Other Species / Isoforms
  PFKFB3 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K12-ub
LTQSRVQkIWVPVDH
0 1
PFKFB3 (human) LTQSRVQkIWVPVDH K12-ub
PFKFB3 iso4 (human) gap -
PFKFB3 (mouse) LTQSRVQKIWVPVDH K12
PFKFB3 (rat) LTQSRVQKIWVPVDH K12
S22-p
VPVDHRPsLPRSCGP
Upstream
0 3
Treatment
  • ischemia
PFKFB3 (human) VPVDHRPsLPRSCGP S22-p
PFKFB3 iso4 (human) gap -
PFKFB3 (mouse) VPVDHRPsLPRSCGP S22-p
PFKFB3 (rat) VPVDHRPSLPRSCGP S22
K97-ub
PDNEEAMkVRKQCAL
0 1
PFKFB3 (human) PDNEEAMkVRKQCAL K97-ub
PFKFB3 iso4 (human) PDNEEAMKVRKQCAL K111
PFKFB3 (mouse) PDNEEAMRVRKQCAL R97
PFKFB3 (rat) PDNEEAMRVRKQCAL R97
K111-ub
LAALRDVkSYLAkEG
0 8
PFKFB3 (human) LAALRDVkSYLAkEG K111-ub
PFKFB3 iso4 (human) LAALRDVKSYLAKEG K125
PFKFB3 (mouse) LAALRDVKSYLTKEG K111
PFKFB3 (rat) LAALRDVKSYLTKEG K111
K116-ub
DVkSYLAkEGGQIAV
0 1
PFKFB3 (human) DVkSYLAkEGGQIAV K116-ub
PFKFB3 iso4 (human) DVKSYLAKEGGQIAV K130
PFKFB3 (mouse) DVKSYLTKEGGQIAV K116
PFKFB3 (rat) DVKSYLTKEGGQIAV K116
S172-p
IMEVKISsPDYkDCN
0 1
PFKFB3 (human) IMEVKISsPDYkDCN S172-p
PFKFB3 iso4 (human) IMEVKISSPDYKDCN S186
PFKFB3 (mouse) IMEVKISSPDYKDCN S172
PFKFB3 (rat) IMEVKISSPDYKDCN S172
K176-ub
KISsPDYkDCNSAEA
0 1
PFKFB3 (human) KISsPDYkDCNSAEA K176-ub
PFKFB3 iso4 (human) KISSPDYKDCNSAEA K190
PFKFB3 (mouse) KISSPDYKDCNSAEA K176
PFKFB3 (rat) KISSPDYKDCNSAEA K176
K189-ub
EAMDDFMkRISCyEA
0 1
PFKFB3 (human) EAMDDFMkRISCyEA K189-ub
PFKFB3 iso4 (human) EAMDDFMKRISCYEA K203
PFKFB3 (mouse) EAMDDFMKRINCyEA K189
PFKFB3 (rat) EAMDDFMKRINCYEA K189
Y194-p
FMkRISCyEASYQPL
0 6
PFKFB3 (human) FMkRISCyEASYQPL Y194-p
PFKFB3 iso4 (human) FMKRISCYEASYQPL Y208
PFKFB3 (mouse) FMKRINCyEASYQPL Y194-p
PFKFB3 (rat) FMKRINCYEASYQPL Y194
K205-ub
YQPLDPDkCDRDLSL
0 1
PFKFB3 (human) YQPLDPDkCDRDLSL K205-ub
PFKFB3 iso4 (human) YQPLDPDKCDRDLSL K219
PFKFB3 (mouse) YQPLDPDKCDRDLSL K205
PFKFB3 (rat) YQPLDPDKCDRDLSF K205
K214-ub
DRDLSLIkVIDVGRR
0 2
PFKFB3 (human) DRDLSLIkVIDVGRR K214-ub
PFKFB3 iso4 (human) DRDLSLIKVIDVGRR K228
PFKFB3 (mouse) DRDLSLIKVIDVGRR K214
PFKFB3 (rat) DRDLSFIKVIDVGRR K214
S269-p
QGRIGGDsGLSsRGK
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
  • protein degradation
Kinase, in vitro:
  • IKKB (human)
Putative in vivo kinases:
  • IKKB (human)
PFKFB3 (human) QGRIGGDsGLSsRGK S269-p
PFKFB3 iso4 (human) QGRIGGDSGLSSRGK S283
PFKFB3 (mouse) QGKIGGDSSLSSRGK S269
PFKFB3 (rat) QGKIGGDSGLSSRGK S269
S273-p
GGDsGLSsRGKkFAS
0 2
PFKFB3 (human) GGDsGLSsRGKkFAS S273-p
PFKFB3 iso4 (human) GGDSGLSSRGKKFAS S287
PFKFB3 (mouse) GGDSSLSSRGKKFAN S273
