIQNTGDYYDLY T59
SHP-2 (mouse) THIKIQNTGDyyDLy T59
SHP-2 (rat) THIKIQNTGDyyDLY T59
Y62-p
KIQNTGDyyDLyGGE
Upstream
0 2114
Regulatory protein:
  • AR (mouse)
  • ERG (mouse)
  • FCER1A (mouse)
  • PTP1B (mouse)
Treatment
  • PDGF
SHP-2 (human) KIQNtGDyyDLyGGE Y62-p
SHP-2 iso1 (human) KIQNTGDYYDLYGGE Y62
SHP-2 (mouse) KIQNTGDyyDLyGGE Y62-p
SHP-2 (rat) KIQNTGDyyDLYGGE Y62-p
Y63-p
IQNTGDyyDLyGGEK
Upstream
Downstream
1 84
Effects on Modified Protein
  • enzymatic activity, inhibited
  • phosphorylation
Effects on Biological Processes:
  • cell growth, altered
Putative in vivo kinases:
  • Abl (human)
  • Arg (human)
Regulatory protein:
  • PTP1B (mouse)
Treatment
  • PDGF
SHP-2 (human) IQNtGDyyDLyGGEK Y63-p
SHP-2 iso1 (human) IQNTGDYYDLYGGEK Y63
SHP-2 (mouse) IQNTGDyyDLyGGEK Y63-p
SHP-2 (rat) IQNTGDyyDLYGGEK Y63-p
Y66-p
TGDyyDLyGGEKFAT
0 15
SHP-2 (human) tGDyyDLyGGEKFAT Y66-p
SHP-2 iso1 (human) TGDYYDLYGGEKFAt Y66
SHP-2 (mouse) TGDyyDLyGGEKFAT Y66-p
SHP-2 (rat) TGDyyDLYGGEKFAT Y66
T73
yGGEKFATLAELVQY
1 0
SHP-2 (human) yGGEKFATLAELVQy T73
SHP-2 iso1 (human) YGGEKFAtLAELVQY T73-p
SHP-2 (mouse) yGGEKFATLAELVQY T73
SHP-2 (rat) YGGEKFATLAELVQY T73
Y80
TLAELVQYYMEHHGQ
0 1
SHP-2 (human) TLAELVQyYMEHHGQ Y80-p
SHP-2 iso1 (human) tLAELVQYYMEHHGQ Y80
SHP-2 (mouse) TLAELVQYYMEHHGQ Y80
SHP-2 (rat) TLAELVQYYMEHHGQ Y80
K91-ub
HHGQLKEkNGDVIEL
0 1
SHP-2 (human) HHGQLKEKNGDVIEL K91
SHP-2 iso1 (human) HHGQLKEKNGDVIEL K91
SHP-2 (mouse) HHGQLKEkNGDVIEL K91-ub
SHP-2 (rat) HHGQLKEKNGDVIEL K91
K120
FHGHLSGKEAEKLLT
0 1
SHP-2 (human) FHGHLSGKEAEkLLT K120
SHP-2 iso1 (human) FHGHLSGKEAEKLLT K120
SHP-2 (mouse) FHGHLSGKEAEKLLT K120
SHP-2 (rat) FHGHLSGkEAEkLLT K120-ac
K120
FHGHLSGKEAEKLLT
0 1
SHP-2 (human) FHGHLSGkEAEkLLT K120-ub
SHP-2 iso1 (human) FHGHLSGKEAEKLLT K120
SHP-2 (mouse) FHGHLSGKEAEKLLT K120
SHP-2 (rat) FHGHLSGKEAEkLLT K120
K124
LSGKEAEKLLTEKGK
0 1
SHP-2 (human) LSGkEAEKLLTEKGk K124
SHP-2 iso1 (human) LSGKEAEKLLTEKGK K124
SHP-2 (mouse) LSGKEAEKLLTEKGK K124
SHP-2 (rat) LSGkEAEkLLTEKGk K124-ac
K124
LSGKEAEKLLTEKGK
0 1
SHP-2 (human) LSGkEAEkLLTEKGk K124-ub
SHP-2 iso1 (human) LSGKEAEKLLTEKGK K124
SHP-2 (mouse) LSGKEAEKLLTEKGK K124
SHP-2 (rat) LSGkEAEKLLTEKGk K124
K131
KLLTEKGKHGSFLVR
0 1
SHP-2 (human) kLLTEKGKHGSFLVR K131
