Other Species / Isoforms
  MEKK2 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S26
KASRPALSLQETRKA
0 8
MEKK2 (human) KASRPALsLQETRKA S26-p
MEKK2 (mouse) KASRPALSLQETRKA S26
MEKK2 (rat) KASRPALSLQETRKA S26
S109
AVELLDRSIHMKSLK
0 1
MEKK2 (human) AVELLDRsIHMKSLK S109-p
MEKK2 (mouse) AVELLDRSIHMKSLK S109
MEKK2 (rat) AVELLDRSIHMKSLK S109
S153-p
AERKKRLsVVGPPNR
Upstream
Downstream
2 61
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • PKACA (human)
Putative in vivo kinases:
  • PKACA (human)
Treatment
  • IBMX
  • insulin
  • LPS
  • mPKI
  • NKH_477
  • PGE2
MEKK2 (human) AERKKRLsIIGPtsR S153-p
MEKK2 (mouse) AERKKRLsVVGPPNR S153-p
MEKK2 (rat) AERKKRLsVVGPPNR S153-p
P158
RLsVVGPPNRDRssP
0 1
MEKK2 (human) RLsIIGPtsRDRssP T158-p
MEKK2 (mouse) RLsVVGPPNRDRssP P158
MEKK2 (rat) RLsVVGPPNRDRssP P158
N159
LsVVGPPNRDRssPP
0 3
MEKK2 (human) LsIIGPtsRDRssPP S159-p
MEKK2 (mouse) LsVVGPPNRDRssPP N159
MEKK2 (rat) LsVVGPPNRDRssPP N159
S163-p
GPPNRDRssPPPGYI
0 16
MEKK2 (human) GPtsRDRssPPPGyI S163-p
MEKK2 (mouse) GPPNRDRssPPPGYI S163-p
MEKK2 (rat) GPPNRDRssPPPGYI S163-p
S164-p
PPNRDRssPPPGYIP
1 33
MEKK2 (human) PtsRDRssPPPGyIP S164-p
MEKK2 (mouse) PPNRDRssPPPGYIP S164-p
MEKK2 (rat) PPNRDRssPPPGYIP S164-p
Y169
RssPPPGYIPDILHQ
0 1
MEKK2 (human) RssPPPGyIPDELHQ Y169-p
MEKK2 (mouse) RssPPPGYIPDILHQ Y169
MEKK2 (rat) RssPPPGYIPDELHQ Y169
S232-p
DGESYPKsRMPRAQs
0 1
MEKK2 (human) DGESYPKSRMPRAQs S232
MEKK2 (mouse) DGESYPKsRMPRAQs S232-p
MEKK2 (rat) DGESYPKSRMPRAQs S232
S239-p
sRMPRAQsyPDNHQE
Upstream
1 284
Regulatory protein:
  • RICTOR (mouse)
MEKK2 (human) SRMPRAQsyPDNHQE S239-p
MEKK2 (mouse) sRMPRAQsyPDNHQE S239-p
MEKK2 (rat) SRMPRAQsYPDNHQE S239-p
Y240-p
RMPRAQsyPDNHQEF
0 22
MEKK2 (human) RMPRAQsyPDNHQEF Y240-p
MEKK2 (mouse) RMPRAQsyPDNHQEF Y240-p
MEKK2 (rat) RMPRAQsYPDNHQEF Y240
T248-p
PDNHQEFtDYDNPIF
0 19
MEKK2 (human) PDNHQEFsDyDNPIF S248-p
MEKK2 (mouse) PDNHQEFtDYDNPIF T248-p
MEKK2 (rat) PDNHQEFSDYDNPIF S248
Y250
NHQEFtDYDNPIFEK
0 109
MEKK2 (human) NHQEFsDyDNPIFEk Y250-p
MEKK2 (mouse) NHQEFtDYDNPIFEK Y250
MEKK2 (rat) NHQEFSDYDNPIFEK Y250
K257
YDNPIFEKFGKGGtY
0 1
MEKK2 (human) yDNPIFEkFGkGGtY K257-ub
MEKK2 (mouse) YDNPIFEKFGKGGtY K257
MEKK2 (rat) YDNPIFEKFGKGGTY K257
K260
PIFEKFGKGGtYPRR
1 0
MEKK2 (human) PIFEkFGkGGtYPRR K260-me
MEKK2 (mouse) PIFEKFGKGGtYPRR K260
MEKK2 (rat) PIFEKFGKGGTYPRR K260
K260
PIFEKFGKGGtYPRR
0 1
MEKK2 (human) PIFEkFGkGGtYPRR K260-m1
