Other Species / Isoforms
  WNK4 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S47-p
PRRVRRFsGKAEPRP
Upstream
1 3
Treatment
  • angiotensin_2
  • bisindolylmaleimide
  • colforsin
  • H-89
  • phorbol_ester
WNK4 (human) PRRARRFsGKAEPRP S47-p
WNK4 (mouse) PRRVRRFsGKAEPRP S47-p
WNK4 (rat) PRRVRRFSGKAEPRP S47
S64-p
SRPSRRSsVDLGLLS
Upstream
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, induced
Treatment
  • angiotensin_2
  • bisindolylmaleimide
  • colforsin
  • furosemide
  • H-89
  • high-salt diet
  • low-salt diet
  • phorbol_ester
WNK4 (human) SRLSRRSsVDLGLLS S64-p
WNK4 (mouse) SRPSRRSsVDLGLLS S64-p
WNK4 (rat) SRPSRRSSVDLGLLS S64
S95-p
DSAGPTRsPPSSSKE
0 3
WNK4 (human) AGPGPARsPPPSSKE S97-p
WNK4 (mouse) DSAGPTRsPPSSSKE S95-p
WNK4 (rat) DSAGPMRSPPSNSKE S95
C121
VKAVDSACPELTGSS
0 1
WNK4 (human) KAAEDSArPELPDSA R124-m1
WNK4 (mouse) VKAVDSACPELTGSS C121
WNK4 (rat) VKAADSACPELTVSS C121
K154-ub
RRREQEEkEDTETQA
1 0
WNK4 (human) RRREQEEKEDMETQA K157
WNK4 (mouse) RRREQEEkEDTETQA K154-ub
WNK4 (rat) RRREQEEKEDTETQA K154
K172-ub
SPDGRYLkFDIEIGR
1 0
WNK4 (human) SPDGRYLKFDIEIGR K175
WNK4 (mouse) SPDGRYLkFDIEIGR K172-ub
WNK4 (rat) SPDGRYLKFDIEIGR K172
K183-ub
EIGRGSFkTVYRGLD
1 0
WNK4 (human) EIGRGSFKTVYRGLD K186
WNK4 (mouse) EIGRGSFkTVYRGLD K183-ub
WNK4 (rat) EIGRGSFKTVYRGLD K183
S216
RAERQRFSEEVEMLk
0 1
WNK4 (human) RAERQRFsEEVEMLk S219-p
WNK4 (mouse) RAERQRFSEEVEMLk S216
WNK4 (rat) RAERQRFSEEVEMLK S216
K223
SEEVEMLKGLQHPNI
0 1
WNK4 (human) sEEVEMLkGLQHPNI K226-m1
WNK4 (mouse) SEEVEMLKGLQHPNI K223
WNK4 (rat) SEEVEMLKGLQHPNI K223
K223-ub
SEEVEMLkGLQHPNI
1 0
WNK4 (human) sEEVEMLKGLQHPNI K226
WNK4 (mouse) SEEVEMLkGLQHPNI K223-ub
WNK4 (rat) SEEVEMLKGLQHPNI K223
S236
NIVRFYDSWkSVLRG
0 1
WNK4 (human) NIVRFYDsWKSVLRG S239-p
WNK4 (mouse) NIVRFYDSWkSVLRG S236
WNK4 (rat) NIVRFYDSWKSVLRG S236
K238-ub
VRFYDSWkSVLRGQV
1 0
WNK4 (human) VRFYDsWKSVLRGQV K241
WNK4 (mouse) VRFYDSWkSVLRGQV K238-ub
WNK4 (rat) VRFYDSWKSVLRGQV K238
S311-p
NVFITGPsGSVKIGD
0 1
WNK4 (human) NVFITGPTGSVKIGD T314
WNK4 (mouse) NVFITGPsGSVKIGD S311-p
WNK4 (rat) NVFITGPSGSVKIGD S311
K325-ub
DLGLATLkRAsFAKs
1 4
WNK4 (human) DLGLATLkRAsFAKs K328-ub
WNK4 (mouse) DLGLATLkRAsFAKs K325-ub
WNK4 (rat) DLGLATLKRASFAKs K325
S328-p
LATLkRAsFAKsVIG
Upstream
0 6
Treatment
  • LPA
WNK4 (human) LATLkRAsFAKsVIG S331-p
WNK4 (mouse) LATLkRAsFAKsVIG S328-p
WNK4 (rat) LATLKRASFAKsVIG S328
S332-p
kRAsFAKsVIGTPEF
Upstream
Downstream
4 14
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Putative upstream phosphatases:
