Other Species / Isoforms
  MLKL (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S52-p
LQDQGKRsVPSEKLt
0 2
MLKL (human) LQDQGKRsVPSEKLt S52-p
MLKL (mouse) LQAQGKKNLPDDITA N52
MLKL (rat) LQAQEKKSLPSDITA S52
T59-p
sVPSEKLtTAMNRFK
0 2
MLKL (human) sVPSEKLtTAMNRFK T59-p
MLKL (mouse) KNLPDDITAALGRFD T58
MLKL (rat) KSLPSDITAALGRFE T58
K78
EANGEIEKFSNRSNI
0 1
MLKL (human) EANGEIEKFSNRSNI K78
MLKL (mouse) EANQQIEkFsKKSHI K77-ac
MLKL (rat) EARQQIEKFSQKSNI K77
S80
NGEIEKFSNRSNICR
0 1
MLKL (human) NGEIEKFSNRSNICR S80
MLKL (mouse) NQQIEkFsKKSHIWK S79-p
MLKL (rat) RQQIEKFSQKSNIWK S79
S92-p
ICRFLTAsQDKILFK
0 1
MLKL (human) ICRFLTAsQDKILFK S92-p
MLKL (mouse) WKFVSVGNDKILFHE N92
MLKL (rat) WKFATVGSDKILFHE S92
S106-p
KDVNRKLsDVWKELS
0 2
MLKL (human) KDVNRKLsDVWKELS S106-p
MLKL (mouse) HEVNEKLRDVWEELL R105
MLKL (rat) HEVNEKLRDIWEELL R105
S125-p
VEQRMPVsPIsQGAS
Upstream
1 19
Treatment
  • nocodazole
MLKL (human) VEQRMPVsPIsQGAS S125-p
MLKL (mouse) VYHWNTVsDVSQPAS S124-p
MLKL (rat) VDQWKSDSEVSQPAS S124
S128-p
RMPVsPIsQGASWAQ
0 1
MLKL (human) RMPVsPIsQGASWAQ S128-p
MLKL (mouse) WNTVsDVSQPASWQQ S127
MLKL (rat) WKSDSEVSQPASWQQ S127
S161-p
DNEKIEAsLRRLEIN
0 2
MLKL (human) DNEKIEAsLRRLEIN S161-p
MLKL (mouse) GNENMKVILMQLQIs I151
MLKL (rat) GNENMKVILVKLQIS I151
N168
sLRRLEINMKEIkET
1 1
MLKL (human) sLRRLEINMKEIkET N168
MLKL (mouse) ILMQLQIsVEEINKT S158-p
MLKL (rat) ILVKLQISMEEIKEA S158
K173-ub
EINMKEIkETLRQYL
0 1
MLKL (human) EINMKEIkETLRQYL K173-ub
MLKL (mouse) QIsVEEINKTLKQCS N163
MLKL (rat) QISMEEIKEALKQCS K163
S239
FKKLQAGSIAIVRQt
1 1
MLKL (human) FKKLQAGSIAIVRQt S239
MLKL (mouse) FNNPQAEsVGIVRFT S228-p
MLKL (rat) FNNPKAESVGIVRLT S228
T246-p
SIAIVRQtFNKEIKT
0 1
MLKL (human) SIAIVRQtFNKEIKT T246-p
MLKL (mouse) sVGIVRFTFNDEIKT T235
MLKL (rat) SVGIVRLTFNEEIKT T235
S259
KTMKKFESPNILRIF
1 1
MLKL (human) KTMKKFESPNILRIF S259
MLKL (mouse) KTMKKFDsPNILRIF S248-p
MLKL (rat) KTMKKFDSPNILRIF S248
T302-p
LDREKDLtLGKRMVL
0 1
MLKL (human) LDREKDLtLGKRMVL T302-p
MLKL (mouse) LDREKDLTMSVRSLL T291
MLKL (rat) LDRDKDLTMSVRSLL T291
K331-ub
EAPELHGkIRsSNFL
0 3
MLKL (human) EAPELHGkIRsSNFL K331-ub