MEKK2 (mouse) PIFEKFGKGGtYPRR K260
MEKK2 (rat) PIFEKFGKGGTYPRR K260
T263-p
EKFGKGGtYPRRYHV
0 4
MEKK2 (human) EkFGkGGtYPRRYHV T263-p
MEKK2 (mouse) EKFGKGGtYPRRYHV T263-p
MEKK2 (rat) EKFGKGGTYPRRYHV T263
T283-p
EYNDGRKtFPRARRT
Upstream
Downstream
1 5
Effects on Modified Protein
  • enzymatic activity, inhibited
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • cell growth, induced
  • transcription, inhibited
Putative in vivo kinases:
  • MEKK2 (mouse)
MEKK2 (human) EYNDGRKtFPRARRt T283-p
MEKK2 (mouse) EYNDGRKtFPRARRT T283-p
MEKK2 (rat) EYNDGRKTFPRARRT T283
T290
tFPRARRTQGTSFRS
0 1
MEKK2 (human) tFPRARRtQGTSLRs T290-p
MEKK2 (mouse) tFPRARRTQGTSFRS T290
MEKK2 (rat) TFPRARRTQGTSFRS T290
S297
TQGTSFRSPVSFSPT
0 3
MEKK2 (human) tQGTSLRsPVsFsPT S297-p
MEKK2 (mouse) TQGTSFRSPVSFSPT S297
MEKK2 (rat) TQGTSFRSPVSFSPT S297
S300
TSFRSPVSFSPTDHS
0 1
MEKK2 (human) TSLRsPVsFsPTDHS S300-p
MEKK2 (mouse) TSFRSPVSFSPTDHS S300
MEKK2 (rat) TSFRSPVSFSPTDHS S300
S302
FRSPVSFSPTDHSLS
0 2
MEKK2 (human) LRsPVsFsPTDHSLS S302-p
MEKK2 (mouse) FRSPVSFSPTDHSLS S302
MEKK2 (rat) FRSPVSFSPTDHSLS S302
T310-p
PTDHSLStSSGSSVF
0 1
MEKK2 (human) PTDHSLSTssGssIF T310
MEKK2 (mouse) PTDHSLStSSGSSVF T310-p
MEKK2 (rat) PTDHSLSTSSGSSIF T310
S311
TDHSLStSSGSSVFT
0 1
MEKK2 (human) TDHSLSTssGssIFT S311-p
MEKK2 (mouse) TDHSLStSSGSSVFT S311
MEKK2 (rat) TDHSLSTSSGSSIFT S311
S312
DHSLStSSGSSVFTP
0 1
MEKK2 (human) DHSLSTssGssIFTP S312-p
MEKK2 (mouse) DHSLStSSGSSVFTP S312
MEKK2 (rat) DHSLSTSSGSSIFTP S312
S314
SLStSSGSSVFTPEY
0 1
MEKK2 (human) SLSTssGssIFTPEY S314-p
MEKK2 (mouse) SLStSSGSSVFTPEY S314
MEKK2 (rat) SLSTSSGSSIFTPEY S314
S315
LStSSGSSVFTPEYD
0 1
MEKK2 (human) LSTssGssIFTPEYD S315-p
MEKK2 (mouse) LStSSGSSVFTPEYD S315
MEKK2 (rat) LSTSSGSSIFTPEYE S315
S331-p
SRIRRRGsDIDNPtL
Upstream
1 47
Regulatory protein:
  • Raptor (mouse)
MEKK2 (human) SRIRRRGsDIDNPtL S331-p
MEKK2 (mouse) SRIRRRGsDIDNPtL S331-p
MEKK2 (rat) SRIRRRGsDIDNPTL S331-p
T337-p
GsDIDNPtLTVtDIs
0 6
MEKK2 (human) GsDIDNPtLTVMDIs T337-p
MEKK2 (mouse) GsDIDNPtLTVtDIs T337-p
MEKK2 (rat) GsDIDNPTLTVTDIS T337
T341-p
DNPtLTVtDIsPPsR
0 2
MEKK2 (human) DNPtLTVMDIsPPsR M341
MEKK2 (mouse) DNPtLTVtDIsPPsR T341-p
MEKK2 (rat) DNPTLTVTDISPPSR T341
S344-p
tLTVtDIsPPsRsPR
Upstream
0 19
Treatment
  • insulin
MEKK2 (human) tLTVMDIsPPsRsPR S344-p
MEKK2 (mouse) tLTVtDIsPPsRsPR S344-p
MEKK2 (rat) TLTVTDISPPSRSPR S344
S347-p
VtDIsPPsRsPRAPT
0 4