  • PPP1CA (human)
Treatment
  • angiotensin_2
  • bisindolylmaleimide
  • colforsin
WNK4 (human) kRAsFAKsVIGTPEF S335-p
WNK4 (mouse) kRAsFAKsVIGTPEF S332-p
WNK4 (rat) KRASFAKsVIGTPEF S332-p
K384-ub
NAAQIYRkVTSGTkP
1 0
WNK4 (human) NAAQIYRKVTSGRKP K387
WNK4 (mouse) NAAQIYRkVTSGTkP K384-ub
WNK4 (rat) NAAQIYRKVTSGTKP K384
K390-ub
RkVTSGTkPNSFYkV
1 0
WNK4 (human) RKVTSGRKPNSFHKV K393
WNK4 (mouse) RkVTSGTkPNSFYkV K390-ub
WNK4 (rat) RKVTSGTKPNSFYKV K390
K396-ub
TkPNSFYkVKMPEVK
0 1
WNK4 (human) RKPNSFHKVKIPEVK K399
WNK4 (mouse) TkPNSFYkVKMPEVK K396-ub
WNK4 (rat) TKPNSFYKVKMPEVK K396
K447-ub
AEEDDGEkPGLkLWL
1 0
WNK4 (human) AEEDDGEKPGLKLWL K450
WNK4 (mouse) AEEDDGEkPGLkLWL K447-ub
WNK4 (rat) AEEDDGEKPGLKLWL K447
K451-ub
DGEkPGLkLWLRMED
1 0
WNK4 (human) DGEKPGLKLWLRMED K454
WNK4 (mouse) DGEkPGLkLWLRMED K451-ub
WNK4 (rat) DGEKPGLKLWLRMED K451
S572
SFLFRHASYSSTTSD
1 1
WNK4 (human) PFLFRHAsYSSTTSD S575-p
WNK4 (mouse) SFLFRHASYSSTTSD S572
WNK4 (rat) SFLFRHASYSSTTSD S572
K662-ub
QMRKNPVkTLRRRPR
1 0
WNK4 (human) QMRRPPGRNLRRRPR R666
WNK4 (mouse) QMRKNPVkTLRRRPR K662-ub
WNK4 (rat) QMRKNPVKTLRRRPR K662
T675
PRSRLRVTsVSDQSD
0 1
WNK4 (human) PRSRLRVtsVSDQND T679-p
WNK4 (mouse) PRSRLRVTsVSDQSD T675
WNK4 (rat) PRSRLRVTSVSDQSD T675
S676-p
RSRLRVTsVSDQSDR
Upstream
0 3
Treatment
  • insulin
  • LY294002
WNK4 (human) RSRLRVtsVSDQNDR S680-p
WNK4 (mouse) RSRLRVTsVSDQSDR S676-p
WNK4 (rat) RSRLRVTSVSDQSDR S676
S781-p
PNAEPQRsIsPEQRS
0 1
WNK4 (human) SNEELQSSTSLEHRS S789
WNK4 (mouse) PNAEPQRsIsPEQRS S781-p
WNK4 (rat) SDAELQRSISPEQRS S781
S783-p
AEPQRsIsPEQRSWA
0 6
WNK4 (human) EELQSSTSLEHRSWT S791
WNK4 (mouse) AEPQRsIsPEQRSWA S783-p
WNK4 (rat) AELQRSISPEQRSWA S783
K990-ub
APISEEGkPQLVGRF
1 0
WNK4 (human) APISEEGKPQLVGRF K1010
WNK4 (mouse) APISEEGkPQLVGRF K990-ub
WNK4 (rat) APISEEGKPQLVGRF K990
S1002
GRFQVTSSKEPAEPP
1 0
WNK4 (human) GRFQVTSskEPAEPL S1022-p
WNK4 (mouse) GRFQVTSSKEPAEPP S1002
WNK4 (rat) GRFQVTSSKEPAEPP S1002
K1003
RFQVTSSKEPAEPPL
1 0
WNK4 (human) RFQVTSskEPAEPLP K1023-ub
WNK4 (mouse) RFQVTSSKEPAEPPL K1003
WNK4 (rat) RFQVTSSKEPAEPPL K1003
S1014-p
EPPLQPAsPTLSRSL
0 7
WNK4 (human) PLPLQPTSPTLSGSP S1035
WNK4 (mouse) EPPLQPAsPTLSRSL S1014-p
WNK4 (rat) EPPLQPAsPTLsRSL S1014-p
S1018
QPAsPTLSRSLKLPS
0 1
WNK4 (human) QPTSPTLSGSPKPST S1039
WNK4 (mouse) QPAsPTLSRSLKLPS S1018
WNK4 (rat) QPAsPTLsRSLKLPT S1018-p
S1052-p
TREALAEsDRAAEGL
Upstream
0 1
Treatment
  • insulin
WNK4 (human) TREALAESDRAAEGL S1073