SHP-2 iso1 (human) KLLTEKGKHGSFLVR K131
SHP-2 (mouse) KLLTEKGKHGSFLVR K131
SHP-2 (rat) kLLTEKGkHGSFLVR K131-ac
K131
KLLTEKGKHGSFLVR
0 1
SHP-2 (human) kLLTEKGkHGSFLVR K131-ub
SHP-2 iso1 (human) KLLTEKGKHGSFLVR K131
SHP-2 (mouse) KLLTEKGKHGSFLVR K131
SHP-2 (rat) kLLTEKGKHGSFLVR K131
S142
FLVRESQSHPGDFVL
0 2
SHP-2 (human) FLVRESQsHPGDFVL S142-p
SHP-2 iso1 (human) FLVRESQSHPGDFVL S142
SHP-2 (mouse) FLVRESQSHPGDFVL S142
SHP-2 (rat) FLVRESQSHPGDFVL S142
T153
DFVLSVRTGDDKGES
0 3
SHP-2 (human) DFVLSVRtGDDKGES T153-p
SHP-2 iso1 (human) DFVLSVRTGDDKGES T153
SHP-2 (mouse) DFVLSVRTGDDKGES T153
SHP-2 (rat) DFVLSVRTGDDKGES T153
S165
GESNDGKSKVTHVMI
0 1
SHP-2 (human) GESNDGKsKVTHVMI S165-p
SHP-2 iso1 (human) GESNDGKSKVTHVMI S165
SHP-2 (mouse) GESNDGKSKVTHVMI S165
SHP-2 (rat) GESNDSKSKVTHVMI S165
K178
MIRCQELKYDVGGGE
0 1
SHP-2 (human) MIRCQELkyDVGGGE K178-ac
SHP-2 iso1 (human) MIRCQELKYDVGGGE K178
SHP-2 (mouse) MIRCQELKYDVGGGE K178
SHP-2 (rat) MIRCQELKYDVGGGE K178
Y179
IRCQELKYDVGGGER
0 3
SHP-2 (human) IRCQELkyDVGGGER Y179-p
SHP-2 iso1 (human) IRCQELKYDVGGGER Y179
SHP-2 (mouse) IRCQELKYDVGGGER Y179
SHP-2 (rat) IRCQELKYDVGGGER Y179
S189
GGGERFDSLTDLVEH
1 1
SHP-2 (human) GGGERFDsLTDLVEH S189-p
SHP-2 iso1 (human) GGGERFDsLTDLVEH S189-p
SHP-2 (mouse) GGGERFDSLTDLVEH S189
SHP-2 (rat) GGGERFDSLTDLVEH S189
K198-ac
TDLVEHYkKNPMVET
0 4
SHP-2 (human) TDLVEHYkKNPMVET K198-ac
SHP-2 iso1 (human) TDLVEHYKKNPMVET K198
SHP-2 (mouse) TDLVEHYkKNPMVET K198-ac
SHP-2 (rat) TDLVEHYkKNPMVET K198-ac
K198
TDLVEHYKKNPMVET
0 1
SHP-2 (human) TDLVEHYkKNPMVET K198-ub
SHP-2 iso1 (human) TDLVEHYKKNPMVET K198
SHP-2 (mouse) TDLVEHYKKNPMVET K198
SHP-2 (rat) TDLVEHYKKNPMVET K198
K235
SRVRELSKLAETTDK
0 1
SHP-2 (human) SRVRELSkLAETTDk K235-ub
SHP-2 iso1 (human) SRVRELSKLAETTDK K235
SHP-2 (mouse) SRVRELSKLAETTDK K235
SHP-2 (rat) SRVRELSKLAETTDK K235
K242
KLAETTDKVKQGFWE
0 1
SHP-2 (human) kLAETTDkVkQGFWE K242-ub
SHP-2 iso1 (human) KLAETTDKVKQGFWE K242
SHP-2 (mouse) KLAETTDKVKQGFWE K242
SHP-2 (rat) KLAETTDKVKQGFWE K242
K244
AETTDKVKQGFWEEF
0 1
SHP-2 (human) AETTDkVkQGFWEEF K244-ub
SHP-2 iso1 (human) AETTDKVKQGFWEEF K244
SHP-2 (mouse) AETTDKVKQGFWEEF K244
SHP-2 (rat) AETTDKVKQGFWEEF K244
K260
TLQQQECKLLYSRKE
0 1
SHP-2 (human) TLQQQECkLLysRKE K260-ub