MEKK2 (human) VMDIsPPsRsPRAPT S347-p
MEKK2 (mouse) VtDIsPPsRsPRAPT S347-p
MEKK2 (rat) VTDISPPSRSPRAPT S347
S349-p
DIsPPsRsPRAPTNW
0 7
MEKK2 (human) DIsPPsRsPRAPTNW S349-p
MEKK2 (mouse) DIsPPsRsPRAPTNW S349-p
MEKK2 (rat) DISPPSRSPRAPTNW S349
K360
PTNWRLGKLLGQGAF
0 2
MEKK2 (human) PTNWRLGkLLGQGAF K360-ub
MEKK2 (mouse) PTNWRLGKLLGQGAF K360
MEKK2 (rat) PTNWRLGKLLGQGAF K360
K385
TGRELAVKQVQFNPE
0 2
MEKK2 (human) TGRELAVkQVQFDPD K385-ub
MEKK2 (mouse) TGRELAVKQVQFNPE K385
MEKK2 (rat) TGRELAVKQVQFNPD K385
K411
ECEIQLLKNLLHERI
0 1
MEKK2 (human) ECEIQLLkNLLHERI K411-ub
MEKK2 (mouse) ECEIQLLKNLLHERI K411
MEKK2 (rat) ECEIQLLKNLLHERI K411
T432
LRDPQEKTLSIFMEL
0 2
MEKK2 (human) LRDPQEKtLSIFMEY T432-p
MEKK2 (mouse) LRDPQEKTLSIFMEL T432
MEKK2 (rat) LRDPQEKTLSIFMEY T432
K450
GSIKDQLKAYGALTE
0 1
MEKK2 (human) GSIKDQLkAYGALTE K450-ub
MEKK2 (mouse) GSIKDQLKAYGALTE K450
MEKK2 (rat) GSIKDQLKAYGALTE K450
Y463
TENVTRKYTRQILEG
0 1
MEKK2 (human) TENVTRKYTRQILEG Y463
MEKK2 (mouse) TENVTRKYTRQILEG Y463
MEKK2 (rat) TENVTRKyTRQILEG Y463-p
S493
GANILRDSTGNIKLG
0 1
MEKK2 (human) GANILRDsTGNVkLG S493-p
MEKK2 (mouse) GANILRDSTGNIKLG S493
MEKK2 (rat) GANILRDSTGNIKLG S493
K498
RDSTGNIKLGDFGAS
0 1
MEKK2 (human) RDsTGNVkLGDFGAs K498-ub
MEKK2 (mouse) RDSTGNIKLGDFGAS K498
MEKK2 (rat) RDSTGNIKLGDFGAS K498
S505
KLGDFGASKRLQTIC
0 2
MEKK2 (human) kLGDFGAsKRLQTIC S505-p
MEKK2 (mouse) KLGDFGASKRLQTIC S505
MEKK2 (rat) KLGDFGASKRLQTIC S505
S514-p
RLQTICLsGtGMKsV
0 5
MEKK2 (human) RLQTICLsGtGMKsV S514-p
MEKK2 (mouse) RLQTICLsGtGMKsV S514-p
MEKK2 (rat) RLQTICLSGTGMKSV S514
T516-p
QTICLsGtGMKsVTG
0 2
MEKK2 (human) QTICLsGtGMKsVtG T516-p
MEKK2 (mouse) QTICLsGtGMKsVTG T516-p
MEKK2 (rat) QTICLSGTGMKSVTG T516
S520-p
LsGtGMKsVTGTPYW
Upstream
2 3
Putative in vivo kinases:
  • MEKK2 (mouse)
MEKK2 (human) LsGtGMKsVtGtPYW S520-p
MEKK2 (mouse) LsGtGMKsVTGTPYW S520-p
MEKK2 (rat) LSGTGMKSVTGTPYW S520
T522
GtGMKsVTGTPYWMS
1 1
MEKK2 (human) GtGMKsVtGtPYWMS T522-p
MEKK2 (mouse) GtGMKsVTGTPYWMS T522
MEKK2 (rat) GTGMKSVTGTPYWMS T522
T524
GMKsVTGTPYWMSPE
1 1
MEKK2 (human) GMKsVtGtPYWMSPE T524-p
MEKK2 (mouse) GMKsVTGTPYWMSPE T524
MEKK2 (rat) GMKSVTGTPYWMSPE T524
K581
ATQPTNPKLPPHVSD
0 1
MEKK2 (human) ATQPTNPkLPPHVSD K581-ub
MEKK2 (mouse) ATQPTNPKLPPHVSD K581
MEKK2 (rat) ATQPTNPKLPPHVSD K581
K602-ub
KRIFVEAkLRPSAEE
0 6
MEKK2 (human) KRIFVEAkLRPSADE K602-ub
MEKK2 (mouse) KRIFVEAkLRPSAEE K602-ub
MEKK2 (rat) KRIFVEAKLRPSAEE K602