Other Species / Isoforms
  p70S6K (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S40
DQPEDAGSEDELEEG
2 7
p70S6K (human) DQPEDAGsEDELEEG S40
p70S6K iso2 (human) DQPEDAGSEDELEEG S17
p70S6K (mouse) DQPEDAGSEDELEEG S40
p70S6K (rat) DQPEDAGsEDELEEG S40
p70S6K iso2 (rat) DQPEDAGsEDELEEG S17
p70S6K (fruit fly) IELDDVDLEPELCIN L40
S53
EGGQLNESMDHGGVG
1 0
p70S6K (human) EGGQLNEsMDHGGVG S53
p70S6K iso2 (human) EGGQLNESMDHGGVG S30
p70S6K (mouse) EGGQLNESMDHGGVG S53
p70S6K (rat) EGGQLNESMDHGGVG S53
p70S6K iso2 (rat) EGGQLNESMDHGGVG S30
p70S6K (fruit fly) PELCINLHQDTEGQE H49
Y62
DHGGVGPYELGMEHC
1 0
p70S6K (human) DHGGVGPYELGMEHC Y62
p70S6K iso2 (human) DHGGVGPYELGMEHC Y39
p70S6K (mouse) DHGGVGPYELGMEHC Y62
p70S6K (rat) DHGGVGPyELGMEHC Y62
p70S6K iso2 (rat) DHGGVGPYELGMEHC Y39
p70S6K (fruit fly) gap -
T140
NAKDTAHtKAERNIL
Upstream
0 1
Treatment
  • refeeding
p70S6K (human) NAKDTAHTKAERNIL T140
p70S6K iso2 (human) NAKDTAHTKAERNIL T117
p70S6K (mouse) NAKDTAHtKAERNIL T140
p70S6K (rat) NAKDTAHTKAERNIL T140
p70S6K iso2 (rat) NAKDTAHTKAERNIL T117
p70S6K (fruit fly) NQKDTAHTRAERNIL T126
S243
DFGLCKEsIHDGtVt
0 6
p70S6K (human) DFGLCKEsIHDGtVt S243
p70S6K iso2 (human) DFGLCKESIHDGTVT S220
p70S6K (mouse) DFGLCKEsIHDGtVt S243
p70S6K (rat) DFGLCKESIHDGTVT S243
p70S6K iso2 (rat) DFGLCKESIHDGTVT S220
p70S6K (fruit fly) DFGLCKEHIQEGIVT H229
T248
KEsIHDGtVtHtFCG
0 6
p70S6K (human) KEsIHDGtVtHtFCG T248
p70S6K iso2 (human) KESIHDGTVTHtFCG T225
p70S6K (mouse) KEsIHDGtVtHtFCG T248
p70S6K (rat) KESIHDGTVTHtFCG T248
p70S6K iso2 (rat) KESIHDGTVTHTFCG T225
p70S6K (fruit fly) KEHIQEGIVTHTFCG I234
T250
sIHDGtVtHtFCGtI
0 12
p70S6K (human) sIHDGtVtHtFCGtI T250
p70S6K iso2 (human) SIHDGTVTHtFCGTI T227
p70S6K (mouse) sIHDGtVtHtFCGtI T250
p70S6K (rat) SIHDGTVTHtFCGTI T250
p70S6K iso2 (rat) SIHDGTVTHTFCGTI T227
p70S6K (fruit fly) HIQEGIVTHTFCGTI T236
T252
HDGtVtHtFCGtIEY
Upstream
35 19
Regulatory protein:
  • mTOR (mouse)
  • PDK1 (human)
  • PDK1 (mouse)
  • RICTOR (mouse)
view more >
Treatment
  • insulin
  • LPS
  • meal feeding
  • rapamycin
  • troglitazone
  • wortmannin
view more >
p70S6K (human) HDGtVtHtFCGtIEY T252
p70S6K iso2 (human) HDGTVTHtFCGTIEY T229
p70S6K (mouse) HDGtVtHtFCGtIEY T252
p70S6K (rat) HDGTVTHtFCGTIEY T252
p70S6K iso2 (rat) HDGTVTHTFCGTIEY T229
p70S6K (fruit fly) QEGIVTHTFCGTIEY T238
T256
VtHtFCGtIEYMAPE
0 6
p70S6K (human) VtHtFCGtIEYMAPE T256
p70S6K iso2 (human) VTHtFCGTIEYMAPE T233
p70S6K (mouse) VtHtFCGtIEYMAPE T256
p70S6K (rat) VTHtFCGTIEYMAPE T256
p70S6K iso2 (rat) VTHTFCGTIEYMAPE T233
p70S6K (fruit fly) VTHTFCGTIEYMAPE T242
T390
DSKFTRQtPVDsPDD
Upstream
3 14
Treatment
  • cisplatin