SHP-2 iso1 (human) TLQQQECKLLYSRKE K260
SHP-2 (mouse) TLQQQECKLLYSRKE K260
SHP-2 (rat) TLQQQECKLLYSRKE K260
Y263
QQECKLLYSRKEGQR
0 8
SHP-2 (human) QQECkLLysRKEGQR Y263-p
SHP-2 iso1 (human) QQECKLLYSRKEGQR Y263
SHP-2 (mouse) QQECKLLYSRKEGQR Y263
SHP-2 (rat) QQECKLLYSRKEGQR Y263
S264
QECKLLYSRKEGQRQ
0 1
SHP-2 (human) QECkLLysRKEGQRQ S264-p
SHP-2 iso1 (human) QECKLLYSRKEGQRQ S264
SHP-2 (mouse) QECKLLYSRKEGQRQ S264
SHP-2 (rat) QECKLLYSRKEGQRQ S264
K274
EGQRQENKNKNRyKN
0 1
SHP-2 (human) EGQRQENkNkNRykN K274-ac
SHP-2 iso1 (human) EGQRQENKNKNRYKN K274
SHP-2 (mouse) EGQRQENKNKNRyKN K274
SHP-2 (rat) EGQRQENKNKNRYkN K274
K276
QRQENKNKNRyKNIL
0 1
SHP-2 (human) QRQENkNkNRykNIL K276-ac
SHP-2 iso1 (human) QRQENKNKNRYKNIL K276
SHP-2 (mouse) QRQENKNKNRyKNIL K276
SHP-2 (rat) QRQENKNKNRYkNIL K276
Y279-p
ENKNKNRyKNILPFD
Upstream
Downstream
1 63
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • cell cycle regulation
Putative in vivo kinases:
  • Arg (human)
SHP-2 (human) ENkNkNRykNILPFD Y279-p
SHP-2 iso1 (human) ENKNKNRYKNILPFD Y279
SHP-2 (mouse) ENKNKNRyKNILPFD Y279-p
SHP-2 (rat) ENKNKNRYkNILPFD Y279
K280
NKNKNRyKNILPFDH
0 2
SHP-2 (human) NkNkNRykNILPFDH K280-ac
SHP-2 iso1 (human) NKNKNRYKNILPFDH K280
SHP-2 (mouse) NKNKNRyKNILPFDH K280
SHP-2 (rat) NKNKNRYkNILPFDH K280-ac
K280
NKNKNRyKNILPFDH
0 1
SHP-2 (human) NkNkNRykNILPFDH K280-ub
SHP-2 iso1 (human) NKNKNRYKNILPFDH K280
SHP-2 (mouse) NKNKNRyKNILPFDH K280
SHP-2 (rat) NKNKNRYKNILPFDH K280
S302
GDPNEPVSDyINANI
0 20
SHP-2 (human) GDPNEPVsDyINANI S302-p
SHP-2 iso1 (human) GDPNEPVSDYINANI S302
SHP-2 (mouse) GDPNEPVSDyINANI S302
SHP-2 (rat) GDPNEPVSDYINANI S302
Y304-p
PNEPVSDyINANIIM
Upstream
Downstream
2 56
Effects on Modified Protein
  • molecular association, regulation
Putative in vivo kinases:
  • JAK1 (mouse)
  • JAK2 (mouse)
SHP-2 (human) PNEPVsDyINANIIM Y304-p
SHP-2 iso1 (human) PNEPVSDYINANIIM Y304
SHP-2 (mouse) PNEPVSDyINANIIM Y304-p
SHP-2 (rat) PNEPVSDYINANIIM Y304
K317
IMPEFETKCNNSKPK
0 1
SHP-2 (human) IMPEFETkCNNSKPK K317-ub
SHP-2 iso1 (human) IMPEFETKCNNSKPK K317
SHP-2 (mouse) IMPEFETKCNNSKPK K317
SHP-2 (rat) IMPEFETKCNNSKPK K317
Y327-p
NSKPKKSyIATQGCL
Upstream
1 0
Putative in vivo kinases:
  • JAK1 (mouse)
  • JAK2 (mouse)
SHP-2 (human) NSKPKKSYIATQGCL Y327
