Other Species / Isoforms
  TNK1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S60
RPAQRRLsEALKRLR
0 3
TNK1 (human) RPAQRRLsEALKRLR S60
TNK1 iso2 (human) RPAQRRLSEALKRLR S60
TNK1 (mouse) RPAQRRLNEALKRYR N60
TNK1 iso2 (mouse) RPAQRRLNEALKRYR N60
TNK1 (rat) RPAQRRLTEALKRYR T60
S68
EALKRLRsGPKSKNW
Upstream
0 1
Treatment
  • nocodazole
TNK1 (human) EALKRLRsGPKSKNW S68
TNK1 iso2 (human) EALKRLRSGPKSKNW S68
TNK1 (mouse) EALKRYRSGVKSKNW S68
TNK1 iso2 (mouse) EALKRYRSGVKSKNW S68
TNK1 (rat) EALKRYRSGVKSKNW S68
Y77
PKSKNWVyKILGGFA
0 4
TNK1 (human) PKSKNWVyKILGGFA Y77
TNK1 iso2 (human) PKSKNWVYKILGGFA Y77
TNK1 (mouse) VKSKNWVYKILGGFA Y77
TNK1 iso2 (mouse) VKSKNWVYKILGGFA Y77
TNK1 (rat) VKSKNWVYKILGGFA Y77
S94
HKEPTLPsDsPRHLP
0 1
TNK1 (human) HKEPTLPsDsPRHLP S94
TNK1 iso2 (human) HKEPTLPSDSPRHLP S94
TNK1 (mouse) QKEIPPRSDSPLCFH S94
TNK1 iso2 (mouse) QKEIPPRSDSPLCFH S94
TNK1 (rat) QKEIPPYSDSLPHLH S94
S96
EPTLPsDsPRHLPEP
Upstream
0 7
Treatment
  • MG132_withdrawal
  • nocodazole
  • thymidine
TNK1 (human) EPTLPsDsPRHLPEP S96
TNK1 iso2 (human) EPTLPSDSPRHLPEP S96
TNK1 (mouse) EIPPRSDSPLCFHEP S96
TNK1 iso2 (mouse) EIPPRSDSPLCFHEP S96
TNK1 (rat) EIPPYSDSLPHLHEP S96
S139
RGLWTLPsGKSVPVA
0 1
TNK1 (human) RGLWTLPsGKSVPVA S139
TNK1 iso2 (human) RGLWTLPSGKSVPVA S139
TNK1 (mouse) RGLWTLPSGQSIPVA S139
TNK1 iso2 (mouse) RGLWTLPSGQSIPVA S139
TNK1 (rat) QGLWTLPGGQSIPVA G139
T209
GSLHARLtAPAPtPP
0 1
TNK1 (human) GSLHARLtAPAPtPP T209
TNK1 iso2 (human) GSLHARLTAPAPTPP T209
TNK1 (mouse) GSLHARLTAPAPTPP T209
TNK1 iso2 (mouse) GSLHARLTAPAPTPP T209
TNK1 (rat) GSLHARLTAPAPMPP T209
T214
RLtAPAPtPPLLVAL
0 1
TNK1 (human) RLtAPAPtPPLLVAL T214
TNK1 iso2 (human) RLTAPAPTPPLLVAL T214
TNK1 (mouse) RLTAPAPTPPLPVAL T214
TNK1 iso2 (mouse) RLTAPAPTPPLPVAL T214
TNK1 (rat) RLTAPAPMPPLPVTL M214
Y235
QLAGAMAyLGARGLV
0 3
TNK1 (human) QLAGAMAyLGARGLV Y235
TNK1 iso2 (human) QLAGAMAYLGARGLV Y235
TNK1 (mouse) QLAGAMAYLGSCGLV Y235
TNK1 iso2 (mouse) QLAGAMAYLGSCGLV Y235
TNK1 (rat) QLAGAMAYLGSCGLV Y235
T248
LVHRDLAtRNLLLAs
0 1
TNK1 (human) LVHRDLAtRNLLLAs T248
TNK1 iso2 (human) LVHRDLATRNLLLAS T248
TNK1 (mouse) LVHRDLATRNLLLAS T248
TNK1 iso2 (mouse) LVHRDLATRNLLLAS T248
TNK1 (rat) LVHRDLATRNLLLAS T248
S255
tRNLLLAsPRtIKVA
Upstream
0 8
Treatment
  • nocodazole
  • thymidine
TNK1 (human) tRNLLLAsPRtIKVA S255
TNK1 iso2 (human) TRNLLLASPRTIKVA S255
TNK1 (mouse) TRNLLLASPRMIKVA S255
TNK1 iso2 (mouse) TRNLLLASPRMIKVA S255
TNK1 (rat) TRNLLLASPRKIKVA S255
T258
LLLAsPRtIKVADFG
0 1
TNK1 (human) LLLAsPRtIKVADFG T258