PFKFB3 (rat) GGDSGLSSRGKKFAN S273
K277-ub
GLSsRGKkFASALsk
0 2
PFKFB3 (human) GLSsRGKkFASALsk K277-ub
PFKFB3 iso4 (human) GLSSRGKKFASALSK K291
PFKFB3 (mouse) SLSSRGKKFANALSK K277
PFKFB3 (rat) GLSSRGKKFANALSK K277
S283-p
KkFASALskFVEEQN
0 1
PFKFB3 (human) KkFASALskFVEEQN S283-p
PFKFB3 iso4 (human) KKFASALSKFVEEQN S297
PFKFB3 (mouse) KKFANALSKFVEEQN S283
PFKFB3 (rat) KKFANALSKFVEEQN S283
K284-ub
kFASALskFVEEQNL
0 1
PFKFB3 (human) kFASALskFVEEQNL K284-ub
PFKFB3 iso4 (human) KFASALSKFVEEQNL K298
PFKFB3 (mouse) KFANALSKFVEEQNL K284
PFKFB3 (rat) KFANALSKFVEEQNL K284
K292-ub
FVEEQNLkDLRVWTS
0 7
PFKFB3 (human) FVEEQNLkDLRVWTS K292-ub
PFKFB3 iso4 (human) FVEEQNLKDLRVWTS K306
PFKFB3 (mouse) FVEEQNLkDLRVWTS K292-ub
PFKFB3 (rat) FVEEQNLKDLRVWTS K292
K302-ub
RVWTSQLkSTIQTAE
0 37
PFKFB3 (human) RVWTSQLkSTIQTAE K302-ub
PFKFB3 iso4 (human) RVWTSQLKSTIQTAE K316
PFKFB3 (mouse) RVWTSQLkSTIQTAE K302-ub
PFKFB3 (rat) RVWTSQLKSTIQTAE K302
K319-ub
RLPYEQWkALNEIDA
0 1
PFKFB3 (human) RLPYEQWkALNEIDA K319-ub
PFKFB3 iso4 (human) RLPYEQWKALNEIDA K333
PFKFB3 (mouse) RLPYEQWKALNEIDA K319
PFKFB3 (rat) RLPYEQWKALNEIDA K319
K352-ub
YALREQDkYYYRYPT
0 1
PFKFB3 (human) YALREQDkYYYRYPT K352-ub
PFKFB3 iso4 (human) YALREQDKYYYRYPT K366
PFKFB3 (mouse) YALREQDKYYYRYPT K352
PFKFB3 (rat) YALREQDKYYYRYPT K352
Y363-p
RYPTGESyQDLVQRL
0 1
PFKFB3 (human) RYPTGESyQDLVQRL Y363-p
PFKFB3 iso4 (human) RYPTGESYQDLVQRL Y377
PFKFB3 (mouse) RYPTGESYQDLVQRL Y363
PFKFB3 (rat) RYPTGESYQDLVQRL Y363
K411-ub
AEEMPYLkCPLHTVL
0 1
PFKFB3 (human) AEEMPYLkCPLHTVL K411-ub
PFKFB3 iso4 (human) AEEMPYLKCPLHTVL K425
PFKFB3 (mouse) AEEMPYLKCPLHTVL K411
PFKFB3 (rat) AEEMPYLKCPLHTVL K411
S461-p
NPLMRRNsVtPLAsP
Upstream
Downstream
9 128
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • Akt1 (human)
  • AMPKA1 (human)
  • AMPKA1 (rat)
  • MAPKAPK2 (human)
  • PKACA (human)
  • PKCA (human)
Putative in vivo kinases:
  • Akt1 (human)
  • AMPKA1 (human)
  • MAPKAPK2 (human)
Treatment
  • 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
  • Akt_inhibitor_VIII
  • angiotensin_2
  • anisomycin
  • antagomir
  • dasatinib
  • GSK2334470
  • hypertonic_buffer
  • hypoxia
  • LY294002
  • oligomycin
  • PD98059
  • PF3644022
  • PFK-015
  • PFK158
  • SB203580
  • selumetinib
  • serum
  • SII_angiotensin_2
  • torin_2
  • vemurafenib
PFKFB3 (human) NPLMRRNsVtPLAsP S461-p
PFKFB3 iso4 (human) NPLMRRNSVTPLASP S475
PFKFB3 (mouse) NPLMRRNsVtPLAsP S461-p
PFKFB3 (rat) NPLMRRNsVTPLASP S490-p
T463-p
LMRRNsVtPLAsPEP