WNK4 (mouse) TREALAEsDRAAEGL S1052-p
WNK4 (rat) TREALAESDRAAEGL S1052
Y1092
PSPVWMNYSYSSLCL
1 1
WNK4 (human) PSPVWMNySySSLCL Y1113-p
WNK4 (mouse) PSPVWMNYSYSSLCL Y1092
WNK4 (rat) PSPVWMNYSYSSLCL Y1092
Y1094
PVWMNYSYSSLCLSS
1 1
WNK4 (human) PVWMNySySSLCLSS Y1115-p
WNK4 (mouse) PVWMNYSYSSLCLSS Y1094
WNK4 (rat) PVWMNYSYSSLCLSS Y1094
K1123-ub
ELQNLRQkHLSEVEA
1 0
WNK4 (human) ELQSLRQKHLSEVEt K1144
WNK4 (mouse) ELQNLRQkHLSEVEA K1123-ub
WNK4 (rat) ELQNLRQKHLSEVEA K1123
A1130
kHLSEVEALQTLQkk
0 1
WNK4 (human) KHLSEVEtLQtLQKK T1151-p
WNK4 (mouse) kHLSEVEALQTLQkk A1130
WNK4 (rat) KHLSEVEALQTLQKK A1130
T1133
SEVEALQTLQkkEIE
0 1
WNK4 (human) SEVEtLQtLQKKEIE T1154-p
WNK4 (mouse) SEVEALQTLQkkEIE T1133
WNK4 (rat) SEVEALQTLQKKEIE T1133
K1136-ub
EALQTLQkkEIEDLY
1 0
WNK4 (human) EtLQtLQKKEIEDLy K1157
WNK4 (mouse) EALQTLQkkEIEDLY K1136-ub
WNK4 (rat) EALQTLQKKEIEDLY K1136
K1137-ub
ALQTLQkkEIEDLYS
1 0
WNK4 (human) tLQtLQKKEIEDLyS K1158
WNK4 (mouse) ALQTLQkkEIEDLYS K1137-ub
WNK4 (rat) ALQTLQKKEIEDLYS K1137
Y1143
kkEIEDLYSRLGKQP
1 1
WNK4 (human) KKEIEDLySRLGKQP Y1164-p
WNK4 (mouse) kkEIEDLYSRLGKQP Y1143
WNK4 (rat) KKEIEDLYSRLGKQP Y1143
S1169-p
SCRQRRLsKGsFPTS
Upstream
Downstream
6 4
Effects on Modified Protein
  • activity, inhibited
Kinase, in vitro:
  • SGK1 (human)
Putative in vivo kinases:
  • SGK1 (human)
Treatment
  • angiotensin_2
  • bisindolylmaleimide
  • colforsin
  • H-89
  • insulin
  • MK-2206
  • phorbol_ester
WNK4 (human) SSRQRRLsKGSFPTS S1190-p
WNK4 (mouse) SCRQRRLsKGsFPTS S1169-p
WNK4 (rat) SCRQRRLSKGSFPTS S1169
S1172-p
QRRLsKGsFPTSRRN
Upstream
0 3
Treatment
  • insulin
  • MK-2206
WNK4 (human) QRRLsKGSFPTSRRN S1193
WNK4 (mouse) QRRLsKGsFPTSRRN S1172-p
WNK4 (rat) QRRLSKGSFPTSRRN S1172
S1180-p
FPTSRRNsLQRSDLP
Upstream
2 2
Treatment
  • angiotensin_2
  • bisindolylmaleimide
  • colforsin
  • H-89
  • phorbol_ester
WNK4 (human) FPTSRRNsLQRSEPP S1201-p
WNK4 (mouse) FPTSRRNsLQRSDLP S1180-p
WNK4 (rat) FPTSRRNSLQRSDLP S1180
S1196-p
PGIMRRNsLSGSSTG
Upstream
Downstream
5 20
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • SGK1 (human)
  • WNK4 (mouse)
Treatment
  • angiotensin_2
  • bisindolylmaleimide
  • colforsin
  • furosemide
  • H-89
  • high-salt diet
  • low-salt diet
  • phorbol_ester
WNK4 (human) PGIMRRNsLSGSStG S1217-p
WNK4 (mouse) PGIMRRNsLSGSSTG S1196-p
WNK4 (rat) PGIMRRNsLSGSSTG S1196-p
T1202
NsLSGSSTGSQEQRA
0 1
WNK4 (human) NsLSGSStGSQEQRA T1223-p
WNK4 (mouse) NsLSGSSTGSQEQRA T1202
WNK4 (rat) NsLSGSSTGSQEQRA T1202