TNK1 iso2 (human) LLLASPRTIKVADFG T258
TNK1 (mouse) LLLASPRMIKVADFG M258
TNK1 iso2 (mouse) LLLASPRMIKVADFG M258
TNK1 (rat) LLLASPRKIKVADFG K258
Y277
LGGARGRyVMGGPRP
1 4
TNK1 (human)
Y277
TNK1 iso2 (human)
Y277
TNK1 (mouse)
Y277
TNK1 iso2 (mouse)
Y277
TNK1 (rat)
Y277
TNK1 (human) LGGARGRyVMGGPRP Y277
TNK1 iso2 (human) LGGARGRYVMGGPRP Y277
TNK1 (mouse) LGGARGRYVMGGPRP Y277
TNK1 iso2 (mouse) LGGARGRYVMGGPRP Y277
TNK1 (rat) LGGARGRYVMGGPRP Y277
Y287
GGPRPIPyAWCAPES
0 3
TNK1 (human) GGPRPIPyAWCAPES Y287
TNK1 iso2 (human) GGPRPIPYAWCAPES Y287
TNK1 (mouse) GGPRPIPYAWCAPES Y287
TNK1 iso2 (mouse) GGPRPIPYAWCAPES Y287
TNK1 (rat) GGPRPIPYAWCAPES Y287
Y353
PLCSRALysLALRCW
Upstream
0 4
Treatment
  • MG132_withdrawal
TNK1 (human) PLCSRALysLALRCW Y353
TNK1 iso2 (human) PLCSRALYSLALRCW Y353
TNK1 (mouse) PLCSRALYSLALRCW Y354
TNK1 iso2 (mouse) PLCSRALYSLALRCW Y354
TNK1 (rat) ALCSRALYSLALRCW Y354
S354
LCSRALysLALRCWA
Upstream
0 1
Treatment
  • MG132_withdrawal
TNK1 (human) LCSRALysLALRCWA S354
TNK1 iso2 (human) LCSRALYSLALRCWA S354
TNK1 (mouse) LCSRALYSLALRCWA S355
TNK1 iso2 (mouse) LCSRALYSLALRCWA S355
TNK1 (rat) LCSRALYSLALRCWA S355
S411
PITVIEGSSSFHSPD
0 3
TNK1 (human) PITVIEGSSSFHSPD S411
TNK1 iso2 (human) PITVIEGsPDSTIWK S411
TNK1 (mouse) PITIIEGSLDTATWK S412
TNK1 iso2 (mouse) gap -
TNK1 (rat) PITIIEGSPDTTTWK S412
S468
RGDQHPGsIDGDRKK
Upstream
0 6
Treatment
  • MG132_withdrawal
TNK1 (human) RGDQHPGsIDGDRKK S468
TNK1 iso2 (human) RGDQHPGSIDGDRKK S463
TNK1 (mouse) HGEKCRGGTDGDREK G464
TNK1 iso2 (mouse) gap -
TNK1 (rat) RGEKYRGGTDGDREK G464
S500
LERMKGIsRsLEsVL
0 1
TNK1 (human) LERMKGIsRsLEsVL S500
TNK1 iso2 (human) LERMKGISRSLESVL S495
TNK1 (mouse) LQRMRGISKsLESVL S496
TNK1 iso2 (mouse) gap -
TNK1 (rat) LQRMKGISKsLESVL S496
S502
RMKGIsRsLEsVLsL
Upstream
Downstream
1 28
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • cell growth, inhibited
Kinase, in vitro:
  • Chk1 (human)
  • MARK1 (human)
  • MARK3 (human)
Putative in vivo kinases:
  • MARK4 (human)
Treatment
  • BMS-345541
  • dasatinib
  • KN-92
  • KN-93
  • LJI-308
  • MRT67307
  • siRNA
  • STO-609
TNK1 (human) RMKGIsRsLEsVLsL S502
TNK1 iso2 (human) RMKGISRSLESVLSL S497
TNK1 (mouse) RMRGISKsLESVLSL S498
TNK1 iso2 (mouse) gap -
TNK1 (rat) RMKGISKsLESVLSL S498
S505
GIsRsLEsVLsLGPR
0 2
TNK1 (human) GIsRsLEsVLsLGPR S505
TNK1 iso2 (human) GISRSLESVLSLGPR S500
TNK1 (mouse) GISKsLESVLSLGPR S501
TNK1 iso2 (mouse) gap -
TNK1 (rat) GISKsLESVLSLGPR S501
S508
RsLEsVLsLGPRPtG
0 3
TNK1 (human) RsLEsVLsLGPRPtG S508
