Other Species / Isoforms
  TH (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
T3
_____MPTPSASSPQ
0 1
TH (human) _____MPtPDATTPQ T3-p
TH iso2 (human) _____MPTPDATTPQ T3
TH iso3 (human) _____MPTPDATTPQ T3
TH iso4 (human) _____MPTPDATTPQ T3
TH (mouse) _____MPTPSASSPQ T3
TH (rat) _____MPTPSAPsPQ T3
TH (cow) _____MPTPNAASPQ T3
S8
MPTPSASSPQPKGFR
5 1
TH (human) MPtPDATTPQAKGFR T8
TH iso2 (human) MPTPDATTPQAKGFR T8
TH iso3 (human) MPTPDATTPQAKGFR T8
TH iso4 (human) MPTPDATTPQAKGFR T8
TH (mouse) MPTPSASSPQPKGFR S8
TH (rat) MPTPSAPsPQPKGFR S8-p
TH (cow) MPTPNAASPQAKGFR S8
S19-p
KGFRRAVsEQDtKQA
Upstream
Downstream
44 13
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • neural plasticity
Putative upstream phosphatases:
  • PPP2CA (human)
Regulatory protein:
  • AHCYL1 (human)
  • IREB2 (mouse)
  • SNCA (human)
  • SNCA (mouse)
Treatment
  • fostriecin
  • LPA
  • okadaic_acid
  • raclopride
  • tyrosine
TH (human) KGFRRAVsELDAKQA S19-p
TH iso2 (human) KGFRRAVsELDAKQA S19-p
TH iso3 (human) KGFRRAVsELDAKQA S19-p
TH iso4 (human) KGFRRAVsELDAKQA S19-p
TH (mouse) KGFRRAVsEQDtKQA S19-p
TH (rat) KGFRRAVsEQDAKQA S19-p
TH (cow) KGFRRAVsELDAKQA S19-p
T23-p
RAVsEQDtKQAEAVt
Upstream
0 1
Treatment
  • LPA
TH (human) RAVsELDAKQAEAIM A23
TH iso2 (human) RAVsELDAKQAEAIM A23
TH iso3 (human) RAVsELDAKQAEAIM A23
TH iso4 (human) RAVsELDAKQAEAIM A23
TH (mouse) RAVsEQDtKQAEAVt T23-p
TH (rat) RAVsEQDAKQAEAVT A23
TH (cow) RAVsELDAKQAEAIM A23
T30-p
tKQAEAVtsPRFIGR
Upstream
0 1
Treatment
  • LPA
TH (human) AKQAEAIMVRGQGAP M30
TH iso2 (human) AKQAEAIMGAPGPSL M30
TH iso3 (human) AKQAEAIMsPRFIGR M30
TH iso4 (human) AKQAEAIMVRGQsPR M30
TH (mouse) tKQAEAVtsPRFIGR T30-p
TH (rat) AKQAEAVTsPRFIGR T30
TH (cow) AKQAEAIMsPRFVGR M30
S31-p
KQAEAVtsPRFIGRR
Upstream
Downstream
40 7
TH (mouse)
S31-p
TH (rat)
S31-p
Effects on Modified Protein
  • enzymatic activity, induced
  • protein stabilization
Effects on Biological Processes:
  • neural plasticity
Kinase, in vitro:
  • CDK5 (human)
  • ERK1 (human)
  • ERK2 (human)
Putative in vivo kinases:
  • CDK5 (mouse)
  • ERK1 (mouse)
  • ERK2 (mouse)
Regulatory protein:
  • CLOCK (mouse)
  • IREB2 (mouse)
  • PPP2R5A (mouse)
  • SNCA (mouse)
Treatment
  • clozapine
  • depolarization
  • eticlopride
  • haloperidol
  • phorbol_ester
  • raclopride
  • seliciclib
  • SL327
  • tyrosine
  • U0126
TH (human) SYTPTPRsPRFIGRR S62-p
TH iso2 (human) SYTPTPRsPRFIGRR S58-p
TH iso3 (human) KQAEAIMsPRFIGRR S31-p
TH iso4 (human) AIMVRGQsPRFIGRR S35-p
TH (mouse) KQAEAVtsPRFIGRR S31-p
TH (rat) KQAEAVTsPRFIGRR S31-p
