Other Species / Isoforms
  IRF3 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S14-p
RILPWLVsQLDLGQL
0 2
IRF3 (human) RILPWLVsQLDLGQL S14-p
IRF3 (mouse) RILPWLVSQLDLGQL S14
IRF3 (rat) LILPWLVSQLDLGQL S14
K29-ub
EGVAWVNkSRTRFRI
0 1
IRF3 (human) EGVAWVNkSRTRFRI K29-ub
IRF3 (mouse) EGVAWLDESRTRFRI E29
IRF3 (rat) KGVAWLDESRTKFRI E29
K70-ub
AYVPGRDkPDLPtWk
1 2
IRF3 (human) AYVPGRDkPDLPtWk K70-ub
IRF3 (mouse) AYTPGKDKPDVSTWK K70
IRF3 (rat) AYTPGKDKPDLSTWK K70
K70-sm
AYVPGRDkPDLPtWk
1 0
IRF3 (human) AYVPGRDkPDLPtWk K70-sm
IRF3 (mouse) AYTPGKDKPDVSTWK K70
IRF3 (rat) AYTPGKDKPDLSTWK K70
T75-p
RDkPDLPtWkRNFRS
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • MST1 (human)
Putative in vivo kinases:
  • MST1 (human)
IRF3 (human) RDkPDLPtWkRNFRS T75-p
IRF3 (mouse) KDKPDVSTWKRNFRS T75
IRF3 (rat) KDKPDLSTWKRNFRS T75
K77-ub
kPDLPtWkRNFRSAL
Downstream
1 1
Effects on Modified Protein
  • ubiquitination
IRF3 (human) kPDLPtWkRNFRSAL K77-ub
IRF3 (mouse) KPDVSTWKRNFRSAL K77
IRF3 (rat) KPDLSTWKRNFRSAL K77
K87-ub
FRSALNRkEGLRLAE
1 0
IRF3 (human) FRSALNRkEGLRLAE K87-ub
IRF3 (mouse) FRSALNRkEVLRLAA K87-ub
IRF3 (rat) FRSALNRKEVLRLAE K87
K87-sm
FRSALNRkEGLRLAE
1 0
IRF3 (human) FRSALNRkEGLRLAE K87-sm
IRF3 (mouse) FRSALNRKEVLRLAA K87
IRF3 (rat) FRSALNRKEVLRLAE K87
S97-p
LRLAEDRsKDPHDPH
2 1
IRF3 (human) LRLAEDRsKDPHDPH S97-p
IRF3 (mouse) LRLAADNsKDPYDPH S97-p
IRF3 (rat) LRLAEDRSKDPFDPH S97
K105
KDPHDPHKIYEFVNS
0 1
IRF3 (human) KDPHDPHKIYEFVNS K105
IRF3 (mouse) KDPYDPHkVyEFVTP K105-ac
IRF3 (rat) KDPFDPHKVYEFVTP K105
Y107
PHDPHKIYEFVNSGV
0 1
IRF3 (human) PHDPHKIYEFVNSGV Y107
IRF3 (mouse) PYDPHkVyEFVTPGA Y107-p
IRF3 (rat) PFDPHKVYEFVTPGG Y107
T122
GDFSQPDTsPDTNGG
0 1
IRF3 (human) GDFSQPDTsPDTNGG T122
IRF3 (mouse) RDFVHLGAsPDtNGK A122
IRF3 (rat) RDFVHLDtSPDTNGK T123-p
S123-p
DFSQPDTsPDTNGGG
Upstream
Downstream
2 11
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • GSK3A (human)
  • GSK3B (human)
Putative in vivo kinases:
  • Cot (human)
  • GSK3B (human)
Treatment
  • lithium
IRF3 (human) DFSQPDTsPDTNGGG S123-p
IRF3 (mouse) DFVHLGAsPDtNGKS S123-p
IRF3 (rat) DFVHLDtSPDTNGKS S124
T126
QPDTsPDTNGGGSTS
0 1
IRF3 (human) QPDTsPDTNGGGSTS T126
IRF3 (mouse) HLGAsPDtNGKSsLP T126-p
IRF3 (rat) HLDtSPDTNGKSSLS T127
S131
PDTNGGGSTSDtQED
0 4
IRF3 (human) PDTNGGGSTSDtQED S131
IRF3 (mouse) PDtNGKSsLPHsQEN S131-p
IRF3 (rat) PDTNGKSSLSDHQED S132
T135-p
GGGSTSDtQEDILDE
Upstream
Downstream
2 31
Effects on Modified Protein
  • intracellular localization
  • protein stabilization
Kinase, in vitro:
  • DNAPK (human)