  • etoposide
  • insulin
  • topotecan
view more >
p70S6K (human) DSKFTRQtPVDsPDD T390
p70S6K iso2 (human) DSKFTRQTPVDsPDD T367
p70S6K (mouse) DSKFTRQtPVDsPDD T390
p70S6K (rat) DSKFTRQTPVDsPDD T390
p70S6K iso2 (rat) DSKFTRQTPVDSPDD T367
p70S6K (fruit fly) DTRFTRQIPVDSPDD I376
S394
TRQtPVDsPDDSTLS
Upstream
18 15
p70S6K (human)
S394
p70S6K (mouse)
S394
p70S6K (rat)
S394
Regulatory protein:
  • AMPKA1 (mouse)
  • Cas-L (human)
  • FOXO1A (human)
  • FOXO1A (mouse)
  • FOXO3A (human)
  • FOXO3A (mouse)
  • PDK1 (human)
  • RICTOR (mouse)
  • SESN3 (human)
  • STAT4 (mouse)
view more >
Treatment
  • 4-HT
  • acadesine
  • antigenic stimulation
  • B7
  • fructose
  • glucose
  • H2O2
  • IL-12
  • insulin
  • LY294002
  • rapamycin
  • serum
view more >
p70S6K (human) TRQtPVDsPDDStLS S394
p70S6K iso2 (human) TRQTPVDsPDDSTLS S371
p70S6K (mouse) TRQtPVDsPDDSTLS S394
p70S6K (rat) TRQTPVDsPDDSTLS S394
p70S6K iso2 (rat) TRQTPVDSPDDSTLS S371
p70S6K (fruit fly) TRQIPVDSPDDTTLS S380
T399
VDsPDDSTLSESANQ
0 1
p70S6K (human) VDsPDDStLSEsANQ T399
p70S6K iso2 (human) VDsPDDSTLSESANQ T376
p70S6K (mouse) VDsPDDSTLSESANQ T399
p70S6K (rat) VDsPDDSTLSESANQ T399
p70S6K iso2 (rat) VDSPDDSTLSESANQ T376
p70S6K (fruit fly) VDSPDDTTLSESANL T385
S403
DDSTLSESANQVFLG
1 2
p70S6K (human) DDStLSEsANQVFLG S403
p70S6K iso2 (human) DDSTLSESANQVFLG S380
p70S6K (mouse) DDSTLSESANQVFLG S403
p70S6K (rat) DDSTLSESANQVFLG S403
p70S6K iso2 (rat) DDSTLSESANQVFLG S380
p70S6K (fruit fly) DDTTLSESANLIFQG S389
T412
NQVFLGFtYVAPSVL
Upstream
Downstream
512 12
p70S6K (human)
T412
p70S6K iso2 (human)
T389
p70S6K (mouse)
T412
p70S6K (rat)
T412
p70S6K iso2 (rat)
T389
p70S6K (fruit fly)
T398
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • signaling pathway regulation
  • translation, induced
Kinase, in vitro:
  • mTOR (human)
Putative in vivo kinases:
  • mTOR (human)
  • PIK3C2A (human)
Regulatory protein:
  • 4E-BP1 (mouse)
  • ADRB3 (human)
  • Akt1 (human)
  • Akt1 (mouse)
  • ALDOB (human)
  • AML3 (mouse)
  • AMPKA1 (human)
  • AMPKA1 (mouse)
  • AMPKA2 (mouse)
  • AMPKB1 (mouse)
  • ASB2 (mouse)
  • Bcl-xL (human)
  • CDK1 (mouse)
  • CPT2 (mouse)
  • DEDD (mouse)
  • DEPDC5 (human)
  • DKK1 (human)
  • DNAPK (mouse)
  • Ezrin (mouse)
  • FAK (human)
  • FKBP12 (mouse)
  • FLCN (human)
  • FNIP1 (human)
  • FOXO1A (mouse)
  • Fyn (mouse)
  • GLUT1 (mouse)
  • GRB10 (human)
  • GRN (mouse)
  • HBP1 (human)
  • HRas (human)
  • IFITM3 (human)
  • IFITM3 (rat)
  • IGF2BP2 (mouse)
  • IKKB (human)
  • IRS1 (human)
  • K17 (mouse)
  • KRas (mouse)
  • LAMTOR1 (mouse)
  • LAMTOR2 (mouse)
  • LKB1 (human)
  • LKB1 (mouse)
  • LST8 (mouse)