MLKL (mouse) HSETLHRNISSSSFL N318
MLKL (rat) HSGTLHGNISSSSFL N318
S334-p
ELHGkIRsSNFLVTQ
0 1
MLKL (human) ELHGkIRsSNFLVTQ S334-p
MLKL (mouse) TLHRNISSSSFLVAG S321
MLKL (rat) TLHGNISSSSFLVAG S321
K354-ac
LAGFELRkTQtsMSL
0 2
MLKL (human) LAGFELRkTQtsMSL K354-ac
MLKL (mouse) LAGFELSKTQNsIsR K341
MLKL (rat) LAGFELSKTQTSISR K341
T357-p
FELRkTQtsMSLGTt
Upstream
Downstream
5 1
Effects on Modified Protein
  • intracellular localization
  • protein conformation
Putative in vivo kinases:
  • RIPK3 (human)
MLKL (human) FELRkTQtsMSLGTt T357-p
MLKL (mouse) FELSKTQNsIsRtAK N344
MLKL (rat) FELSKTQTSISRATK T344
S358-p
ELRkTQtsMSLGTtR
Upstream
Downstream
17 1
MLKL (human)
S358-p
MLKL (mouse)
S345-p
Effects on Modified Protein
  • intracellular localization
  • protein conformation
Putative in vivo kinases:
  • RIPK3 (human)
MLKL (human) ELRkTQtsMSLGTtR S358-p
MLKL (mouse) ELSKTQNsIsRtAKS S345-p
MLKL (rat) ELSKTQTSISRATKS S345
S360
RkTQtsMSLGTtREK
1 1
MLKL (human) RkTQtsMSLGTtREK S360
MLKL (mouse) SKTQNsIsRtAKSTK S347-p
MLKL (rat) SKTQTSISRATKSTK S347
T363
QtsMSLGTtREKTDR
1 2
MLKL (human) QtsMSLGTtREKTDR T363
MLKL (mouse) TQNsIsRtAKSTKAE T349-p
MLKL (rat) TQTSISRATKSTKAE A349
T364-p
tsMSLGTtREKTDRV
0 1
MLKL (human) tsMSLGTtREKTDRV T364-p
MLKL (mouse) QNsIsRtAKSTKAER A350
MLKL (rat) QTSISRATKSTKAER T350
K372-ub
REKTDRVkstAYLSP
0 1
MLKL (human) REKTDRVkstAYLSP K372-ub
MLKL (mouse) STKAERSSstIYVSP S359
MLKL (rat) STKAERFSSTAYVSP S359
S373-p
EKTDRVkstAYLSPQ
0 2
MLKL (human) EKTDRVkstAYLSPQ S373-p
MLKL (mouse) TKAERSSstIYVSPE S360-p
MLKL (rat) TKAERFSSTAYVSPE S360
T374-p
KTDRVkstAYLSPQE
0 2
MLKL (human) KTDRVkstAYLSPQE T374-p
MLKL (mouse) KAERSSstIYVSPER T361-p
MLKL (rat) KAERFSSTAYVSPER T361
S393-p
FYQYDVKsEIYSFGI
0 1
MLKL (human) FYQYDVKsEIYSFGI S393-p
MLKL (mouse) FCLYDIKAEIYSFGI A380
MLKL (rat) FCKYDTKAEIYSFGI A380
S417-p
IPFQGCNsEKIRKLV
0 1
MLKL (human) IPFQGCNsEKIRKLV S417-p
MLKL (mouse) IPFEGCDSKKIRELV S404
MLKL (rat) IPFEGCDSEKIYELV S404
S454
ECRAHDPSVRPSVDE
1 0
MLKL (human) ECRAHDPSVRPSVDE S454
MLKL (mouse) ECRAHEPsQRPSVDG S441-p
MLKL (rat) ECRAHEPSNRPSADG S441