SHP-2 iso1 (human) NSKPKKSYIATQGCL Y327
SHP-2 (mouse) NSKPKKSyIATQGCL Y327-p
SHP-2 (rat) NSKPKKSYIATQGCL Y327
K389
VMRVRNVKESAAHDY
0 1
SHP-2 (human) VMRVRNVkESAAHDY K389-ub
SHP-2 iso1 (human) VMRVRNVKESAAHDY K389
SHP-2 (mouse) VMRVRNVKESAAHDY K389
SHP-2 (rat) VMRVRNVRESAAHDY R389
T411
SKVGQGNTERTVWQY
0 1
SHP-2 (human) SKVGQGNtERTVWQY T411-p
SHP-2 iso1 (human) QALLQGNTERTVWQY T415
SHP-2 (mouse) SKVGQGNTERTVWQY T411
SHP-2 (rat) QALLQGNTERTVWQY T415
K482
LIDIIREKGVDCDID
0 3
SHP-2 (human) LIDIIREkGVDCDID K482-ac
SHP-2 iso1 (human) LIDIIREKGVDCDID K486
SHP-2 (mouse) LIDIIREKGVDCDID K482
SHP-2 (rat) LIDIIREkGVDCDID K486-ac
Y511-p
MVQTEAQyRFIYMAV
1 39
SHP-2 (human) MVQTEAQyRFIyMAV Y511-p
SHP-2 iso1 (human) MVQTEAQyRFIYMAV Y515-p
SHP-2 (mouse) MVQTEAQyRFIYMAV Y511-p
SHP-2 (rat) MVQTEAQYRFIYMAV Y515
Y515
EAQyRFIYMAVQHYI
0 16
SHP-2 (human) EAQyRFIyMAVQHYI Y515-p
SHP-2 iso1 (human) EAQyRFIYMAVQHYI Y519
SHP-2 (mouse) EAQyRFIYMAVQHYI Y515
SHP-2 (rat) EAQYRFIYMAVQHYI Y519
S535-p
RIEEEQKsKRKGHEy
0 1
SHP-2 (human) RIEEEQKsKRkGHEy S535-p
SHP-2 iso1 (human) RIEEEQKSKRKGHEy S539
SHP-2 (mouse) RIEEEQKsKRKGHEy S535-p
SHP-2 (rat) RIEEEQKSKRKGHEy S539
K538
EEQKsKRKGHEytNI
0 1
SHP-2 (human) EEQKsKRkGHEytNI K538-ub
SHP-2 iso1 (human) EEQKSKRKGHEyTNI K542
SHP-2 (mouse) EEQKsKRKGHEytNI K538
SHP-2 (rat) EEQKSKRKGHEyTNI K542
Y542-p
sKRKGHEytNIKYSL
Upstream
Downstream
27 452
SHP-2 (human)
Y542-p
SHP-2 iso1 (human)
Y546-p
SHP-2 (mouse)
Y542-p
SHP-2 (rat)
Y546-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell adhesion, altered
Kinase, in vitro:
  • Abl (human)
Treatment
  • EGF
  • FGF1
  • GSK2334470
  • GSK650394
  • IL-1a
  • imatinib
  • insulin
  • LY294002
  • MK-2206
  • PDGF
  • SU6656
  • Torin1
SHP-2 (human) sKRkGHEytNIKysL Y542-p
SHP-2 iso1 (human) SKRKGHEyTNIKYSL Y546-p
SHP-2 (mouse) sKRKGHEytNIKYSL Y542-p
SHP-2 (rat) SKRKGHEyTNIKYSL Y546-p
T543-p
KRKGHEytNIKYSLV
0 30
SHP-2 (human) KRkGHEytNIKysLA T543-p
SHP-2 iso1 (human) KRKGHEyTNIKYSLA T547
SHP-2 (mouse) KRKGHEytNIKYSLV T543-p
SHP-2 (rat) KRKGHEyTNIKYSLV T547
Y547
HEytNIKYSLVDQTS
0 2
SHP-2 (human) HEytNIKysLADQts Y547-p
SHP-2 iso1 (human) HEyTNIKYSLADQTS Y551
SHP-2 (mouse) HEytNIKYSLVDQTS Y547
SHP-2 (rat) HEyTNIKYSLVDQTS Y551
S548
EytNIKYSLVDQTSG
0 1