  • mAChR M3 (human)
  • MAPKAPK5 (mouse)
  • MFGE8 (human)
  • MKK6 (human)
  • Mnk1 (mouse)
  • Mnk2 (mouse)
  • MTHFD2 (human)
  • mTOR (human)
  • mTOR (mouse)
  • P2X7 (mouse)
  • P38A (mouse)
  • P38B (human)
  • P38B (mouse)
  • p53 (mouse)
  • p70S6K (human)
  • PCTP (human)
  • PDK1 (mouse)
  • PIK3CA (human)
  • PIK3R1 (human)
  • PIP4K2C (mouse)
  • PKAR1A (human)
  • PKCI (mouse)
  • PKM iso2 (human)
  • PRAS40 iso3 (human)
  • PSEN1 (mouse)
  • PTEN (mouse)
  • PTGER3 (mouse)
  • Raptor (human)
  • Raptor (mouse)
  • Rb (mouse)
  • RHEB (human)
  • RHEB (mouse)
  • RICTOR (human)
  • RICTOR (mouse)
  • ROCK1 (mouse)
  • RRAGA (human)
  • RRAGB (human)
  • RRAGC (human)
  • RRAGC (mouse)
  • RRAGD (human)
  • SESN1 (human)
  • SESN1 (mouse)
  • SESN2 (human)
  • SESN2 (mouse)
  • SGK1 (human)
  • Sin1 (human)
  • Sin1 (mouse)
  • syndecan-4 (mouse)
  • TBC1D1 (mouse)
  • TBK1 (human)
  • THEM2 (human)
  • TSC1 (human)
  • TSC1 (mouse)
  • TSC2 (human)
  • TSC2 (mouse)
  • UBXN2A (human)
  • ULK1 (mouse)
  • USP1 (human)
  • VEGF iso1 (human)
  • Vimentin (human)
view more >
Treatment
  • 1-MT
  • 15d-PGJ2
  • 2-deoxyglucose
  • 991
  • acadesine
  • actinomycin_D
  • adiponectin
  • adriamycin
  • AMDE-1
  • amino_acid_starvation
  • amino_acids
  • anisomycin
  • antibody
  • arsenite
  • AS252424
  • ATP
  • BAPTA-AM
  • butaprost
  • butyrate
  • BX795
  • calorie_restriction
  • calyculin_A
  • cannabidiol
  • carboplatin
  • catalase
  • CC260
  • cell_detachment
  • CNO
  • compound_C
  • culturing_of_cells
  • cycloheximide
  • dexamethasone
  • eccentric contractions
  • EGF
  • exercise
  • extract
  • fasting
  • formate
  • fructose
  • glucose
  • glucose_starvation
  • H2O2
  • hepatitis C virus expression
  • high-fat diet
  • hypoxia
  • IBMX
  • IC87114
  • IDO5L
  • IFN-gamma
  • IGF-1
  • IL-11
  • IL-2
  • IL-3
  • IL-4
  • imatinib
  • insulin
  • ionomycin
  • ipatasertib
  • ischemia/reperfusion
  • JAK_inhibitor_I
  • kainic_acid
  • KU-0063794
  • L-744,832
  • L-glutamine_withdrawal
  • leptin
  • leucine
  • lithium
  • LPS
  • LY294002
  • meal feeding
  • metformin
  • miRNA
  • MPP+
  • myocardial infarction
  • NAC
  • NADPH
  • NBD_peptide
  • nitric_oxide
  • NKH_477
  • norepinephrine
  • NP68
  • okadaic_acid
  • orexin
  • ouabain
  • palbociclib
  • palmitate
  • PD184352
  • PD98059
  • PDGF
  • PGE2
  • PGRN
  • phorbol_ester
  • PI-103
  • PIF
  • PIK90
  • pilocarpine
  • PP242
  • pressure
  • PTX
  • RAD001
  • rapamycin
  • refeeding
  • resatorvid
  • retinoic_acid
  • S961
  • SB202190
  • SB203580
  • SC-514
  • SC-79