Putative in vivo kinases:
  • DNAPK (human)
Treatment
  • dsDNA
  • virus infection
IRF3 (human) GGGSTSDtQEDILDE T135-p
IRF3 (mouse) GKSsLPHsQENLPKL S135-p
IRF3 (rat) GKSSLSDHQEDLLEL H136
P153
NMVLAPLPDPGPPSL
2 0
IRF3 (human) NMVLAPLPDPGPPSL P153
IRF3 (mouse) GLILGPLkDEGSSDL K152-sm
IRF3 (rat) HMALGPLPDEGSSDL P153
S173-p
PCPQPLRsPsLDNPt
Upstream
Downstream
5 8
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • transcription, altered
  • transcription, inhibited
Kinase, in vitro:
  • GSK3A (human)
  • GSK3B (human)
  • JNK1 (human)
  • TBK1 (human)
Putative in vivo kinases:
  • Cot (human)
  • GSK3B (human)
  • JNK1 (human)
  • MEKK2 (human)
Regulatory protein:
  • TAK1 (human)
Treatment
  • lithium
  • selumetinib
  • SP600125
  • vemurafenib
IRF3 (human) PCPQPLRsPsLDNPt S173-p
IRF3 (mouse) DPSQQLPsPNVNNFL S171-p
IRF3 (rat) DPSQPPLSPIVNNFP S172
S175-p
PQPLRsPsLDNPtPF
Upstream
Downstream
1 7
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • TBK1 (human)
Putative in vivo kinases:
  • Cot (human)
Treatment
  • metastatic potential
IRF3 (human) PQPLRsPsLDNPtPF S175-p
IRF3 (mouse) SQQLPsPNVNNFLNP N173
IRF3 (rat) SQPPLSPIVNNFPNP I174
T180-p
sPsLDNPtPFPNLGP
Upstream
Downstream
2 0
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • GSK3A (human)
  • GSK3B (human)
Putative in vivo kinases:
  • Cot (human)
  • GSK3B (human)
Treatment
  • lithium
IRF3 (human) sPsLDNPtPFPNLGP T180-p
IRF3 (mouse) gap -
IRF3 (rat) gap -
S188-p
PFPNLGPsENPLkRL
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Putative in vivo kinases:
  • Cot (human)
IRF3 (human) PFPNLGPsENPLkRL S188-p
IRF3 (mouse) NFLNPAPQENPLKQL Q183
IRF3 (rat) NFPNPAPQENPLRQL Q184
K193-ub
GPsENPLkRLLVPGE
Upstream
Downstream
1 4
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • apoptosis, induced
Regulatory protein:
  • DHX58 (human)
Treatment
  • siRNA
IRF3 (human) GPsENPLkRLLVPGE K193-ub
IRF3 (mouse) APQENPLKQLLAEEQ K188
IRF3 (rat) APQENPLRQLLAEEQ R189
T253-p
PDPGMSLtDRGVMsY
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • MST1 (human)
Putative in vivo kinases:
  • MST1 (human)
IRF3 (human) PDPGMSLtDRGVMsY T253-p
IRF3 (mouse) PDPEGFLTDKLVKEY T246
IRF3 (rat) PDPEEFLTDRLVREY T248
S259-p
LtDRGVMsYVRHVLS
Upstream
0 1
Regulatory protein:
  • PRP4 (human)
IRF3 (human) LtDRGVMsYVRHVLS S259-p
IRF3 (mouse) LTDKLVKEYVGQVLK E252
IRF3 (rat) LTDRLVREYVRQVLK E254
Y292-p
RLGHCHTyWAVSEEL
Upstream
Downstream
1 1
Effects on Modified Protein
  • activity, induced
Effects on Biological Processes:
  • transcription, induced