SHP-2 (human) EytNIKysLADQtsG S548-p
SHP-2 iso1 (human) EyTNIKYSLADQTSG S552
SHP-2 (mouse) EytNIKYSLVDQTSG S548
SHP-2 (rat) EyTNIKYSLVDQTSG S552
T553
KYSLVDQTSGDQsPL
0 10
SHP-2 (human) KysLADQtsGDQsPL T553-p
SHP-2 iso1 (human) KYSLADQTSGDQSPL T557
SHP-2 (mouse) KYSLVDQTSGDQsPL T553
SHP-2 (rat) KYSLVDQTSGDQsPL T557
S554
YSLVDQTSGDQsPLP
0 1
SHP-2 (human) ysLADQtsGDQsPLP S554-p
SHP-2 iso1 (human) YSLADQTSGDQSPLP S558
SHP-2 (mouse) YSLVDQTSGDQsPLP S554
SHP-2 (rat) YSLVDQTSGDQsPLP S558
S558-p
DQTSGDQsPLPPCTP
0 16
SHP-2 (human) DQtsGDQsPLPPCtP S558-p
SHP-2 iso1 (human) DQTSGDQSPLPPCTP S562
SHP-2 (mouse) DQTSGDQsPLPPCTP S558-p
SHP-2 (rat) DQTSGDQsPLPPCTP S562-p
T564
QsPLPPCTPTPPCAE
0 17
SHP-2 (human) QsPLPPCtPtPPCAE T564-p
SHP-2 iso1 (human) QSPLPPCTPTPPCAE T568
SHP-2 (mouse) QsPLPPCTPTPPCAE T564
SHP-2 (rat) QsPLPPCTPtPPCAE T568
T566
PLPPCTPTPPCAEMR
0 6
SHP-2 (human) PLPPCtPtPPCAEMR T566-p
SHP-2 iso1 (human) PLPPCTPTPPCAEMR T570
SHP-2 (mouse) PLPPCTPTPPCAEMR T566
SHP-2 (rat) PLPPCTPtPPCAEMR T570-p
S576-p
CAEMREDsARVyENV
3 11
SHP-2 (human) CAEMREDsARVyENV S576-p
SHP-2 iso1 (human) CAEMREDSARVyENV S580
SHP-2 (mouse) CAEMREDsARVyENV S576-p
SHP-2 (rat) CAEMREDsARVyENV S580-p
Y580-p
REDsARVyENVGLMQ
Upstream
Downstream
16 1233
SHP-2 (human)
Y580-p
SHP-2 iso1 (human)
Y584-p
SHP-2 (mouse)
Y580-p
SHP-2 (rat)
Y584-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
Kinase, in vitro:
  • Abl (human)
  • Arg (human)
Putative in vivo kinases:
  • Abl (human)
  • Arg (human)
Regulatory protein:
  • ERG (mouse)
Treatment
  • EGF
  • FGF1
  • imatinib
  • insulin
  • PDGF
  • SU6656
SHP-2 (human) REDsARVyENVGLMQ Y580-p
SHP-2 iso1 (human) REDSARVyENVGLMQ Y584-p
SHP-2 (mouse) REDsARVyENVGLMQ Y580-p
SHP-2 (rat) REDsARVyENVGLMQ Y584-p
R590
VGLMQQQRsFR____
0 3
SHP-2 (human) VGLMQQQksFR____ K590-ub
SHP-2 iso1 (human) VGLMQQQKSFR____ K594
SHP-2 (mouse) VGLMQQQRsFR____ R590
SHP-2 (rat) VGLMQQQRSFR____ R594
R590
VGLMQQQRsFR____
1 0
SHP-2 (human) VGLMQQQKsFR____ K590
SHP-2 iso1 (human) VGLMQQQkSFR____ K594-sm
SHP-2 (mouse) VGLMQQQRsFR____ R590
SHP-2 (rat) VGLMQQQRSFR____ R594
S591-p
GLMQQQRsFR_____
1 53
SHP-2 (human) GLMQQQksFR_____ S591-p
SHP-2 iso1 (human) GLMQQQkSFR_____ S595
SHP-2 (mouse) GLMQQQRsFR_____ S591-p
SHP-2 (rat) GLMQQQRSFR_____ S595