Upstream
Downstream
1 18
Effects on Biological Processes:
  • cell growth, induced
Putative in vivo kinases:
  • CDK6 (human)
Treatment
  • angiotensin_2
  • SII_angiotensin_2
PFKFB3 (human) LMRRNsVtPLAsPEP T463-p
PFKFB3 iso4 (human) LMRRNSVTPLASPEP T477
PFKFB3 (mouse) LMRRNsVtPLAsPEP T463-p
PFKFB3 (rat) LMRRNsVTPLASPEP T492
S467-p
NsVtPLAsPEPtKKP
Upstream
Downstream
2 56
Effects on Biological Processes:
  • cell growth, induced
Putative in vivo kinases:
  • CDK6 (human)
Treatment
  • angiotensin_2
  • SII_angiotensin_2
PFKFB3 (human) NsVtPLAsPEPtKKP S467-p
PFKFB3 iso4 (human) NSVTPLASPEPTKKP S481
PFKFB3 (mouse) NsVtPLAsPEPTKKP S467-p
PFKFB3 (rat) NsVTPLASPEPTKKP S496
T471-p
PLAsPEPtKKPRINs
0 2
PFKFB3 (human) PLAsPEPtKKPRINs T471-p
PFKFB3 iso4 (human) PLASPEPTKKPRINS T485
PFKFB3 (mouse) PLAsPEPTKKPRINs T471
PFKFB3 (rat) PLASPEPTKKPRINS T500
S478-p
tKKPRINsFEEHVAS
Upstream
Downstream
2 11
Effects on Modified Protein
  • enzymatic activity, induced
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
Kinase, in vitro:
  • Pim2 (human)
Putative in vivo kinases:
  • Pim2 (human)
Treatment
  • anisomycin
  • siRNA
PFKFB3 (human) tKKPRINsFEEHVAS S478-p
PFKFB3 iso4 (human) TKKPRINSFEEHVAS S492
PFKFB3 (mouse) TKKPRINsFEERVAs S478-p
PFKFB3 (rat) TKKPRINSFEEHVAS S507
S485
sFEEHVASTSAALPS
0 1
PFKFB3 (human) sFEEHVASTSAALPS S485
PFKFB3 iso4 (human) SFEEHVASTSAALPS S499
PFKFB3 (mouse) sFEERVAstsAALPS S485-p
PFKFB3 (rat) SFEEHVASTSAALPS S514
T486
FEEHVASTSAALPSC
0 1
PFKFB3 (human) FEEHVASTSAALPSC T486
PFKFB3 iso4 (human) FEEHVASTSAALPSC T500
PFKFB3 (mouse) FEERVAstsAALPSC T486-p
PFKFB3 (rat) FEEHVASTSAALPSC T515
S487
EEHVASTSAALPSCL
0 1
PFKFB3 (human) EEHVASTSAALPSCL S487
PFKFB3 iso4 (human) EEHVASTSAALPSCL S501
PFKFB3 (mouse) EERVAstsAALPSCL S487-p
PFKFB3 (rat) EEHVASTSAALPSCL S516
S510
PGQNMKGSRSSADSS
0 1
PFKFB3 (human) PGQNMKGSRSSADSS S510
PFKFB3 iso4 (human) PGQNMKGSRSSADSS S524
PFKFB3 (mouse) PGQNMKSsRsGADss S510-p
PFKFB3 (rat) gap -
S512
QNMKGSRSSADSSRK
0 1
PFKFB3 (human) QNMKGSRSSADSSRK S512
PFKFB3 iso4 (human) QNMKGSRSSADSSRK S526
PFKFB3 (mouse) QNMKSsRsGADssQK S512-p
PFKFB3 (rat) LGKACLRTVCHIFSK T544
S516
GSRSSADSSRKH___
0 1
PFKFB3 (human) GSRSSADSSRKH___ S516
PFKFB3 iso4 (human) GSRSSADSSRKH___ S530
PFKFB3 (mouse) SsRsGADssQKH___ S516-p
PFKFB3 (rat) CLRTVCHIFSKFSPY I548
S517
SRSSADSSRKH____
0 1
PFKFB3 (human) SRSSADSSRKH____ S517
PFKFB3 iso4 (human) SRSSADSSRKH____ S531
PFKFB3 (mouse) sRsGADssQKH____ S517-p
PFKFB3 (rat) LRTVCHIFSKFSPY_ F549