Putative in vivo kinases:
  • Abl (human)
  • Arg (human)
Treatment
  • nilotinib
IRF3 (human) RLGHCHTyWAVSEEL Y292-p
IRF3 (mouse) RLGHSHAFWALGEEL F285
IRF3 (rat) RLGHSHSFWALGEEL F287
K313-ub
GPDGEVPkDkEGGVF
Upstream
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • apoptosis, induced
Regulatory protein:
  • DHX58 (human)
Treatment
  • siRNA
IRF3 (human) GPDGEVPkDkEGGVF K313-ub
IRF3 (mouse) GPDGEVHKDKDGAVF K306
IRF3 (rat) GPDGEVPKDKNGVVF K308
K315-ub
DGEVPkDkEGGVFDL
Upstream
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • apoptosis, induced
Regulatory protein:
  • DHX58 (human)
Treatment
  • siRNA
IRF3 (human) DGEVPkDkEGGVFDL K315-ub
IRF3 (mouse) DGEVHKDKDGAVFDL K308
IRF3 (rat) DGEVPKDKNGVVFDL K310
S339-p
FTEGSGRsPRYALWF
Upstream
Downstream
3 1
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • transcription, altered
Regulatory protein:
  • IKKE (human)
  • TBK1 (human)
Treatment
  • LPS
  • Newcastle_disease_virus
  • poly(I-C)
  • siRNA
IRF3 (human) FTEGSGRsPRYALWF S339-p
IRF3 (mouse) FMEGSGHsPRYTLWF S332-p
IRF3 (rat) FMEGSRHSPRYTLWF S334
T370-p
VMVKVVPtCLRALVE
0 6
IRF3 (human) VMVKVVPtCLRALVE T370-p
IRF3 (mouse) VMVKVVPTCLkELLE T363
IRF3 (rat) VMVKVVPTCLKELLE T365
R373
KVVPtCLRALVEMAR
0 1
IRF3 (human) KVVPtCLRALVEMAR R373
IRF3 (mouse) KVVPTCLkELLEMAR K366-ub
IRF3 (rat) KVVPTCLKELLEMAR K368
S385-p
MARVGGAssLENtVD
Upstream
Downstream
9 2
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • TBK1 (human)
Putative in vivo kinases:
  • Akt3 (human)
Regulatory protein:
  • DHCR7 (human)
Treatment
  • 7-DHC
  • Newcastle_disease_virus
  • siRNA
  • virus infection
IRF3 (human) MARVGGAssLENtVD S385-p
IRF3 (mouse) MAREGGAssLKTVDL S378-p
IRF3 (rat) MAREGGASSLKTVDL S380
S386-p
ARVGGAssLENtVDL
Upstream
Downstream
13 6
IRF3 (human)
S386-p
IRF3 (mouse)
S379-p
IRF3 (rat)
S381-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • IKKE (human)
  • TBK1 (human)
Putative in vivo kinases:
  • IKKE (human)
  • TBK1 (human)
Regulatory protein:
  • ADAR (human)
  • DHCR7 (human)
  • IKKE (human)
  • MAVS (human)
  • MST1 (human)
  • ROBO3 (human)
  • TBK1 (human)
  • TICAM1 (human)
Treatment
  • AY9944
  • LPS
  • Newcastle_disease_virus
  • poly(I-C)
  • virus infection
IRF3 (human) ARVGGAssLENtVDL S386-p
IRF3 (mouse) AREGGAssLKTVDLH S379-p
IRF3 (rat) AREGGASSLKTVDLH S381
T390-p
GAssLENtVDLHIsN
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Treatment
  • virus infection
IRF3 (human) GAssLENtVDLHIsN T390-p
IRF3 (mouse) GGAssLKTVDLHIsN T382
IRF3 (rat) GGASSLKTVDLHISN T384