TH (cow) KQAEAIMsPRFVGRR S31-p
S40-p
RFIGRRQsLIEDARK
Upstream
Downstream
58 16
TH (human)
S71-p
TH iso2 (human)
S67-p
TH iso3 (human)
S40-p
TH iso4 (human)
S44-p
TH (mouse)
S40-p
TH (rat)
S40-p
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • neural plasticity
Kinase, in vitro:
  • PKACA (human)
Putative upstream phosphatases:
  • PPP2CA (mouse)
Regulatory protein:
  • GH receptor (mouse)
  • IREB2 (mouse)
  • PPP2R5A (mouse)
  • SNCA (human)
  • SNCA (mouse)
Treatment
  • caffeine
  • CGS_21680
  • clozapine
  • colforsin
  • eticlopride
  • haloperidol
  • isoflurane
  • ketamine
  • leptin
  • okadaic_acid
  • papaverine
  • phorbol_ester
  • propofol
  • quinpirole
  • raclopride
  • rolipram
  • rottlerin
  • SL327
  • tyrosine
TH (human) RFIGRRQsLIEDARK S71-p
TH iso2 (human) RFIGRRQsLIEDARK S67-p
TH iso3 (human) RFIGRRQsLIEDARK S40-p
TH iso4 (human) RFIGRRQsLIEDARK S44-p
TH (mouse) RFIGRRQsLIEDARK S40-p
TH (rat) RFIGRRQsLIEDARK S40-p
TH (cow) RFVGRRQsLIQDARK S40-p
S88
AVLNLLFSLRGTKPS
0 1
TH (human) AVLNLLFsPRATKPS S118-p
TH iso2 (human) AVLNLLFSPRATKPS S114
TH iso3 (human) AVLNLLFSPRATKPS S87
TH iso4 (human) AVLNLLFSPRATKPS S91
TH (mouse) AVLNLLFSLRGTKPS S88
TH (rat) AVLNLLFSLRGTKPS S88
TH (cow) AVLTLLFALPPTRPP A81
S153
LSSVRRVSDDVRSAR
1 0
TH (human) LSGVRQVSEDVRSPA S183
TH iso2 (human) LSGVRQVSEDVRSPA S179
TH iso3 (human) LSGVRQVSEDVRSPA S152
TH iso4 (human) LSGVRQVSEDVRSPA S156
TH (mouse) LSSVRRVSDDVRSAR S153
TH (rat) LSSVRRVsDDVRSAR S153-p
TH (cow) LSALRRVAEDVRAAG A146
Y200
PGFSDQAYRQRRKLI
0 1
TH (human) PGFSDQVyRQRRKLI Y230-p
TH iso2 (human) PGFSDQVYRQRRKLI Y226
TH iso3 (human) PGFSDQVYRQRRKLI Y199
TH iso4 (human) PGFSDQVYRQRRKLI Y203
TH (mouse) PGFSDQAYRQRRKLI Y200
TH (rat) PGFSDQVYRQRRKLI Y200
TH (cow) PGFSDQAYRQRRKLI Y193
Y389
QNGELKAYGAGLLSS
0 1
TH (human) QNGEVKAyGAGLLSS Y419-p
TH iso2 (human) QNGEVKAYGAGLLSS Y415
TH iso3 (human) QNGEVKAYGAGLLSS Y388
TH iso4 (human) QNGEVKAYGAGLLSS Y392
TH (mouse) QNGELKAYGAGLLSS Y389
TH (rat) QNGELKAYGAGLLSS Y389
TH (cow) QNGEVKAYGAGLLSS Y382
S405
GELLHSLSEEPEVRA
1 0
TH (human) GELLHCLSEEPEIRA S435
TH iso2 (human) GELLHCLSEEPEIRA S431
TH iso3 (human) GELLHCLsEEPEIRA S404-p
TH iso4 (human) GELLHCLSEEPEIRA S408
TH (mouse) GELLHSLSEEPEVRA S405
TH (rat) GELLHSLSEEPEVRA S405
TH (cow) GELLHSLSEEPEIRA S398
S472-p
LAIDVLDsPHTIRRS
0 4
TH (human) LAIDVLDsPQAVRRS S502-p
TH iso2 (human) LAIDVLDSPQAVRRS S498
TH iso3 (human) LAIDVLDSPQAVRRS S471
TH iso4 (human) LAIDVLDSPQAVRRS S475
TH (mouse) LAIDVLDsPHTIRRS S472-p
TH (rat) LAIDVLDsPHTIQRS S472-p
TH (cow) LAIDVLDSPHAIRHA S465