  • serum
  • serum_starvation
  • serum_withdrawal
  • siRNA
  • SOD
  • sulprostone
  • TAC
  • tamoxifen
  • TGF-beta
  • thapsigargin
  • threat conditioning
  • TNF
  • Torin1
  • troglitazone
  • U0126
  • UV
  • Wnt
  • Wnt10b
  • Wnt3a
  • wortmannin
view more >
p70S6K (human) NQVFLGFtyVAPsVL T412
p70S6K iso2 (human) NQVFLGFtYVAPSVL T389
p70S6K (mouse) NQVFLGFtYVAPSVL T412
p70S6K (rat) NQVFLGFtYVAPSVL T412
p70S6K iso2 (rat) NQVFLGFtYVAPSVL T389
p70S6K (fruit fly) NLIFQGFTYVAPSIL T398
Y413
QVFLGFtYVAPSVLE
0 2
p70S6K (human) QVFLGFtyVAPsVLE Y413
p70S6K iso2 (human) QVFLGFtYVAPSVLE Y390
p70S6K (mouse) QVFLGFtYVAPSVLE Y413
p70S6K (rat) QVFLGFtYVAPSVLE Y413
p70S6K iso2 (rat) QVFLGFtYVAPSVLE Y390
p70S6K (fruit fly) LIFQGFTYVAPSILE Y399
S417
GFtYVAPSVLESVKE
0 1
p70S6K (human) GFtyVAPsVLEsVKE S417
p70S6K iso2 (human) GFtYVAPSVLESVKE S394
p70S6K (mouse) GFtYVAPSVLESVKE S417
p70S6K (rat) GFtYVAPSVLESVKE S417
p70S6K iso2 (rat) GFtYVAPSVLESVKE S394
p70S6K (fruit fly) GFTYVAPSILEDMHR S403
S421
VAPSVLESVKEKFsF
0 2
p70S6K (human) VAPsVLEsVKEKFsF S421
p70S6K iso2 (human) VAPSVLESVKEKFSF S398
p70S6K (mouse) VAPSVLESVKEKFsF S421
p70S6K (rat) VAPSVLESVKEKFSF S421
p70S6K iso2 (rat) VAPSVLESVKEKFSF S398
p70S6K (fruit fly) VAPSILEDMHRANRM D407
S427
ESVKEKFsFEPKIRs
Upstream
5 13
Treatment
  • GSK2334470
  • insulin
  • LY294002
  • MK-2206
  • Torin1
view more >
p70S6K (human) EsVKEKFsFEPKIRs S427
p70S6K iso2 (human) ESVKEKFSFEPKIRs S404
p70S6K (mouse) ESVKEKFsFEPKIRs S427
p70S6K (rat) ESVKEKFSFEPKIRs S427
p70S6K iso2 (rat) ESVKEKFSFEPKIRS S404
p70S6K (fruit fly) ILEDMHRANRMPARS A411
S434
sFEPKIRsPRRFIGs
Upstream
Downstream
29 1
Effects on Modified Protein
  • molecular association, regulation
Regulatory protein:
  • DEDD (mouse)
  • ULK1 (mouse)
Treatment
  • IGF-1
  • rapamycin
p70S6K (human) sFEPKIRsPRRFIGs S434
p70S6K iso2 (human) SFEPKIRsPRRFIGs S411
p70S6K (mouse) sFEPKIRsPRRFIGs S434
p70S6K (rat) SFEPKIRsPRRFIGs S434
p70S6K iso2 (rat) SFEPKIRSPRRFIGS S411
p70S6K (fruit fly) ANRMPARSPRRTPRQ S418
S441
sPRRFIGsPRtPVsP
Upstream
11 118
Regulatory protein:
  • FLT3 (mouse)
Treatment
  • insulin
  • LPS
  • LY294002
  • MK-2206
  • rapamycin
  • troglitazone
view more >
p70S6K (human) sPRRFIGsPRtPVsP S441
p70S6K iso2 (human) sPRRFIGsPRtPVsP S418
p70S6K (mouse) sPRRFIGsPRtPVsP S441
p70S6K (rat) sPRRFIGsPRtPVsP S441
p70S6K iso2 (rat) SPRRFIGSPRtPVsP S418
p70S6K (fruit fly) PARSPRRTPRQLPDS T422
T444
RFIGsPRtPVsPVKF
Upstream
Downstream
111 142
p70S6K (human)
T444
p70S6K (mouse)
T444
p70S6K (rat)
T444
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell differentiation, altered
Regulatory protein:
  • CD82 (mouse)
  • DEDD (mouse)
  • FKBP12 (mouse)
  • IFITM3 (human)
  • IFITM3 (rat)
  • IGF1 (mouse)
  • mTOR (mouse)
  • PKCI (mouse)
  • ULK1 (mouse)
view more >
Treatment
  • adriamycin
  • angiotensin_2
  • antibody
  • BAPTA-AM
  • benzo(a)pyrene
  • BI-D1870
  • calorie_restriction
  • catalase
  • formate
  • H2O2
  • IGF-1
  • IL-2
  • IL-7
  • insulin
  • LPS
  • LY294002
  • MK-2206
  • NAC
  • NADPH
  • NP68
  • NTCU
  • PD98059
  • pomegranate_wine
  • PP2
  • pressure
  • rapamycin
  • SB203580
  • SOD
  • Torin1
  • troglitazone
  • U0126
  • UV
  • wortmannin
view more >
p70S6K (human) RFIGsPRtPVsPVKF T444
p70S6K iso2 (human) RFIGsPRtPVsPVKF T421
p70S6K (mouse) RFIGsPRtPVsPVKF T444
p70S6K (rat) RFIGsPRtPVsPVKF T444
p70S6K iso2 (rat) RFIGSPRtPVsPVKF T421
p70S6K (fruit fly) gap -
S447
GsPRtPVsPVKFsPG
Upstream
Downstream
107 299
p70S6K (human)
S447
p70S6K (mouse)
S447
p70S6K (rat)
S447
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell differentiation, altered
Regulatory protein:
  • CD82 (mouse)
  • DEDD (mouse)
  • FKBP12 (mouse)
  • FLT3 (mouse)
  • IFITM3 (human)
  • IFITM3 (rat)
  • IGF1 (mouse)
  • mTOR (mouse)
  • PKCI (mouse)
  • ULK1 (mouse)
view more >
Treatment
  • adriamycin
  • angiotensin_2
  • antibody
  • BAPTA-AM
  • benzo(a)pyrene
  • BI-D1870
  • calorie_restriction
  • catalase
  • formate
  • H2O2
  • IGF-1
  • IL-2
  • IL-7
  • insulin
  • LPS
  • LY294002
  • NAC
  • NADPH
  • NP68
  • NTCU
  • PD98059
  • pomegranate_wine
  • PP2
  • pressure
  • rapamycin
  • SB203580
  • SOD
  • Torin1
  • U0126
  • UV
  • wortmannin
view more >
p70S6K (human) GsPRtPVsPVKFsPG S447
p70S6K iso2 (human) GsPRtPVsPVKFsPG S424
p70S6K (mouse) GsPRtPVsPVKFsPG S447
p70S6K (rat) GsPRtPVsPVKFsPG S447
p70S6K iso2 (rat) GSPRtPVsPVKFSPG S424
p70S6K (fruit fly) gap -
S452
PVsPVKFsPGDFWGR
Upstream
2 98
Treatment
  • insulin
  • LY294002
  • MK-2206
view more >
p70S6K (human) PVsPVKFsPGDFWGR S452
p70S6K iso2 (human) PVsPVKFsPGDFWGR S429
p70S6K (mouse) PVsPVKFsPGDFWGR S452
p70S6K (rat) PVsPVKFsPGDFWGR S452
p70S6K iso2 (rat) PVsPVKFSPGDFWGR S429
p70S6K (fruit fly) RRTPRQLPDSSFRLQ P427
S462
DFWGRGASASTANPQ
0 1
p70S6K (human) DFWGRGAsASTANPQ S462
p70S6K iso2 (human) DFWGRGASASTANPQ S439
p70S6K (mouse) DFWGRGASASTANPQ S462
p70S6K (rat) DFWGRGASASTANPQ S462
p70S6K iso2 (rat) DFWGRGASASTANPQ S439
p70S6K (fruit fly) SFRLQFPSANVGANA S437
T470
ASTANPQTPVEYPME
1 0
p70S6K (human) ASTANPQtPVEYPME T470
p70S6K iso2 (human) ASTANPQTPVEYPME T447
p70S6K (mouse) ASTANPQTPVEYPME T470
p70S6K (rat) ASTANPQTPVEYPME T470
p70S6K iso2 (rat) ASTANPQTPVEYPME T447
p70S6K (fruit fly) gap -