TNK1 iso2 (human) RSLESVLSLGPRPTG S503
TNK1 (mouse) KsLESVLSLGPRPtG S504
TNK1 iso2 (mouse) gap -
TNK1 (rat) KsLESVLSLGPRPAG S504
T514
LsLGPRPtGGGssPP
0 9
TNK1 (human) LsLGPRPtGGGssPP T514
TNK1 iso2 (human) LSLGPRPTGGGSSPP T509
TNK1 (mouse) LSLGPRPtGGGSSPP T510
TNK1 iso2 (mouse) gap -
TNK1 (rat) LSLGPRPAGGGSSPP A510
S518
PRPtGGGssPPEIRQ
0 3
TNK1 (human) PRPtGGGssPPEIRQ S518
TNK1 iso2 (human) PRPTGGGSSPPEIRQ S513
TNK1 (mouse) PRPtGGGSSPPELRR S514
TNK1 iso2 (mouse) gap -
TNK1 (rat) PRPAGGGSSPPELRR S514
S519
RPtGGGssPPEIRQA
Upstream
0 14
Treatment
  • ischemia
  • selumetinib
  • vemurafenib
TNK1 (human) RPtGGGssPPEIRQA S519
TNK1 iso2 (human) RPTGGGSSPPEIRQA S514
TNK1 (mouse) RPtGGGSSPPELRRT S515
TNK1 iso2 (mouse) gap -
TNK1 (rat) RPAGGGSSPPELRRG S515
S546
RPPLSSSsPQPsQPs
0 1
TNK1 (human) RPPLSSSsPQPsQPs S546
TNK1 iso2 (human) RPPLSSSSPQPSQPS S541
TNK1 (mouse) RPPIICNSSQPTQPH S549
TNK1 iso2 (mouse) gap -
TNK1 (rat) PRPPIICSSQPIQPH S550
S550
SSSsPQPsQPsRERL
0 1
TNK1 (human) SSSsPQPsQPsRERL S550
TNK1 iso2 (human) SSSSPQPSQPSRERL S545
TNK1 (mouse) ICNSSQPTQPHKARP T553
TNK1 iso2 (mouse) gap -
TNK1 (rat) IICSSQPIQPHRVRP I554
S553
sPQPsQPsRERLPWP
0 1
TNK1 (human) sPQPsQPsRERLPWP S553
TNK1 iso2 (human) SPQPSQPSRERLPWP S548
TNK1 (mouse) SSQPTQPHKARPKRE H556
TNK1 iso2 (mouse) gap -
TNK1 (rat) SSQPIQPHRVRPKRE H557
S582
ARKAAALsGGLLsDP
0 3
TNK1 (human) ARKAAALsGGLLsDP S582
TNK1 iso2 (human) ARKAAALSGGLLSDP S577
TNK1 (mouse) ASKATVPSGGPLSDP S582
TNK1 iso2 (mouse) gap -
TNK1 (rat) SSKVTIPPGGPLSDS P583
S587
ALsGGLLsDPELQRK
0 1
TNK1 (human) ALsGGLLsDPELQRK S587
TNK1 iso2 (human) ALSGGLLSDPELQRK S582
TNK1 (mouse) VPSGGPLSDPEWQRK S587
TNK1 iso2 (mouse) gap -
TNK1 (rat) IPPGGPLSDSEWQRK S588
T612
VTHQECQtALGATGG
0 1
TNK1 (human) VTHQECQtALGATGG T612
TNK1 iso2 (human) VTHQECQTALGATGG T607
TNK1 (mouse) VTYQECQVALRTTGG V612
TNK1 iso2 (mouse) gap -
TNK1 (rat) VTYQECQMALRTMGG M613
Y651
CWRILEHyQWDLSAA
0 1
TNK1 (human) CWRILEHyQWDLSAA Y651
TNK1 iso2 (human) CWRILEHYQWDLSAA Y646
TNK1 (mouse) CRRILEHHQWDLSAA H651
TNK1 iso2 (mouse) gap -
TNK1 (rat) CRRILEHHHWDLSAA H652
S659
QWDLSAAsRyVLARP
0 1
TNK1 (human) QWDLSAAsRyVLARP S659
TNK1 iso2 (human) QWDLSAASRYVLARP S654
TNK1 (mouse) QWDLSAASRYILARS S659
TNK1 iso2 (mouse) gap -
TNK1 (rat) HWDLSAASRYVLARS S660
Y661
DLSAAsRyVLARP__
Upstream
0 44
Treatment
  • MG132
TNK1 (human) DLSAAsRyVLARP__ Y661
TNK1 iso2 (human) DLSAASRYVLARP__ Y656
TNK1 (mouse) DLSAASRYILARS__ Y661
TNK1 iso2 (mouse) gap -
TNK1 (rat) DLSAASRYVLARS__ Y662