S396-p
NtVDLHIsNsHPLsL
Upstream
Downstream
44 4
IRF3 (human)
S396-p
IRF3 (mouse)
S388-p
IRF3 (rat)
S390-p
Effects on Modified Protein
  • activity, induced
  • activity, inhibited
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
  • protein degradation
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • IKKE (human)
  • TBK1 (human)
Putative in vivo kinases:
  • IKKB (human)
  • IKKE (human)
  • TBK1 (human)
Regulatory protein:
  • DDX3 (human)
  • DDX58 (human)
  • EGFR (human)
  • GSK3B (human)
  • IFI35 (human)
  • IKKE (human)
  • MAVS (human)
  • MST1 (human)
  • ROBO3 (human)
  • TBK1 (human)
  • TFG (human)
  • TICAM1 (human)
  • TNFAIP3 (human)
  • TRIAD3 (human)
Treatment
  • CpG
  • dexamethasone
  • double-stranded_RNA
  • dsDNA
  • KU-0063794
  • LPS
  • poly(dA:dT)
  • poly(I-C)
  • RO-3306
  • siRNA
  • virus infection
IRF3 (human) NtVDLHIsNsHPLsL S396-p
IRF3 (mouse) KTVDLHIsNSQPISL S388-p
IRF3 (rat) KTVDLHISNSQPISL S390
S398-p
VDLHIsNsHPLsLts
Upstream
Downstream
7 1
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • IKKE (human)
  • TBK1 (human)
Putative in vivo kinases:
  • IKKB (human)
  • TBK1 (human)
Treatment
  • virus infection
IRF3 (human) VDLHIsNsHPLsLts S398-p
IRF3 (mouse) VDLHIsNSQPISLtS S390
IRF3 (rat) VDLHISNSQPISLTS S392
S402-p
IsNsHPLsLtsDQYK
Upstream
Downstream
7 2
Effects on Modified Protein
  • activity, induced
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • IKKE (human)
  • TBK1 (human)
Putative in vivo kinases:
  • IKKB (human)
  • IKKE (human)
  • TBK1 (human)
Treatment
  • virus infection
IRF3 (human) IsNsHPLsLtsDQYK S402-p
IRF3 (mouse) IsNSQPISLtSDQYK S394
IRF3 (rat) ISNSQPISLTSDQYK S396
T404-p
NsHPLsLtsDQYKAY
Upstream
Downstream
7 1
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • TBK1 (human)
Putative in vivo kinases:
  • IKKB (human)
  • TBK1 (human)
Treatment
  • virus infection
IRF3 (human) NsHPLsLtsDQYKAY T404-p
IRF3 (mouse) NSQPISLtSDQYKAY T396-p
IRF3 (rat) NSQPISLTSDQYKAC T398
S405-p
sHPLsLtsDQYKAYL
Upstream
Downstream
6 0
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • TBK1 (human)
Putative in vivo kinases:
  • IKKB (human)
  • TBK1 (human)
Treatment
  • virus infection
IRF3 (human) sHPLsLtsDQYKAYL S405-p
IRF3 (mouse) SQPISLtSDQYKAYL S397
IRF3 (rat) SQPISLTSDQYKACL S399
-
under review
1 0
IRF3 (human) under review -
IRF3 (mouse) under review -
IRF3 (rat) VKRLVMVKVVPTCLK K361
-
under review
2 0
IRF3 (human) under review -
IRF3 (mouse) under review -
IRF3 (rat) VKRLVMVKVVPTCLK K361